Daniel Grupel
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grupel.com
Daniel Grupel
@grupel.com
Infectious diseases, zoonoses, tropical medicine
I feel very uncomfortable with this practice, especially given the change in candida epidemiology and the increase in non-albicans candida; it seems like more azole exposure is an expensive price for this intervention with very low-level evidence of benefit.
January 8, 2025 at 3:46 PM
Already read, bookmarked and saved last week 😎 thanks!
November 24, 2024 at 11:23 AM
A🆕️🔥 Propensity score analysis of nationwide prospective cohort
Efficacy & safety of Antistaphylococcal penicillin/cefazolin based combination treatment [AG/GENT,VAN, DAP, RIF] Vs monotherapy in patients with MSSA left-sided native valve IE #IEWiki #idsky
www.journalofinfection.com/article/S016...
November 18, 2024 at 8:07 AM
Interesting 🇦🇺 scrub typhus outbreak (attack rate ~7%, 5 🏥, 0 ☠️)

Challenges:
-poor adherence to doxy ppx by troops
-significant IgM cross-reactivity (see fig 3 😳)
-geographic dispersion of cases after training exercise (cases diagnosed in non-endemic area)

#SkyID

wwwnc.cdc.gov/eid/article/...
Scrub Typhus Outbreak among Soldiers in Coastal Training Area, Australia, 2022
Scrub Typhus Outbreak among Soldiers, Australia
wwwnc.cdc.gov
November 18, 2024 at 8:07 AM
1/Important study published in JAMA today - Investigated artemisinin partial resistance in Ugandan children with complicated malaria. Findings highlight critical concerns for malaria treatment in high-burden settings.
jamanetwork.com/journals/jam...
Artemisinin Partial Resistance in Ugandan Children With Complicated Malaria
This study assesses artemisinin partial resistance, Pfkelch13 variations, and malaria recrudescence in Ugandan children with complicated malaria.
jamanetwork.com
November 18, 2024 at 8:07 AM
Wow! Amazing work Ilan!
November 17, 2024 at 4:21 PM
So many typos! it's so much harder to post a proper thread here without the ability to edit the entire thread and not just individual posts...
August 27, 2023 at 5:23 AM
It's still great seeing your findings supported by new data!
August 27, 2023 at 5:13 AM
A group from Germany published a new study on eBioMedicine, showing a similar effect on the immunological, not clinical side - specifically better T cell response when getting both doses on the same side!
www.thelancet.com/journals/ebi...
While it's a shame they didn't quote us >>
August 27, 2023 at 5:13 AM
That getting both doses on the same side is probably better! This was associated with a decreased chance of being PCR infected (PCR positive) in the short term, and with fewer hospitalizations for COVID-19. We published this here: www.sciencedirect.com/science/arti...
Then, two weeks ago >>
Effect of same-arm versus cross-arm administration of sequential doses of BNT162b2 on short-term vac...
We sought to test whether administering the second BNT162B2 vaccine dose on the cross-arm or the same arm as the first dose creates a more robust loca…
www.sciencedirect.com
August 27, 2023 at 5:10 AM