Manx Neurobiologist
@garyrlewin.bsky.social
Manxman Scientist. Neurobiologist, Group Leader, Interests: ion channels, extreme biology, mole-rats, sensory transduction, touch, pain, social brain, flying
www.mdc-berlin.de/lewin
www.mdc-berlin.de/lewin
Published! Check out our latest work on sensory mechanotransduction. PIezo2 gene deletion barely impacts mechanically-activated currents in mouse sensory neurons. Is the cell body a good model for in vivo transduction? www.cell.com/biophysj/pdf...
www.cell.com
November 4, 2025 at 7:49 AM
Published! Check out our latest work on sensory mechanotransduction. PIezo2 gene deletion barely impacts mechanically-activated currents in mouse sensory neurons. Is the cell body a good model for in vivo transduction? www.cell.com/biophysj/pdf...
We were very happy to help, in a very small way, in getting this beautiful structure out. The structure is remarkably conserved considering the famous 28S ribosomal RNA split. I suspect that the split has as yet unknown biological repercussions in this remarkable animal..
We have a new preprint for you. Naked mole rats are very long-lived rodents and have increased translational fidelity.
Interestingly, 28S ribosomal RNA is split. Here we investigated the structure of the ribosome by single particle cryo-EM. Take a look.
www.biorxiv.org/content/10.1...
Interestingly, 28S ribosomal RNA is split. Here we investigated the structure of the ribosome by single particle cryo-EM. Take a look.
www.biorxiv.org/content/10.1...
Cryo-EM structure of the naked mole-rat ribosome reveals a stabilized split 28S rRNA
The naked mole-rat (Heterocephalus glaber) is a long-lived mammal with remarkable resistance to cancer and hypoxia, suggesting the evolution of robust proteostasis networks. The ribosome, the central ...
www.biorxiv.org
October 29, 2025 at 2:49 PM
We were very happy to help, in a very small way, in getting this beautiful structure out. The structure is remarkably conserved considering the famous 28S ribosomal RNA split. I suspect that the split has as yet unknown biological repercussions in this remarkable animal..
Check out this new paper from Stefan Lechner's lab showing with minflux nanoscopy how PIEZO1 channels cluster and invagininate the membrane. Glad we could make a small contribution to this nice story!
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Cluster nanoarchitecture and structural diversity of PIEZO1 at rest and during activation in intact cells
MINFLUX nanoscopy reveals subcellular distribution and conformational diversity of PIEZO1 channels in intact cells.
www.science.org
October 25, 2025 at 11:37 PM
Check out this new paper from Stefan Lechner's lab showing with minflux nanoscopy how PIEZO1 channels cluster and invagininate the membrane. Glad we could make a small contribution to this nice story!
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Sam has now started her new group at the Helmholtz Center for Infection Research Diseases. Congratulations! I wish her the very best for her independent career. The time Sam spent with us was hugely successful in many respects and we will all be sad to see her go..
Delighted to be starting a new research group at @helmholtzhzi.bsky.social ! Happy to chat about working together! #pain #infection #electrophysiology
www.helmholtz-hzi.de/en/research/...
www.helmholtz-hzi.de/en/research/...
October 2, 2025 at 10:33 AM
Sam has now started her new group at the Helmholtz Center for Infection Research Diseases. Congratulations! I wish her the very best for her independent career. The time Sam spent with us was hugely successful in many respects and we will all be sad to see her go..
Widely accepted findings should be validated. For example, mechanically-activated currents (MA-currents) in sensory neurons depend on PIEZO2..right?. Here we show that PIEZO2 is NOT associated with a huge loss of MA-currents in sensory neurons. #ion channels #sensory www.biorxiv.org/content/10.1...
Mechanically-gated currents in mouse sensory neurons lacking PIEZO2
Touch sensation starts with the opening of mechanically-gated activated ion channels at neuroglial endings of mechanoreceptors in the skin. The function of around half of low threshold mechanoreceptor...
www.biorxiv.org
August 4, 2025 at 11:05 AM
Widely accepted findings should be validated. For example, mechanically-activated currents (MA-currents) in sensory neurons depend on PIEZO2..right?. Here we show that PIEZO2 is NOT associated with a huge loss of MA-currents in sensory neurons. #ion channels #sensory www.biorxiv.org/content/10.1...
bbc.com/news/article...
I worked as a tram driver for two summers with this fella (nearly 40 years ago!)...he is right, best job I ever had
I worked as a tram driver for two summers with this fella (nearly 40 years ago!)...he is right, best job I ever had
Driver celebrates 'unbelievably unique' 50-year horse tram career
Tram driver Peter Cannon is celebrating half a century working on the Douglas Bay Horse Tramway.
bbc.com
July 6, 2025 at 10:17 AM
bbc.com/news/article...
I worked as a tram driver for two summers with this fella (nearly 40 years ago!)...he is right, best job I ever had
I worked as a tram driver for two summers with this fella (nearly 40 years ago!)...he is right, best job I ever had
Read about how a book about extraordinary animals with Russ Hodge and Kat Menschik came to be.
www.stiftung-charite.de/en/our-fundi....
www.stiftung-charite.de/en/our-fundi....
www.stiftung-charite.de
June 30, 2025 at 11:25 AM
Read about how a book about extraordinary animals with Russ Hodge and Kat Menschik came to be.
www.stiftung-charite.de/en/our-fundi....
www.stiftung-charite.de/en/our-fundi....
Reposted by Manx Neurobiologist
This has been a great #lndw25 on @campusbuch.bsky.social! Thank you for everyone who made this happen! 🎉
June 28, 2025 at 11:16 PM
This has been a great #lndw25 on @campusbuch.bsky.social! Thank you for everyone who made this happen! 🎉
Reposted by Manx Neurobiologist
Wonderful visit @mdc-berlin.bsky.social thanks @hannahornberg.bsky.social for the invitation and congrats @khallaf.bsky.social for showing me such cool data on naked mole rats!
Incredibly special and inspiring talk today by @dulaclab.bsky.social at @mdc-berlin.bsky.social. Thanks to @hannahornberg.bsky.social for inviting Cathrine to visit!
June 20, 2025 at 8:55 PM
Wonderful visit @mdc-berlin.bsky.social thanks @hannahornberg.bsky.social for the invitation and congrats @khallaf.bsky.social for showing me such cool data on naked mole rats!
Proud to a part of this great study from the lab of Annette Hammes. A new role for mechanosensitive PIEZO2 channels in the development of the coronary arteries.
www.nature.com/articles/s44...
www.nature.com/articles/s44...
June 27, 2025 at 1:02 PM
Proud to a part of this great study from the lab of Annette Hammes. A new role for mechanosensitive PIEZO2 channels in the development of the coronary arteries.
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Reposted by Manx Neurobiologist
#LNDW is celebrating 25 years of science and discovery – with a special reduced price of one night for just €5.
The #mdcBerlin and others open their labs on June 28, 2025. Visit us at #CampusBuch!
Our full program here 👉 www.mdc-berlin.de/long-night-s... 👈
The #mdcBerlin and others open their labs on June 28, 2025. Visit us at #CampusBuch!
Our full program here 👉 www.mdc-berlin.de/long-night-s... 👈
May 26, 2025 at 5:01 PM
#LNDW is celebrating 25 years of science and discovery – with a special reduced price of one night for just €5.
The #mdcBerlin and others open their labs on June 28, 2025. Visit us at #CampusBuch!
Our full program here 👉 www.mdc-berlin.de/long-night-s... 👈
The #mdcBerlin and others open their labs on June 28, 2025. Visit us at #CampusBuch!
Our full program here 👉 www.mdc-berlin.de/long-night-s... 👈
I left my 50s today..celebrated by walking to the top of Snaefell. The top of the lovely Isle of man.
May 14, 2025 at 3:10 PM
I left my 50s today..celebrated by walking to the top of Snaefell. The top of the lovely Isle of man.
Back in Pretoria for more mole-rat fun..special smell and touch abilities to be measured!
May 8, 2025 at 12:33 PM
Back in Pretoria for more mole-rat fun..special smell and touch abilities to be measured!
Reposted by Manx Neurobiologist
Excited to share the first preprint from the lab, led by the talented trio: PhD student Rosalba, master student Erika and technician Maria. We examined the roles of the translational modulators MNK1 and MNK2 and found that they have distinct functions at the synapse www.biorxiv.org/content/10.1...
Distinct roles for MNK1 and MNK2 in social and cognitive behavior through kinase-specific regulation of the synaptic proteome and phosphoproteome
Local mRNA translation is required for adaptive changes in the synaptic proteome. The mitogen-activated protein kinase (MAPK) interacting protein kinases 1 and 2 (MNK1 and MNK2) have emerged as key re...
www.biorxiv.org
December 23, 2024 at 12:28 PM
Excited to share the first preprint from the lab, led by the talented trio: PhD student Rosalba, master student Erika and technician Maria. We examined the roles of the translational modulators MNK1 and MNK2 and found that they have distinct functions at the synapse www.biorxiv.org/content/10.1...
Reposted by Manx Neurobiologist
From an #AI-powered search engine for omics data to a scalable drug screening platform for neuromuscular diseases – 4 of our labs present their projects at @biovaria.bsky.social #techtransfer networking event!
www.biovaria.org/
@danilexn.bsky.social@nukappa.bsky.social @garyrlewin.bsky.social
www.biovaria.org/
@danilexn.bsky.social@nukappa.bsky.social @garyrlewin.bsky.social
April 10, 2025 at 3:00 PM
From an #AI-powered search engine for omics data to a scalable drug screening platform for neuromuscular diseases – 4 of our labs present their projects at @biovaria.bsky.social #techtransfer networking event!
www.biovaria.org/
@danilexn.bsky.social@nukappa.bsky.social @garyrlewin.bsky.social
www.biovaria.org/
@danilexn.bsky.social@nukappa.bsky.social @garyrlewin.bsky.social
physoc.onlinelibrary.wiley.com/doi/full/10....
Our latest paper is now published, open access of course. Check it out! Mechanotransduction and regeneration! More to come soon..
Our latest paper is now published, open access of course. Check it out! Mechanotransduction and regeneration! More to come soon..
The mechanotransduction protein STOML3 is required for proprioceptor plasticity following peripheral nerve regeneration
Nerve regeneration is associated with the plasticity of sensory neurons such that even muscle afferents directed to the skin form mechanosensitive receptive fields appropriate for the new target. STO...
physoc.onlinelibrary.wiley.com
March 31, 2025 at 8:31 PM
physoc.onlinelibrary.wiley.com/doi/full/10....
Our latest paper is now published, open access of course. Check it out! Mechanotransduction and regeneration! More to come soon..
Our latest paper is now published, open access of course. Check it out! Mechanotransduction and regeneration! More to come soon..
Reposted by Manx Neurobiologist
Honored to present my work on naked mole rats from @garyrlewin.bsky.social at the @modolfor.bsky.social symposium (@silkesachse.bsky.social) during the Göttingen Neuroscience Meeting #NWG @neurowissg.bsky.social —and finally getting the famous and amazing Drosophila from @katrinvogt.bsky.social!!
March 26, 2025 at 3:23 PM
Honored to present my work on naked mole rats from @garyrlewin.bsky.social at the @modolfor.bsky.social symposium (@silkesachse.bsky.social) during the Göttingen Neuroscience Meeting #NWG @neurowissg.bsky.social —and finally getting the famous and amazing Drosophila from @katrinvogt.bsky.social!!
This came out today a 26 min interview with me about touch. In German. It turned out pretty good #pain #painresearch #touch
www.ardaudiothek.de/episode/wiss...
www.ardaudiothek.de/episode/wiss...
Podcast: Faszination Tastsinn: Wie wir fühlen und be-greifen
Der Neurobiologe Gary Lewin erforscht am Max-Delbrück-Zentrum die Geheimnisse unseres Tastsinns und kommt dabei dem Geheimnis, wie unser Fühlen funktioniert, näher. Von Anna Corves
www.ardaudiothek.de
March 16, 2025 at 9:46 PM
This came out today a 26 min interview with me about touch. In German. It turned out pretty good #pain #painresearch #touch
www.ardaudiothek.de/episode/wiss...
www.ardaudiothek.de/episode/wiss...
Looking forward to a mole-rat bonanza next week!
mpinb.mpg.de/en/events/ev...
mpinb.mpg.de/en/events/ev...
BIOMORA24 - Unique Biology of Mole-Rats - MAX PLANCK INSTITUTE FOR NEUROBIOLOGY OF BEHAVIOR — CAESAR
mpinb.mpg.de
November 20, 2024 at 11:00 PM
Looking forward to a mole-rat bonanza next week!
mpinb.mpg.de/en/events/ev...
mpinb.mpg.de/en/events/ev...
www.bcf.uni-freiburg.de/ringvorlesun...
Will be giving a public lecture on touch next monday, in Freiburg!
Will be giving a public lecture on touch next monday, in Freiburg!
Gary Lewin, Max-Delbrück-Center Berlin: Berührung auf molekularer Ebene — Bernstein Center Freiburg
Molekulare Physiologie der somatosensorischen Wahrnehmung | Max-Delbrück-Center | Berlin
[Ringvorlesung]
www.bcf.uni-freiburg.de
November 15, 2024 at 7:41 PM
www.bcf.uni-freiburg.de/ringvorlesun...
Will be giving a public lecture on touch next monday, in Freiburg!
Will be giving a public lecture on touch next monday, in Freiburg!