Furthermore, with the help of a heterotypic system, we point out the more contractile cell in the duo as the choreographer of the biased swirl, setting both its rhythm and direction.

Our results show that even in such a minimalistic configuration, endothelial cells spontaneously display a robust, rightward bias that can be modulated by the magnitude of the contractile forces produced by the doublets.

During my PhD, we tried address this question by simplifying a cell collective to its bare minimum: a doublet.