Edda Schulz
@eddaschulz.bsky.social
Group Leader at MPI Molgen, Berlin, Germany
Interested in quantitative biology, gene regulation, epigenetics, system biology and X-chromosome inactivation.
https://www.molgen.mpg.de/schulz-lab
Interested in quantitative biology, gene regulation, epigenetics, system biology and X-chromosome inactivation.
https://www.molgen.mpg.de/schulz-lab
📣 SAVE THE DATE
Next X-inactivation meeting in Sapporo, Japan, 19-23 October 2026. Visit x-inactivation-meeting.org to join our mailing list. 🧬 speakers @dandergassen.bsky.social @marnieblewitt.bsky.social @heard65.bsky.social @crougeulle.bsky.social @sexchrlab.bsky.social @zhouqi1982.bsky.social
Next X-inactivation meeting in Sapporo, Japan, 19-23 October 2026. Visit x-inactivation-meeting.org to join our mailing list. 🧬 speakers @dandergassen.bsky.social @marnieblewitt.bsky.social @heard65.bsky.social @crougeulle.bsky.social @sexchrlab.bsky.social @zhouqi1982.bsky.social
November 17, 2025 at 11:39 AM
📣 SAVE THE DATE
Next X-inactivation meeting in Sapporo, Japan, 19-23 October 2026. Visit x-inactivation-meeting.org to join our mailing list. 🧬 speakers @dandergassen.bsky.social @marnieblewitt.bsky.social @heard65.bsky.social @crougeulle.bsky.social @sexchrlab.bsky.social @zhouqi1982.bsky.social
Next X-inactivation meeting in Sapporo, Japan, 19-23 October 2026. Visit x-inactivation-meeting.org to join our mailing list. 🧬 speakers @dandergassen.bsky.social @marnieblewitt.bsky.social @heard65.bsky.social @crougeulle.bsky.social @sexchrlab.bsky.social @zhouqi1982.bsky.social
🎯 Why It Matters: High Xist Levels are required for silencing the entire chromosome.
🎛️ Using CasTuner and enhancer deletions we show that Xist expression and silencing efficiency are dose-dependent 📈: reduced Xist RNA = impaired X-chromosome silencing
🎛️ Using CasTuner and enhancer deletions we show that Xist expression and silencing efficiency are dose-dependent 📈: reduced Xist RNA = impaired X-chromosome silencing
October 6, 2025 at 1:02 PM
🎯 Why It Matters: High Xist Levels are required for silencing the entire chromosome.
🎛️ Using CasTuner and enhancer deletions we show that Xist expression and silencing efficiency are dose-dependent 📈: reduced Xist RNA = impaired X-chromosome silencing
🎛️ Using CasTuner and enhancer deletions we show that Xist expression and silencing efficiency are dose-dependent 📈: reduced Xist RNA = impaired X-chromosome silencing
🔹 Phase 2 (High-Level Boost): Late TFs activate distal enhancers
→ They drive high Xist RNA levels needed for robust silencing.
→ They drive high Xist RNA levels needed for robust silencing.
October 6, 2025 at 1:02 PM
🔹 Phase 2 (High-Level Boost): Late TFs activate distal enhancers
→ They drive high Xist RNA levels needed for robust silencing.
→ They drive high Xist RNA levels needed for robust silencing.
The Xist switch has two distinct phases:
🔹 Phase 1 (Binary ON/OFF): Early TFs target proximal regulatory elements
→ They sense X-chromosome number (XX vs XY) to trigger initial Xist upregulation—ensuring female-specific activation.
🔹 Phase 1 (Binary ON/OFF): Early TFs target proximal regulatory elements
→ They sense X-chromosome number (XX vs XY) to trigger initial Xist upregulation—ensuring female-specific activation.
October 6, 2025 at 1:02 PM
The Xist switch has two distinct phases:
🔹 Phase 1 (Binary ON/OFF): Early TFs target proximal regulatory elements
→ They sense X-chromosome number (XX vs XY) to trigger initial Xist upregulation—ensuring female-specific activation.
🔹 Phase 1 (Binary ON/OFF): Early TFs target proximal regulatory elements
→ They sense X-chromosome number (XX vs XY) to trigger initial Xist upregulation—ensuring female-specific activation.