EPIGENETIC HULK
@epigenetichulk.bsky.social
EPIGENETIC HULK SMASH PUNY GENOME. MAKE GENOME GO. LOCATION: NOT CENTROMERE, THAT FOR SURE
NUCLEOSOME NOMENCLATURE JUST FINE! WHY BE SO CRAZY! {[("H3meLIKEY2"])} www.cell.com/molecular-ce...
A needed nomenclature for nucleosomes
Keogh et al. propose a nomenclature to clearly and concisely describe the post-translational
modifications, proteoforms, and nucleoforms that drive chromatin function. This communicates
experimental n...
www.cell.com
October 6, 2025 at 10:07 PM
NUCLEOSOME NOMENCLATURE JUST FINE! WHY BE SO CRAZY! {[("H3meLIKEY2"])} www.cell.com/molecular-ce...
🎵WHY DO ENHANCER!
SUDDENLY APPEAR!
EVERY TIME!
THEY ARE NEAR!?!
JUST LIKE ME!
THEY LONG TO BE!
CLOSE TO POLII! 🎵
www.nature.com/articles/s41...
SUDDENLY APPEAR!
EVERY TIME!
THEY ARE NEAR!?!
JUST LIKE ME!
THEY LONG TO BE!
CLOSE TO POLII! 🎵
www.nature.com/articles/s41...
Distal enhancers loop to proximal enhancers, not to promoters - Nature Reviews Molecular Cell Biology
This Comment posits that enhancers stimulate the transcription machinery only through short-range interactions and, therefore, that enhancer activity at a distance is mediated by chromatin loops betwe...
www.nature.com
September 9, 2025 at 5:42 PM
🎵WHY DO ENHANCER!
SUDDENLY APPEAR!
EVERY TIME!
THEY ARE NEAR!?!
JUST LIKE ME!
THEY LONG TO BE!
CLOSE TO POLII! 🎵
www.nature.com/articles/s41...
SUDDENLY APPEAR!
EVERY TIME!
THEY ARE NEAR!?!
JUST LIKE ME!
THEY LONG TO BE!
CLOSE TO POLII! 🎵
www.nature.com/articles/s41...
1992 CALLED THEY WANT THEIR MECHANISM BACK! CHROMATIN REMODELER REMODEL CHROMATIN! SOMETIME THIS GOOD FOR TXN! SOMETIME BLOCK IT! GOOD JOB WITH THE NUCLEOSOMES!
Check it out, Chromatin Kids!
Chromatin remodeller does stuff to Transcription Factors!
Functions where it is seldom seen!
Both decreases and increases chromatin accessibility!
How cool is that?
Chromatin remodeller does stuff to Transcription Factors!
Functions where it is seldom seen!
Both decreases and increases chromatin accessibility!
How cool is that?
The chromatin remodeller CHD4 controls both nucleosome integrity and transcription factor binding to promote activity of active regulatory elements and to prevent activation of silent enhancers https://www.biorxiv.org/content/10.1101/2025.08.29.672645v1
August 30, 2025 at 8:13 PM
1992 CALLED THEY WANT THEIR MECHANISM BACK! CHROMATIN REMODELER REMODEL CHROMATIN! SOMETIME THIS GOOD FOR TXN! SOMETIME BLOCK IT! GOOD JOB WITH THE NUCLEOSOMES!
IT BEST HEALTH! FOR SKIN! MAYBE ELAINE FUCHS INVOLVED! NEED CELLULAR EPIGENETICS FOR EVERYTHING PLEASE!
August 27, 2025 at 11:02 PM
IT BEST HEALTH! FOR SKIN! MAYBE ELAINE FUCHS INVOLVED! NEED CELLULAR EPIGENETICS FOR EVERYTHING PLEASE!
CRAMP! SO ANNOYING BUT NEEDS TO KEEP LINKER HISTONES! EPIGENETIC HULK DO WITHOUT! UNLESS IT THE BAND SO THEN COOL! www.cell.com/molecular-ce...
CRAMP1 drives linker histone expression to enable Polycomb repression
Challenging the prevailing view that H1 linker histones represent a general feature
of repressed chromatin, Matthews et al. show a specific requirement for H1 in epigenetic
repression by PRC2. Ablatio...
www.cell.com
June 16, 2025 at 7:54 PM
CRAMP! SO ANNOYING BUT NEEDS TO KEEP LINKER HISTONES! EPIGENETIC HULK DO WITHOUT! UNLESS IT THE BAND SO THEN COOL! www.cell.com/molecular-ce...
www.cell.com/cell/abstrac... PERTURB EVERYTHING! LOOK AT IT IT! OK GOOD PLAN IF WANT TO KNOW WHAT ONE LITTLE CELL CARES! ALL THESE EVERYTHING STUFF DON'T SMASH REAL BIOLOGY! ONLY PERIPHERAL EASY TO HIT STUFF!
www.cell.com
June 13, 2025 at 5:20 AM
www.cell.com/cell/abstrac... PERTURB EVERYTHING! LOOK AT IT IT! OK GOOD PLAN IF WANT TO KNOW WHAT ONE LITTLE CELL CARES! ALL THESE EVERYTHING STUFF DON'T SMASH REAL BIOLOGY! ONLY PERIPHERAL EASY TO HIT STUFF!
EPIGENETIC HULK READY TO SMASH AGAIN! GET IN LOSERS!
June 13, 2025 at 4:30 AM
EPIGENETIC HULK READY TO SMASH AGAIN! GET IN LOSERS!