Billy Li
@dsrna.bsky.social
ADAR, RNA editing, RNA sensing, interferon, innate immunity, inflammation, human genetics | Professor @ Stanford University | Co-founder @ AIRNA
I’m excited that this review co-written with my colleague and friend Carl Walkley is now published! We focused on genetic studies, from mouse to human, that uncover the functional importance and mechanisms of RNA editing enzyme ADAR1 and reveal exciting therapeutic potential. #ADAR #RNAediting
New online! Leveraging genetics to understand ADAR1-mediated RNA editing in health and disease
Leveraging genetics to understand ADAR1-mediated RNA editing in health and disease
Nature Reviews Genetics, Published online: 14 April 2025; doi:10.1038/s41576-025-00830-5ADAR1-mediating RNA editing enables the cell to distinguish between endogenous and viral RNA. Li and Walkley review findings from human and mouse genetics that have revealed the mechanisms of ADAR1-mediated RNA editing, which are now providing insights for the development of potential therapies that target these mechanisms.
www.nature.com
April 15, 2025 at 1:45 AM
I’m excited that this review co-written with my colleague and friend Carl Walkley is now published! We focused on genetic studies, from mouse to human, that uncover the functional importance and mechanisms of RNA editing enzyme ADAR1 and reveal exciting therapeutic potential. #ADAR #RNAediting
Happy April Fool’s Day! But the news from AIRNA is no joke! It’s been incredibly rewarding and humbling to witness the journey of RNA base editing, from the early days in the labs of my co-founder Thorsten Stafforst and mine, to the remarkable progress we see today. #ADAR #RNAediting
AIRNA Raises Oversubscribed $155 Million Series B Financing to Fund Phase 1/2 Clinical Trial for Alpha-1 Antitrypsin Deficiency and Future Pipeline — Airna
Financing led by Venrock Healthcare Capital Partners with co-lead Forbion Growth, and participation from RTW Investments, Nextech Invest, and other new
airna.com
April 2, 2025 at 12:27 AM
Happy April Fool’s Day! But the news from AIRNA is no joke! It’s been incredibly rewarding and humbling to witness the journey of RNA base editing, from the early days in the labs of my co-founder Thorsten Stafforst and mine, to the remarkable progress we see today. #ADAR #RNAediting
A nice article written by Vivien Marx @naturemethods.bsky.social featuring RNA editing, from biology to therapy. I enjoyed talking with her to offer my 2 cents. Exciting times ahead! #ADAR
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Taking control with RNA - Nature Methods
As they study the emerging roles of RNA in disease and homeostasis, some scientists use RNA editing to direct precise RNA changes that shape cellular events.
www.nature.com
February 5, 2025 at 3:28 AM
A nice article written by Vivien Marx @naturemethods.bsky.social featuring RNA editing, from biology to therapy. I enjoyed talking with her to offer my 2 cents. Exciting times ahead! #ADAR
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Billy Li
Time for a 🧵 on our new paper from the Walkley lab in @scienceimmuno.bsky.social.
If you're into RNA editing by ADARs, double-stranded RNA (dsRNA) sensing, post-transcriptional gene regulation and CRISPR screening, then read on! 1/X
www.science.org/doi/10.1126/...
#RNASky #ImmunoSky
If you're into RNA editing by ADARs, double-stranded RNA (dsRNA) sensing, post-transcriptional gene regulation and CRISPR screening, then read on! 1/X
www.science.org/doi/10.1126/...
#RNASky #ImmunoSky
GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing
GGNBP2, CNOT10, and CNOT11 are required for innate immune response after the loss of ADAR1-mediated editing of self dsRNA.
www.science.org
December 6, 2024 at 1:31 AM
Time for a 🧵 on our new paper from the Walkley lab in @scienceimmuno.bsky.social.
If you're into RNA editing by ADARs, double-stranded RNA (dsRNA) sensing, post-transcriptional gene regulation and CRISPR screening, then read on! 1/X
www.science.org/doi/10.1126/...
#RNASky #ImmunoSky
If you're into RNA editing by ADARs, double-stranded RNA (dsRNA) sensing, post-transcriptional gene regulation and CRISPR screening, then read on! 1/X
www.science.org/doi/10.1126/...
#RNASky #ImmunoSky