Heini M Natri
@heinimnatri.bsky.social
Research Assistant Professor within the Division of Bioinnovation and Genome Sciences at the Translational Genomics Research Institute, part of City of Hope. heinin.github.io
Reposted by Heini M Natri
A #ScienceSignaling study examines the activities of ligand-based #CARTcells and shows they induce proliferative signaling events within target cells, a finding that has implications for the design and application of future CAR T cells in the clinic. https://scim.ag/47CxSMB
CSF1R-CAR T cells induce CSF1R signaling and can promote target cell proliferation
Chimeric antigen receptor–stimulated responses in target cells may affect target cell clearance by CAR T cells.
scim.ag
November 12, 2025 at 4:00 PM
A #ScienceSignaling study examines the activities of ligand-based #CARTcells and shows they induce proliferative signaling events within target cells, a finding that has implications for the design and application of future CAR T cells in the clinic. https://scim.ag/47CxSMB
I was interviewed for an article about autism and the gut microbiome published yesterday in @science.org. Check it out! www.science.org/content/arti...
Research linking gut microbes to autism is deeply flawed, critics say
Amid growing investment in the field, a new paper argues it rests on shaky foundations
www.science.org
November 14, 2025 at 5:45 PM
I was interviewed for an article about autism and the gut microbiome published yesterday in @science.org. Check it out! www.science.org/content/arti...
What a great webinar featuring @drmbothapsych.bsky.social. An important reminder: dehumanization of autistic people and moral disengagement motivate remediation. pmc.ncbi.nlm.nih.gov/articles/PMC...
November 14, 2025 at 5:39 PM
What a great webinar featuring @drmbothapsych.bsky.social. An important reminder: dehumanization of autistic people and moral disengagement motivate remediation. pmc.ncbi.nlm.nih.gov/articles/PMC...
Our work was highlighted by @jguerriero.bsky.social at #SITC25 today, session "Cellular Therapies for Solid Tumors, Cell Therapies beyond CAR T Cells." Check out the pre-print on BioRxiv! @sitcancer.bsky.social @sgholamin.bsky.social @nebanovich.bsky.social
November 8, 2025 at 10:26 PM
Our work was highlighted by @jguerriero.bsky.social at #SITC25 today, session "Cellular Therapies for Solid Tumors, Cell Therapies beyond CAR T Cells." Check out the pre-print on BioRxiv! @sitcancer.bsky.social @sgholamin.bsky.social @nebanovich.bsky.social
Excited to be attending my first SITC Annual Meeting! On Friday, Brandon Fischer from @nebanovich.bsky.social will present a poster on some of our work on Chlorotoxin CAR T cells. Check it out! #SITC25
November 6, 2025 at 5:16 PM
Excited to be attending my first SITC Annual Meeting! On Friday, Brandon Fischer from @nebanovich.bsky.social will present a poster on some of our work on Chlorotoxin CAR T cells. Check it out! #SITC25
Reposted by Heini M Natri
#SITC25 Science Preview: Examine immune regulatory subsets in tumors with Jennifer Guerriero, PhD, Sergio Quezada, PhD, UCL News, @bcellbruno.bsky.social, Florent Ginhoux, PhD and Aurélien Marabelle, MD, PhD Gustave Roussy 🏥 View session details: https://ow.ly/TqBo50XgUsp
October 23, 2025 at 6:02 PM
#SITC25 Science Preview: Examine immune regulatory subsets in tumors with Jennifer Guerriero, PhD, Sergio Quezada, PhD, UCL News, @bcellbruno.bsky.social, Florent Ginhoux, PhD and Aurélien Marabelle, MD, PhD Gustave Roussy 🏥 View session details: https://ow.ly/TqBo50XgUsp
Reposted by Heini M Natri
In every civilization, people end up sorted into levels of socio-economic status (SES). We explore the history, present, and future of scientific research on the complicated relationship between SES and DNA in @naturehumbehav.bsky.social💰🧬🎓
Link: rdcu.be/efacK
Thread below 👇🏽
Link: rdcu.be/efacK
Thread below 👇🏽
March 26, 2025 at 11:16 AM
In every civilization, people end up sorted into levels of socio-economic status (SES). We explore the history, present, and future of scientific research on the complicated relationship between SES and DNA in @naturehumbehav.bsky.social💰🧬🎓
Link: rdcu.be/efacK
Thread below 👇🏽
Link: rdcu.be/efacK
Thread below 👇🏽
Reposted by Heini M Natri
I wrote about how genetic risk works in the context of embryo selection and how people often think about it all wrong. A short 🧵:
What we talk about when we talk about risk
How embryo selection exploits our flawed intuitions about risk
open.substack.com
August 10, 2025 at 7:08 PM
I wrote about how genetic risk works in the context of embryo selection and how people often think about it all wrong. A short 🧵:
Reposted by Heini M Natri
The use of dichotomized labels for traits that are actually continuous has bothered me ever since I started working on complex trait genetics. Sasha's blog post provides an excellent explanation of why this matters in the context of polygenic risk and embryo selection.
I wrote about how genetic risk works in the context of embryo selection and how people often think about it all wrong. A short 🧵:
What we talk about when we talk about risk
How embryo selection exploits our flawed intuitions about risk
open.substack.com
August 10, 2025 at 7:33 PM
The use of dichotomized labels for traits that are actually continuous has bothered me ever since I started working on complex trait genetics. Sasha's blog post provides an excellent explanation of why this matters in the context of polygenic risk and embryo selection.
Reposted by Heini M Natri
Genetics is transforming lives—but communication is key. Join our webinar to explore how to engage communities, promote understanding, and advocate for justice in genomics.
📅November 12
Register now: learning.ashg.org/products/mee...
#ASHG
📅November 12
Register now: learning.ashg.org/products/mee...
#ASHG
October 28, 2025 at 8:21 PM
Genetics is transforming lives—but communication is key. Join our webinar to explore how to engage communities, promote understanding, and advocate for justice in genomics.
📅November 12
Register now: learning.ashg.org/products/mee...
#ASHG
📅November 12
Register now: learning.ashg.org/products/mee...
#ASHG
Reposted by Heini M Natri
Bulk of the lab are presenting posters today!
October 17, 2025 at 2:31 PM
Bulk of the lab are presenting posters today!
Reposted by Heini M Natri
WOW! Our survey of scientists who stopped using Twitter and started using Bluesky is now the #1 most-shared on social media article in the history of the journal Integrative and Comparative Biology! Thanks for reading it, everyone! @sicbjournals.bsky.social
doi.org/10.1093/icb/... 🧪
doi.org/10.1093/icb/... 🧪
Scientists no Longer Find Twitter Professionally Useful, and have Switched to Bluesky
Synopsis. Social media has become widely used by the scientific community for a variety of professional uses, including networking and public outreach. For
doi.org
October 15, 2025 at 7:29 PM
WOW! Our survey of scientists who stopped using Twitter and started using Bluesky is now the #1 most-shared on social media article in the history of the journal Integrative and Comparative Biology! Thanks for reading it, everyone! @sicbjournals.bsky.social
doi.org/10.1093/icb/... 🧪
doi.org/10.1093/icb/... 🧪
The council is deciding your faith… #ashg25 @pacbio.bsky.social
October 16, 2025 at 1:50 AM
The council is deciding your faith… #ashg25 @pacbio.bsky.social
Reposted by Heini M Natri
Really hope someone posts from the Engaging Communities session this morning! I'm bummed it's at the same exact time as the sex & gender session 😭 #ASHG25
October 15, 2025 at 12:17 PM
Really hope someone posts from the Engaging Communities session this morning! I'm bummed it's at the same exact time as the sex & gender session 😭 #ASHG25
Reposted by Heini M Natri
For those interested in #Indigenous #Genomics and #ASHG25 in Boston, here are some interested posters/talks/events coming out of the Tsosie Lab, @nativebio.bsky.social, and @d4itdr.bsky.social. For those looking for Friday plans, attend our Ancillary Event, debuting a #Tribal #data repository!
October 14, 2025 at 2:29 PM
For those interested in #Indigenous #Genomics and #ASHG25 in Boston, here are some interested posters/talks/events coming out of the Tsosie Lab, @nativebio.bsky.social, and @d4itdr.bsky.social. For those looking for Friday plans, attend our Ancillary Event, debuting a #Tribal #data repository!
Reposted by Heini M Natri
After a short *3 hour* flight delay excited to be in the air on the way to Boston for #ASHG25. Looking forward to sharing the lab's work.
October 14, 2025 at 10:05 PM
After a short *3 hour* flight delay excited to be in the air on the way to Boston for #ASHG25. Looking forward to sharing the lab's work.
Getting ready for our 8:30 session in room 252ABC. Join us to discuss genes, traits and identities, and navigating sex, gender, and sexuality in genomics. #ASHG25
October 15, 2025 at 12:07 PM
Getting ready for our 8:30 session in room 252ABC. Join us to discuss genes, traits and identities, and navigating sex, gender, and sexuality in genomics. #ASHG25
Reposted by Heini M Natri
Related: If any other trans or nonbinary folk are attending #ASHG25, I would love to connect!
Especially students who haven't had a chance to meet an older trans scientist. I wish I had that kind of mentor, but I'm happy to try to be that for others 💖🏳️⚧️🧬
Especially students who haven't had a chance to meet an older trans scientist. I wish I had that kind of mentor, but I'm happy to try to be that for others 💖🏳️⚧️🧬
"You make the best of it all and hope you can help make it a little better for the gurl after you."
- Miss Major, 2023 💔
- Miss Major, 2023 💔
October 14, 2025 at 1:32 PM
Related: If any other trans or nonbinary folk are attending #ASHG25, I would love to connect!
Especially students who haven't had a chance to meet an older trans scientist. I wish I had that kind of mentor, but I'm happy to try to be that for others 💖🏳️⚧️🧬
Especially students who haven't had a chance to meet an older trans scientist. I wish I had that kind of mentor, but I'm happy to try to be that for others 💖🏳️⚧️🧬
Reposted by Heini M Natri
Vaccines are safe and effective.
Autism isn't caused by vaccines, and autistic people and their families deserve our support.
When you want information, ask your doctor.
It's more important than ever for all of us to speak plainly, truthfully, and directly about public health.
Autism isn't caused by vaccines, and autistic people and their families deserve our support.
When you want information, ask your doctor.
It's more important than ever for all of us to speak plainly, truthfully, and directly about public health.
October 14, 2025 at 1:33 AM
Vaccines are safe and effective.
Autism isn't caused by vaccines, and autistic people and their families deserve our support.
When you want information, ask your doctor.
It's more important than ever for all of us to speak plainly, truthfully, and directly about public health.
Autism isn't caused by vaccines, and autistic people and their families deserve our support.
When you want information, ask your doctor.
It's more important than ever for all of us to speak plainly, truthfully, and directly about public health.
I want to invite the speakers and moderators of the session “Autism Spectrum Disorder: From Genetic Variation to Neurobiology” to attend my talk on community engagement and the following Q&A, with highlights from autism genetics. Wednesday 8:30, room 253ABC, level 2. 🙂#ASHG25
October 14, 2025 at 5:00 PM
I want to invite the speakers and moderators of the session “Autism Spectrum Disorder: From Genetic Variation to Neurobiology” to attend my talk on community engagement and the following Q&A, with highlights from autism genetics. Wednesday 8:30, room 253ABC, level 2. 🙂#ASHG25
I'm looking forward to attending #ASHG25 next week in Boston! I have the honor and privilege to be presenting at the Featured Symposium "Genes, Traits, and Identities: Navigating Sex, Gender, and Sexuality in Modern Research" on Wed, Oct 15, 8:30-10am. 1/5
October 10, 2025 at 9:29 PM
I'm looking forward to attending #ASHG25 next week in Boston! I have the honor and privilege to be presenting at the Featured Symposium "Genes, Traits, and Identities: Navigating Sex, Gender, and Sexuality in Modern Research" on Wed, Oct 15, 8:30-10am. 1/5
Reposted by Heini M Natri
jamanetwork.com/journals/jam.... Acetaminophen (Tylenol) does not cause autism in this very large study 🧪 #medsky
Acetaminophen Use During Pregnancy and Children’s Risk of Autism, ADHD, and Intellectual Disability
This nationwide cohort study with sibling control analysis examines the association of acetaminophen use during pregnancy with children’s risk of autism, ADHD, and intellectual disability.
jamanetwork.com
September 22, 2025 at 12:55 PM
jamanetwork.com/journals/jam.... Acetaminophen (Tylenol) does not cause autism in this very large study 🧪 #medsky
Some thoughts about today’s announcement on Tylenol, “the autism epidemic”, and the $50M NIH initiative ADSI. 1/
September 23, 2025 at 1:00 AM
Some thoughts about today’s announcement on Tylenol, “the autism epidemic”, and the $50M NIH initiative ADSI. 1/
Reposted by Heini M Natri
Why do so many disease risk variants show no regulatory effects in GTEx and/or other standard eQTL studies?
What do we mean when we say a regulatory effect is "context-specific" and how do we define the context?
We explored these questions using brain organoids and oxygen stress.
What do we mean when we say a regulatory effect is "context-specific" and how do we define the context?
We explored these questions using brain organoids and oxygen stress.
June 9, 2025 at 12:03 AM
Why do so many disease risk variants show no regulatory effects in GTEx and/or other standard eQTL studies?
What do we mean when we say a regulatory effect is "context-specific" and how do we define the context?
We explored these questions using brain organoids and oxygen stress.
What do we mean when we say a regulatory effect is "context-specific" and how do we define the context?
We explored these questions using brain organoids and oxygen stress.