Harshith C Y
@harshithcy.bsky.social
Postdoctoral Researcher in Prof. Cyril Zipfel group at University of Zurich. PhD from NCBS, Bengaluru, India.
Reposted by Harshith C Y
My main work as postdoc @plantophagy.bsky.social lab in @gmivienna.bsky.social is out in @natplants.nature.com 🌱🎉
We asked how can protein complexes diversify without compromising their function and explored this question using the plant #exocyst complex.
www.nature.com/articles/s41...
We asked how can protein complexes diversify without compromising their function and explored this question using the plant #exocyst complex.
www.nature.com/articles/s41...
Electrostatic changes enabled the diversification of an exocyst subunit via protein complex escape - Nature Plants
The evolutionary diversification of an exocyst subunit was enabled by electrostatic shifts leading to its dissociation from the ancestral complex.
www.nature.com
October 31, 2025 at 1:57 PM
My main work as postdoc @plantophagy.bsky.social lab in @gmivienna.bsky.social is out in @natplants.nature.com 🌱🎉
We asked how can protein complexes diversify without compromising their function and explored this question using the plant #exocyst complex.
www.nature.com/articles/s41...
We asked how can protein complexes diversify without compromising their function and explored this question using the plant #exocyst complex.
www.nature.com/articles/s41...
Reposted by Harshith C Y
This Halloween, we have a spooky evolutionary story for you.
The brainchild of @delaconcepcionjc.bsky.social, Nick Irwin and our fantastic collaborators is now out in @natplants.nature.com www.nature.com/articles/s41...
Here’s why I love this work — and why I think you’ll enjoy it too. 👇
The brainchild of @delaconcepcionjc.bsky.social, Nick Irwin and our fantastic collaborators is now out in @natplants.nature.com www.nature.com/articles/s41...
Here’s why I love this work — and why I think you’ll enjoy it too. 👇
October 31, 2025 at 10:19 AM
This Halloween, we have a spooky evolutionary story for you.
The brainchild of @delaconcepcionjc.bsky.social, Nick Irwin and our fantastic collaborators is now out in @natplants.nature.com www.nature.com/articles/s41...
Here’s why I love this work — and why I think you’ll enjoy it too. 👇
The brainchild of @delaconcepcionjc.bsky.social, Nick Irwin and our fantastic collaborators is now out in @natplants.nature.com www.nature.com/articles/s41...
Here’s why I love this work — and why I think you’ll enjoy it too. 👇
Reposted by Harshith C Y
By the @cellsensing.bsky.social and Zipfel labs: The plant receptor kinase HSL3 senses a cyclic, disulfide-bond stabilized peptide phytocytokine. www.biorxiv.org/content/10.1...
October 25, 2025 at 7:19 AM
By the @cellsensing.bsky.social and Zipfel labs: The plant receptor kinase HSL3 senses a cyclic, disulfide-bond stabilized peptide phytocytokine. www.biorxiv.org/content/10.1...
Reposted by Harshith C Y
#LatestPublication
@harshithcy.bsky.social from @shivaprasadpv.bsky.social's lab identified the role of transcription factor OsWRKY53 that dictates wound responses in rice. It fine-tunes wound responses by turning on defence-related genes while turning down growth-related ones.
bit.ly/4ojkJgT
@harshithcy.bsky.social from @shivaprasadpv.bsky.social's lab identified the role of transcription factor OsWRKY53 that dictates wound responses in rice. It fine-tunes wound responses by turning on defence-related genes while turning down growth-related ones.
bit.ly/4ojkJgT
OsWRKY53 dictates wound responses in rice through fine‐tuning crosstalk between PEP and PSK‐mediated signalling
Wound response in plants is a dynamic event involving a significant transcriptional reprogramming. Monocots display distinct phenotypes upon wounding, and the molecular mechanism involved in early si...
bit.ly
October 14, 2025 at 12:41 PM
#LatestPublication
@harshithcy.bsky.social from @shivaprasadpv.bsky.social's lab identified the role of transcription factor OsWRKY53 that dictates wound responses in rice. It fine-tunes wound responses by turning on defence-related genes while turning down growth-related ones.
bit.ly/4ojkJgT
@harshithcy.bsky.social from @shivaprasadpv.bsky.social's lab identified the role of transcription factor OsWRKY53 that dictates wound responses in rice. It fine-tunes wound responses by turning on defence-related genes while turning down growth-related ones.
bit.ly/4ojkJgT
Reposted by Harshith C Y
🍅🌱 SPECIAL ISSUE RESEARCH 🌱🍅
Resistance against bacterial wilt in tomato is linked to variety-specific proteomic changes; the CAPE1 peptide restricts Ralstonia solancearum growth in planta - Zhang et al. 🦠🍅
🔗 doi.org/10.1093/jxb/...
#PlantScience 🧪 @bactodeath.bsky.social
Resistance against bacterial wilt in tomato is linked to variety-specific proteomic changes; the CAPE1 peptide restricts Ralstonia solancearum growth in planta - Zhang et al. 🦠🍅
🔗 doi.org/10.1093/jxb/...
#PlantScience 🧪 @bactodeath.bsky.social
October 12, 2025 at 11:55 AM
🍅🌱 SPECIAL ISSUE RESEARCH 🌱🍅
Resistance against bacterial wilt in tomato is linked to variety-specific proteomic changes; the CAPE1 peptide restricts Ralstonia solancearum growth in planta - Zhang et al. 🦠🍅
🔗 doi.org/10.1093/jxb/...
#PlantScience 🧪 @bactodeath.bsky.social
Resistance against bacterial wilt in tomato is linked to variety-specific proteomic changes; the CAPE1 peptide restricts Ralstonia solancearum growth in planta - Zhang et al. 🦠🍅
🔗 doi.org/10.1093/jxb/...
#PlantScience 🧪 @bactodeath.bsky.social
Reposted by Harshith C Y
💡 SPECIAL ISSUE VIEWPOINT 💡
Immune proteases are promising targets for protein engineering 🛠️ to boost disease resistance in plants 🌾 - Schuster et al.
🔗 doi.org/10.1093/jxb/...
#PlantScience 🧪 @marischuster.bsky.social @aciattoni.bsky.social
Immune proteases are promising targets for protein engineering 🛠️ to boost disease resistance in plants 🌾 - Schuster et al.
🔗 doi.org/10.1093/jxb/...
#PlantScience 🧪 @marischuster.bsky.social @aciattoni.bsky.social
October 6, 2025 at 10:32 AM
💡 SPECIAL ISSUE VIEWPOINT 💡
Immune proteases are promising targets for protein engineering 🛠️ to boost disease resistance in plants 🌾 - Schuster et al.
🔗 doi.org/10.1093/jxb/...
#PlantScience 🧪 @marischuster.bsky.social @aciattoni.bsky.social
Immune proteases are promising targets for protein engineering 🛠️ to boost disease resistance in plants 🌾 - Schuster et al.
🔗 doi.org/10.1093/jxb/...
#PlantScience 🧪 @marischuster.bsky.social @aciattoni.bsky.social
Reposted by Harshith C Y
🧬 How have tiny immune-signaling peptides evolved across the plant kingdom?
Comparative analysis of small secreted peptide signaling during defense response: insights from vascular and non-vascular plants https://bit.ly/4eAUnmZ
Comparative analysis of small secreted peptide signaling during defense response: insights from vascular and non-vascular plants https://bit.ly/4eAUnmZ
August 16, 2025 at 7:00 AM
🧬 How have tiny immune-signaling peptides evolved across the plant kingdom?
Comparative analysis of small secreted peptide signaling during defense response: insights from vascular and non-vascular plants https://bit.ly/4eAUnmZ
Comparative analysis of small secreted peptide signaling during defense response: insights from vascular and non-vascular plants https://bit.ly/4eAUnmZ
Reposted by Harshith C Y
📣 NEW PREPRINT 📝
We identified evolutionary origins of many fungal effectors!
We show that fungi secrete lots of antimicrobial proteins, and that some of them were repurposed by plant pathogens for host immune suppression.
www.biorxiv.org/content/10.1...
cc @teamthomma.bsky.social
We identified evolutionary origins of many fungal effectors!
We show that fungi secrete lots of antimicrobial proteins, and that some of them were repurposed by plant pathogens for host immune suppression.
www.biorxiv.org/content/10.1...
cc @teamthomma.bsky.social
Plant-associated fungi co-opt ancient antimicrobials for host manipulation
Evolutionary histories of effector proteins secreted by fungal pathogens to mediate plant colonization remain largely elusive. While most functionally characterized effectors modulate plant immunity, ...
www.biorxiv.org
August 15, 2025 at 7:47 AM
📣 NEW PREPRINT 📝
We identified evolutionary origins of many fungal effectors!
We show that fungi secrete lots of antimicrobial proteins, and that some of them were repurposed by plant pathogens for host immune suppression.
www.biorxiv.org/content/10.1...
cc @teamthomma.bsky.social
We identified evolutionary origins of many fungal effectors!
We show that fungi secrete lots of antimicrobial proteins, and that some of them were repurposed by plant pathogens for host immune suppression.
www.biorxiv.org/content/10.1...
cc @teamthomma.bsky.social
Reposted by Harshith C Y
If you’re enjoying some calm while others are on holiday, here’s a #NEW #preprint to dive into — led by the brilliant @vbcscitraining.bsky.social student A. Abdrakhmanov:
👇 A quick thread + link:
www.biorxiv.org/content/10.1...
👇 A quick thread + link:
www.biorxiv.org/content/10.1...
Ancestral P-body proteins rewired for autophagic recycling in the early land plant Marchantia polymorpha
Processing bodies (P-bodies) are conserved ribonucleoprotein (RNP) granules central to RNA metabolism across eukaryotes. Although the mechanisms underlying their assembly are well understood, the path...
www.biorxiv.org
August 11, 2025 at 5:44 AM
If you’re enjoying some calm while others are on holiday, here’s a #NEW #preprint to dive into — led by the brilliant @vbcscitraining.bsky.social student A. Abdrakhmanov:
👇 A quick thread + link:
www.biorxiv.org/content/10.1...
👇 A quick thread + link:
www.biorxiv.org/content/10.1...
Reposted by Harshith C Y
Excited this paper is finally published! We focused on the inner concave surface of LRR RKs to expand bacterial flagellin perception in plants. Selection indicates expanded perception is more common than previously thought. Experiments led by @jerrytli.bsky.social www.nature.com/articles/s41...
Unlocking expanded flagellin perception through rational receptor engineering - Nature Plants
Receptor kinase FLS2 detects the flg22 epitope of bacterial flagellin. Here the authors identify key residues on FLS2’s concave surface that enable expanded perception of flg22 variants, allowing the ...
www.nature.com
July 29, 2025 at 1:18 AM
Excited this paper is finally published! We focused on the inner concave surface of LRR RKs to expand bacterial flagellin perception in plants. Selection indicates expanded perception is more common than previously thought. Experiments led by @jerrytli.bsky.social www.nature.com/articles/s41...
Reposted by Harshith C Y
Uncertainty in the timing of diversification of flowering plants rests with equivocal interpretation of their fossil record royalsocietypublishing.org/doi/10.1098/...
July 6, 2025 at 8:56 AM
Uncertainty in the timing of diversification of flowering plants rests with equivocal interpretation of their fossil record royalsocietypublishing.org/doi/10.1098/...
Reposted by Harshith C Y
Bacteria leverage a secretion system to kill and scavenge nutrients from nearby competitors.
Learn more in a new #SciencePerspective: scim.ag/44y3iC6
Learn more in a new #SciencePerspective: scim.ag/44y3iC6
June 28, 2025 at 2:07 PM
Bacteria leverage a secretion system to kill and scavenge nutrients from nearby competitors.
Learn more in a new #SciencePerspective: scim.ag/44y3iC6
Learn more in a new #SciencePerspective: scim.ag/44y3iC6
Reposted by Harshith C Y
Excited to share our #bioRxiv #preprint on HIR2, RLKs and membrane organisation in #Arabidopsis. We used many exciting techniques like #sptPALM, #AlphaFold and #BN-PAGE 🌱
Arabidopsis HYPERSENSITIVE INDUCED REACTION 2 affects plasma membrane receptor pathways and organization https://www.biorxiv.org/content/10.1101/2025.04.11.648320v1
April 15, 2025 at 5:24 AM
Excited to share our #bioRxiv #preprint on HIR2, RLKs and membrane organisation in #Arabidopsis. We used many exciting techniques like #sptPALM, #AlphaFold and #BN-PAGE 🌱
Reposted by Harshith C Y
📜 Plant cell wall structure and dynamics in plant–pathogen interactions and pathogen defence
🧑🔬 Kristina S. Munzert, Timo Engelsdorf
📔 @jxbotany.bsky.social
🔗 academic.oup.com/jxb/advance-...
#️⃣ #PlantScience #PlantImmunity #DarwinReview #PlantCellWalls
🧑🔬 Kristina S. Munzert, Timo Engelsdorf
📔 @jxbotany.bsky.social
🔗 academic.oup.com/jxb/advance-...
#️⃣ #PlantScience #PlantImmunity #DarwinReview #PlantCellWalls
Plant cell wall structure and dynamics in plant–pathogen interactions and pathogen defence
This review discusses the role of plant cell walls in determining plant resistance and highlights the contributions of the host, pathogens, and multifactor
academic.oup.com
December 10, 2024 at 11:08 AM
📜 Plant cell wall structure and dynamics in plant–pathogen interactions and pathogen defence
🧑🔬 Kristina S. Munzert, Timo Engelsdorf
📔 @jxbotany.bsky.social
🔗 academic.oup.com/jxb/advance-...
#️⃣ #PlantScience #PlantImmunity #DarwinReview #PlantCellWalls
🧑🔬 Kristina S. Munzert, Timo Engelsdorf
📔 @jxbotany.bsky.social
🔗 academic.oup.com/jxb/advance-...
#️⃣ #PlantScience #PlantImmunity #DarwinReview #PlantCellWalls