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edenchang.bsky.social
@edenchang.bsky.social
150 followers 900 following 2 posts
RA Kuo lab https://www.hsia-laboratory.com/
PhD Coyle lab https://www.coylelab.org/
Postdoc Rosen lab
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edenchang.bsky.social
Big congrats, Qixiang! Super cool study 🎉
November 10, 2025 at 3:25 AM
edenchang.bsky.social
Congrats CJ and all authors!! 🎉
October 31, 2025 at 12:40 AM
Reposted
janhuemar.bsky.social
We propose that the reshaping of chromatin and the binding in a cluster-like manner can be one of the solutions to the so-called search problem. We hypothesize that this binding in high concentrations of Oct4 might be key to explaining how silenced genes are activated in cellular reprogramming.
A mechanism for Oct4 binding to closed chromatin. We hypothesize that the sampling of inaccessible regions of the genome might be aided by the formation of clusters that grow bigger in the presence of chromatin, facilitating the finding of specific target genes in cellular reprogramming.
October 21, 2025 at 9:59 AM