Use of voriconazole to predict susceptibility and resistance to isavuconazole for Aspergillus fumigatus using CLSI methods and interpretive criteria

High rate of agreement suggests vori susceptibility can predict isa susceptibility in A fumigatus w/ CLSI AFST

journals.asm.org/doi/10.1128/...

In today’s MMWR, largest blastomycosis outbreak in 🇺🇸:

-162 cases in a single paper mill in Michigan (20% of all employees)
-Primarily 🫁 symptoms
-18 (12%) 🏥, 1 death
-0 environmental samples of mill were PCR pos for blasto

#IDSky

www.cdc.gov/mmwr/volumes...

Strategy for penicillin allergy delabeling by non-allergists

For very low risk non-allergic index reactions, direct delabeling w/o testing is reasonable whereas a single step challenge may be considered for patients who are anxious or desire additional reassurance.

doi.org/10.1016/j.ja...

#IDSky

My new book, Everything Is Tuberculosis, explores the history of our deadliest infectious disease. It's also about our horrifying present: TB still kills kills over a million people per year, even though it's been curable since the 1950s.

Signed copies can be ordered at everythingistb.com

My Top 5 Antibiotic Allergy Papers - #5
▶️Gadde et al. JAMA 1993; 270 (20)
▶️ A paper before its time. Skin testing for #penicillinallergy in patients with ID indication!
▶️ 7.1% + ; PPL & MDM utilisation; safety (1/128+ required adrenaline); Allergy LOSS WITH TIME.
jamanetwork.com/journals/jam...