Hamperl Lab
@hamperllab.bsky.social
We are professional DNA traffic controllers and study how transcription and replication are moving smoothly (most of the time).
Our latest research is online in the @biorxivpreprint.bsky.social! 🧬🎉
🔎 We have developed a novel, single-cell real-time approach to monitor R-loop generated TRCs, and we have shown R-loop-mediated, replisome-controlled transcription repression.
www.biorxiv.org/cgi/content/...
🔎 We have developed a novel, single-cell real-time approach to monitor R-loop generated TRCs, and we have shown R-loop-mediated, replisome-controlled transcription repression.
www.biorxiv.org/cgi/content/...
Replisome progression regulates R-loop mediated transcriptional repression
Maintaining cellular proliferation necessitates the synchronized activity of diverse molecular machineries operating in parallel on the genome. Wide-spread transcription and R-loop formation can inter...
www.biorxiv.org
August 4, 2025 at 12:50 PM
Our latest research is online in the @biorxivpreprint.bsky.social! 🧬🎉
🔎 We have developed a novel, single-cell real-time approach to monitor R-loop generated TRCs, and we have shown R-loop-mediated, replisome-controlled transcription repression.
www.biorxiv.org/cgi/content/...
🔎 We have developed a novel, single-cell real-time approach to monitor R-loop generated TRCs, and we have shown R-loop-mediated, replisome-controlled transcription repression.
www.biorxiv.org/cgi/content/...
Such a nice review for one of our latest research works!
🔬 Stephan Hamperl uncovered how clashes between #gene reading & #DNA copying inside cells drive disease. Their tools reveal new insights into #cancer, ageing & development.
Read more 👉 europa.eu/!H7RtjQ
#FrontierResearch #GeneEditing #Genetics #Oncology @www.helmholtz-munich.de
Read more 👉 europa.eu/!H7RtjQ
#FrontierResearch #GeneEditing #Genetics #Oncology @www.helmholtz-munich.de
Revealing cellular conflict role in disease and development
Understanding the conflicts that happen within our cells could shed new light not only on disease progression, but also on how our bodies...
europa.eu
August 4, 2025 at 12:44 PM
Such a nice review for one of our latest research works!
Two days of science, international cooking, and breathtaking hikes in the Bavarian Alps—our lab retreat in Mittenwald had it all! Great discussions, great food, and even better company.
March 24, 2025 at 11:38 AM
Two days of science, international cooking, and breathtaking hikes in the Bavarian Alps—our lab retreat in Mittenwald had it all! Great discussions, great food, and even better company.
Reposted by Hamperl Lab
🚨Paper Alert!
👏 Big congrats to @marcelwerner.bsky.social, ManuelTrauner & rest of @hamperllab.bsky.social team for this brilliant work!
🧬 Check out their amazing research diving into how #TRCs and DOT1L impact genome stability.
A must-read 🧵 for #transcription, #replication & #epigenetics fans👇!
👏 Big congrats to @marcelwerner.bsky.social, ManuelTrauner & rest of @hamperllab.bsky.social team for this brilliant work!
🧬 Check out their amazing research diving into how #TRCs and DOT1L impact genome stability.
A must-read 🧵 for #transcription, #replication & #epigenetics fans👇!
I am delighted to share the main work of my PhD project in the @hamperllab.bsky.social now out in @narjournal.bsky.social. TRCs drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery.
academic.oup.com/nar/article/...
#TRC #r-loop #chromatin
More below 👇
academic.oup.com/nar/article/...
#TRC #r-loop #chromatin
More below 👇
Transcription-replication conflicts drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery
Abstract. Progressing transcription and replication machineries profoundly impact their underlying chromatin template. Consequently, transcription-replicat
academic.oup.com
March 18, 2025 at 5:08 PM
🚨Paper Alert!
👏 Big congrats to @marcelwerner.bsky.social, ManuelTrauner & rest of @hamperllab.bsky.social team for this brilliant work!
🧬 Check out their amazing research diving into how #TRCs and DOT1L impact genome stability.
A must-read 🧵 for #transcription, #replication & #epigenetics fans👇!
👏 Big congrats to @marcelwerner.bsky.social, ManuelTrauner & rest of @hamperllab.bsky.social team for this brilliant work!
🧬 Check out their amazing research diving into how #TRCs and DOT1L impact genome stability.
A must-read 🧵 for #transcription, #replication & #epigenetics fans👇!
Reposted by Hamperl Lab
How can we improve gene regulatory network inference from noisy scRNA-seq data? Our new review in @molsystbiol.org explores the latest methods integrating prior knowledge to enhance reliability. Plus, some suggestions on how to improve benchmarking!
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Leveraging prior knowledge to infer gene regulatory networks from single-cell RNA-sequencing data | Molecular Systems Biology
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
www.embopress.org
February 12, 2025 at 8:05 PM
How can we improve gene regulatory network inference from noisy scRNA-seq data? Our new review in @molsystbiol.org explores the latest methods integrating prior knowledge to enhance reliability. Plus, some suggestions on how to improve benchmarking!
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Proud to share our latest publication in @narjournal.bsky.social! A fantastic team effort led by @marcelwerner.bsky.social and Manuel T., where we explore the chromatin dynamics at transcription-replication conflicts (TRC) sites and their impact on genome stability using a novel TRC reporter system.
I am delighted to share the main work of my PhD project in the @hamperllab.bsky.social now out in @narjournal.bsky.social. TRCs drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery.
academic.oup.com/nar/article/...
#TRC #r-loop #chromatin
More below 👇
academic.oup.com/nar/article/...
#TRC #r-loop #chromatin
More below 👇
Transcription-replication conflicts drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery
Abstract. Progressing transcription and replication machineries profoundly impact their underlying chromatin template. Consequently, transcription-replicat
academic.oup.com
February 20, 2025 at 3:35 PM
Proud to share our latest publication in @narjournal.bsky.social! A fantastic team effort led by @marcelwerner.bsky.social and Manuel T., where we explore the chromatin dynamics at transcription-replication conflicts (TRC) sites and their impact on genome stability using a novel TRC reporter system.
Reposted by Hamperl Lab
Best first bsky post posible 4us:
2025 INTERNSHIP CALL IS NOW OPEN!
Ready for an adventure this summer?
Join our 2025 #Epigenetics #SummerInternship at Helmholtz Munich! Dive into AI, stem cells, nutrition and cutting-edge research, while gaining hands-on experience.
Apply now! 👉 bit.ly/40g1BWL
2025 INTERNSHIP CALL IS NOW OPEN!
Ready for an adventure this summer?
Join our 2025 #Epigenetics #SummerInternship at Helmholtz Munich! Dive into AI, stem cells, nutrition and cutting-edge research, while gaining hands-on experience.
Apply now! 👉 bit.ly/40g1BWL
January 15, 2025 at 2:18 PM
Best first bsky post posible 4us:
2025 INTERNSHIP CALL IS NOW OPEN!
Ready for an adventure this summer?
Join our 2025 #Epigenetics #SummerInternship at Helmholtz Munich! Dive into AI, stem cells, nutrition and cutting-edge research, while gaining hands-on experience.
Apply now! 👉 bit.ly/40g1BWL
2025 INTERNSHIP CALL IS NOW OPEN!
Ready for an adventure this summer?
Join our 2025 #Epigenetics #SummerInternship at Helmholtz Munich! Dive into AI, stem cells, nutrition and cutting-edge research, while gaining hands-on experience.
Apply now! 👉 bit.ly/40g1BWL