Join Kuang and @timcraggs.bsky.social on 20th November to discuss his findings in more detail as part of our next Exciting Seminar - 'Mapping the global conformation of the Rag GTPase heterodimer with single-molecule FRET' > us06web.zoom.us/meeting/regi... 🧵 4/4

#structuralbiology #biophysics

@shenk0128.bsky.social's recent work exemplifies this beautifully. Starting from atomic structures, he and Doxsey used smFRET to determine the relative populations of different states present in dynamic equilibrium under different conditions to unpick the detailed mechanism of their system. 🧵 3/4

For many proteins, it has become evident that function is not defined by a single static structure. Instead, it is the dynamic interconversion between multiple conformations that enables and regulates their biological activity. 🧵 2/4

Erin is currently hiring for a fully funded PhD position to work collaboratively between her lab, Tim Craggs and Exciting Instruments. Find out more about her work here > cuttslab.uk