Ghina BADIH
ghinabadih.bsky.social
Ghina BADIH
@ghinabadih.bsky.social
Reposted by Ghina BADIH
@ghinabadih.bsky.social and Laetitia Kurzawa from CytoMorphoLab concluded that "contractile forces direct the chiral swirling of cells".
November 21, 2025 at 1:15 PM
Grateful to everyone who contributed to this work and made it possible! @alex-schaef.bsky.social Ben Vianay Pauline Smilovici @lblanchoin.bsky.social @manuelthery.bsky.social Laëtitia Kurzawa
November 18, 2025 at 5:32 PM
For all the twists, turns, and forces behind the swirl, you can sneak a peak at the full article, which I am thrilled to announce is now available @pnas.org: www.pnas.org/doi/10.1073/...
November 18, 2025 at 5:32 PM
Furthermore, with the help of a heterotypic system, we point out the more contractile cell in the duo as the choreographer of the biased swirl, setting both its rhythm and direction.
November 18, 2025 at 5:32 PM
Our results show that even in such a minimalistic configuration, endothelial cells spontaneously display a robust, rightward bias that can be modulated by the magnitude of the contractile forces produced by the doublets.
November 18, 2025 at 5:32 PM
During my PhD, we tried address this question by simplifying a cell collective to its bare minimum: a doublet.
November 18, 2025 at 5:32 PM
Yes, the cells constituting our body do have handedness - an intriguing phenomenon that orchestrates large-scale collective motions indispensable for morphogenesis and embryonic development. But, how do cell collectives make such an important decision with much ease and (pre)determination?!
November 18, 2025 at 5:32 PM