@faurelab.bsky.social
Neuroscience lab. We study decision making, exploration and addiction. We are interested in inter-individual variability.
Reposted
You just finished your PhD and you are looking for a postdoc to study stress-dependent modulation of learning. We are using the powerful fly model to understand the underlying circuits and mechanisms. You can apply here:
emploi.cnrs.fr/Offres/CDD/U...
emploi.cnrs.fr/Offres/CDD/U...
Portail Emploi CNRS - Offre d'emploi - Postdoc position (M/F) in Neuroscience, stress modulation of learning (H/F)
emploi.cnrs.fr
September 15, 2025 at 10:25 AM
You just finished your PhD and you are looking for a postdoc to study stress-dependent modulation of learning. We are using the powerful fly model to understand the underlying circuits and mechanisms. You can apply here:
emploi.cnrs.fr/Offres/CDD/U...
emploi.cnrs.fr/Offres/CDD/U...
Big news for @laurenmac.bsky.social !
2025 is quite a year: CNRS position + ERC Starting Grant
Her project DeMARRe will study how adolescent exploration & risk-taking shape neural circuits and resilience in adulthood.
@cnrs.fr @espciparispsl.bsky.social
www.insb.cnrs.fr/fr/personne/...
2025 is quite a year: CNRS position + ERC Starting Grant
Her project DeMARRe will study how adolescent exploration & risk-taking shape neural circuits and resilience in adulthood.
@cnrs.fr @espciparispsl.bsky.social
www.insb.cnrs.fr/fr/personne/...
Lauren Reynolds
www.insb.cnrs.fr
September 17, 2025 at 8:44 AM
Big news for @laurenmac.bsky.social !
2025 is quite a year: CNRS position + ERC Starting Grant
Her project DeMARRe will study how adolescent exploration & risk-taking shape neural circuits and resilience in adulthood.
@cnrs.fr @espciparispsl.bsky.social
www.insb.cnrs.fr/fr/personne/...
2025 is quite a year: CNRS position + ERC Starting Grant
Her project DeMARRe will study how adolescent exploration & risk-taking shape neural circuits and resilience in adulthood.
@cnrs.fr @espciparispsl.bsky.social
www.insb.cnrs.fr/fr/personne/...
Reposted
1
To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!
🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...
To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!
🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...
July 27, 2025 at 5:26 PM
1
To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!
🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...
To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!
🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...
Reposted
Alcool et nicotine : un même circuit cérébral à l’origine de la récompense et de l’anxiété
👋 @cnrs-paris.bsky.social @espciparispsl.bsky.social
✍️ @faurelab.bsky.social & Fabio Marti
👉 Lire l'article dans buff.ly/vE1j6LP
buff.ly/fD5DOxu
👋 @cnrs-paris.bsky.social @espciparispsl.bsky.social
✍️ @faurelab.bsky.social & Fabio Marti
👉 Lire l'article dans buff.ly/vE1j6LP
buff.ly/fD5DOxu
July 10, 2025 at 5:00 AM
Alcool et nicotine : un même circuit cérébral à l’origine de la récompense et de l’anxiété
👋 @cnrs-paris.bsky.social @espciparispsl.bsky.social
✍️ @faurelab.bsky.social & Fabio Marti
👉 Lire l'article dans buff.ly/vE1j6LP
buff.ly/fD5DOxu
👋 @cnrs-paris.bsky.social @espciparispsl.bsky.social
✍️ @faurelab.bsky.social & Fabio Marti
👉 Lire l'article dans buff.ly/vE1j6LP
buff.ly/fD5DOxu
Nicotine doesn’t just “turn on” the brain’s reward circuits — it reshapes them. Our new paper in Nature Communications shows that activating reward-linked dopamine neurons also sets off a feedback loop that drives negative emotional states.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Nicotine engages a VTA-NAc feedback loop to inhibit amygdala-projecting dopamine neurons and induce anxiety-like behaviors - Nature Communications
Drugs of abuse exert both motivational and emotional effects. Here, the authors show that nicotine and ethanol activate a VTA–NAc loop that inhibits dopamine neurons projecting to the amygdala, thereb...
www.nature.com
July 5, 2025 at 1:19 PM
Nicotine doesn’t just “turn on” the brain’s reward circuits — it reshapes them. Our new paper in Nature Communications shows that activating reward-linked dopamine neurons also sets off a feedback loop that drives negative emotional states.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Our work on the role of the interpeduncular nucleus in nicotine reward ( www.cell.com/neuron/abstr... ) is featured in a Neuron Preview ! Brandon J Henderson highlights how a new regulatory circuit controlling nicotine reinforcement has been uncovered. www.cell.com/neuron/abstr...
Slowing the drive: A new regulatory break for nicotine reward-related behaviors
In this issue of Neuron, Jehl et al. developed a “suicide” antagonist to demonstrate
that the interpeduncular nucleus acts as a regulatory controller of nicotine reward-related
behavior through connec...
www.cell.com
June 19, 2025 at 1:02 PM
Our work on the role of the interpeduncular nucleus in nicotine reward ( www.cell.com/neuron/abstr... ) is featured in a Neuron Preview ! Brandon J Henderson highlights how a new regulatory circuit controlling nicotine reinforcement has been uncovered. www.cell.com/neuron/abstr...
Yesss! So happy to see this, totally deserved!
Thrilled to share that I have obtained a permanent position at CNRS 🎉🎉🎉
Thanks so much to everyone that supported me along the way, and especially @faurelab.bsky.social !
Thanks so much to everyone that supported me along the way, and especially @faurelab.bsky.social !
June 13, 2025 at 4:18 PM
Yesss! So happy to see this, totally deserved!
Reposted
Our work on rubber hand embodiment in mice is out @plosbiology.org! We show that just like in humans, visuo-tactile pairing can lead mice to an embodiment-like behavior with respect to an artificial limb.
Embodiment of an artificial limb in mice
Body ownership disorders can be triggered by disease or body damage in humans. This study shows, using an automated, videography-based procedure, that mice also display quantifiable behavioral markers...
journals.plos.org
June 5, 2025 at 9:06 PM
Our work on rubber hand embodiment in mice is out @plosbiology.org! We show that just like in humans, visuo-tactile pairing can lead mice to an embodiment-like behavior with respect to an artificial limb.
Reposted
Nouvel article avec mes ami-es belges E. Chaves et A. de Kerchove où on décrit l'effet de l'activation de populations de neurones du striatum sur les stratégies de décision. On a essayé de sortir d'une définition "par l'expérimentateur" de la performance des souris.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Direct and indirect striatal projecting neurons exert strategy-dependent effects on decision-making
In the dorsomedial striatum, d-SPNs increase risk seeking, while iSPNs amplify the value of large gains in decision making.
www.science.org
May 28, 2025 at 7:20 PM
Nouvel article avec mes ami-es belges E. Chaves et A. de Kerchove où on décrit l'effet de l'activation de populations de neurones du striatum sur les stratégies de décision. On a essayé de sortir d'une définition "par l'expérimentateur" de la performance des souris.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted
Hot off the press:
The excellent Maheva Andriatsilavo and colleagues show how a temporal sequence of stochastic molecular mechanisms allow the emergence of stereotyped individualised neuronal circuits. Just published in Nature Neuroscience:
rdcu.be/ek010
The excellent Maheva Andriatsilavo and colleagues show how a temporal sequence of stochastic molecular mechanisms allow the emergence of stereotyped individualised neuronal circuits. Just published in Nature Neuroscience:
rdcu.be/ek010
Sequential and independent probabilistic events regulate differential axon targeting during development in Drosophila melanogaster
Nature Neuroscience - The developmental origin of behavioral individuality is unclear. The authors show that a temporal sequence of genetically encoded stochastic mechanisms explains variation in...
rdcu.be
May 7, 2025 at 11:26 AM
Hot off the press:
The excellent Maheva Andriatsilavo and colleagues show how a temporal sequence of stochastic molecular mechanisms allow the emergence of stereotyped individualised neuronal circuits. Just published in Nature Neuroscience:
rdcu.be/ek010
The excellent Maheva Andriatsilavo and colleagues show how a temporal sequence of stochastic molecular mechanisms allow the emergence of stereotyped individualised neuronal circuits. Just published in Nature Neuroscience:
rdcu.be/ek010
Reposted
I have an opening in my lab for a postdoctoral fellow to work on projects that relate to the mechanisms of neurotransmitter release by dopamine neurons and/or on how inflammatory signals infuence the functionning of these neurons. Please share.
April 24, 2025 at 9:34 PM
I have an opening in my lab for a postdoctoral fellow to work on projects that relate to the mechanisms of neurotransmitter release by dopamine neurons and/or on how inflammatory signals infuence the functionning of these neurons. Please share.
The interpeduncular nucleus (IPN) dampens nicotine reward via β4* nAChRs and IPN→LDTg projections. Blocking this pathway enhances VTA responses and CPP: A nicotine-specific brake embedded in the mesolimbic system.
New paper from the lab out in @cp-neuron.bsky.social www.cell.com/neuron/abstr...
New paper from the lab out in @cp-neuron.bsky.social www.cell.com/neuron/abstr...
The interpeduncular nucleus blunts the rewarding effect of nicotine
Nicotine activates the dopamine reward system to promote consumption and addiction,
but the brain has a natural brake to counteract it. Jehl, Ciscato, Vicq, Guyon, et al.
identified the interpeduncula...
www.cell.com
April 21, 2025 at 5:01 PM
The interpeduncular nucleus (IPN) dampens nicotine reward via β4* nAChRs and IPN→LDTg projections. Blocking this pathway enhances VTA responses and CPP: A nicotine-specific brake embedded in the mesolimbic system.
New paper from the lab out in @cp-neuron.bsky.social www.cell.com/neuron/abstr...
New paper from the lab out in @cp-neuron.bsky.social www.cell.com/neuron/abstr...
Reposted
Registrations for the Symposium for the Biology of decision making (SBDM) in Lyon 2025 are finally open! sbdm2025.github.io Please spread the message!
April 8, 2025 at 6:18 PM
Registrations for the Symposium for the Biology of decision making (SBDM) in Lyon 2025 are finally open! sbdm2025.github.io Please spread the message!
New preprint from the lab and @clementsolie.bsky.social on social organization & neuromodulation! Read the full preprint here: www.biorxiv.org/content/10.1... @espciparispsl.bsky.social @cnrsbiologie.bsky.social
Dopaminergic mechanisms of dynamical social specialization in mouse microsocieties
Social organization and division of labor are fundamental to animal societies, but how do these structures emerge from individual interactions, and what role does neuromodulation play in shaping them?...
www.biorxiv.org
February 11, 2025 at 12:47 PM
New preprint from the lab and @clementsolie.bsky.social on social organization & neuromodulation! Read the full preprint here: www.biorxiv.org/content/10.1... @espciparispsl.bsky.social @cnrsbiologie.bsky.social
Reposted
This is one of my favourite papers for a while.
Theoretically informed, technically accomplished, well-written and argued, articulates explanation 👏
By @jeremie-n.bsky.social and colleagues.
I would love to teach it but it may be a lot...
www.nature.com/articles/s41...
Theoretically informed, technically accomplished, well-written and argued, articulates explanation 👏
By @jeremie-n.bsky.social and colleagues.
I would love to teach it but it may be a lot...
www.nature.com/articles/s41...
Dopamine builds and reveals reward-associated latent behavioral attractors - Nature Communications
The reason why manipulating dopamine (DA) activity can affect both action latency, action direction, and movement vigor, but only in certain animal states and behavioral settings is not fully understo...
www.nature.com
January 22, 2025 at 10:03 AM
This is one of my favourite papers for a while.
Theoretically informed, technically accomplished, well-written and argued, articulates explanation 👏
By @jeremie-n.bsky.social and colleagues.
I would love to teach it but it may be a lot...
www.nature.com/articles/s41...
Theoretically informed, technically accomplished, well-written and argued, articulates explanation 👏
By @jeremie-n.bsky.social and colleagues.
I would love to teach it but it may be a lot...
www.nature.com/articles/s41...
Superb study from Thomas Preat's team here @espciparispsl.bsky.social @cnrsbiologie.bsky.social , showing that astrocytes use redox H₂O₂ signaling to support memory in Drosophila. Amyloid-β disrupts this process, linking it to cognitive deficits in Alzheimer’s. www.nature.com/articles/s42...
Astrocyte-to-neuron H2O2 signalling supports long-term memory formation in Drosophila and is impaired in an Alzheimer’s disease model - Nature Metabolism
Rabah et al. discover an astrocyte-to-neuron hydrogen peroxide signalling cascade, which is crucial for long-term memory formation in Drosophila. This signalling is found to be inhibited by amyloid-β ...
www.nature.com
February 5, 2025 at 1:35 PM
Superb study from Thomas Preat's team here @espciparispsl.bsky.social @cnrsbiologie.bsky.social , showing that astrocytes use redox H₂O₂ signaling to support memory in Drosophila. Amyloid-β disrupts this process, linking it to cognitive deficits in Alzheimer’s. www.nature.com/articles/s42...
Reposted
#RésultatScientifique🔎Comment la dopamine peut-elle orchestrer à la fois l’apprentissage et la motivation ? @jeremie-n.bsky.social propose une réponse à cette question dans @naturecomms.bsky.social ⤵️
🤝 @cnrsoccitanieest.bsky.social @umontpellier.bsky.social @cnrsinformatics.bsky.social
🤝 @cnrsoccitanieest.bsky.social @umontpellier.bsky.social @cnrsinformatics.bsky.social
De l’apprentissage à l’action : la dopamine révèle nos apprentissages cachés
La dopamine, une molécule clé dans le cerveau, est essentielle à l’
buff.ly
January 22, 2025 at 7:00 AM
#RésultatScientifique🔎Comment la dopamine peut-elle orchestrer à la fois l’apprentissage et la motivation ? @jeremie-n.bsky.social propose une réponse à cette question dans @naturecomms.bsky.social ⤵️
🤝 @cnrsoccitanieest.bsky.social @umontpellier.bsky.social @cnrsinformatics.bsky.social
🤝 @cnrsoccitanieest.bsky.social @umontpellier.bsky.social @cnrsinformatics.bsky.social
Reposted
🚨 !!! Postdoc Position Available !!! 🚨
Join our team at the Neuromodulation Institute (Hôpital St-Anne) in Paris, France. Work on cutting-edge research involving voltammetric recordings in human patients and machine learning.
🧠🟦 / 🧠🤖 / 🧠🩺
#AcademicSky #postdoc
Join our team at the Neuromodulation Institute (Hôpital St-Anne) in Paris, France. Work on cutting-edge research involving voltammetric recordings in human patients and machine learning.
🧠🟦 / 🧠🤖 / 🧠🩺
#AcademicSky #postdoc
November 14, 2024 at 9:48 AM
🚨 !!! Postdoc Position Available !!! 🚨
Join our team at the Neuromodulation Institute (Hôpital St-Anne) in Paris, France. Work on cutting-edge research involving voltammetric recordings in human patients and machine learning.
🧠🟦 / 🧠🤖 / 🧠🩺
#AcademicSky #postdoc
Join our team at the Neuromodulation Institute (Hôpital St-Anne) in Paris, France. Work on cutting-edge research involving voltammetric recordings in human patients and machine learning.
🧠🟦 / 🧠🤖 / 🧠🩺
#AcademicSky #postdoc
"Dopamine builds and reveals reward-associated latent behavioral attractors". This study combines computational modeling and experimental work to reveal how DA not only teaches, but also motivates, i.e by creating and using pathways toward goals. www.nature.com/articles/s41...
Dopamine builds and reveals reward-associated latent behavioral attractors - Nature Communications
The reason why manipulating dopamine (DA) activity can affect both action latency, action direction, and movement vigor, but only in certain animal states and behavioral settings is not fully understo...
www.nature.com
November 14, 2024 at 10:01 PM
"Dopamine builds and reveals reward-associated latent behavioral attractors". This study combines computational modeling and experimental work to reveal how DA not only teaches, but also motivates, i.e by creating and using pathways toward goals. www.nature.com/articles/s41...
Reposted
Paper from my PD with @faurelab.bsky.social came out a couple weeks ago #neuroskyence #neuroscience
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Transient nicotine exposure in early adolescent male mice freezes their dopamine circuits in an immature state - Nature Communications
How nicotine impacts the adolescent development of neural circuitry is not fully understood. Here authors show that early adolescent nicotine exposure in male mice blocked the maturation of nicotine-e...
www.nature.com
November 11, 2024 at 9:01 AM
Paper from my PD with @faurelab.bsky.social came out a couple weeks ago #neuroskyence #neuroscience
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Adolescence is a critical period for nicotine addiction.
We found that early nicotine exposure "freezes” dopamine circuits in an immature state, leading to lifelong vulnerability. Details can be checked in new Lab preprint www.biorxiv.org/content/10.1... - Congrats @laurenmac.bsky.social
We found that early nicotine exposure "freezes” dopamine circuits in an immature state, leading to lifelong vulnerability. Details can be checked in new Lab preprint www.biorxiv.org/content/10.1... - Congrats @laurenmac.bsky.social
November 8, 2023 at 2:31 PM
Adolescence is a critical period for nicotine addiction.
We found that early nicotine exposure "freezes” dopamine circuits in an immature state, leading to lifelong vulnerability. Details can be checked in new Lab preprint www.biorxiv.org/content/10.1... - Congrats @laurenmac.bsky.social
We found that early nicotine exposure "freezes” dopamine circuits in an immature state, leading to lifelong vulnerability. Details can be checked in new Lab preprint www.biorxiv.org/content/10.1... - Congrats @laurenmac.bsky.social