@eamonmc.bsky.social
Reposted
New preprint on #LongReadTranscriptomics from @fabianjetzinger.bsky.social #LongTREC. How you combine replicates in long-read experiments matters more than you think — it shapes detection of both known and novel transcripts! A must read for Long read RNA-seq users!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
To join or not to join: handling biological replicates in long-read RNA sequencing data
Long-read RNA sequencing (lrRNA-seq) has revolutionized transcriptomics facilitating the study of alternative splicing and resulting in identification of thousands of novel transcripts. While isoform ...
www.biorxiv.org
December 15, 2025 at 8:25 AM
New preprint on #LongReadTranscriptomics from @fabianjetzinger.bsky.social #LongTREC. How you combine replicates in long-read experiments matters more than you think — it shapes detection of both known and novel transcripts! A must read for Long read RNA-seq users!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted
The ‘‘inactive’’ X chromosome (Xi) is active.
Xi regulates gene expression from the active X.
1/n
Xi regulates gene expression from the active X.
1/n
October 27, 2025 at 11:40 AM
The ‘‘inactive’’ X chromosome (Xi) is active.
Xi regulates gene expression from the active X.
1/n
Xi regulates gene expression from the active X.
1/n
Reposted
We’re thrilled to announce the first symposium dedicated to #LongReadsTranscriptomics, taking place in Valencia, Spain!
More information available at: 👉 longtrec.eu/VALT/
Meet the #LongReadsTranscriptomics community, connect with experts, and explore the latest advances in this research area.
More information available at: 👉 longtrec.eu/VALT/
Meet the #LongReadsTranscriptomics community, connect with experts, and explore the latest advances in this research area.
October 27, 2025 at 11:15 AM
We’re thrilled to announce the first symposium dedicated to #LongReadsTranscriptomics, taking place in Valencia, Spain!
More information available at: 👉 longtrec.eu/VALT/
Meet the #LongReadsTranscriptomics community, connect with experts, and explore the latest advances in this research area.
More information available at: 👉 longtrec.eu/VALT/
Meet the #LongReadsTranscriptomics community, connect with experts, and explore the latest advances in this research area.
Reposted
We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics.
www.biorxiv.org/content/10.1...
(1/n)
www.biorxiv.org/content/10.1...
(1/n)
September 22, 2025 at 5:29 AM
We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics.
www.biorxiv.org/content/10.1...
(1/n)
www.biorxiv.org/content/10.1...
(1/n)
Reposted
Conditional generation of real antigen-specific T cell receptor sequences @natmachintell.nature.com
www.nature.com/articles/s42...
www.nature.com/articles/s42...
September 8, 2025 at 8:07 PM
Conditional generation of real antigen-specific T cell receptor sequences @natmachintell.nature.com
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Reposted
DNA copy number variation is strongly buffered at the protein level.
The buffering is much stronger than at the RNA level.
The buffering is much stronger than at the RNA level.
August 8, 2025 at 11:07 AM
DNA copy number variation is strongly buffered at the protein level.
The buffering is much stronger than at the RNA level.
The buffering is much stronger than at the RNA level.
Reposted
Mechanotransduction in the nucleus
Multiple TFs transmit mechanical forces into transcriptional regulation.
Nuclear shape, size, and chromatin abnormalities are common features of many diseases.
Multiple TFs transmit mechanical forces into transcriptional regulation.
Nuclear shape, size, and chromatin abnormalities are common features of many diseases.
August 6, 2025 at 11:01 AM
Mechanotransduction in the nucleus
Multiple TFs transmit mechanical forces into transcriptional regulation.
Nuclear shape, size, and chromatin abnormalities are common features of many diseases.
Multiple TFs transmit mechanical forces into transcriptional regulation.
Nuclear shape, size, and chromatin abnormalities are common features of many diseases.
Reposted
One week on, and we're still processing an amazing week at #ISMBECCB2025. We have learned so much and have been inspired by others to have some great ideas. One thing is undeniable - the future of computational biology is very bright!
August 1, 2025 at 8:19 AM
One week on, and we're still processing an amazing week at #ISMBECCB2025. We have learned so much and have been inspired by others to have some great ideas. One thing is undeniable - the future of computational biology is very bright!
Reposted
Dont miss your second chance to catch all our #LongTREC posters on day 4 of #ISMBECCB2025 ! Also, dont miss an exciting talk by
@tianyuanliu.bsky.social - "Transcriptome Universal Single-isoform Control (TUSCO) A framework for evaluating transcriptome quality." 15:40–15:50 Track iRNA · Room 02N
@tianyuanliu.bsky.social - "Transcriptome Universal Single-isoform Control (TUSCO) A framework for evaluating transcriptome quality." 15:40–15:50 Track iRNA · Room 02N
July 24, 2025 at 10:37 AM
Dont miss your second chance to catch all our #LongTREC posters on day 4 of #ISMBECCB2025 ! Also, dont miss an exciting talk by
@tianyuanliu.bsky.social - "Transcriptome Universal Single-isoform Control (TUSCO) A framework for evaluating transcriptome quality." 15:40–15:50 Track iRNA · Room 02N
@tianyuanliu.bsky.social - "Transcriptome Universal Single-isoform Control (TUSCO) A framework for evaluating transcriptome quality." 15:40–15:50 Track iRNA · Room 02N
Reposted
Dont miss our #Longtrec posters today at #ISMBECCB2025! Also, make sure to get to room 02N, the iRNA track for Leda Katopodis' exciting talk - "Charting the tRNAome in health and disease with AMaNITA" #tRNA #RNAMods #Epitranscriptome
We're looking forward to meeting you!!
We're looking forward to meeting you!!
July 23, 2025 at 7:20 AM
Dont miss our #Longtrec posters today at #ISMBECCB2025! Also, make sure to get to room 02N, the iRNA track for Leda Katopodis' exciting talk - "Charting the tRNAome in health and disease with AMaNITA" #tRNA #RNAMods #Epitranscriptome
We're looking forward to meeting you!!
We're looking forward to meeting you!!
Reposted
We at #LongTREC are super excited for day 2 of #ISMBECCB2025! We are also very excited about our posters and talks this Wednesday and Thursday. Download this flyer to make it easy to catch up on all the latest long-read transcriptomics research. #LongReadTranscriptomics
July 22, 2025 at 7:41 AM
We at #LongTREC are super excited for day 2 of #ISMBECCB2025! We are also very excited about our posters and talks this Wednesday and Thursday. Download this flyer to make it easy to catch up on all the latest long-read transcriptomics research. #LongReadTranscriptomics
Reposted
Second day of #ismbeccb2025 conference, @iscb.bsky.social CEO Diane Covats reminds us the commitment of the society with sustainability.Sign up the green Pledge tinyurl.com/GreenISCB, participate in the challenges and help to reduce our carbon footprint
July 22, 2025 at 8:00 AM
Second day of #ismbeccb2025 conference, @iscb.bsky.social CEO Diane Covats reminds us the commitment of the society with sustainability.Sign up the green Pledge tinyurl.com/GreenISCB, participate in the challenges and help to reduce our carbon footprint
Reposted
Dont miss any of our #LongTREC communications at #ISMBECCB2025. Download this flyer to make catching all the latest & hottest long-read transcriptomics research simple.
@anaconesa.bsky.social
@anaconesa.bsky.social
July 21, 2025 at 12:30 PM
Dont miss any of our #LongTREC communications at #ISMBECCB2025. Download this flyer to make catching all the latest & hottest long-read transcriptomics research simple.
@anaconesa.bsky.social
@anaconesa.bsky.social
Reposted
@longtrec.bsky.social is presenting the latest & hottest long-read transcriptomics research at #ISMBECCB2025! Posters D-176 (isONclust3), C-207 (Multisample isoforms), C-237 (TSS prediction), D-202 (Single-cellSQANTI), and talks at iRNA (TUSCO, Amanita) and HitSeq (SQANTI-reads) @hitseq.bsky.social
July 21, 2025 at 10:28 AM
@longtrec.bsky.social is presenting the latest & hottest long-read transcriptomics research at #ISMBECCB2025! Posters D-176 (isONclust3), C-207 (Multisample isoforms), C-237 (TSS prediction), D-202 (Single-cellSQANTI), and talks at iRNA (TUSCO, Amanita) and HitSeq (SQANTI-reads) @hitseq.bsky.social
Reposted
It has been very exciting to meet all the participants and their eagerness to learn about #LongReadsTranscriptomics
📣 We have kicked off at the Earlham Institute, and everyone is to learn all about #LongReadsTranscriptomics at our #LongTREC Summer School.
Starting with an introduction of our network from @anaconesa.bsky.social and a quick getting to know our participants - both trainers and trainees!
Starting with an introduction of our network from @anaconesa.bsky.social and a quick getting to know our participants - both trainers and trainees!
July 14, 2025 at 9:10 AM
It has been very exciting to meet all the participants and their eagerness to learn about #LongReadsTranscriptomics
Reposted
Day 1 of our #SummerSchool : @carolinamonzo.bsky.social , Satrio Wibowo, Mahmud Sami Aydin and @tianyuanliu.bsky.social introducing participants to #LongReads sequencing technologies, how to design #lrRNAseq experiments, library preparation strategies for #lrRNAseq, mapping, QC and more!
July 14, 2025 at 1:24 PM
Day 1 of our #SummerSchool : @carolinamonzo.bsky.social , Satrio Wibowo, Mahmud Sami Aydin and @tianyuanliu.bsky.social introducing participants to #LongReads sequencing technologies, how to design #lrRNAseq experiments, library preparation strategies for #lrRNAseq, mapping, QC and more!
Reposted
🌎🗣️ First day at the LongTREC #SummerSchool @earlhaminst.bsky.social and the energy is already incredible!
It’s amazing to see how quickly meaningful connections are forming. Scientific progress doesn’t happen in isolation — it’s built through collaboration, shared knowledge, and open dialogue.
It’s amazing to see how quickly meaningful connections are forming. Scientific progress doesn’t happen in isolation — it’s built through collaboration, shared knowledge, and open dialogue.
July 14, 2025 at 2:55 PM
🌎🗣️ First day at the LongTREC #SummerSchool @earlhaminst.bsky.social and the energy is already incredible!
It’s amazing to see how quickly meaningful connections are forming. Scientific progress doesn’t happen in isolation — it’s built through collaboration, shared knowledge, and open dialogue.
It’s amazing to see how quickly meaningful connections are forming. Scientific progress doesn’t happen in isolation — it’s built through collaboration, shared knowledge, and open dialogue.
Reposted
🎥 The LongTREC video Continues: Juan Francisco Cervilla Martínez! Juan Francisco is a Doctoral Candidate at the @earlhaminst.bsky.social , working under the supervision of Wilfried Haerty. His research focuses on long-read single-cell transcriptomics to uncover Isoform usage within single cells.
July 13, 2025 at 9:48 PM
🎥 The LongTREC video Continues: Juan Francisco Cervilla Martínez! Juan Francisco is a Doctoral Candidate at the @earlhaminst.bsky.social , working under the supervision of Wilfried Haerty. His research focuses on long-read single-cell transcriptomics to uncover Isoform usage within single cells.
Reposted
A brief summary of the #LongCyclingForFuture bike trip that our LongTREC bikers have made from London to Norwich, passing via Cambridge. Join us to congratulate them on this adventure while raising awareness of the carbon footprint impact of scientific travel.
@anaconesa.bsky.social
@anaconesa.bsky.social
July 13, 2025 at 9:55 PM
A brief summary of the #LongCyclingForFuture bike trip that our LongTREC bikers have made from London to Norwich, passing via Cambridge. Join us to congratulate them on this adventure while raising awareness of the carbon footprint impact of scientific travel.
@anaconesa.bsky.social
@anaconesa.bsky.social
Reposted
Tian is an extremely passionate and dedicated young researcher that is constantly trying to push the frontiers of knowledge. He is also extremely considerate and always bring us presents when he travels back from visiting his family in China!!!
📽️ Next in the LongTREC Series: Tianyuan Liu!
tianyuanliu.bsky.social is a Doctoral Candidate at @i2sysbio.es under the supervision of @anaconesa.bsky.social He explains the question he wants to answer: "How does the exact chromatin landscape at a promoter decide which RNA isoform is made?"
tianyuanliu.bsky.social is a Doctoral Candidate at @i2sysbio.es under the supervision of @anaconesa.bsky.social He explains the question he wants to answer: "How does the exact chromatin landscape at a promoter decide which RNA isoform is made?"
July 13, 2025 at 4:06 PM
Tian is an extremely passionate and dedicated young researcher that is constantly trying to push the frontiers of knowledge. He is also extremely considerate and always bring us presents when he travels back from visiting his family in China!!!
Reposted
Leda is really lucky to work in such an amazing scientific environment. She is our expert in tRNAs. Did you know that RNAs is much more that one linear sequence? They can be modified in many different ways before translation. Leda wants to crack the code and find how this impacts cancer. Go, Leda!
Next up in our LongTREC video series is Leda Katopodi!
Leda is doing exciting research at @crg.eu, working with
@evamarianovoa.bsky.social
to explore the role of epitranscriptomic modifications of #tRNAs in cancer and beyond!
#CancerResearch #tRNAs #RNAMods #Epitranscriptomics
Leda is doing exciting research at @crg.eu, working with
@evamarianovoa.bsky.social
to explore the role of epitranscriptomic modifications of #tRNAs in cancer and beyond!
#CancerResearch #tRNAs #RNAMods #Epitranscriptomics
July 13, 2025 at 4:10 PM
Leda is really lucky to work in such an amazing scientific environment. She is our expert in tRNAs. Did you know that RNAs is much more that one linear sequence? They can be modified in many different ways before translation. Leda wants to crack the code and find how this impacts cancer. Go, Leda!
Reposted
Here’s a quick 1-minute video where I share what my PhD is about as part of the @longtrec.bsky.social Marie Skłodowska-Curie Doctoral Network — feel free to take a look if you’re curious!
🌊 Exploring the Ocean’s Genetic Secrets! Guided by @jm-aury.bsky.social and France Denoeud, @lafucarmen.bsky.social Doctoral Candidate at Genoscope - Centre National de Séquençage, shares how she's using long-reads on marine samples from the Tara Oceans expedition to explore genetic novelty.
July 13, 2025 at 3:18 PM
Here’s a quick 1-minute video where I share what my PhD is about as part of the @longtrec.bsky.social Marie Skłodowska-Curie Doctoral Network — feel free to take a look if you’re curious!
Reposted
📽️ Next in the LongTREC Series: Tianyuan Liu!
tianyuanliu.bsky.social is a Doctoral Candidate at @i2sysbio.es under the supervision of @anaconesa.bsky.social He explains the question he wants to answer: "How does the exact chromatin landscape at a promoter decide which RNA isoform is made?"
tianyuanliu.bsky.social is a Doctoral Candidate at @i2sysbio.es under the supervision of @anaconesa.bsky.social He explains the question he wants to answer: "How does the exact chromatin landscape at a promoter decide which RNA isoform is made?"
July 13, 2025 at 3:51 PM
📽️ Next in the LongTREC Series: Tianyuan Liu!
tianyuanliu.bsky.social is a Doctoral Candidate at @i2sysbio.es under the supervision of @anaconesa.bsky.social He explains the question he wants to answer: "How does the exact chromatin landscape at a promoter decide which RNA isoform is made?"
tianyuanliu.bsky.social is a Doctoral Candidate at @i2sysbio.es under the supervision of @anaconesa.bsky.social He explains the question he wants to answer: "How does the exact chromatin landscape at a promoter decide which RNA isoform is made?"
Reposted
Next up in our LongTREC video series is Leda Katopodi!
Leda is doing exciting research at @crg.eu, working with
@evamarianovoa.bsky.social
to explore the role of epitranscriptomic modifications of #tRNAs in cancer and beyond!
#CancerResearch #tRNAs #RNAMods #Epitranscriptomics
Leda is doing exciting research at @crg.eu, working with
@evamarianovoa.bsky.social
to explore the role of epitranscriptomic modifications of #tRNAs in cancer and beyond!
#CancerResearch #tRNAs #RNAMods #Epitranscriptomics
July 13, 2025 at 4:00 PM
Next up in our LongTREC video series is Leda Katopodi!
Leda is doing exciting research at @crg.eu, working with
@evamarianovoa.bsky.social
to explore the role of epitranscriptomic modifications of #tRNAs in cancer and beyond!
#CancerResearch #tRNAs #RNAMods #Epitranscriptomics
Leda is doing exciting research at @crg.eu, working with
@evamarianovoa.bsky.social
to explore the role of epitranscriptomic modifications of #tRNAs in cancer and beyond!
#CancerResearch #tRNAs #RNAMods #Epitranscriptomics