Prof G
@gavingiovannoni.bsky.social
Gavin Giovannoni is a neurologist in the Faculty of Medicine at Queen Mary University of London. His current research is focused on the Epstein-Barr virus as a possible cause of multiple sclerosis. Gavin is an active MS blogger.
#MS_Selfie Q&A 123: treating MS over the age of 70
If I were over 70 and had MS, I would advocate for a proactive approach to my MS treatment. Do you agree? =>
If I were over 70 and had MS, I would advocate for a proactive approach to my MS treatment. Do you agree? =>
Q&A 123: treating MS over the age of 70
If I were over 70 and had MS, I would advocate for a proactive approach to my MS treatment.
gavingiovannoni.substack.com
November 11, 2025 at 11:44 AM
#MS_Selfie Q&A 123: treating MS over the age of 70
If I were over 70 and had MS, I would advocate for a proactive approach to my MS treatment. Do you agree? =>
If I were over 70 and had MS, I would advocate for a proactive approach to my MS treatment. Do you agree? =>
#MS_Selfie Breaking News: Fenebrutinib Press Release
My predictions may be correct. What were yours? Is this the game-changer we were hoping for? => gavingiovannoni.substack.com/p/breaking-n...
My predictions may be correct. What were yours? Is this the game-changer we were hoping for? => gavingiovannoni.substack.com/p/breaking-n...
Breaking news: Fenebrutinib Press Release
My predictions may be correct.
gavingiovannoni.substack.com
November 11, 2025 at 7:34 AM
#MS_Selfie Breaking News: Fenebrutinib Press Release
My predictions may be correct. What were yours? Is this the game-changer we were hoping for? => gavingiovannoni.substack.com/p/breaking-n...
My predictions may be correct. What were yours? Is this the game-changer we were hoping for? => gavingiovannoni.substack.com/p/breaking-n...
#MS_Selfie Newsletter: Are you aware of SAW? Would you want to know if you had smouldering MS?
I am acutely aware of how often you have been gaslit when it comes to smouldering MS. Please share your experiences => buff.ly/xKWBbf4
I am acutely aware of how often you have been gaslit when it comes to smouldering MS. Please share your experiences => buff.ly/xKWBbf4
Are you aware of SAW? Would you want to know if you had smouldering MS?
I am acutely aware of how often you, as people with MS or a spouse, partner or family member of someone with MS, have been gaslit when it comes to smouldering MS.
gavingiovannoni.substack.com
November 2, 2025 at 6:06 PM
#MS_Selfie Newsletter: Are you aware of SAW? Would you want to know if you had smouldering MS?
I am acutely aware of how often you have been gaslit when it comes to smouldering MS. Please share your experiences => buff.ly/xKWBbf4
I am acutely aware of how often you have been gaslit when it comes to smouldering MS. Please share your experiences => buff.ly/xKWBbf4
#MS_Selfie Q&A 122: Comorbid Graves disease
Another option is teriflunomide, which does not cause chronic immunosuppression and may help your Graves orbitopathy. buff.ly/5Jfzz2H
Another option is teriflunomide, which does not cause chronic immunosuppression and may help your Graves orbitopathy. buff.ly/5Jfzz2H
Q&A 122: Comorbid Graves disease
Another option is teriflunomide, which does not cause chronic immunosuppression and may help your Graves orbitopathy.
gavingiovannoni.substack.com
October 31, 2025 at 7:14 AM
#MS_Selfie Q&A 122: Comorbid Graves disease
Another option is teriflunomide, which does not cause chronic immunosuppression and may help your Graves orbitopathy. buff.ly/5Jfzz2H
Another option is teriflunomide, which does not cause chronic immunosuppression and may help your Graves orbitopathy. buff.ly/5Jfzz2H
#MS_Selfie Q&A 121: Is ofatumumab superior to ocrelizumab?
Ocrelizumab showed a trend toward statistical significance, but didn’t make the final cut. Does this mean ofatumumab is superior to ocrelizumab? What do you think? =>
Ocrelizumab showed a trend toward statistical significance, but didn’t make the final cut. Does this mean ofatumumab is superior to ocrelizumab? What do you think? =>
Q&A 121: Is ofatumumab superior to ocrelizumab?
Ocrelizumab showed a trend toward statistical significance, but didn’t make the final cut. Does this mean ofatumumab is superior to ocrelizumab?
gavingiovannoni.substack.com
October 29, 2025 at 11:44 AM
#MS_Selfie Q&A 121: Is ofatumumab superior to ocrelizumab?
Ocrelizumab showed a trend toward statistical significance, but didn’t make the final cut. Does this mean ofatumumab is superior to ocrelizumab? What do you think? =>
Ocrelizumab showed a trend toward statistical significance, but didn’t make the final cut. Does this mean ofatumumab is superior to ocrelizumab? What do you think? =>
# MS_Selfie Newsletter - MS and divorce
If I were to design a comprehensive MS service, I would ensure that relationship counselling was part of the core services we offer. Do you agree? => gavingiovannoni.substack.com/p/ms-and-div...
If I were to design a comprehensive MS service, I would ensure that relationship counselling was part of the core services we offer. Do you agree? => gavingiovannoni.substack.com/p/ms-and-div...
MS and divorce
If I were to design a comprehensive MS service, I would ensure that relationship counselling was part of the core services we offer.
gavingiovannoni.substack.com
October 28, 2025 at 11:44 AM
# MS_Selfie Newsletter - MS and divorce
If I were to design a comprehensive MS service, I would ensure that relationship counselling was part of the core services we offer. Do you agree? => gavingiovannoni.substack.com/p/ms-and-div...
If I were to design a comprehensive MS service, I would ensure that relationship counselling was part of the core services we offer. Do you agree? => gavingiovannoni.substack.com/p/ms-and-div...
#MS_Selfie Q&A 120: emotions and MS
Does multiple sclerosis affect your emotional state? Please help and share your experiences => buff.ly/fIRZUY2
Does multiple sclerosis affect your emotional state? Please help and share your experiences => buff.ly/fIRZUY2
Q&A 120: emotions
Does multiple sclerosis affect your emotional state?
gavingiovannoni.substack.com
October 26, 2025 at 3:25 AM
#MS_Selfie Q&A 120: emotions and MS
Does multiple sclerosis affect your emotional state? Please help and share your experiences => buff.ly/fIRZUY2
Does multiple sclerosis affect your emotional state? Please help and share your experiences => buff.ly/fIRZUY2
Will this MSARD Editorial on "When does multiple sclerosis start?" impact the field of MS and change the way we think about the disease? => www.msard-journal.com/article/S221...
When does multiple sclerosis start?
The question of when multiple sclerosis (MS) starts is not a trivial one. It has implications for primary and secondary MS prevention studies (Giovannoni et al., 2025a; Zane et al., 2025). A recent…
www.msard-journal.com
October 26, 2025 at 3:22 AM
Will this MSARD Editorial on "When does multiple sclerosis start?" impact the field of MS and change the way we think about the disease? => www.msard-journal.com/article/S221...
#MS_Selfie Newsletter - Nitrofurantoin warning: please read
Nitrofurantoin is a commonly prescribed antibiotic for urinary tract infections (UTIs) and is also used long-term as a urinary antiseptic to prevent UTIs. => buff.ly/7gPsotL
Nitrofurantoin is a commonly prescribed antibiotic for urinary tract infections (UTIs) and is also used long-term as a urinary antiseptic to prevent UTIs. => buff.ly/7gPsotL
Nitrofurantoin warning: please read
Nitrofurantoin is a commonly prescribed antibiotic for urinary tract infections (UTIs) and is also used long-term as a urinary antiseptic to prevent UTIs.
gavingiovannoni.substack.com
October 8, 2025 at 6:56 AM
#MS_Selfie Newsletter - Nitrofurantoin warning: please read
Nitrofurantoin is a commonly prescribed antibiotic for urinary tract infections (UTIs) and is also used long-term as a urinary antiseptic to prevent UTIs. => buff.ly/7gPsotL
Nitrofurantoin is a commonly prescribed antibiotic for urinary tract infections (UTIs) and is also used long-term as a urinary antiseptic to prevent UTIs. => buff.ly/7gPsotL
#MS_Selfie: Which formulation of HRT would you recommend?
"It is encouraging to see these large-scale reconsiderations of the beneficial effects of HRT. However, it is upsetting that a generation of women missed out on the process.” => buff.ly/XI08YEN
"It is encouraging to see these large-scale reconsiderations of the beneficial effects of HRT. However, it is upsetting that a generation of women missed out on the process.” => buff.ly/XI08YEN
Which formulation of HRT would you recommend?
"It is encouraging to see these large-scale reconsiderations of the beneficial effects of HRT. However, it is upsetting that a generation of women missed out on the process.”
gavingiovannoni.substack.com
October 6, 2025 at 8:52 AM
#MS_Selfie: Which formulation of HRT would you recommend?
"It is encouraging to see these large-scale reconsiderations of the beneficial effects of HRT. However, it is upsetting that a generation of women missed out on the process.” => buff.ly/XI08YEN
"It is encouraging to see these large-scale reconsiderations of the beneficial effects of HRT. However, it is upsetting that a generation of women missed out on the process.” => buff.ly/XI08YEN
#MS_Selfie Q&A 118: ECTRIMS 2025 & CAR T-cells
I believe this is one of the most promising therapeutic strategies being tested in MS for several reasons: its CNS and deep tissue penetration, as well as its anti-EBV properties. => buff.ly/dE1kODU
I believe this is one of the most promising therapeutic strategies being tested in MS for several reasons: its CNS and deep tissue penetration, as well as its anti-EBV properties. => buff.ly/dE1kODU
Q&A 118: ECTRIMS 2025 & CAR T-cells
I believe this is one of the most promising therapeutic strategies being tested in MS for several reasons: its CNS and deep tissue penetration, as well as its anti-EBV properties.
gavingiovannoni.substack.com
October 3, 2025 at 7:06 AM
#MS_Selfie Q&A 118: ECTRIMS 2025 & CAR T-cells
I believe this is one of the most promising therapeutic strategies being tested in MS for several reasons: its CNS and deep tissue penetration, as well as its anti-EBV properties. => buff.ly/dE1kODU
I believe this is one of the most promising therapeutic strategies being tested in MS for several reasons: its CNS and deep tissue penetration, as well as its anti-EBV properties. => buff.ly/dE1kODU
#MS_Selfie Q&A 117: ECTRIMS 2025 - EBV & MS
If EBV is necessary for the development of MS, why wouldn't we consider including EBV serology as part of the MS diagnosis? => buff.ly/h5QHqgM
If EBV is necessary for the development of MS, why wouldn't we consider including EBV serology as part of the MS diagnosis? => buff.ly/h5QHqgM
Q&A 117: ECTRIMS 2025 - EBV & MS
If EBV is necessary for the development of MS, why wouldn't we consider including EBV serology as part of the MS diagnosis?
gavingiovannoni.substack.com
October 2, 2025 at 4:09 PM
#MS_Selfie Q&A 117: ECTRIMS 2025 - EBV & MS
If EBV is necessary for the development of MS, why wouldn't we consider including EBV serology as part of the MS diagnosis? => buff.ly/h5QHqgM
If EBV is necessary for the development of MS, why wouldn't we consider including EBV serology as part of the MS diagnosis? => buff.ly/h5QHqgM
#MS_Selfie ECTRIMS 2025: blowing my own horn
The highlight of the meeting was my presentation of the ocrelizumab results in the PPMS O’HAND study, which were positive. buff.ly/EWHOuBw
The highlight of the meeting was my presentation of the ocrelizumab results in the PPMS O’HAND study, which were positive. buff.ly/EWHOuBw
ECTRIMS 2025: blowing my own horn
The highlight of the meeting was my presentation of the ocrelizumab results in the PPMS O’HAND study, which were positive.
gavingiovannoni.substack.com
September 29, 2025 at 3:28 PM
#MS_Selfie ECTRIMS 2025: blowing my own horn
The highlight of the meeting was my presentation of the ocrelizumab results in the PPMS O’HAND study, which were positive. buff.ly/EWHOuBw
The highlight of the meeting was my presentation of the ocrelizumab results in the PPMS O’HAND study, which were positive. buff.ly/EWHOuBw
#MS_Selfie Q&A 116: Which antiviral?
There is a fine line between being an innovator and a quack. The observational data strongly support moving forward with EBV antiviral strategies in MS .... buff.ly/8CaFvBv
There is a fine line between being an innovator and a quack. The observational data strongly support moving forward with EBV antiviral strategies in MS .... buff.ly/8CaFvBv
Q&A 116: which antiviral?
There is a fine line between being an innovator and a quack. The observational data strongly support moving forward with EBV antiviral strategies in MS ....
gavingiovannoni.substack.com
September 19, 2025 at 1:51 AM
#MS_Selfie Q&A 116: Which antiviral?
There is a fine line between being an innovator and a quack. The observational data strongly support moving forward with EBV antiviral strategies in MS .... buff.ly/8CaFvBv
There is a fine line between being an innovator and a quack. The observational data strongly support moving forward with EBV antiviral strategies in MS .... buff.ly/8CaFvBv
What a journey for people with MS and their HCPs. Natalizumab has taught us a great deal about MS. We try to tell the story in this review paper => buff.ly/WWjC7Ql
September 18, 2025 at 4:49 AM
What a journey for people with MS and their HCPs. Natalizumab has taught us a great deal about MS. We try to tell the story in this review paper => buff.ly/WWjC7Ql
#MS_Selfie - Prof G's response to the AI-generated newsletter
Prof G's response to the AI-generated newsletter
One of Gemini’s scotomas (blind spots) was the lack of mention of a systemic or local toxin driving MS pathology.
gavingiovannoni.substack.com
September 17, 2025 at 9:44 AM
#MS_Selfie - Prof G's response to the AI-generated newsletter
#MS_Selfie Q&A 115: AHSCT or not?
Anxiety and uncertainty are not good bedfellows when considering treatment options for multiple sclerosis. Should this young woman have the option of AHSCT? => buff.ly/e7bwckp
Anxiety and uncertainty are not good bedfellows when considering treatment options for multiple sclerosis. Should this young woman have the option of AHSCT? => buff.ly/e7bwckp
Q&A 115: AHSCT or not?
Anxiety and uncertainty are not good bedfellows when considering treatment options for multiple sclerosis.
gavingiovannoni.substack.com
September 15, 2025 at 2:34 PM
#MS_Selfie Q&A 115: AHSCT or not?
Anxiety and uncertainty are not good bedfellows when considering treatment options for multiple sclerosis. Should this young woman have the option of AHSCT? => buff.ly/e7bwckp
Anxiety and uncertainty are not good bedfellows when considering treatment options for multiple sclerosis. Should this young woman have the option of AHSCT? => buff.ly/e7bwckp
#MS_Selfie: How useful is AI-generated content in the field of MS?
I have been having a back-and-forth argument with colleagues about the value of AI in MS research. I therefore asked Google Gemini Pro 2.5 Deep Research the following question: ... -> buff.ly/v3ot0m6
I have been having a back-and-forth argument with colleagues about the value of AI in MS research. I therefore asked Google Gemini Pro 2.5 Deep Research the following question: ... -> buff.ly/v3ot0m6
How useful is AI-generated content in the field of MS?
I have been having a back-and-forth argument with colleagues about the value of AI in MS research. I therefore asked Google Gemini Pro 2.5 Deep Research the following question:
gavingiovannoni.substack.com
September 13, 2025 at 11:49 AM
#MS_Selfie: How useful is AI-generated content in the field of MS?
I have been having a back-and-forth argument with colleagues about the value of AI in MS research. I therefore asked Google Gemini Pro 2.5 Deep Research the following question: ... -> buff.ly/v3ot0m6
I have been having a back-and-forth argument with colleagues about the value of AI in MS research. I therefore asked Google Gemini Pro 2.5 Deep Research the following question: ... -> buff.ly/v3ot0m6
#MS_Selfie Q&A 114: Muscle loss and sarcopenia on GLP-1 receptor agonists
If you have been prescribed a GLP-1 RA, did your HCP assess your muscle function at baseline and provide you with information about how to prevent muscle loss? Are you having regular assessments? => buff.ly/qn6S9wI
If you have been prescribed a GLP-1 RA, did your HCP assess your muscle function at baseline and provide you with information about how to prevent muscle loss? Are you having regular assessments? => buff.ly/qn6S9wI
Q&A 114: Muscle loss and sarcopenia on GLP-1 receptor agonists
If you have been prescribed a GLP-1 RA, did your HCP assess your muscle function at baseline and provide you with information about how to prevent muscle loss? Are you having regular assessments?
gavingiovannoni.substack.com
September 12, 2025 at 9:20 AM
#MS_Selfie Q&A 114: Muscle loss and sarcopenia on GLP-1 receptor agonists
If you have been prescribed a GLP-1 RA, did your HCP assess your muscle function at baseline and provide you with information about how to prevent muscle loss? Are you having regular assessments? => buff.ly/qn6S9wI
If you have been prescribed a GLP-1 RA, did your HCP assess your muscle function at baseline and provide you with information about how to prevent muscle loss? Are you having regular assessments? => buff.ly/qn6S9wI
#MS_Selfie Q&A 113: Should I take creatine supplements?
If you have started taking creatine, have you noted any impact on your MS symptoms, level of functioning and quality of life? => buff.ly/LumDjFy
If you have started taking creatine, have you noted any impact on your MS symptoms, level of functioning and quality of life? => buff.ly/LumDjFy
Q&A 113: Should I take creatine supplements?
If you have started taking creatine, have you noted any impact on your MS symptoms, level of functioning and quality of life?
gavingiovannoni.substack.com
September 11, 2025 at 8:16 AM
#MS_Selfie Q&A 113: Should I take creatine supplements?
If you have started taking creatine, have you noted any impact on your MS symptoms, level of functioning and quality of life? => buff.ly/LumDjFy
If you have started taking creatine, have you noted any impact on your MS symptoms, level of functioning and quality of life? => buff.ly/LumDjFy
Burnout RX: HCP's silent struggle impact.economist.com/health/healt...
Burnout RX: HCP's silent struggle
Burnout RX—the hidden social and economic costs of a silent crisis among healthcare professionals
impact.economist.com
September 11, 2025 at 5:46 AM
Burnout RX: HCP's silent struggle impact.economist.com/health/healt...
#MS_Selfie - Energy drinks vs. Coffee
Are you self-medicating MS-related symptoms using energy drinks or coffee? => buff.ly/2CGG9Za
Are you self-medicating MS-related symptoms using energy drinks or coffee? => buff.ly/2CGG9Za
Energy drinks vs. Coffee
Are you self-medicating MS-related symptoms using energy drinks or coffee?
gavingiovannoni.substack.com
September 10, 2025 at 10:09 AM
#MS_Selfie - Energy drinks vs. Coffee
Are you self-medicating MS-related symptoms using energy drinks or coffee? => buff.ly/2CGG9Za
Are you self-medicating MS-related symptoms using energy drinks or coffee? => buff.ly/2CGG9Za
#MS_Selfie Q&A 112: Latent TB
Q&A 112: Latent TB
If you are going to go ahead with cladribine, I recommend TB prophylaxis, but this needs to be done via a TB clinic. I would not recommend INH alone, but the two-drug combination.
gavingiovannoni.substack.com
September 9, 2025 at 12:14 PM
#MS_Selfie Q&A 112: Latent TB
#MS_Seflie Q&A 111 (a Nelson): Glucagon-like peptide-1 receptor agonists (GLP-1RAs)
Should I start tirzepatide or semaglutide to treat my MS? => buff.ly/OueDpzp
Should I start tirzepatide or semaglutide to treat my MS? => buff.ly/OueDpzp
Q&A 111: Glucagon-like peptide-1 receptor agonists (GLP-1RAs)
Should I start tirzepatide or semaglutide to treat my MS?
gavingiovannoni.substack.com
September 4, 2025 at 12:36 PM
#MS_Seflie Q&A 111 (a Nelson): Glucagon-like peptide-1 receptor agonists (GLP-1RAs)
Should I start tirzepatide or semaglutide to treat my MS? => buff.ly/OueDpzp
Should I start tirzepatide or semaglutide to treat my MS? => buff.ly/OueDpzp
DR KRISTEN KRYSKO WINS 2025 RACHEL HORNE PRIZE FOR WOMEN’S RESEARCH IN MULTIPLE SCLEROSIS
DR KRISTEN KRYSKO WINS 2025 RACHEL HORNE PRIZE FOR WOMEN’S RESEARCH IN MULTIPLE SCLEROSIS
Women's Health & Research MS is finally getting the recognition it deserves.
gavingiovannoni.substack.com
September 3, 2025 at 5:16 PM
DR KRISTEN KRYSKO WINS 2025 RACHEL HORNE PRIZE FOR WOMEN’S RESEARCH IN MULTIPLE SCLEROSIS