Paul Frankland
@franklandlab.bsky.social
The neuroscience of memory, West Ham Utd, baguettes and other random stuff
Neuroscientist at Hospital for Sick Children/University of Toronto
Neuroscientist at Hospital for Sick Children/University of Toronto
New paper from the lab 🚨
Led by Ali Golbabaei, this study explores the how the composition of prefrontal cortical engrams changes with memory age:
authors.elsevier.com/a/1lzT-3BtfH...
Led by Ali Golbabaei, this study explores the how the composition of prefrontal cortical engrams changes with memory age:
authors.elsevier.com/a/1lzT-3BtfH...
authors.elsevier.com
October 22, 2025 at 6:50 PM
New paper from the lab 🚨
Led by Ali Golbabaei, this study explores the how the composition of prefrontal cortical engrams changes with memory age:
authors.elsevier.com/a/1lzT-3BtfH...
Led by Ali Golbabaei, this study explores the how the composition of prefrontal cortical engrams changes with memory age:
authors.elsevier.com/a/1lzT-3BtfH...
New paper from the lab led by Ali Golbabaei. If you’re interested in systems consolidation, generalization and hippocampal neurogenesis a short 🧵 follows:
authors.elsevier.com/a/1lsO73QW8S...
authors.elsevier.com/a/1lsO73QW8S...
authors.elsevier.com
October 1, 2025 at 12:39 AM
New paper from the lab led by Ali Golbabaei. If you’re interested in systems consolidation, generalization and hippocampal neurogenesis a short 🧵 follows:
authors.elsevier.com/a/1lsO73QW8S...
authors.elsevier.com/a/1lsO73QW8S...
Now seen all the greats. Messi, both Ronaldo’s, Ronaldinho and Alan Devonshire.
September 27, 2025 at 11:04 PM
Now seen all the greats. Messi, both Ronaldo’s, Ronaldinho and Alan Devonshire.
Watching 38 year old man walk around for 90 mins
September 27, 2025 at 9:51 PM
Watching 38 year old man walk around for 90 mins
Reposted by Paul Frankland
In summary, we established whole-genome, multimodal single-cell history tracing, applicable to a wide range of experimental systems.
Our lab is now applying HisTrac to study id specification and plasticity (e.g., memory) and we look forward to sharing exciting results soon!
Our lab is now applying HisTrac to study id specification and plasticity (e.g., memory) and we look forward to sharing exciting results soon!
August 16, 2025 at 7:15 AM
In summary, we established whole-genome, multimodal single-cell history tracing, applicable to a wide range of experimental systems.
Our lab is now applying HisTrac to study id specification and plasticity (e.g., memory) and we look forward to sharing exciting results soon!
Our lab is now applying HisTrac to study id specification and plasticity (e.g., memory) and we look forward to sharing exciting results soon!
Working From Dome
August 14, 2025 at 7:13 PM
Working From Dome
Fantastic afternoon (so far) at the Skydome.
July 20, 2025 at 5:48 PM
Fantastic afternoon (so far) at the Skydome.
Checking out Toronto’s day-old park (Biidaasige Park) on my morning run. Beautiful in the morning sun.
July 19, 2025 at 11:32 AM
Checking out Toronto’s day-old park (Biidaasige Park) on my morning run. Beautiful in the morning sun.
Reposted by Paul Frankland
Role and influence, yes. But, the biological mechanisms? Maybe not in a functional/systems/computational model...
Mind you, though I am not objective here, I basically buy @franklandlab.bsky.social's account of infantile amnesia as being driven by neurogenesis:
www.science.org/doi/full/10....
Mind you, though I am not objective here, I basically buy @franklandlab.bsky.social's account of infantile amnesia as being driven by neurogenesis:
www.science.org/doi/full/10....
www.science.org
June 25, 2025 at 12:02 AM
Role and influence, yes. But, the biological mechanisms? Maybe not in a functional/systems/computational model...
Mind you, though I am not objective here, I basically buy @franklandlab.bsky.social's account of infantile amnesia as being driven by neurogenesis:
www.science.org/doi/full/10....
Mind you, though I am not objective here, I basically buy @franklandlab.bsky.social's account of infantile amnesia as being driven by neurogenesis:
www.science.org/doi/full/10....
Reposted by Paul Frankland
It was a great pleasure to host Paul Frankand @franklandlab.bsky.social as the keynote speaker at the Dutch Neuroscience Meeting 2025 and at the Donders Institute. Big thanks to Paul for accepting our invitation, for the fantastic talks and discussions!
June 20, 2025 at 10:12 PM
It was a great pleasure to host Paul Frankand @franklandlab.bsky.social as the keynote speaker at the Dutch Neuroscience Meeting 2025 and at the Donders Institute. Big thanks to Paul for accepting our invitation, for the fantastic talks and discussions!
For anyone in the memory field, an incredible summary and tribute to Endel Tulving from Gus Craik. Read it for the writing alone.
royalsocietypublishing.org/action/oidcS...
royalsocietypublishing.org/action/oidcS...
May 30, 2025 at 10:52 PM
For anyone in the memory field, an incredible summary and tribute to Endel Tulving from Gus Craik. Read it for the writing alone.
royalsocietypublishing.org/action/oidcS...
royalsocietypublishing.org/action/oidcS...
Never open a ‘Decision on manuscript XXX…’ email on a Friday. Nothing good ever comes of it.
May 29, 2025 at 4:23 PM
Never open a ‘Decision on manuscript XXX…’ email on a Friday. Nothing good ever comes of it.
Appreciating the free wifi on my @aircanada.bsky.social flight to the US this morning. Remember when hotels used to charge for wifi? This is the start of the wave for free wifi on flights. No carrier can afford not to offer it.
May 27, 2025 at 1:56 PM
Appreciating the free wifi on my @aircanada.bsky.social flight to the US this morning. Remember when hotels used to charge for wifi? This is the start of the wave for free wifi on flights. No carrier can afford not to offer it.
... in situations that _do not_ match the original training conditions... 🤦♂️
We studied this using engram labeling tools in mice. We find that consolidation promotes gradual rewiring of hippocampal engrams in ways which promote their promiscuous activation in situations that match the original training conditions: They guide behavior a more general set of scenarios.
6/n
6/n
May 14, 2025 at 9:00 PM
... in situations that _do not_ match the original training conditions... 🤦♂️
Reposted by Paul Frankland
If you are in Toronto on Tuesday next week, please consider coming to see a FREE public lecture on memory, delivered by the amazing @sjo09.bsky.social and @barense.bsky.social . Tix at this link can-acn.org/meeting-2025... Please repost and hope to see you there!
CAN 2025 Public Lectures: Neuroscience of memory and tools for making our memories stronger – Canadian Association for Neuroscience
can-acn.org
May 14, 2025 at 7:15 PM
If you are in Toronto on Tuesday next week, please consider coming to see a FREE public lecture on memory, delivered by the amazing @sjo09.bsky.social and @barense.bsky.social . Tix at this link can-acn.org/meeting-2025... Please repost and hope to see you there!
Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation.
rdcu.be/el18q
A short thread follows for those interested.
1/n
rdcu.be/el18q
A short thread follows for those interested.
1/n
Systems consolidation reorganizes hippocampal engram circuitry
Nature - A study shows that loss of memory precision associated with systems consolidation can be explained by neurogenesis-dependent reorganization of engram circuitry within the hippocampus over...
rdcu.be
May 14, 2025 at 4:32 PM
Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation.
rdcu.be/el18q
A short thread follows for those interested.
1/n
rdcu.be/el18q
A short thread follows for those interested.
1/n
New baguette review: Bakery Pompette on College.
A French bakery in little Italy. Owners super charming; I really wanted to like this more.
It is a GREAT looking baguette, and the crust is close to perfection. BUT neither salty or airy enough, imo. A little too much Ace Bakery.
This gets a 7/10.
A French bakery in little Italy. Owners super charming; I really wanted to like this more.
It is a GREAT looking baguette, and the crust is close to perfection. BUT neither salty or airy enough, imo. A little too much Ace Bakery.
This gets a 7/10.
May 11, 2025 at 4:04 PM
New baguette review: Bakery Pompette on College.
A French bakery in little Italy. Owners super charming; I really wanted to like this more.
It is a GREAT looking baguette, and the crust is close to perfection. BUT neither salty or airy enough, imo. A little too much Ace Bakery.
This gets a 7/10.
A French bakery in little Italy. Owners super charming; I really wanted to like this more.
It is a GREAT looking baguette, and the crust is close to perfection. BUT neither salty or airy enough, imo. A little too much Ace Bakery.
This gets a 7/10.
💯
1990s seminar.
Senior prof: Asks question
Speaker (new assistant prof): Offers answer
Senior prof: “well you obviously haven’t a clue, so I’ll answer it for you”. Bangs on about his work for next 5 mins.
Replacing the bluster and aggression with civility and politeness = progress.
1990s seminar.
Senior prof: Asks question
Speaker (new assistant prof): Offers answer
Senior prof: “well you obviously haven’t a clue, so I’ll answer it for you”. Bangs on about his work for next 5 mins.
Replacing the bluster and aggression with civility and politeness = progress.
A bit of gentle questioning is OK but I am glad we have lost the culture of savage critique. I was scarred early on by seeing a senior scientist demolish a PhD student in their first-ever SFN presentation and it was awful. I became terrified myself of giving talks for quite a while after.
May 4, 2025 at 2:02 PM
💯
1990s seminar.
Senior prof: Asks question
Speaker (new assistant prof): Offers answer
Senior prof: “well you obviously haven’t a clue, so I’ll answer it for you”. Bangs on about his work for next 5 mins.
Replacing the bluster and aggression with civility and politeness = progress.
1990s seminar.
Senior prof: Asks question
Speaker (new assistant prof): Offers answer
Senior prof: “well you obviously haven’t a clue, so I’ll answer it for you”. Bangs on about his work for next 5 mins.
Replacing the bluster and aggression with civility and politeness = progress.
Who’s here for next Pope odds?
April 21, 2025 at 3:30 PM
Who’s here for next Pope odds?
Registration is open for a few more weeks but if you’re a trainee and want to be considered for one of the four talking slots please register before this weekend. We are selecting speakers on Monday.
www.eventbrite.ca/e/neural-cir...
www.eventbrite.ca/e/neural-cir...
April 17, 2025 at 2:40 AM
Registration is open for a few more weeks but if you’re a trainee and want to be considered for one of the four talking slots please register before this weekend. We are selecting speakers on Monday.
www.eventbrite.ca/e/neural-cir...
www.eventbrite.ca/e/neural-cir...
Thrilled to share new work from the lab, led by Adam Ramsaran:
authors.elsevier.com/a/1kva73QW8S...
authors.elsevier.com/a/1kva73QW8S...
authors.elsevier.com
April 10, 2025 at 4:52 PM
Thrilled to share new work from the lab, led by Adam Ramsaran:
authors.elsevier.com/a/1kva73QW8S...
authors.elsevier.com/a/1kva73QW8S...
Who’s here for some retro SfN? 1996
March 28, 2025 at 11:02 PM
Who’s here for some retro SfN? 1996
Reposted by Paul Frankland
Program for the "Neural Circuits and Behaviour" CAN 2025 satellite is now available! We have a great day planned, and are especially looking for trainees to join the event - we'll select four trainees for talks, with a prize for best trainee talk. Details: www.eventbrite.ca/e/neural-cir...
March 24, 2025 at 8:39 PM
Program for the "Neural Circuits and Behaviour" CAN 2025 satellite is now available! We have a great day planned, and are especially looking for trainees to join the event - we'll select four trainees for talks, with a prize for best trainee talk. Details: www.eventbrite.ca/e/neural-cir...
We have no memories for events from our earliest childhood years (aka infantile amnesia). Is it because we can't form them or can't keep them? Our Perspective on exciting new work from @tristansyates.bsky.social and colleagues.
Babies form fleeting memories | Science www.science.org/doi/10.1126/...
Babies form fleeting memories | Science www.science.org/doi/10.1126/...
Babies form fleeting memories
The human hippocampus constructs short-lived memories from around 1 year of age
www.science.org
March 20, 2025 at 6:42 PM
We have no memories for events from our earliest childhood years (aka infantile amnesia). Is it because we can't form them or can't keep them? Our Perspective on exciting new work from @tristansyates.bsky.social and colleagues.
Babies form fleeting memories | Science www.science.org/doi/10.1126/...
Babies form fleeting memories | Science www.science.org/doi/10.1126/...