Our miRNA story is now in @science.org ! We found a microRNA, not a protein, that finally solved a long-standing evolutionary mystery of wing coloration in butterflies and moths. (1/n)
www.science.org/doi/10.1126/...

Hofstenia miamia is an emerging model species for regeneration and embryology. We report this in-depth identification and developmental profiling of Hofstenia microRNAs.

📢 Preprint! How does the environment of a father before conception influence offspring?

Even more, how do paternal genetics & ages interact with exposures to affect F1 outcome?

We tested this systematically, with intriguing findings & some cautionary tales🧵...

www.biorxiv.org/content/10.1...

And another new preprint from the lab, led by S. Paul, K. Ilkhani, and N. Strozewski, in collaboration with Shvartsman lab: we identify ERK-dependent phosphosites in Capicua (Cic), and show in vivo that mutating these sites turns Cic into a “super-repressor”.
www.biorxiv.org/content/10.1...

New preprint from the lab, led by Melissa Brown: we uncover a function for #Drosophila Minibrain/DYRK1A in the neuroepithelium, and show that Mnb engages the Reps/Rlip/Rala signaling network to control brain development.
www.biorxiv.org/content/10.1...

It's finally out! Our second single cell "atlas", this time of the mouse seminal vesicle -- probably the last major tissue in mammals to be subject to single cell RNA-seq. 1/n (let's see if I can figure out threading on bsky)

doi.org/10.1101/2024...

Mutations in Argonaute proteins can significantly disrupt the miRNA biogenesis and functionality in target repression, and cause neurodevelopmental diseases. But how? Check out our new paper about modeling Argonaute Syndrome in C. elegans.👇👇👇👇
www.pnas.org/doi/10.1073/...

Sometimes I come across a paper that reinforces all over again why I found/find biology so fascinating. This answers a question my son asked me once when he was young. Had no answer for him then but will forward him this!
www.nature.com/articles/s41...

Hello fly people!! The 2024 Fly Board election ballots are live. I am running for President, and would be privileged and humbled to serve our community and advocate for fly research. My statement is linked below. But all candidates are great, please vote/RT! 🪰

genetics-gsa.org/2024-fly-ele...

Cell biology is .... truly awesome.

My take on what cell biology means to me in the latest issue of Cell celebrating their 50 years. I really enjoyed reading the pieces from everyone. authors.elsevier.com/c/1iS4aL7PXm...

Big day for the Ogden Lab! Today is my 15th anniversary of having a lab at St. Jude Children's Research Hospital - AND - Our latest paper led by @erichall.bsky.social just dropped! Interested in cell communication and tissue development? If so, ✔️ it out! 🧪 👩‍🔬

www.cell.com/cell/fulltex...

A great bunch of folks did this, but I have to mostly highlight the incomparable Qiangzong Yin. Also kudos and thanks to JM Peters, with a very complementary MS on sperm 3D structure...we cosubmitted with them and had nothing but a wonderful and open experience with them. Happy Holidays y'all!!
n/n

Hey hey! It's finally out, almost a year to the day after we posted the preprint! I've already done a short Skytorial on this, but the upshot is that we think most, if not all, measures of mouse sperm chromatin are artifacts of cell-free DNA. 1/n

doi: 10.1101/gr.277845.123

over a decade ago, Hong Duan and Josh Kavaler figured out that KO of Drosophila mir-279/996, encoding related seed members with overlapping function, selectively obliterates development of "Johnston's Organ" (JO), the insect auditory center (i.e. "ear"). 2/5

A nice review by Hugo Bellen and colleagues on the use of model organisms (flies, worms, zebrafish) for functional analysis of human rare genetic diseases
#Drosophila
www.nature.com/articles/s41...