Exciting Instruments
@ei-science.bsky.social
Built to unlock the power of single-molecule fluorescence spectroscopy
🚨 Happening this Thursday! @timcraggs.bsky.social and @shenk0128.bsky.social discussing:
→ cutting-edge single-molecule science
→ insights into the mechanism and regulation of the Rag GTPase heterodimer
Register here: buff.ly/GcdLpHI #seminar #proteins #singlemolecule #biophysics #biochemistry
→ cutting-edge single-molecule science
→ insights into the mechanism and regulation of the Rag GTPase heterodimer
Register here: buff.ly/GcdLpHI #seminar #proteins #singlemolecule #biophysics #biochemistry
November 18, 2025 at 8:29 AM
🚨 Happening this Thursday! @timcraggs.bsky.social and @shenk0128.bsky.social discussing:
→ cutting-edge single-molecule science
→ insights into the mechanism and regulation of the Rag GTPase heterodimer
Register here: buff.ly/GcdLpHI #seminar #proteins #singlemolecule #biophysics #biochemistry
→ cutting-edge single-molecule science
→ insights into the mechanism and regulation of the Rag GTPase heterodimer
Register here: buff.ly/GcdLpHI #seminar #proteins #singlemolecule #biophysics #biochemistry
Professor Robb says: "Our EI-FLEX platform has been central to understanding the molecular details of viral replication and drug action. It’s quickly become a core instrument across many aspects of our virology research." Read her paper here - doi.org/10.1093/nar/... #smFRET #drugdevelopment
Mechanistic insights into the activity of SARS-CoV-2 RNA polymerase inhibitors using single-molecule FRET
Abstract. The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has resulted in significant global mortality, with over 7 million cases reported. Despite
doi.org
November 17, 2025 at 10:31 AM
Professor Robb says: "Our EI-FLEX platform has been central to understanding the molecular details of viral replication and drug action. It’s quickly become a core instrument across many aspects of our virology research." Read her paper here - doi.org/10.1093/nar/... #smFRET #drugdevelopment
⚡ What do you get when you combine a meaningful mission, innovative solutions, and an epic group of people? Something extremely Exciting 😉 We're looking for brilliant people to fill these roles & more > excitinginstruments.com/careers/
#lifesciencejobs #startupjobs #sheffieldjobs #hiring #scaleup
#lifesciencejobs #startupjobs #sheffieldjobs #hiring #scaleup
November 12, 2025 at 9:15 AM
⚡ What do you get when you combine a meaningful mission, innovative solutions, and an epic group of people? Something extremely Exciting 😉 We're looking for brilliant people to fill these roles & more > excitinginstruments.com/careers/
#lifesciencejobs #startupjobs #sheffieldjobs #hiring #scaleup
#lifesciencejobs #startupjobs #sheffieldjobs #hiring #scaleup
🤔 Who is familiar with the traditional structure–function paradigm that a protein’s atomic structure determines its function? 🧵 1/4
November 11, 2025 at 9:46 AM
🤔 Who is familiar with the traditional structure–function paradigm that a protein’s atomic structure determines its function? 🧵 1/4
🇨🇭 Meet Roman at #PSDI2025 (poster PO21) to see how our tools reveal drug-induced conformational changes, bringing static structures to life. Then 🇦🇹 join him & Tim at the 8th Austrian Cryo-EM Symposium. DM us to connect! #cryoem #drugdiscovery #structuralbiology
November 10, 2025 at 8:22 AM
🇨🇭 Meet Roman at #PSDI2025 (poster PO21) to see how our tools reveal drug-induced conformational changes, bringing static structures to life. Then 🇦🇹 join him & Tim at the 8th Austrian Cryo-EM Symposium. DM us to connect! #cryoem #drugdiscovery #structuralbiology
📢 Our Exciting Seminars are back! Join @timcraggs.bsky.social & @shenk0128.bsky.social on Nov 20 for 'Mapping the global conformation of the Rag GTPase heterodimer with single-molecule FRET' > us06web.zoom.us/meeting/regi...
#biophysics #lifescienceevent #molecularmedicine #biochemistry #smfret
#biophysics #lifescienceevent #molecularmedicine #biochemistry #smfret
November 7, 2025 at 10:06 AM
📢 Our Exciting Seminars are back! Join @timcraggs.bsky.social & @shenk0128.bsky.social on Nov 20 for 'Mapping the global conformation of the Rag GTPase heterodimer with single-molecule FRET' > us06web.zoom.us/meeting/regi...
#biophysics #lifescienceevent #molecularmedicine #biochemistry #smfret
#biophysics #lifescienceevent #molecularmedicine #biochemistry #smfret
✨ Watch Dr Erin Cutts use the EI-FLEX and imagine the discoveries you could make yourself! We’re offering labs and core facilities a 2 month EI-FLEX trial at no cost. Run your own samples and see the data for yourself. Apply by Dec 15 → bit.ly/4ojRDhF
#singlemolecule #biophysics #lifescience
#singlemolecule #biophysics #lifescience
November 4, 2025 at 9:25 AM
✨ Watch Dr Erin Cutts use the EI-FLEX and imagine the discoveries you could make yourself! We’re offering labs and core facilities a 2 month EI-FLEX trial at no cost. Run your own samples and see the data for yourself. Apply by Dec 15 → bit.ly/4ojRDhF
#singlemolecule #biophysics #lifescience
#singlemolecule #biophysics #lifescience
What happens when fluorescence detection reaches nanosecond precision? Recent work in time-resolved single-molecule FRET from Howard et al. using the EI-FLEX reveals fast, transient conformations and connects photon-level observables with structural and dynamic models - biorxiv.org/content/10.1...
The transitional kinetics between open and closed Rep structures can be tuned by salt via two intermediate states
DNA helicases undergo conformational changes; however, their structural dynamics are poorly understood. Here, we study single molecules of superfamily 1A DNA helicase Rep, which undergo conformational...
biorxiv.org
November 3, 2025 at 11:34 AM
What happens when fluorescence detection reaches nanosecond precision? Recent work in time-resolved single-molecule FRET from Howard et al. using the EI-FLEX reveals fast, transient conformations and connects photon-level observables with structural and dynamic models - biorxiv.org/content/10.1...
🚀 Exciting news! Submit a short proposal on how you'd use the EI-FLEX in your lab for a chance at a 2-month, no-obligation trial! Plus: see smFRET in action, upcoming seminars and more 👉 www.linkedin.com/pulse/octobe...
#biophysics #lifescience #moleculardynamics #singlemolecule
#biophysics #lifescience #moleculardynamics #singlemolecule
October roundup
Hi there, I hope you're doing well. I'm excited to say our Exciting Seminars will be back with a bang in November! Join me and Kuang Shen from UMass Chan Medical School as we explore his latest smFRET...
www.linkedin.com
October 30, 2025 at 11:59 AM
🚀 Exciting news! Submit a short proposal on how you'd use the EI-FLEX in your lab for a chance at a 2-month, no-obligation trial! Plus: see smFRET in action, upcoming seminars and more 👉 www.linkedin.com/pulse/octobe...
#biophysics #lifescience #moleculardynamics #singlemolecule
#biophysics #lifescience #moleculardynamics #singlemolecule
How can our stable, compact, and easy-to-use single-molecule tools bring your static models to life? Check out the poster our Senior Application Scientist shared at last week’s Advances in Structural Analysis of Biomolecules conference👇 #structuralbiology #singlemolecule #molecularbiology
October 29, 2025 at 1:07 PM
How can our stable, compact, and easy-to-use single-molecule tools bring your static models to life? Check out the poster our Senior Application Scientist shared at last week’s Advances in Structural Analysis of Biomolecules conference👇 #structuralbiology #singlemolecule #molecularbiology
Cut prep time, skip immobilisation, and get real-time molecular insights with Fluorescence Correlation Spectroscopy (FCS).
✓ In-solution, label–mix–measure
✓ Setup in a day
✓ First results in minutes
Spend less time prepping, more time discovering. Find out more > bit.ly/47pRqm1
#fcs #kinetics
✓ In-solution, label–mix–measure
✓ Setup in a day
✓ First results in minutes
Spend less time prepping, more time discovering. Find out more > bit.ly/47pRqm1
#fcs #kinetics
October 27, 2025 at 2:09 PM
Cut prep time, skip immobilisation, and get real-time molecular insights with Fluorescence Correlation Spectroscopy (FCS).
✓ In-solution, label–mix–measure
✓ Setup in a day
✓ First results in minutes
Spend less time prepping, more time discovering. Find out more > bit.ly/47pRqm1
#fcs #kinetics
✓ In-solution, label–mix–measure
✓ Setup in a day
✓ First results in minutes
Spend less time prepping, more time discovering. Find out more > bit.ly/47pRqm1
#fcs #kinetics
Average doesn't really exist... so why measure it?
Our compact and easy-to-use instrument has been designed to help researchers access dynamic single-molecule insights from their own lab benchtops.
Find out more about the EI-FLEX and book a demo bit.ly/3KZK3Ku
#singlemolecule #smfret #fcs
Our compact and easy-to-use instrument has been designed to help researchers access dynamic single-molecule insights from their own lab benchtops.
Find out more about the EI-FLEX and book a demo bit.ly/3KZK3Ku
#singlemolecule #smfret #fcs
October 22, 2025 at 7:44 AM
Average doesn't really exist... so why measure it?
Our compact and easy-to-use instrument has been designed to help researchers access dynamic single-molecule insights from their own lab benchtops.
Find out more about the EI-FLEX and book a demo bit.ly/3KZK3Ku
#singlemolecule #smfret #fcs
Our compact and easy-to-use instrument has been designed to help researchers access dynamic single-molecule insights from their own lab benchtops.
Find out more about the EI-FLEX and book a demo bit.ly/3KZK3Ku
#singlemolecule #smfret #fcs
🚀 Join our mission to democratise single-molecule analysis! We’re hiring:
Scientific Creative Writer
Product Manager – Assay Kits
Field Application Scientists
Apply now 👉 excitinginstruments.com/careers?utm_...
#sheffieldjobs #startupjobs #lifescience #hiring
Scientific Creative Writer
Product Manager – Assay Kits
Field Application Scientists
Apply now 👉 excitinginstruments.com/careers?utm_...
#sheffieldjobs #startupjobs #lifescience #hiring
October 15, 2025 at 7:48 AM
🚀 Join our mission to democratise single-molecule analysis! We’re hiring:
Scientific Creative Writer
Product Manager – Assay Kits
Field Application Scientists
Apply now 👉 excitinginstruments.com/careers?utm_...
#sheffieldjobs #startupjobs #lifescience #hiring
Scientific Creative Writer
Product Manager – Assay Kits
Field Application Scientists
Apply now 👉 excitinginstruments.com/careers?utm_...
#sheffieldjobs #startupjobs #lifescience #hiring
Great chatting dynamic single-molecule data with brilliant scientists at the Crick yesterday! 🇩🇪 Next stop: Advances in Structural Analysis of Biomolecules at Charité Berlin, Oct 23–24. Don’t miss our Senior Application Scientist
Mahmoud’s poster - P017! #structuralbiology #chembiochem #chemphyschem
Mahmoud’s poster - P017! #structuralbiology #chembiochem #chemphyschem
October 14, 2025 at 1:05 PM
Great chatting dynamic single-molecule data with brilliant scientists at the Crick yesterday! 🇩🇪 Next stop: Advances in Structural Analysis of Biomolecules at Charité Berlin, Oct 23–24. Don’t miss our Senior Application Scientist
Mahmoud’s poster - P017! #structuralbiology #chembiochem #chemphyschem
Mahmoud’s poster - P017! #structuralbiology #chembiochem #chemphyschem
Join Tim Craggs, Paul Wheeler & the single-molecule community at The Francis Crick Institute, London - this Monday! ⚡ Dive into the latest single-molecule research, techniques & discoveries. Free to attend - reserve your spot: www.eventbrite.co.uk/e/single-mol...
#biophysics #molecularbiology
#biophysics #molecularbiology
October 9, 2025 at 7:32 AM
Join Tim Craggs, Paul Wheeler & the single-molecule community at The Francis Crick Institute, London - this Monday! ⚡ Dive into the latest single-molecule research, techniques & discoveries. Free to attend - reserve your spot: www.eventbrite.co.uk/e/single-mol...
#biophysics #molecularbiology
#biophysics #molecularbiology
Can smFRET deliver reproducible, absolute distance measurements?
Yes! Check out Hellenkamp et al.'s (2018) paper to learn more > www.nature.com/articles/s41...
#singlemolecule #smfret #biophyics #biochemistry
Yes! Check out Hellenkamp et al.'s (2018) paper to learn more > www.nature.com/articles/s41...
#singlemolecule #smfret #biophyics #biochemistry
Precision and accuracy of single-molecule FRET measurements—a multi-laboratory benchmark study - Nature Methods
A multi-laboratory study finds that single-molecule FRET is a reproducible and reliable approach for determining accurate distances in dye-labeled DNA duplexes.
www.nature.com
October 7, 2025 at 7:58 AM
Can smFRET deliver reproducible, absolute distance measurements?
Yes! Check out Hellenkamp et al.'s (2018) paper to learn more > www.nature.com/articles/s41...
#singlemolecule #smfret #biophyics #biochemistry
Yes! Check out Hellenkamp et al.'s (2018) paper to learn more > www.nature.com/articles/s41...
#singlemolecule #smfret #biophyics #biochemistry
🚀 Since spinning out in 2021, our journey has been an Exciting one! Thrilled to see our CEO & founder @timcraggs.bsky.social named Entrepreneur of the Month by Insider Magazine. Read Tim’s comment below and the article here 👉 flickread.com/edition/html...
#entrepreneur #singlemolecule #sheffield
#entrepreneur #singlemolecule #sheffield
October 2, 2025 at 8:30 AM
🚀 Since spinning out in 2021, our journey has been an Exciting one! Thrilled to see our CEO & founder @timcraggs.bsky.social named Entrepreneur of the Month by Insider Magazine. Read Tim’s comment below and the article here 👉 flickread.com/edition/html...
#entrepreneur #singlemolecule #sheffield
#entrepreneur #singlemolecule #sheffield
🚀 Our 'professor in a box', a quick-watch smFRET explainer video, a very exciting Chair appointment and more... see what we've been up to in September in the latest edition of our newsletter - buff.ly/EDA6U5s
#structuralbiology #moleculardynamics #singlemolecule #smfret #fcs #deeptech #startups
#structuralbiology #moleculardynamics #singlemolecule #smfret #fcs #deeptech #startups
October 1, 2025 at 7:02 AM
🚀 Our 'professor in a box', a quick-watch smFRET explainer video, a very exciting Chair appointment and more... see what we've been up to in September in the latest edition of our newsletter - buff.ly/EDA6U5s
#structuralbiology #moleculardynamics #singlemolecule #smfret #fcs #deeptech #startups
#structuralbiology #moleculardynamics #singlemolecule #smfret #fcs #deeptech #startups
“Absolutely gorgeous!" That's how Edwin Antony describes the data from our EI-FLEX in his Exciting Seminar, where he discusses how DNA context regulates the myriad roles of RPA. Watch the seminar in full to learn more: youtu.be/r0yowVKdXUI
#DNA #singlemolecule #molecularbiology #structuralbiology
#DNA #singlemolecule #molecularbiology #structuralbiology
September 29, 2025 at 11:04 AM
“Absolutely gorgeous!" That's how Edwin Antony describes the data from our EI-FLEX in his Exciting Seminar, where he discusses how DNA context regulates the myriad roles of RPA. Watch the seminar in full to learn more: youtu.be/r0yowVKdXUI
#DNA #singlemolecule #molecularbiology #structuralbiology
#DNA #singlemolecule #molecularbiology #structuralbiology
🚀 Here comes the next big step in our Exciting journey! Thrilled to announce the appointment of Jonathan Rigby as the Chairman of our Board. Find out more about what it means for Exciting Instruments in the press release below.
#innovation #startups #biophysics #Sheffield #pressrelease
#innovation #startups #biophysics #Sheffield #pressrelease
September 25, 2025 at 9:18 AM
🚀 Here comes the next big step in our Exciting journey! Thrilled to announce the appointment of Jonathan Rigby as the Chairman of our Board. Find out more about what it means for Exciting Instruments in the press release below.
#innovation #startups #biophysics #Sheffield #pressrelease
#innovation #startups #biophysics #Sheffield #pressrelease
🤔 How did Groves et al. use the FLEX to reveal insights about SARS-CoV-2’s RNA polymerase? Find out here > doi.org/10.1093/nar/...
Want to know more about the FLEX? Learn more, request a tech spec or book a demo on our website: excitinginstruments.com/ei-flex/?utm... #smfret #RNA #nucleicacids
Want to know more about the FLEX? Learn more, request a tech spec or book a demo on our website: excitinginstruments.com/ei-flex/?utm... #smfret #RNA #nucleicacids
Mechanistic insights into the activity of SARS-CoV-2 RNA polymerase inhibitors using single-molecule FRET
Abstract. The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has resulted in significant global mortality, with over 7 million cases reported. Despite
doi.org
September 22, 2025 at 7:00 AM
🤔 How did Groves et al. use the FLEX to reveal insights about SARS-CoV-2’s RNA polymerase? Find out here > doi.org/10.1093/nar/...
Want to know more about the FLEX? Learn more, request a tech spec or book a demo on our website: excitinginstruments.com/ei-flex/?utm... #smfret #RNA #nucleicacids
Want to know more about the FLEX? Learn more, request a tech spec or book a demo on our website: excitinginstruments.com/ei-flex/?utm... #smfret #RNA #nucleicacids
👋 At the Midlands Biophysics Network meeting today? So are we!
Visit our stand to chat about how we're bringing solution-based single-molecule techniques right to your benchtop - no extensive training required.
#midlandsbiophysicsnetworkmeeting #biophysics #singlemolecule #smfret #fcs
Visit our stand to chat about how we're bringing solution-based single-molecule techniques right to your benchtop - no extensive training required.
#midlandsbiophysicsnetworkmeeting #biophysics #singlemolecule #smfret #fcs
September 18, 2025 at 10:35 AM
👋 At the Midlands Biophysics Network meeting today? So are we!
Visit our stand to chat about how we're bringing solution-based single-molecule techniques right to your benchtop - no extensive training required.
#midlandsbiophysicsnetworkmeeting #biophysics #singlemolecule #smfret #fcs
Visit our stand to chat about how we're bringing solution-based single-molecule techniques right to your benchtop - no extensive training required.
#midlandsbiophysicsnetworkmeeting #biophysics #singlemolecule #smfret #fcs
Thrilled to see long-time #FRET experts moving into single-molecule work with our technology at McMaster University! Plus, our instrument now also supports University at Albany's core facility with #smFRET & #FCS! A very Exciting week! 🙌 #biophysics #singlemolecule #structuralbiology
September 18, 2025 at 8:13 AM
Thrilled to see long-time #FRET experts moving into single-molecule work with our technology at McMaster University! Plus, our instrument now also supports University at Albany's core facility with #smFRET & #FCS! A very Exciting week! 🙌 #biophysics #singlemolecule #structuralbiology
Tim and Paul are ready and waiting at the Biology and Physics of Prokaryotic Chromosomes conference to show you how in-solution, single-molecule fluorescence spectroscopy can help visualise structural dynamics of prokaryotic protein/DNA interactions. Visit our stand for a chat! #prokaryoticproteins
September 16, 2025 at 10:43 AM
Tim and Paul are ready and waiting at the Biology and Physics of Prokaryotic Chromosomes conference to show you how in-solution, single-molecule fluorescence spectroscopy can help visualise structural dynamics of prokaryotic protein/DNA interactions. Visit our stand for a chat! #prokaryoticproteins
Missing biomolecular dynamics at picomolar levels? The EI-FLEX makes single-molecule research quick and easy with precision and stability. Watch Dr. Quinn below and book a demo: excitinginstruments.com/contact-us/?...
#singlemolecule #structuralbiology #moleculardynamics #smFRET #FCS
#singlemolecule #structuralbiology #moleculardynamics #smFRET #FCS
September 16, 2025 at 8:38 AM
Missing biomolecular dynamics at picomolar levels? The EI-FLEX makes single-molecule research quick and easy with precision and stability. Watch Dr. Quinn below and book a demo: excitinginstruments.com/contact-us/?...
#singlemolecule #structuralbiology #moleculardynamics #smFRET #FCS
#singlemolecule #structuralbiology #moleculardynamics #smFRET #FCS