Paul Frankland
@franklandlab.bsky.social
The neuroscience of memory, West Ham Utd, baguettes and other random stuff
Neuroscientist at Hospital for Sick Children/University of Toronto
Neuroscientist at Hospital for Sick Children/University of Toronto
We provide evidence for projection-defined 'sub-engrams' that contribute differentially to memory expression at recent and remote delays.
October 22, 2025 at 6:50 PM
We provide evidence for projection-defined 'sub-engrams' that contribute differentially to memory expression at recent and remote delays.
This adds to an emerging picture that not only do new neurons influence encoding of new memories but they _shape_ and _remodel_ existing memories. These shifts in resolution may facilitate generalization of event based memories beyond the original situation.
October 1, 2025 at 12:39 AM
This adds to an emerging picture that not only do new neurons influence encoding of new memories but they _shape_ and _remodel_ existing memories. These shifts in resolution may facilitate generalization of event based memories beyond the original situation.
Now seen all the greats. Messi, both Ronaldo’s, Ronaldinho and Alan Devonshire.
September 27, 2025 at 11:04 PM
Now seen all the greats. Messi, both Ronaldo’s, Ronaldinho and Alan Devonshire.
Watching 38 year old man walk around for 90 mins
September 27, 2025 at 9:51 PM
Watching 38 year old man walk around for 90 mins
Working From Dome
August 14, 2025 at 7:13 PM
Working From Dome
Fantastic afternoon (so far) at the Skydome.
July 20, 2025 at 5:48 PM
Fantastic afternoon (so far) at the Skydome.
Checking out Toronto’s day-old park (Biidaasige Park) on my morning run. Beautiful in the morning sun.
July 19, 2025 at 11:32 AM
Checking out Toronto’s day-old park (Biidaasige Park) on my morning run. Beautiful in the morning sun.
For anyone in the memory field, an incredible summary and tribute to Endel Tulving from Gus Craik. Read it for the writing alone.
royalsocietypublishing.org/action/oidcS...
royalsocietypublishing.org/action/oidcS...
May 30, 2025 at 10:52 PM
For anyone in the memory field, an incredible summary and tribute to Endel Tulving from Gus Craik. Read it for the writing alone.
royalsocietypublishing.org/action/oidcS...
royalsocietypublishing.org/action/oidcS...
Appreciating the free wifi on my @aircanada.bsky.social flight to the US this morning. Remember when hotels used to charge for wifi? This is the start of the wave for free wifi on flights. No carrier can afford not to offer it.
May 27, 2025 at 1:56 PM
Appreciating the free wifi on my @aircanada.bsky.social flight to the US this morning. Remember when hotels used to charge for wifi? This is the start of the wave for free wifi on flights. No carrier can afford not to offer it.
Amazing work by Sangyoon (pictured here with a celebratory tipple) and by a large supporting cast including Adam Ramsaran, Asim Rashid, and Xiaoyu Chen and others.
8/n
8/n
May 14, 2025 at 4:32 PM
Amazing work by Sangyoon (pictured here with a celebratory tipple) and by a large supporting cast including Adam Ramsaran, Asim Rashid, and Xiaoyu Chen and others.
8/n
8/n
And the driver of this reorganization? Hippocampal neurogenesis! Eliminating hippocampal neurogenesis prevented engram rewiring and ‘froze’ memories in their original precise state. Conversely, promoting hippocampal neurogenesis accelerated hippocampal rewiring and the emergence of gist.
7/n
7/n
May 14, 2025 at 4:32 PM
And the driver of this reorganization? Hippocampal neurogenesis! Eliminating hippocampal neurogenesis prevented engram rewiring and ‘froze’ memories in their original precise state. Conversely, promoting hippocampal neurogenesis accelerated hippocampal rewiring and the emergence of gist.
7/n
7/n
We studied this using engram labeling tools in mice. We find that consolidation promotes gradual rewiring of hippocampal engrams in ways which promote their promiscuous activation in situations that match the original training conditions: They guide behavior a more general set of scenarios.
6/n
6/n
May 14, 2025 at 4:32 PM
We studied this using engram labeling tools in mice. We find that consolidation promotes gradual rewiring of hippocampal engrams in ways which promote their promiscuous activation in situations that match the original training conditions: They guide behavior a more general set of scenarios.
6/n
6/n
So, we all appreciate that event-based memories change both _organizationally_ (e.g., shift from hippocampus to cortex) and _qualitatively_ (e.g., become less precise or more gist like) with time.
3/n
3/n
May 14, 2025 at 4:32 PM
So, we all appreciate that event-based memories change both _organizationally_ (e.g., shift from hippocampus to cortex) and _qualitatively_ (e.g., become less precise or more gist like) with time.
3/n
3/n
New baguette review: Bakery Pompette on College.
A French bakery in little Italy. Owners super charming; I really wanted to like this more.
It is a GREAT looking baguette, and the crust is close to perfection. BUT neither salty or airy enough, imo. A little too much Ace Bakery.
This gets a 7/10.
A French bakery in little Italy. Owners super charming; I really wanted to like this more.
It is a GREAT looking baguette, and the crust is close to perfection. BUT neither salty or airy enough, imo. A little too much Ace Bakery.
This gets a 7/10.
May 11, 2025 at 4:04 PM
New baguette review: Bakery Pompette on College.
A French bakery in little Italy. Owners super charming; I really wanted to like this more.
It is a GREAT looking baguette, and the crust is close to perfection. BUT neither salty or airy enough, imo. A little too much Ace Bakery.
This gets a 7/10.
A French bakery in little Italy. Owners super charming; I really wanted to like this more.
It is a GREAT looking baguette, and the crust is close to perfection. BUT neither salty or airy enough, imo. A little too much Ace Bakery.
This gets a 7/10.
Who’s here for next Pope odds?
April 21, 2025 at 3:30 PM
Who’s here for next Pope odds?
Registration is open for a few more weeks but if you’re a trainee and want to be considered for one of the four talking slots please register before this weekend. We are selecting speakers on Monday.
www.eventbrite.ca/e/neural-cir...
www.eventbrite.ca/e/neural-cir...
April 17, 2025 at 2:40 AM
Registration is open for a few more weeks but if you’re a trainee and want to be considered for one of the four talking slots please register before this weekend. We are selecting speakers on Monday.
www.eventbrite.ca/e/neural-cir...
www.eventbrite.ca/e/neural-cir...
Impoverished environments delay, whereas enriched environments hasten, the emergence of adult-like episodic-like memory function in developing mice.
April 10, 2025 at 4:52 PM
Impoverished environments delay, whereas enriched environments hasten, the emergence of adult-like episodic-like memory function in developing mice.
This work explores sensitive period plasticity mechanisms underlying the developmental emergence of episodic-like memory in mice... and finds that the emergence of adult-like episodic-like memory is modulated by early life experiences
April 10, 2025 at 4:52 PM
This work explores sensitive period plasticity mechanisms underlying the developmental emergence of episodic-like memory in mice... and finds that the emergence of adult-like episodic-like memory is modulated by early life experiences
Here’s the books!
March 28, 2025 at 11:54 PM
Here’s the books!
Who’s here for some retro SfN? 1996
March 28, 2025 at 11:02 PM
Who’s here for some retro SfN? 1996
Early morning skater(boy) at Nathan Phillips Square
March 12, 2025 at 11:40 AM
Early morning skater(boy) at Nathan Phillips Square