Tony Tyson is part of Nature’s 10, a list of people who shaped science in 2025.

Under stress, cells adapt their gene expression programs through changes in transcription and translation. It is unclear how cells determine which mRNAs are translated or repressed. Zedan et al. show that the timing of mRNA production alone determines the selectivity of translation, thereby coupling the processes of transcription and translation.

Rather than adapting to the codon usage of their host, viruses use viral 5′ untranslated regions to initiate translation, which allows them to produce viral proteins in host cells efficiently despite poor codon usage profiles.

Nature - Engineered T cells that have been used to treat ulcerative colitis, rheumatoid arthritis and lupus show promising results.

Nature Reviews Chemistry, Published online: 25 November 2025; doi:10.1038/s41570-025-00770-yGenomic therapy offers a promising strategy for addressing central nervous system disorders. This Review highlights recent advances in chemical strategies and delivery platforms, such as lipid nanoparticles, polymers and oligonucleotide conjugates, and it discusses future directions to improve the application of genomic therapy in brain disorders.

In this interview, Prof. Pandit shares his experiences publishing under an ACS read and publish agreement and reflects on the broader implications of open access at the institutional level—including…