Felipe Melo-Gonzalez
@fm-lab.bsky.social
Laboratorio de Inmunología Traslacional, Universidad Andrés Bello, Chile
Reposted by Felipe Melo-Gonzalez
Review @natrevrheumatol.bsky.social @boutetmarieastrid.bsky.social
The role of the immune system in osteoarthritis: mechanisms, challenges and future directions
www.nature.com/articles/s41...
The role of the immune system in osteoarthritis: mechanisms, challenges and future directions
www.nature.com/articles/s41...
The role of the immune system in osteoarthritis: mechanisms, challenges and future directions - Nature Reviews Rheumatology
This Review provides an update on the role of innate and adaptive immune cells in the pathogenesis of osteoarthritis. The authors discuss emerging therapeutics that target the immune system in osteoar...
www.nature.com
March 13, 2025 at 6:04 PM
Review @natrevrheumatol.bsky.social @boutetmarieastrid.bsky.social
The role of the immune system in osteoarthritis: mechanisms, challenges and future directions
www.nature.com/articles/s41...
The role of the immune system in osteoarthritis: mechanisms, challenges and future directions
www.nature.com/articles/s41...
Reposted by Felipe Melo-Gonzalez
How a fat in our diet (omega-6 linoleic acid)—a dietary long-chain polyunsaturated fatty acid) has the potential to promote tumor growth www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
@science.org
www.science.org/doi/10.1126/...
@science.org
March 13, 2025 at 7:54 PM
How a fat in our diet (omega-6 linoleic acid)—a dietary long-chain polyunsaturated fatty acid) has the potential to promote tumor growth www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
@science.org
www.science.org/doi/10.1126/...
@science.org
Reposted by Felipe Melo-Gonzalez
Altered inflammatory mucosal signatures within their spatial and cellular context during active ileal Crohn’s disease
@jci-insight.bsky.social insight.jci.org/articles/vie...
@jci-insight.bsky.social insight.jci.org/articles/vie...
March 11, 2025 at 7:53 PM
Altered inflammatory mucosal signatures within their spatial and cellular context during active ileal Crohn’s disease
@jci-insight.bsky.social insight.jci.org/articles/vie...
@jci-insight.bsky.social insight.jci.org/articles/vie...
Reposted by Felipe Melo-Gonzalez
Local deactivation of mouth-resident antiviral CD8+ T cells contributes to disease in experimental periodontitis: www.mucosalimmunology.org/article/S193...
March 12, 2025 at 1:30 PM
Local deactivation of mouth-resident antiviral CD8+ T cells contributes to disease in experimental periodontitis: www.mucosalimmunology.org/article/S193...
Reposted by Felipe Melo-Gonzalez
#midweekmicro🔬
Neonatal fungi promote lifelong metabolic health through macrophage-dependent β cell development
@science.org #microsky
www.science.org/doi/10.1126/...
Neonatal fungi promote lifelong metabolic health through macrophage-dependent β cell development
@science.org #microsky
www.science.org/doi/10.1126/...
Neonatal fungi promote lifelong metabolic health through macrophage-dependent β cell development
Loss of early-life microbial diversity is correlated with diabetes, yet mechanisms by which microbes influence disease remain elusive. We report a critical neonatal window in mice when microbiota disr...
www.science.org
March 12, 2025 at 4:43 PM
#midweekmicro🔬
Neonatal fungi promote lifelong metabolic health through macrophage-dependent β cell development
@science.org #microsky
www.science.org/doi/10.1126/...
Neonatal fungi promote lifelong metabolic health through macrophage-dependent β cell development
@science.org #microsky
www.science.org/doi/10.1126/...
Reposted by Felipe Melo-Gonzalez
New online! Microbiota in inflammatory bowel disease: mechanisms of disease and therapeutic opportunities
Microbiota in inflammatory bowel disease: mechanisms of disease and therapeutic opportunities
Nature Reviews Microbiology, Published online: 10 March 2025; doi:10.1038/s41579-025-01163-0In this Review, Iliev, Ananthakrishnan and Guo explore the gut microbiota in inflammatory bowel disease, highlighting bacterial and fungal components, immune…
www.nature.com
March 10, 2025 at 12:59 PM
New online! Microbiota in inflammatory bowel disease: mechanisms of disease and therapeutic opportunities
Reposted by Felipe Melo-Gonzalez
Neutrophils associated with the epithelium function distinctly from those in the lamina propria in the inflamed colon mucosa: www.mucosalimmunology.org/article/S193...
March 10, 2025 at 1:46 PM
Neutrophils associated with the epithelium function distinctly from those in the lamina propria in the inflamed colon mucosa: www.mucosalimmunology.org/article/S193...
Reposted by Felipe Melo-Gonzalez
When gut E. gallinarum go rogue—autoimmunity may follows. 🦠🔥
🔼 IFN-γ+ TH17 differentiation
🔼 IgG3 switch in anti-E. g RNA antibodies
🔼 TLR8 activation → monocyte-driven TH17 induction
🔼 Correlation with renal autoimmunity (mice) & disease activity (SLE patients)
www.science.org/doi/10.1126/...
🔼 IFN-γ+ TH17 differentiation
🔼 IgG3 switch in anti-E. g RNA antibodies
🔼 TLR8 activation → monocyte-driven TH17 induction
🔼 Correlation with renal autoimmunity (mice) & disease activity (SLE patients)
www.science.org/doi/10.1126/...
Translocating gut pathobiont Enterococcus gallinarum induces TH17 and IgG3 anti-RNA–directed autoimmunity in mouse and human
Translocating pathobiont Enterococcus gallinarum promotes human TH17 and anti-RNA IgG3 autoantibody responses in patients with autoimmune disease.
www.science.org
March 9, 2025 at 11:09 AM
When gut E. gallinarum go rogue—autoimmunity may follows. 🦠🔥
🔼 IFN-γ+ TH17 differentiation
🔼 IgG3 switch in anti-E. g RNA antibodies
🔼 TLR8 activation → monocyte-driven TH17 induction
🔼 Correlation with renal autoimmunity (mice) & disease activity (SLE patients)
www.science.org/doi/10.1126/...
🔼 IFN-γ+ TH17 differentiation
🔼 IgG3 switch in anti-E. g RNA antibodies
🔼 TLR8 activation → monocyte-driven TH17 induction
🔼 Correlation with renal autoimmunity (mice) & disease activity (SLE patients)
www.science.org/doi/10.1126/...
Reposted by Felipe Melo-Gonzalez
IL33 protects from recurrent C. difficile infection by restoration of humoral immunity
www.jci.org/articles/vie...
@jclinical-invest.bsky.social
www.jci.org/articles/vie...
@jclinical-invest.bsky.social
March 7, 2025 at 8:02 PM
IL33 protects from recurrent C. difficile infection by restoration of humoral immunity
www.jci.org/articles/vie...
@jclinical-invest.bsky.social
www.jci.org/articles/vie...
@jclinical-invest.bsky.social
Reposted by Felipe Melo-Gonzalez
OUT NOW: ILC3s regulate the gut microbiota via host intestinal galactosylation to limit pathogen infection in mice
#microsky #immunosky
www.nature.com/articles/s41...
#microsky #immunosky
www.nature.com/articles/s41...
ILC3s regulate the gut microbiota via host intestinal galactosylation to limit pathogen infection in mice - Nature Microbiology
Akkermansia muciniphila can promote intestinal pathogen infection in mice via microbial metabolite succinate production, but the expansion of A. muciniphila is strictly controlled by ILC3s through the...
www.nature.com
February 18, 2025 at 10:10 AM
OUT NOW: ILC3s regulate the gut microbiota via host intestinal galactosylation to limit pathogen infection in mice
#microsky #immunosky
www.nature.com/articles/s41...
#microsky #immunosky
www.nature.com/articles/s41...
Reposted by Felipe Melo-Gonzalez
Had the pleasure of writing a commentary for Nature Immunology on this article out today from Nian Liu, Zusen Fan and colleagues.
A really interesting piece of gut NeuroImmunology dissecting the interplay between GABAergic neurons and ILC3.
www.nature.com/articles/s41...
Commentary: rdcu.be/eb28A
A really interesting piece of gut NeuroImmunology dissecting the interplay between GABAergic neurons and ILC3.
www.nature.com/articles/s41...
Commentary: rdcu.be/eb28A
Enteric GABAergic neuron-derived γ-aminobutyric acid initiates expression of Igfbp7 to sustain ILC3 homeostasis - Nature Immunology
Fan and colleagues show that the neurotransmitter GABA signals in intestinal ILC3s to suppress IL-17A production through a regulatory loop that involves suppression of C/EBP-β and induction of Igfb7.
www.nature.com
March 3, 2025 at 5:15 PM
Had the pleasure of writing a commentary for Nature Immunology on this article out today from Nian Liu, Zusen Fan and colleagues.
A really interesting piece of gut NeuroImmunology dissecting the interplay between GABAergic neurons and ILC3.
www.nature.com/articles/s41...
Commentary: rdcu.be/eb28A
A really interesting piece of gut NeuroImmunology dissecting the interplay between GABAergic neurons and ILC3.
www.nature.com/articles/s41...
Commentary: rdcu.be/eb28A