Haoxing Xu
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haoxingxu.bsky.social
Haoxing Xu
@haoxingxu.bsky.social
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Interested in lysosomes, ion channels , organelles
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Reposted by Haoxing Xu
krishnanyamuna.bsky.social
Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
December 17, 2025 at 12:46 AM
Reposted by Haoxing Xu
plosbiology.org
Lysosomes are important for cellular degradation & signal transduction, but decline & change shape with age. This study shows that dysfunctional #aging #lysosomes undergo enlargement (promoted by the TF SKN-1) as a compensatory mechanism to sustain function @plosbiology.org 🧪 plos.io/4pjDX6V
Aging is associated with lysosomal enlargement. Top left: Representative images of three different lysosomal morphologies in the hypodermis during aging. Top right: Ratio of animals exhibiting different lysosomal morphologies in the hypodermis during aging. Chi-square and Fisher’s exact test. n = 34–35 animals. Bottom: Working model of the regulation and function of lysosomal enlargement. Lysosomal enlargement occurs as a response to functional decline during aging. Upon lysosomal dysfunction, the transcription factor SKN-1 is activated to promote lysosomal enlargement by limiting fission in a BORC-dependent manner. This enlargement enhances lysosomal degradation capacity, serving as a beneficial adaptive response. In long-lived glp-1 mutants, SKN-1 activation similarly drives lysosomal enlargement, boosting degradation capacity and contributing to their extended life span.
December 8, 2025 at 5:30 PM