Prof G
@gavingiovannoni.bsky.social
Gavin Giovannoni is a neurologist in the Faculty of Medicine at Queen Mary University of London. His current research is focused on the Epstein-Barr virus as a possible cause of multiple sclerosis. Gavin is an active MS blogger.
#MS_Selfie Newsletter - Bad news: another negative remyelination trial
Bad news is unavoidable; what is important is to reflect on the news, learn lessons, adjust hypotheses or formulate new ones and move forward testing them. => gavingiovannoni.substack.com/p/bad-news-a...
Bad news is unavoidable; what is important is to reflect on the news, learn lessons, adjust hypotheses or formulate new ones and move forward testing them. => gavingiovannoni.substack.com/p/bad-news-a...
Bad news: another negative remyelination trial
Bad news is unavoidable; what is important is to reflect on the news, learn lessons, adjust hypotheses or formulate new ones and move forward testing them.
gavingiovannoni.substack.com
November 26, 2025 at 2:22 PM
#MS_Selfie Newsletter - Bad news: another negative remyelination trial
Bad news is unavoidable; what is important is to reflect on the news, learn lessons, adjust hypotheses or formulate new ones and move forward testing them. => gavingiovannoni.substack.com/p/bad-news-a...
Bad news is unavoidable; what is important is to reflect on the news, learn lessons, adjust hypotheses or formulate new ones and move forward testing them. => gavingiovannoni.substack.com/p/bad-news-a...
#MS_Selfie MS and bipolar disorder
Are people with multiple sclerosis at risk of developing bipolar disorder? => buff.ly/vHUoGEG
Are people with multiple sclerosis at risk of developing bipolar disorder? => buff.ly/vHUoGEG
MS and bipolar disorder
Are people with multiple sclerosis at risk of developing bipolar disorder?
gavingiovannoni.substack.com
November 25, 2025 at 7:20 AM
#MS_Selfie MS and bipolar disorder
Are people with multiple sclerosis at risk of developing bipolar disorder? => buff.ly/vHUoGEG
Are people with multiple sclerosis at risk of developing bipolar disorder? => buff.ly/vHUoGEG
#MS_Selfie Q&A 125: ocrelizumab failures
Almost all of the investigators testing lower doses of anti-CD20 therapies against licensed therapies are conflicted by wanting to save money. Do you agree? => buff.ly/8o9pPV9
Almost all of the investigators testing lower doses of anti-CD20 therapies against licensed therapies are conflicted by wanting to save money. Do you agree? => buff.ly/8o9pPV9
Q&A 125: ocrelizumab failures
Almost all of the investigators testing lower doses of anti-CD20 therapies against licensed therapies are conflicted by wanting to save money.
gavingiovannoni.substack.com
November 22, 2025 at 9:47 AM
#MS_Selfie Q&A 125: ocrelizumab failures
Almost all of the investigators testing lower doses of anti-CD20 therapies against licensed therapies are conflicted by wanting to save money. Do you agree? => buff.ly/8o9pPV9
Almost all of the investigators testing lower doses of anti-CD20 therapies against licensed therapies are conflicted by wanting to save money. Do you agree? => buff.ly/8o9pPV9
#MS_Selfie Q&A 124a: AI and its impact on the practice of neurology
Would you be prepared to be seen by SheBot? Would you trust an AI-empowered neurologist? => buff.ly/A3ZXFrQ
Would you be prepared to be seen by SheBot? Would you trust an AI-empowered neurologist? => buff.ly/A3ZXFrQ
Q&A 124a: AI and its impact on the practice of neurology
Would you be prepared to be seen by SheBot? Would you trust an AI-empowered neurologist?
gavingiovannoni.substack.com
November 20, 2025 at 2:00 PM
#MS_Selfie Q&A 124a: AI and its impact on the practice of neurology
Would you be prepared to be seen by SheBot? Would you trust an AI-empowered neurologist? => buff.ly/A3ZXFrQ
Would you be prepared to be seen by SheBot? Would you trust an AI-empowered neurologist? => buff.ly/A3ZXFrQ
#MS_Selfie Appeal regarding a study on "Acceptance and Commitment Therapy" in MS. This study involves asking people with an MS diagnosis to complete a questionnaire about how MS symptoms impact their day-to-day life .... Please help. Thank you => buff.ly/0e7VC2l
Acceptance and Commitment Therapy Research
This study involves asking people with an MS diagnosis to complete a questionnaire about how MS symptoms impact their day-to-day life ....
gavingiovannoni.substack.com
November 20, 2025 at 9:12 AM
#MS_Selfie Appeal regarding a study on "Acceptance and Commitment Therapy" in MS. This study involves asking people with an MS diagnosis to complete a questionnaire about how MS symptoms impact their day-to-day life .... Please help. Thank you => buff.ly/0e7VC2l
#MS_Selfie Newsletter on the Lazarus effect in MS. Is it real?
When someone transitions from almost being confined to a wheelchair to being able to walk and run, we call this the Lazarus effect. Does CAR T-cell therapy hold promise as a cure for MS? => buff.ly/woSREfb
When someone transitions from almost being confined to a wheelchair to being able to walk and run, we call this the Lazarus effect. Does CAR T-cell therapy hold promise as a cure for MS? => buff.ly/woSREfb
The Lazarus effect in MS
When someone transitions from almost being confined to a wheelchair to being able to walk and run, we call this the Lazarus effect.
gavingiovannoni.substack.com
November 17, 2025 at 9:10 AM
#MS_Selfie Newsletter on the Lazarus effect in MS. Is it real?
When someone transitions from almost being confined to a wheelchair to being able to walk and run, we call this the Lazarus effect. Does CAR T-cell therapy hold promise as a cure for MS? => buff.ly/woSREfb
When someone transitions from almost being confined to a wheelchair to being able to walk and run, we call this the Lazarus effect. Does CAR T-cell therapy hold promise as a cure for MS? => buff.ly/woSREfb
#MS_Selfie Q&A 123: treating MS over the age of 70
If I were over 70 and had MS, I would advocate for a proactive approach to my MS treatment. Do you agree? =>
If I were over 70 and had MS, I would advocate for a proactive approach to my MS treatment. Do you agree? =>
Q&A 123: treating MS over the age of 70
If I were over 70 and had MS, I would advocate for a proactive approach to my MS treatment.
gavingiovannoni.substack.com
November 11, 2025 at 11:44 AM
#MS_Selfie Q&A 123: treating MS over the age of 70
If I were over 70 and had MS, I would advocate for a proactive approach to my MS treatment. Do you agree? =>
If I were over 70 and had MS, I would advocate for a proactive approach to my MS treatment. Do you agree? =>
#MS_Selfie Breaking News: Fenebrutinib Press Release
My predictions may be correct. What were yours? Is this the game-changer we were hoping for? => gavingiovannoni.substack.com/p/breaking-n...
My predictions may be correct. What were yours? Is this the game-changer we were hoping for? => gavingiovannoni.substack.com/p/breaking-n...
Breaking news: Fenebrutinib Press Release
My predictions may be correct.
gavingiovannoni.substack.com
November 11, 2025 at 7:34 AM
#MS_Selfie Breaking News: Fenebrutinib Press Release
My predictions may be correct. What were yours? Is this the game-changer we were hoping for? => gavingiovannoni.substack.com/p/breaking-n...
My predictions may be correct. What were yours? Is this the game-changer we were hoping for? => gavingiovannoni.substack.com/p/breaking-n...
#MS_Selfie Newsletter: Are you aware of SAW? Would you want to know if you had smouldering MS?
I am acutely aware of how often you have been gaslit when it comes to smouldering MS. Please share your experiences => buff.ly/xKWBbf4
I am acutely aware of how often you have been gaslit when it comes to smouldering MS. Please share your experiences => buff.ly/xKWBbf4
Are you aware of SAW? Would you want to know if you had smouldering MS?
I am acutely aware of how often you, as people with MS or a spouse, partner or family member of someone with MS, have been gaslit when it comes to smouldering MS.
gavingiovannoni.substack.com
November 2, 2025 at 6:06 PM
#MS_Selfie Newsletter: Are you aware of SAW? Would you want to know if you had smouldering MS?
I am acutely aware of how often you have been gaslit when it comes to smouldering MS. Please share your experiences => buff.ly/xKWBbf4
I am acutely aware of how often you have been gaslit when it comes to smouldering MS. Please share your experiences => buff.ly/xKWBbf4
#MS_Selfie Q&A 122: Comorbid Graves disease
Another option is teriflunomide, which does not cause chronic immunosuppression and may help your Graves orbitopathy. buff.ly/5Jfzz2H
Another option is teriflunomide, which does not cause chronic immunosuppression and may help your Graves orbitopathy. buff.ly/5Jfzz2H
Q&A 122: Comorbid Graves disease
Another option is teriflunomide, which does not cause chronic immunosuppression and may help your Graves orbitopathy.
gavingiovannoni.substack.com
October 31, 2025 at 7:14 AM
#MS_Selfie Q&A 122: Comorbid Graves disease
Another option is teriflunomide, which does not cause chronic immunosuppression and may help your Graves orbitopathy. buff.ly/5Jfzz2H
Another option is teriflunomide, which does not cause chronic immunosuppression and may help your Graves orbitopathy. buff.ly/5Jfzz2H
#MS_Selfie Q&A 121: Is ofatumumab superior to ocrelizumab?
Ocrelizumab showed a trend toward statistical significance, but didn’t make the final cut. Does this mean ofatumumab is superior to ocrelizumab? What do you think? =>
Ocrelizumab showed a trend toward statistical significance, but didn’t make the final cut. Does this mean ofatumumab is superior to ocrelizumab? What do you think? =>
Q&A 121: Is ofatumumab superior to ocrelizumab?
Ocrelizumab showed a trend toward statistical significance, but didn’t make the final cut. Does this mean ofatumumab is superior to ocrelizumab?
gavingiovannoni.substack.com
October 29, 2025 at 11:44 AM
#MS_Selfie Q&A 121: Is ofatumumab superior to ocrelizumab?
Ocrelizumab showed a trend toward statistical significance, but didn’t make the final cut. Does this mean ofatumumab is superior to ocrelizumab? What do you think? =>
Ocrelizumab showed a trend toward statistical significance, but didn’t make the final cut. Does this mean ofatumumab is superior to ocrelizumab? What do you think? =>
# MS_Selfie Newsletter - MS and divorce
If I were to design a comprehensive MS service, I would ensure that relationship counselling was part of the core services we offer. Do you agree? => gavingiovannoni.substack.com/p/ms-and-div...
If I were to design a comprehensive MS service, I would ensure that relationship counselling was part of the core services we offer. Do you agree? => gavingiovannoni.substack.com/p/ms-and-div...
MS and divorce
If I were to design a comprehensive MS service, I would ensure that relationship counselling was part of the core services we offer.
gavingiovannoni.substack.com
October 28, 2025 at 11:44 AM
# MS_Selfie Newsletter - MS and divorce
If I were to design a comprehensive MS service, I would ensure that relationship counselling was part of the core services we offer. Do you agree? => gavingiovannoni.substack.com/p/ms-and-div...
If I were to design a comprehensive MS service, I would ensure that relationship counselling was part of the core services we offer. Do you agree? => gavingiovannoni.substack.com/p/ms-and-div...
#MS_Selfie Q&A 120: emotions and MS
Does multiple sclerosis affect your emotional state? Please help and share your experiences => buff.ly/fIRZUY2
Does multiple sclerosis affect your emotional state? Please help and share your experiences => buff.ly/fIRZUY2
Q&A 120: emotions
Does multiple sclerosis affect your emotional state?
gavingiovannoni.substack.com
October 26, 2025 at 3:25 AM
#MS_Selfie Q&A 120: emotions and MS
Does multiple sclerosis affect your emotional state? Please help and share your experiences => buff.ly/fIRZUY2
Does multiple sclerosis affect your emotional state? Please help and share your experiences => buff.ly/fIRZUY2
Will this MSARD Editorial on "When does multiple sclerosis start?" impact the field of MS and change the way we think about the disease? => www.msard-journal.com/article/S221...
When does multiple sclerosis start?
The question of when multiple sclerosis (MS) starts is not a trivial one. It has implications for primary and secondary MS prevention studies (Giovannoni et al., 2025a; Zane et al., 2025). A recent…
www.msard-journal.com
October 26, 2025 at 3:22 AM
Will this MSARD Editorial on "When does multiple sclerosis start?" impact the field of MS and change the way we think about the disease? => www.msard-journal.com/article/S221...
#MS_Selfie Newsletter - Nitrofurantoin warning: please read
Nitrofurantoin is a commonly prescribed antibiotic for urinary tract infections (UTIs) and is also used long-term as a urinary antiseptic to prevent UTIs. => buff.ly/7gPsotL
Nitrofurantoin is a commonly prescribed antibiotic for urinary tract infections (UTIs) and is also used long-term as a urinary antiseptic to prevent UTIs. => buff.ly/7gPsotL
Nitrofurantoin warning: please read
Nitrofurantoin is a commonly prescribed antibiotic for urinary tract infections (UTIs) and is also used long-term as a urinary antiseptic to prevent UTIs.
gavingiovannoni.substack.com
October 8, 2025 at 6:56 AM
#MS_Selfie Newsletter - Nitrofurantoin warning: please read
Nitrofurantoin is a commonly prescribed antibiotic for urinary tract infections (UTIs) and is also used long-term as a urinary antiseptic to prevent UTIs. => buff.ly/7gPsotL
Nitrofurantoin is a commonly prescribed antibiotic for urinary tract infections (UTIs) and is also used long-term as a urinary antiseptic to prevent UTIs. => buff.ly/7gPsotL
#MS_Selfie: Which formulation of HRT would you recommend?
"It is encouraging to see these large-scale reconsiderations of the beneficial effects of HRT. However, it is upsetting that a generation of women missed out on the process.” => buff.ly/XI08YEN
"It is encouraging to see these large-scale reconsiderations of the beneficial effects of HRT. However, it is upsetting that a generation of women missed out on the process.” => buff.ly/XI08YEN
Which formulation of HRT would you recommend?
"It is encouraging to see these large-scale reconsiderations of the beneficial effects of HRT. However, it is upsetting that a generation of women missed out on the process.”
gavingiovannoni.substack.com
October 6, 2025 at 8:52 AM
#MS_Selfie: Which formulation of HRT would you recommend?
"It is encouraging to see these large-scale reconsiderations of the beneficial effects of HRT. However, it is upsetting that a generation of women missed out on the process.” => buff.ly/XI08YEN
"It is encouraging to see these large-scale reconsiderations of the beneficial effects of HRT. However, it is upsetting that a generation of women missed out on the process.” => buff.ly/XI08YEN
#MS_Selfie Q&A 118: ECTRIMS 2025 & CAR T-cells
I believe this is one of the most promising therapeutic strategies being tested in MS for several reasons: its CNS and deep tissue penetration, as well as its anti-EBV properties. => buff.ly/dE1kODU
I believe this is one of the most promising therapeutic strategies being tested in MS for several reasons: its CNS and deep tissue penetration, as well as its anti-EBV properties. => buff.ly/dE1kODU
Q&A 118: ECTRIMS 2025 & CAR T-cells
I believe this is one of the most promising therapeutic strategies being tested in MS for several reasons: its CNS and deep tissue penetration, as well as its anti-EBV properties.
gavingiovannoni.substack.com
October 3, 2025 at 7:06 AM
#MS_Selfie Q&A 118: ECTRIMS 2025 & CAR T-cells
I believe this is one of the most promising therapeutic strategies being tested in MS for several reasons: its CNS and deep tissue penetration, as well as its anti-EBV properties. => buff.ly/dE1kODU
I believe this is one of the most promising therapeutic strategies being tested in MS for several reasons: its CNS and deep tissue penetration, as well as its anti-EBV properties. => buff.ly/dE1kODU
#MS_Selfie Q&A 117: ECTRIMS 2025 - EBV & MS
If EBV is necessary for the development of MS, why wouldn't we consider including EBV serology as part of the MS diagnosis? => buff.ly/h5QHqgM
If EBV is necessary for the development of MS, why wouldn't we consider including EBV serology as part of the MS diagnosis? => buff.ly/h5QHqgM
Q&A 117: ECTRIMS 2025 - EBV & MS
If EBV is necessary for the development of MS, why wouldn't we consider including EBV serology as part of the MS diagnosis?
gavingiovannoni.substack.com
October 2, 2025 at 4:09 PM
#MS_Selfie Q&A 117: ECTRIMS 2025 - EBV & MS
If EBV is necessary for the development of MS, why wouldn't we consider including EBV serology as part of the MS diagnosis? => buff.ly/h5QHqgM
If EBV is necessary for the development of MS, why wouldn't we consider including EBV serology as part of the MS diagnosis? => buff.ly/h5QHqgM
#MS_Selfie ECTRIMS 2025: blowing my own horn
The highlight of the meeting was my presentation of the ocrelizumab results in the PPMS O’HAND study, which were positive. buff.ly/EWHOuBw
The highlight of the meeting was my presentation of the ocrelizumab results in the PPMS O’HAND study, which were positive. buff.ly/EWHOuBw
ECTRIMS 2025: blowing my own horn
The highlight of the meeting was my presentation of the ocrelizumab results in the PPMS O’HAND study, which were positive.
gavingiovannoni.substack.com
September 29, 2025 at 3:28 PM
#MS_Selfie ECTRIMS 2025: blowing my own horn
The highlight of the meeting was my presentation of the ocrelizumab results in the PPMS O’HAND study, which were positive. buff.ly/EWHOuBw
The highlight of the meeting was my presentation of the ocrelizumab results in the PPMS O’HAND study, which were positive. buff.ly/EWHOuBw
#MS_Selfie Q&A 116: Which antiviral?
There is a fine line between being an innovator and a quack. The observational data strongly support moving forward with EBV antiviral strategies in MS .... buff.ly/8CaFvBv
There is a fine line between being an innovator and a quack. The observational data strongly support moving forward with EBV antiviral strategies in MS .... buff.ly/8CaFvBv
Q&A 116: which antiviral?
There is a fine line between being an innovator and a quack. The observational data strongly support moving forward with EBV antiviral strategies in MS ....
gavingiovannoni.substack.com
September 19, 2025 at 1:51 AM
#MS_Selfie Q&A 116: Which antiviral?
There is a fine line between being an innovator and a quack. The observational data strongly support moving forward with EBV antiviral strategies in MS .... buff.ly/8CaFvBv
There is a fine line between being an innovator and a quack. The observational data strongly support moving forward with EBV antiviral strategies in MS .... buff.ly/8CaFvBv
What a journey for people with MS and their HCPs. Natalizumab has taught us a great deal about MS. We try to tell the story in this review paper => buff.ly/WWjC7Ql
September 18, 2025 at 4:49 AM
What a journey for people with MS and their HCPs. Natalizumab has taught us a great deal about MS. We try to tell the story in this review paper => buff.ly/WWjC7Ql
#MS_Selfie - Prof G's response to the AI-generated newsletter
Prof G's response to the AI-generated newsletter
One of Gemini’s scotomas (blind spots) was the lack of mention of a systemic or local toxin driving MS pathology.
gavingiovannoni.substack.com
September 17, 2025 at 9:44 AM
#MS_Selfie - Prof G's response to the AI-generated newsletter
#MS_Selfie Q&A 115: AHSCT or not?
Anxiety and uncertainty are not good bedfellows when considering treatment options for multiple sclerosis. Should this young woman have the option of AHSCT? => buff.ly/e7bwckp
Anxiety and uncertainty are not good bedfellows when considering treatment options for multiple sclerosis. Should this young woman have the option of AHSCT? => buff.ly/e7bwckp
Q&A 115: AHSCT or not?
Anxiety and uncertainty are not good bedfellows when considering treatment options for multiple sclerosis.
gavingiovannoni.substack.com
September 15, 2025 at 2:34 PM
#MS_Selfie Q&A 115: AHSCT or not?
Anxiety and uncertainty are not good bedfellows when considering treatment options for multiple sclerosis. Should this young woman have the option of AHSCT? => buff.ly/e7bwckp
Anxiety and uncertainty are not good bedfellows when considering treatment options for multiple sclerosis. Should this young woman have the option of AHSCT? => buff.ly/e7bwckp
#MS_Selfie: How useful is AI-generated content in the field of MS?
I have been having a back-and-forth argument with colleagues about the value of AI in MS research. I therefore asked Google Gemini Pro 2.5 Deep Research the following question: ... -> buff.ly/v3ot0m6
I have been having a back-and-forth argument with colleagues about the value of AI in MS research. I therefore asked Google Gemini Pro 2.5 Deep Research the following question: ... -> buff.ly/v3ot0m6
How useful is AI-generated content in the field of MS?
I have been having a back-and-forth argument with colleagues about the value of AI in MS research. I therefore asked Google Gemini Pro 2.5 Deep Research the following question:
gavingiovannoni.substack.com
September 13, 2025 at 11:49 AM
#MS_Selfie: How useful is AI-generated content in the field of MS?
I have been having a back-and-forth argument with colleagues about the value of AI in MS research. I therefore asked Google Gemini Pro 2.5 Deep Research the following question: ... -> buff.ly/v3ot0m6
I have been having a back-and-forth argument with colleagues about the value of AI in MS research. I therefore asked Google Gemini Pro 2.5 Deep Research the following question: ... -> buff.ly/v3ot0m6
#MS_Selfie Q&A 114: Muscle loss and sarcopenia on GLP-1 receptor agonists
If you have been prescribed a GLP-1 RA, did your HCP assess your muscle function at baseline and provide you with information about how to prevent muscle loss? Are you having regular assessments? => buff.ly/qn6S9wI
If you have been prescribed a GLP-1 RA, did your HCP assess your muscle function at baseline and provide you with information about how to prevent muscle loss? Are you having regular assessments? => buff.ly/qn6S9wI
Q&A 114: Muscle loss and sarcopenia on GLP-1 receptor agonists
If you have been prescribed a GLP-1 RA, did your HCP assess your muscle function at baseline and provide you with information about how to prevent muscle loss? Are you having regular assessments?
gavingiovannoni.substack.com
September 12, 2025 at 9:20 AM
#MS_Selfie Q&A 114: Muscle loss and sarcopenia on GLP-1 receptor agonists
If you have been prescribed a GLP-1 RA, did your HCP assess your muscle function at baseline and provide you with information about how to prevent muscle loss? Are you having regular assessments? => buff.ly/qn6S9wI
If you have been prescribed a GLP-1 RA, did your HCP assess your muscle function at baseline and provide you with information about how to prevent muscle loss? Are you having regular assessments? => buff.ly/qn6S9wI