Emma McGuire
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emsmcg.bsky.social
Emma McGuire
@emsmcg.bsky.social
490 followers 640 following 2 posts
Microbiologist and ID doc at UCLH.
Mum of 2 small people.
Posts Replies Media Videos
Reposted by Emma McGuire
gempill.bsky.social
Do Antimicrobial Stewardship ward rounds reduced use of target antibiotics?
#AMR #antimicrobials 🧪

www.sciencedirect.com/science/arti...
The impact of antimicrobial stewardship ward rounds on antimicrobial use and predictors of advice, uptake, and outcomes
To identify the impact of introducing antimicrobial stewardship (AMS) ward rounds.We used an interrupted time-series approach to investigate the impac…
www.sciencedirect.com
January 26, 2025 at 3:45 PM
Reposted by Emma McGuire
germhuntermd.bsky.social
#IDSky #MedSky required reading:

Multidrug-resistant Gram-negative bacterial infections

Nenad Macesic, Anne-Catrin Uhlemann, Anton Peleg

Review in @thelancet.bsky.social

doi.org/10.1016/S014...
Figure 1 Mechanisms of action of key antibiotics for the treatment of multidrug-resistant Gram-negative bacterial infections Several classes of antibiotics are available for the treatment of multidrug-resistant Gram-negative bacterial infections. Their mechanisms of action focus on key aspects of bacterial cell function, such as inhibiting cell wall synthesis (ie, β-lactams and fosfomycin) and function (ie, polymyxins), protein synthesis (ie, aminoglycosides and tetracyclines), folic acid synthesis (ie, trimethoprim and sulphonamides), and DNA replication (ie, fluoroquinolones). Because of increasing antimicrobial resistance, novel antibiotics have been developed to overcome some of these mechanisms; for example, by inhibiting antibiotic modification (ie, β-lactamase inhibitors) or by altering entry pathways (ie, cefiderocol, which enters via iron transporters). DHF=dihydrofolic acid. PABA=para-aminobenzoic acid. THF=tetrahydrofolate. Figure 2 Diagnostic testing of multidrug-resistant Gram-negative bacteria Diagnosis of multidrug-resistant Gram-negative bacterial infections involves both species identification and antibiotic susceptibility testing. Although clinical microbiology laboratories have undergone automation of these processes and have seen the introduction of proteomic methods, such as MALDI-TOF, delays in turnaround time remain and might affect patient outcomes. New biochemical, molecular (eg, PCR), automated microscopy, and hybridisation-based rapid diagnostics now allow faster detection of antimicrobial resistance, including by testing clinical samples directly. Emerging technologies are seeking to improve both the speed of testing and provide more detailed information regarding the underlying mechanisms of antimicrobial resistance. MALDI-TOF=matrix-assisted laser desorption/ionisation time-of-flight. Figure 3 Summary of new antibiotic agents for the treatment of multidrug-resistant Gram-negative bacterial infections Green=antibiotic is reliably active in vitro and guideline recommended. Yellow=variable activity; antibiotic might be effective if in vitro susceptibility is shown, clinical data might be lacking to support routine use. Red=not recommended, likely absence of in vitro susceptibility. IV=intravenously. *Administered simultaneously via Y-site administration. †Administration was studied in combination with imipenem–cilastatin. Figure 4 Summary of IDSA and ESCMID guidelines for the treatment of multidrug-resistant Gram-negative bacterial infections 3GCephR-E=third-generation cephalosporin-resistant Enterobacterales. AmpC-E=β-lactamase producing Enterobacterales. CRAB=carbapenem-resistant Acinetobacter baumannii. CRE=carbapenem-resistant Enterobacterales. DTR-P aeruginosa=difficult-to-treat resistant-Pseudomonas aeruginosa. ESBL-E=extended-spectrum β-lactamase-producing Enterobacterales. ESCMID=European Society for Clinical Microbiology and Infectious Diseases. IDSA=Infectious Diseases Society of America. MBL=metallo-β-lactamase. UTI=urinary tract infection.
January 17, 2025 at 2:21 PM
Reposted by Emma McGuire
antimicrobial.bsky.social
Antibiotic use increased 16.3% since 2016, driven largely by economic growth in LMIC. Despite concerns on AMR, effective measures like stewardship programs, public awareness, improved infection prevention have helped some high-income nations limit their consumption.

www.pnas.org/doi/10.1073/...
Global trends in antibiotic consumption during 2016–2023 and future projections through 2030 | PNAS
Antibiotic resistance is a global public health threat. Many factors contribute to this issue, with human antibiotic consumption being significant ...
www.pnas.org
December 26, 2024 at 9:54 AM
Reposted by Emma McGuire
gpollara.bsky.social
Start smart, then focus

The UK slogan as applicable now as when first coined, in the world of antimicrobial stewardship
#AMS #AMR #IDSky #ClinMicro @rlester.bsky.social

academic.oup.com/cid/advance-...
Epidemiology and Outcomes of Antibiotic De-escalation in Patients with Suspected Sepsis in US Hospitals
Across 236 US hospitals, de-escalation of anti-MRSA and anti-pseudomonal antibiotics in suspected sepsis was infrequent and variable across hospitals. De-e
academic.oup.com
December 6, 2024 at 10:56 PM
Reposted by Emma McGuire
bhrenton.bsky.social
The HPV vaccine has been recommended in the US since 2006. New study out today shows that cervical cancer deaths in young women in the years that followed have plummeted, decreasing 15% per year from 2013-2015.
jamanetwork.com/journals/jam...
Cervical Cancer Mortality Among US Women Younger Than 25 Years
This study examines trends in cervical cancer mortality in US women aged younger than 25 years before and after the introduction of human papillomavirus vaccines.
jamanetwork.com
November 28, 2024 at 2:43 AM
Reposted by Emma McGuire
colinbrown-id.bsky.social
academic.oup.com/jac/advance-...
Just published the first case of penicillin-resistant group B Streptococcus isolated from a patient in the UK - though of note this was from 2016 and we have not seen any further penicillin resistance since - however a salient reminder that #AMR is ever a possibility
A case of penicillin-resistant group B Streptococcus isolated from a patient in the UK
AbstractObjectives. In England, group B streptococci (GBS; Streptococcus agalactiae) are considered universally susceptible to penicillin. Reports from Afr
academic.oup.com
November 24, 2024 at 1:48 PM