Hao Zhu Lab at UT Southwestern
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haozhulab.bsky.social
Hao Zhu Lab at UT Southwestern
@haozhulab.bsky.social
100 followers 21 following 8 posts
Physician-scientist at Children's Research Institute at UT Southwestern. Focused on #LiverCancer and organ regeneration.
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Reposted by Hao Zhu Lab at UT Southwestern
rjdlab.bsky.social
A true legend.
www.bcm.edu/about-us/lea...
In Memoriam: Bert W. O'Malley, M.D.
In Memoriam: Bert W. O'Malley, M.D....
www.bcm.edu
November 11, 2025 at 7:00 PM
Reposted by Hao Zhu Lab at UT Southwestern
barbmarte.bsky.social
new out in Nature, targeting FSP1 to trigger ferroptosis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Targeting FSP1 triggers ferroptosis in lung cancer - Nature
The ferroptosis suppressor protein FSP1 has a critical role in ferroptosis protection of tumours across multiple in vivo models and is linked to worse prognosis in human lung adenocarcinoma, suggestin...
www.nature.com
November 6, 2025 at 7:39 AM
Reposted by Hao Zhu Lab at UT Southwestern
cri-utsw.bsky.social
ONLINE NOW in @science.org: DeBerardinis Lab discovers protein regulating balance between purine nucleotide production pathways. 🧪
Read more ➡️ cri.utsw.edu/deberardinis...
🔖 full breakdown ⬇️
November 6, 2025 at 7:15 PM
Reposted by Hao Zhu Lab at UT Southwestern
cri-utsw.bsky.social
ONLINE NOW in @science.org: @haozhulab.bsky.social discovers location matters for liver cancer's origins. 🧪
Read more ⬇️ cri.utsw.edu/zhu-lab-show...
🔖 @haozhulab.bsky.social's breakdown ➡️ x.com/Zhu_Lab/stat...
#relentlessdiscovery
Zhu Lab shows location matters for liver cancer’s origins - Children's Medical Center Research Institute (CRI) | Dallas Texas
Hepatocellular carcinoma arises primarily in zone 3 due to glutathione transferase genes that help mutated cells avoid dying Scientists have discovered liver cancers arise in specific metabolic zones,...
cri.utsw.edu
November 6, 2025 at 8:48 PM
Reposted by Hao Zhu Lab at UT Southwestern
dmmjournal.bsky.social
In this Editor's Choice, Maggiore, Zhu @haozhulab.bsky.social and colleagues reveal the high clinical potential of GalNAc-siRNA-based strategies for preventing hepatocellular carcinoma development in high-risk individuals, particularly through targeting ANLN. doi.org/10.1242/dmm....

#HCC #cancer
siCdk1 and siAnln decreased tumor burden in the DEN/PB HCC model. (A) Schematic overview of DEN/PB mouse model. At 2 weeks of age, male mice on the C3H strain background were given a single injection of DEN (25 mg/kg) 4 weeks before the start timepoint (-4w). At 6 weeks of age, mice were placed on 0.05% PB drinking water [start timepoint of 0 weeks (0w)]. Mice were injected with siRNA every other week starting at 12 weeks of age (6w), for a total of nine doses (with 5 mg/kg per dose) and sacrificed 1 week after the final dose (23w). (B) Liver weights for DEN/PB mice at 23 weeks after starting PB water, i.e. the final time point. (C) Liver-to-body-weight ratio for DEN/PB mice at the final time point. (D) Representative images of livers from DEN/PB mice at the final time point. (E) Surface tumor numbers were quantified using front and back images of each liver. (F) Representative immunofluorescence images of DEN/PB livers obtained from mice as indicated. Staining was against GS (red) to indicate the degree of WNT activation. Tumors are outlined by yellow dashed lines. One GS+ tumor was seen in the PBS group. Nuclei were stained with DAPI (blue). Scale bars: 800 μm. For panels B, C and E, the P-values with respect to the PBS group are shown above each group.
October 7, 2025 at 4:01 PM
haozhulab.bsky.social
Introducing 2 new papers from my lab on somatic mutations in liver disease. The 1st is about a mutated gene that leads to improved clone fitness and organismal health (CIDEB). The 2nd is about a mutated gene that leads to improved clone fitness but worse overall health (TBX3). 1/8
July 12, 2025 at 5:04 PM
Reposted by Hao Zhu Lab at UT Southwestern
cri-utsw.bsky.social
Today's #thursdaymotivation is courtesy CRI's @haozhulab.bsky.social: Congrats Gianna Maggiore for your successful #dissertationdefense! Dr. Maggiore's family and lab mates joined to celebrate. Next steps: summertime fun & finishing her M.D. 🎉 #relentlessdiscovery
June 5, 2025 at 8:44 PM