Florian Sure
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f-sure.bsky.social
Florian Sure
@f-sure.bsky.social
7 followers 17 following 2 posts
Postdoc in Renal Physiology @FAU.de Erlangen-Nürnberg,
Active Member of @DLRG
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f-sure.bsky.social
We have a new paper out in Pflügers Archiv! 🎉 We show that acute activation of ENaC by SGK1 critically depends on cleavage of the γ-subunit, indicating an interaction between kinase and protease pathways.

doi.org/10.1007/s004...
#ENaC #SGK1 #Physiology #IonChannels #KidneyResearch
Acute activation of human epithelial sodium channel (ENaC) by serum and glucocorticoid inducible kinase 1 (SGK1) requires prior cleavage of the channel’s γ-subunit at its proximal cleavage site - Pflü...
Serum and glucocorticoid inducible kinase 1 (SGK1) is a key regulator of the epithelial sodium channel (ENaC). In rat ENaC, the serine residue 621 (S621) in the channel’s α-subunit is essential for ac...
doi.org
June 23, 2025 at 12:53 PM
Reposted by Florian Sure
naniontech.bsky.social
In a recent study, researchers developed and validated an automated #patchclamp ( #APC ) approach using the SyncroPatch 384 platform to detect #ENaC - mediated currents in a high-throughput format.

Read more here:
www.nanion.de/news/automat...
Automated patch clamp for ENaC drug discovery - Nanion Technologies
The epithelial sodium channel (ENaC) plays a central role in regulating sodium balance, blood pressure, and pulmonary fluid clearance. Despite its clinical relevance, progress in discovering new ENaC-...
www.nanion.de
May 15, 2025 at 3:45 PM
f-sure.bsky.social
Happy to share our recent research @fau.de on how to measure ENaC using automated patch clamp technique on a platform developed by @naniontech.bsky.social 🎉 doi.org/10.1007/s00424…#researchc#ENaCa#APCP#Sciencece
https://doi.org/10.1007/s00424…
May 8, 2025 at 1:16 PM