Ribosome Biogenesis and Function in Cancer: From Mechanisms to Therapy
#cancerresearch
A comprehensive review by PhD student Kezia Gitareja as part of a special issue www.mdpi.com/3428496

😆 I made up for it by walking 20k around Copenhagen in one day- and surprisingly, I liked the Little Mermaid!

Had the pleasure of serving as an examiner for a PhD thesis defence and visiting the Danish Cancer Institute in Copenhagen 🧬 Two days filled with brilliant science & thoughtful discussion.

Science thrives through connection- across labs, disciplines, and borders. #AcademicTravel

If you see this, quote with flowers from your gallery. 🌿

It’s from a neighbour’s garden and I admire it every time I walk past

6/ Using a small CRISPR-Cas9 synthetic lethal screen with Pol I inhibitors, we uncovered a protective role for RAD54L in nucleolar DDR. Loss of RAD54L increases R-loops and rDNA damage, disrupting nucleolar structure and sensitizing cells to PARP and RNA Pol I inhibitors. 🧬🛠️

5/ We uncovered that upon rDNA damage, nucleolar Pol II binds to intergenic rDNA sequences, generating R-loops. These R-loops recruit DDR factors, playing a pivotal role in the early response to rDNA damage and the nucleolar DDR response. 🧬✨

Congrats Irene 🎉 I’m glad we managed a quick celebration! Here’s to many more great papers and achievements 🥂