Edda Schulz
@eddaschulz.bsky.social
Group Leader at MPI Molgen, Berlin, Germany
Interested in quantitative biology, gene regulation, epigenetics, system biology and X-chromosome inactivation.
https://www.molgen.mpg.de/schulz-lab
Interested in quantitative biology, gene regulation, epigenetics, system biology and X-chromosome inactivation.
https://www.molgen.mpg.de/schulz-lab
🥂 Congratulation to first author Till Schwämmle @tschwammle.bsky.social and all co-authors! @gemnov.bsky.social @nellykanata.bsky.social @jjfroehlich.bsky.social @melissabothe.bsky.social @alexandrammar.bsky.social @aybuge-altay.bsky.social @molgen.mpg.de
October 6, 2025 at 1:02 PM
🥂 Congratulation to first author Till Schwämmle @tschwammle.bsky.social and all co-authors! @gemnov.bsky.social @nellykanata.bsky.social @jjfroehlich.bsky.social @melissabothe.bsky.social @alexandrammar.bsky.social @aybuge-altay.bsky.social @molgen.mpg.de
🎯 Why It Matters: High Xist Levels are required for silencing the entire chromosome.
🎛️ Using CasTuner and enhancer deletions we show that Xist expression and silencing efficiency are dose-dependent 📈: reduced Xist RNA = impaired X-chromosome silencing
🎛️ Using CasTuner and enhancer deletions we show that Xist expression and silencing efficiency are dose-dependent 📈: reduced Xist RNA = impaired X-chromosome silencing
October 6, 2025 at 1:02 PM
🎯 Why It Matters: High Xist Levels are required for silencing the entire chromosome.
🎛️ Using CasTuner and enhancer deletions we show that Xist expression and silencing efficiency are dose-dependent 📈: reduced Xist RNA = impaired X-chromosome silencing
🎛️ Using CasTuner and enhancer deletions we show that Xist expression and silencing efficiency are dose-dependent 📈: reduced Xist RNA = impaired X-chromosome silencing
🔹 Phase 2 (High-Level Boost): Late TFs activate distal enhancers
→ They drive high Xist RNA levels needed for robust silencing.
→ They drive high Xist RNA levels needed for robust silencing.
October 6, 2025 at 1:02 PM
🔹 Phase 2 (High-Level Boost): Late TFs activate distal enhancers
→ They drive high Xist RNA levels needed for robust silencing.
→ They drive high Xist RNA levels needed for robust silencing.
The Xist switch has two distinct phases:
🔹 Phase 1 (Binary ON/OFF): Early TFs target proximal regulatory elements
→ They sense X-chromosome number (XX vs XY) to trigger initial Xist upregulation—ensuring female-specific activation.
🔹 Phase 1 (Binary ON/OFF): Early TFs target proximal regulatory elements
→ They sense X-chromosome number (XX vs XY) to trigger initial Xist upregulation—ensuring female-specific activation.
October 6, 2025 at 1:02 PM
The Xist switch has two distinct phases:
🔹 Phase 1 (Binary ON/OFF): Early TFs target proximal regulatory elements
→ They sense X-chromosome number (XX vs XY) to trigger initial Xist upregulation—ensuring female-specific activation.
🔹 Phase 1 (Binary ON/OFF): Early TFs target proximal regulatory elements
→ They sense X-chromosome number (XX vs XY) to trigger initial Xist upregulation—ensuring female-specific activation.
A cell with two X chromosomes must silence one to survive.
This is done by the Xist gene, a master regulator that coats one X in RNA.
But how does Xist KNOW when to turn on—and only in females?
🔬 Our new study reveals a two-step regulatory logic that decodes sex and development.
This is done by the Xist gene, a master regulator that coats one X in RNA.
But how does Xist KNOW when to turn on—and only in females?
🔬 Our new study reveals a two-step regulatory logic that decodes sex and development.
October 6, 2025 at 1:02 PM
A cell with two X chromosomes must silence one to survive.
This is done by the Xist gene, a master regulator that coats one X in RNA.
But how does Xist KNOW when to turn on—and only in females?
🔬 Our new study reveals a two-step regulatory logic that decodes sex and development.
This is done by the Xist gene, a master regulator that coats one X in RNA.
But how does Xist KNOW when to turn on—and only in females?
🔬 Our new study reveals a two-step regulatory logic that decodes sex and development.
Congratulations, Raquel!
October 2, 2025 at 7:10 AM
Congratulations, Raquel!
congratulations, Jan and team! Sounds really exciting!
September 19, 2025 at 6:00 AM
congratulations, Jan and team! Sounds really exciting!
Wow, that's great! I'm really happy to hear that!
September 6, 2025 at 12:22 PM
Wow, that's great! I'm really happy to hear that!
Congratulations, Andi and team!
August 20, 2025 at 3:01 PM
Congratulations, Andi and team!