Erik Sontheimer 🇺🇸💙🇺🇦
@eriksontheimer.bsky.social
CRISPRologist @ UMass Chan Medical School, RNA Therapeutics Institute. Player for Team Hope, Team Reality, and Team Cat. RNA rules.
Reposted by Erik Sontheimer 🇺🇸💙🇺🇦
SCOTUS: considering race as one factor in a college applicant's file is blatantly unconstitutional
ALSO SCOTUS: considering race as one factor in targeting whom to detain and deport is cool cool cool
ALSO SCOTUS: considering race as one factor in targeting whom to detain and deport is cool cool cool
September 8, 2025 at 4:43 PM
SCOTUS: considering race as one factor in a college applicant's file is blatantly unconstitutional
ALSO SCOTUS: considering race as one factor in targeting whom to detain and deport is cool cool cool
ALSO SCOTUS: considering race as one factor in targeting whom to detain and deport is cool cool cool
Reposted by Erik Sontheimer 🇺🇸💙🇺🇦
Hot off the press from the RTI: Prime assembly with linear DNA donors enables large genomic insertions
pubmed.ncbi.nlm.nih.gov/40667017/?ut... #RNA #RNATherapeutics
pubmed.ncbi.nlm.nih.gov/40667017/?ut... #RNA #RNATherapeutics
Prime assembly with linear DNA donors enables large genomic insertions - PubMed
Targeted insertion of large DNA fragments has promising applications for genome engineering and gene therapy<sup>1,2</sup>. Twin prime editing (PE) guide RNAs (pegRNAs) have enabled relatively large insertions,...
pubmed.ncbi.nlm.nih.gov
August 1, 2025 at 5:03 PM
Hot off the press from the RTI: Prime assembly with linear DNA donors enables large genomic insertions
pubmed.ncbi.nlm.nih.gov/40667017/?ut... #RNA #RNATherapeutics
pubmed.ncbi.nlm.nih.gov/40667017/?ut... #RNA #RNATherapeutics
Reposted by Erik Sontheimer 🇺🇸💙🇺🇦
Thrilled to see our Kiwa story out today! A membrane-associated supercomplex that senses infection and blocks replication and transcription.
www.cell.com/cell/fulltex...
Huge congratulations to Yi and Zhiying for bringing it home, to Thomas for starting us off, and to all the collaborators.
www.cell.com/cell/fulltex...
Huge congratulations to Yi and Zhiying for bringing it home, to Thomas for starting us off, and to all the collaborators.
Kiwa is a membrane-embedded defense supercomplex activated at phage attachment sites
Zhang, Todeschini, and Wu et al. show that the bacterial defense system Kiwa senses
phage attachment at the membrane and assembles a transmembrane complex that halts
infection by blocking phage DNA re...
www.cell.com
July 28, 2025 at 7:43 PM
Thrilled to see our Kiwa story out today! A membrane-associated supercomplex that senses infection and blocks replication and transcription.
www.cell.com/cell/fulltex...
Huge congratulations to Yi and Zhiying for bringing it home, to Thomas for starting us off, and to all the collaborators.
www.cell.com/cell/fulltex...
Huge congratulations to Yi and Zhiying for bringing it home, to Thomas for starting us off, and to all the collaborators.
Reposted by Erik Sontheimer 🇺🇸💙🇺🇦
Fun news: I'm starting my research group at @rti-umasschan.bsky.social as the inaugural Maraganore Fellow! Our lab will focus on the RNA sequence-structure-function relationship in the cellular environment.
Visit our website to explore open positions: schaerfenlab.com
#RNA #Hiring #PostbacJobs
Visit our website to explore open positions: schaerfenlab.com
#RNA #Hiring #PostbacJobs
July 22, 2025 at 4:19 PM
Fun news: I'm starting my research group at @rti-umasschan.bsky.social as the inaugural Maraganore Fellow! Our lab will focus on the RNA sequence-structure-function relationship in the cellular environment.
Visit our website to explore open positions: schaerfenlab.com
#RNA #Hiring #PostbacJobs
Visit our website to explore open positions: schaerfenlab.com
#RNA #Hiring #PostbacJobs
Reposted by Erik Sontheimer 🇺🇸💙🇺🇦
On Thursday, Anastasia Khvorova, PhD, received the 2025 Else Kröner Fresenius Prize for Medical Research, a $2.7 million award, for her pioneering work in the field of RNA-based therapies.
📸: Else Kröner-Fresenius-Stiftung
#EKFprize25 #EKFS #RNA @ekfstiftung.bsky.social @rti-umasschan.bsky.social
📸: Else Kröner-Fresenius-Stiftung
#EKFprize25 #EKFS #RNA @ekfstiftung.bsky.social @rti-umasschan.bsky.social
May 16, 2025 at 2:25 PM
On Thursday, Anastasia Khvorova, PhD, received the 2025 Else Kröner Fresenius Prize for Medical Research, a $2.7 million award, for her pioneering work in the field of RNA-based therapies.
📸: Else Kröner-Fresenius-Stiftung
#EKFprize25 #EKFS #RNA @ekfstiftung.bsky.social @rti-umasschan.bsky.social
📸: Else Kröner-Fresenius-Stiftung
#EKFprize25 #EKFS #RNA @ekfstiftung.bsky.social @rti-umasschan.bsky.social
Reposted by Erik Sontheimer 🇺🇸💙🇺🇦
"The consolidation/RIF plan pulls power away from scientists and puts it in the hands of political employees. It sets up Trump and Musk to kill NIH as an evidence-based science funder. We must stop this plan."
New contributed post on our blog: Please read.
It describes Orban and authoritarianism. 🧪
New contributed post on our blog: Please read.
It describes Orban and authoritarianism. 🧪
The NIH firing plan is really a radical institute merger and an authoritarian takeover
this is an Orbanization of US science: a move to exert political control over discovery, which will kill the US medical research industry and end cancer cures. The plan must be stopped. We can act.
open.substack.com
March 28, 2025 at 4:13 PM
"The consolidation/RIF plan pulls power away from scientists and puts it in the hands of political employees. It sets up Trump and Musk to kill NIH as an evidence-based science funder. We must stop this plan."
New contributed post on our blog: Please read.
It describes Orban and authoritarianism. 🧪
New contributed post on our blog: Please read.
It describes Orban and authoritarianism. 🧪
Pressing question of the day: when will @epigenetichulk start smashing puny genomes on Bluesky?
November 22, 2024 at 5:02 PM
Pressing question of the day: when will @epigenetichulk start smashing puny genomes on Bluesky?