David Shechter
@dshechter.bsky.social
epigenetically engineering a kosher pig
or
how I stopped worrying and learned to love charge, grease, and intrinsic disorder
Professor of Biochemistry
Albert Einstein College of Medicine
or
how I stopped worrying and learned to love charge, grease, and intrinsic disorder
Professor of Biochemistry
Albert Einstein College of Medicine
Reposted by David Shechter
How does PRMT5 link splicing to mRNA export?
Out in Mol Cell: by methylating Sm proteins, PRMT5 releases mRNAs that would otherwise remain trapped on chromatin.
Meet GRIPPs: Genomically Retained Incompletely Processed Polyadenylated Transcripts.
🔗 authors.elsevier.com/a/1lwyj3vVUP...
Out in Mol Cell: by methylating Sm proteins, PRMT5 releases mRNAs that would otherwise remain trapped on chromatin.
Meet GRIPPs: Genomically Retained Incompletely Processed Polyadenylated Transcripts.
🔗 authors.elsevier.com/a/1lwyj3vVUP...
authors.elsevier.com
October 13, 2025 at 4:57 PM
How does PRMT5 link splicing to mRNA export?
Out in Mol Cell: by methylating Sm proteins, PRMT5 releases mRNAs that would otherwise remain trapped on chromatin.
Meet GRIPPs: Genomically Retained Incompletely Processed Polyadenylated Transcripts.
🔗 authors.elsevier.com/a/1lwyj3vVUP...
Out in Mol Cell: by methylating Sm proteins, PRMT5 releases mRNAs that would otherwise remain trapped on chromatin.
Meet GRIPPs: Genomically Retained Incompletely Processed Polyadenylated Transcripts.
🔗 authors.elsevier.com/a/1lwyj3vVUP...
How does PRMT5 link splicing to mRNA export?
Out in Mol Cell: by methylating Sm proteins, PRMT5 releases mRNAs that would otherwise remain trapped on chromatin.
Meet GRIPPs: Genomically Retained Incompletely Processed Polyadenylated Transcripts.
🔗 authors.elsevier.com/a/1lwyj3vVUP...
Out in Mol Cell: by methylating Sm proteins, PRMT5 releases mRNAs that would otherwise remain trapped on chromatin.
Meet GRIPPs: Genomically Retained Incompletely Processed Polyadenylated Transcripts.
🔗 authors.elsevier.com/a/1lwyj3vVUP...
authors.elsevier.com
October 13, 2025 at 4:57 PM
How does PRMT5 link splicing to mRNA export?
Out in Mol Cell: by methylating Sm proteins, PRMT5 releases mRNAs that would otherwise remain trapped on chromatin.
Meet GRIPPs: Genomically Retained Incompletely Processed Polyadenylated Transcripts.
🔗 authors.elsevier.com/a/1lwyj3vVUP...
Out in Mol Cell: by methylating Sm proteins, PRMT5 releases mRNAs that would otherwise remain trapped on chromatin.
Meet GRIPPs: Genomically Retained Incompletely Processed Polyadenylated Transcripts.
🔗 authors.elsevier.com/a/1lwyj3vVUP...
Reposted by David Shechter
"We added the requested experiments and thank the reviewers for their helpful suggestions"
September 9, 2025 at 5:40 PM
"We added the requested experiments and thank the reviewers for their helpful suggestions"
Reposted by David Shechter
EPIGENETIC HULK READY TO SMASH AGAIN! GET IN LOSERS!
June 13, 2025 at 4:30 AM
EPIGENETIC HULK READY TO SMASH AGAIN! GET IN LOSERS!
Reposted by David Shechter
#NIH is hanging by a thread. The #CDC has been decimated. #RFK Jr. and Russell #Vought are psychopaths--I don't say this frivolously--they are cold, calculating, inflicting violence on millions through public policy. It is where we are right now. These men are not normal. 1/
August 28, 2025 at 9:55 AM
Reposted by David Shechter
We’re 7 months in, and “Pentagon plans military deployment in Chicago” is a headline in the Washington Post. And because it’s city number three, we’re already numbing to it.
If you read this about any other democracy in the world, you’d conclude that it was well on the road to a dictatorship.
If you read this about any other democracy in the world, you’d conclude that it was well on the road to a dictatorship.
Pentagon plans military deployment in Chicago as Trump eyes crackdown
President Donald Trump said Chicago is his next likely target to crack down on urban crime. Military planning has been ongoing for weeks, officials say.
www.washingtonpost.com
August 24, 2025 at 12:22 PM
We’re 7 months in, and “Pentagon plans military deployment in Chicago” is a headline in the Washington Post. And because it’s city number three, we’re already numbing to it.
If you read this about any other democracy in the world, you’d conclude that it was well on the road to a dictatorship.
If you read this about any other democracy in the world, you’d conclude that it was well on the road to a dictatorship.
Why can’t cells live without PRMT5? Our new transformative work inspired and led by
@jacobroth13.bsky.social (who defends his thesis tomorrow!) shows that this arginine methyltransferase is critical for histone production and genome stability.
Full story: www.biorxiv.org/content/10.1...
1/5
@jacobroth13.bsky.social (who defends his thesis tomorrow!) shows that this arginine methyltransferase is critical for histone production and genome stability.
Full story: www.biorxiv.org/content/10.1...
1/5
PRMT5 activity sustains histone production to maintain genome integrity
Histone proteins package DNA into nucleosomes, forming chromatin and thereby safeguarding genome integrity. Proper histone expression is essential for cell proliferation and chromatin organization, ye...
www.biorxiv.org
August 14, 2025 at 11:11 AM
Reposted by David Shechter
Situation on 14th St and W St. NW, with federal agents -- no specific agency identified -- pulling cars over for checks. They arrested a Black woman in this car.
BIG crowd of people shouting at police.
"Fuck you!"
"What is wrong with you!"
"You don't need to terrorize people like this!"
BIG crowd of people shouting at police.
"Fuck you!"
"What is wrong with you!"
"You don't need to terrorize people like this!"
August 14, 2025 at 1:45 AM
Situation on 14th St and W St. NW, with federal agents -- no specific agency identified -- pulling cars over for checks. They arrested a Black woman in this car.
BIG crowd of people shouting at police.
"Fuck you!"
"What is wrong with you!"
"You don't need to terrorize people like this!"
BIG crowd of people shouting at police.
"Fuck you!"
"What is wrong with you!"
"You don't need to terrorize people like this!"
Reposted by David Shechter
Release from HHS: HHS will wind down its development of the mRNA vaccine development activities under the Biomedical Advanced Research and Development Authority (BARDA).
August 5, 2025 at 10:04 PM
Release from HHS: HHS will wind down its development of the mRNA vaccine development activities under the Biomedical Advanced Research and Development Authority (BARDA).
Reposted by David Shechter
Shout out to the WSJ journalists who reported on Vought’s impoundment by footnote, causing the White House to walk it back. Impact journalism!!
UPDATE: The pause was scrapped Tuesday evening after intervention by top White House officials. www.wsj.com/politics/pol...
Trump Administration Scraps Effort to Pause Health-Research Funding
The administration halted and then restarted billions in new research grants flowing from the National Institutes of Health.
www.wsj.com
July 30, 2025 at 4:00 AM
Shout out to the WSJ journalists who reported on Vought’s impoundment by footnote, causing the White House to walk it back. Impact journalism!!
Reposted by David Shechter
Why can’t cells live without PRMT5? Our new transformative work inspired and led by
@jacobroth13.bsky.social (who defends his thesis tomorrow!) shows that this arginine methyltransferase is critical for histone production and genome stability.
Full story: www.biorxiv.org/content/10.1...
1/5
@jacobroth13.bsky.social (who defends his thesis tomorrow!) shows that this arginine methyltransferase is critical for histone production and genome stability.
Full story: www.biorxiv.org/content/10.1...
1/5
PRMT5 activity sustains histone production to maintain genome integrity
Histone proteins package DNA into nucleosomes, forming chromatin and thereby safeguarding genome integrity. Proper histone expression is essential for cell proliferation and chromatin organization, ye...
www.biorxiv.org
July 10, 2025 at 3:50 PM
Why can’t cells live without PRMT5? Our new transformative work inspired and led by
@jacobroth13.bsky.social (who defends his thesis tomorrow!) shows that this arginine methyltransferase is critical for histone production and genome stability.
Full story: www.biorxiv.org/content/10.1...
1/5
@jacobroth13.bsky.social (who defends his thesis tomorrow!) shows that this arginine methyltransferase is critical for histone production and genome stability.
Full story: www.biorxiv.org/content/10.1...
1/5
Why can’t cells live without PRMT5? Our new transformative work inspired and led by
@jacobroth13.bsky.social (who defends his thesis tomorrow!) shows that this arginine methyltransferase is critical for histone production and genome stability.
Full story: www.biorxiv.org/content/10.1...
1/5
@jacobroth13.bsky.social (who defends his thesis tomorrow!) shows that this arginine methyltransferase is critical for histone production and genome stability.
Full story: www.biorxiv.org/content/10.1...
1/5
PRMT5 activity sustains histone production to maintain genome integrity
Histone proteins package DNA into nucleosomes, forming chromatin and thereby safeguarding genome integrity. Proper histone expression is essential for cell proliferation and chromatin organization, ye...
www.biorxiv.org
July 10, 2025 at 3:50 PM
Why can’t cells live without PRMT5? Our new transformative work inspired and led by
@jacobroth13.bsky.social (who defends his thesis tomorrow!) shows that this arginine methyltransferase is critical for histone production and genome stability.
Full story: www.biorxiv.org/content/10.1...
1/5
@jacobroth13.bsky.social (who defends his thesis tomorrow!) shows that this arginine methyltransferase is critical for histone production and genome stability.
Full story: www.biorxiv.org/content/10.1...
1/5
Reposted by David Shechter
Reposted by David Shechter
Powerful statement by Sen. Alex Padilla.
Please notice that anytime senators or representatives try to conduct oversight, they’re blocked.
In this case, a sitting US senator was tackled to the ground and handcuffed—for asking a question.
Where the hell has Chuck Schumer been on this?
Please notice that anytime senators or representatives try to conduct oversight, they’re blocked.
In this case, a sitting US senator was tackled to the ground and handcuffed—for asking a question.
Where the hell has Chuck Schumer been on this?
June 12, 2025 at 7:52 PM
Powerful statement by Sen. Alex Padilla.
Please notice that anytime senators or representatives try to conduct oversight, they’re blocked.
In this case, a sitting US senator was tackled to the ground and handcuffed—for asking a question.
Where the hell has Chuck Schumer been on this?
Please notice that anytime senators or representatives try to conduct oversight, they’re blocked.
In this case, a sitting US senator was tackled to the ground and handcuffed—for asking a question.
Where the hell has Chuck Schumer been on this?
For all my NYC Chromatin / Epigenetics / Gene Expression colleagues - the registration and abstract deadline for our Summer '25 symposium is this Friday. Attendance is free (lunch and coffee breaks provided), but we need you to sign up! See here: mailchi.mp/cbee4a4e6267...
May 12, 2025 at 1:51 PM
For all my NYC Chromatin / Epigenetics / Gene Expression colleagues - the registration and abstract deadline for our Summer '25 symposium is this Friday. Attendance is free (lunch and coffee breaks provided), but we need you to sign up! See here: mailchi.mp/cbee4a4e6267...
Reposted by David Shechter
Excited for this summer’s NYC Chromatin Club!
Grad students & postdocs: submit your abstracts for a chance to present a poster or talk. Come connect w/ fellow epigenetic New Yorkers!
#NYCChromatinClub
@dshechter.bsky.social @vivrisca.bsky.social @epicypher.bsky.social
@kjarmache.bsky.social
Grad students & postdocs: submit your abstracts for a chance to present a poster or talk. Come connect w/ fellow epigenetic New Yorkers!
#NYCChromatinClub
@dshechter.bsky.social @vivrisca.bsky.social @epicypher.bsky.social
@kjarmache.bsky.social
May 5, 2025 at 3:01 AM
Excited for this summer’s NYC Chromatin Club!
Grad students & postdocs: submit your abstracts for a chance to present a poster or talk. Come connect w/ fellow epigenetic New Yorkers!
#NYCChromatinClub
@dshechter.bsky.social @vivrisca.bsky.social @epicypher.bsky.social
@kjarmache.bsky.social
Grad students & postdocs: submit your abstracts for a chance to present a poster or talk. Come connect w/ fellow epigenetic New Yorkers!
#NYCChromatinClub
@dshechter.bsky.social @vivrisca.bsky.social @epicypher.bsky.social
@kjarmache.bsky.social
Reposted by David Shechter
TTLL4 glutamyltransferase is a therapeutic target for NPM1-mutated acute myeloid leukemia https://www.biorxiv.org/content/10.1101/2025.04.07.647605v1
April 10, 2025 at 2:48 AM
TTLL4 glutamyltransferase is a therapeutic target for NPM1-mutated acute myeloid leukemia https://www.biorxiv.org/content/10.1101/2025.04.07.647605v1
Reposted by David Shechter
TTLL4 glutamyltransferase is a therapeutic target for NPM1-mutated acute myeloid leukemia https://www.biorxiv.org/content/10.1101/2025.04.07.647605v1
April 10, 2025 at 2:48 AM
TTLL4 glutamyltransferase is a therapeutic target for NPM1-mutated acute myeloid leukemia https://www.biorxiv.org/content/10.1101/2025.04.07.647605v1
We discovered a new AML vulnerability:
TTLL4 glutamylates NPM1c and helps leukemia cells thrive.
Knock it down and cells differentiate and survival improves.
Collab between our lab and @Gritsman_lab—funded by NIH and DoD/CDMRP. Preprint: bit.ly/42oZl09 /1
TTLL4 glutamylates NPM1c and helps leukemia cells thrive.
Knock it down and cells differentiate and survival improves.
Collab between our lab and @Gritsman_lab—funded by NIH and DoD/CDMRP. Preprint: bit.ly/42oZl09 /1
TTLL4 glutamyltransferase is a therapeutic target for NPM1-mutated acute myeloid leukemia
NPM1-mutated acute myeloid leukemia (AML) is defined by aberrant cytoplasmic localization of the mutant NPM1c protein, and therapeutic strategies targeting this specific disease remain limited. Here, ...
bit.ly
April 10, 2025 at 2:35 PM
We discovered a new AML vulnerability:
TTLL4 glutamylates NPM1c and helps leukemia cells thrive.
Knock it down and cells differentiate and survival improves.
Collab between our lab and @Gritsman_lab—funded by NIH and DoD/CDMRP. Preprint: bit.ly/42oZl09 /1
TTLL4 glutamylates NPM1c and helps leukemia cells thrive.
Knock it down and cells differentiate and survival improves.
Collab between our lab and @Gritsman_lab—funded by NIH and DoD/CDMRP. Preprint: bit.ly/42oZl09 /1
Reposted by David Shechter
Every post Trump makes about tariffs sounds like a late night used car commercial. Waiting for the post that starts with “I just spoke to my manager and I think we can get you down to ten percent…”
we are living in the stupidest time ever in US history with each day getting increasingly dumber
April 9, 2025 at 5:41 PM
Every post Trump makes about tariffs sounds like a late night used car commercial. Waiting for the post that starts with “I just spoke to my manager and I think we can get you down to ten percent…”
Reposted by David Shechter
Director of the Nat'l Institute of Child Health and Human Development (NICHD) was summarily dismissed yesterday. So here's your reminder that birth defects kill twice as many American kids as cancer. But there is no St. Jude's for birth defects. Only the NICHD.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
‘One of the darkest days’: NIH purges agency leadership amid mass layoffs
In shock move, four institute directors at the US biomedical agency are removed from their posts.
www.nature.com
April 2, 2025 at 3:38 PM
Director of the Nat'l Institute of Child Health and Human Development (NICHD) was summarily dismissed yesterday. So here's your reminder that birth defects kill twice as many American kids as cancer. But there is no St. Jude's for birth defects. Only the NICHD.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by David Shechter
Analysis of Terminated NIH Grants with Word Clouds
First, using the titles of grants not to Columbia...
Gender and DEI predominate
First, using the titles of grants not to Columbia...
Gender and DEI predominate
March 29, 2025 at 11:02 PM
Analysis of Terminated NIH Grants with Word Clouds
First, using the titles of grants not to Columbia...
Gender and DEI predominate
First, using the titles of grants not to Columbia...
Gender and DEI predominate
Reposted by David Shechter
14 pages of terminated NIH grants--everyone should read through the list. The sweep is VERY broad, including "The Impact of the Herpes Zoster Vaccine on Herpes Zoster Ophthalmicus" & "Mitochondrial-based Determinants of Sex Differences in Acute Kidney Injury"🧪 1/n
taggs.hhs.gov/Content/Data...
taggs.hhs.gov/Content/Data...
taggs.hhs.gov
March 26, 2025 at 3:38 PM
14 pages of terminated NIH grants--everyone should read through the list. The sweep is VERY broad, including "The Impact of the Herpes Zoster Vaccine on Herpes Zoster Ophthalmicus" & "Mitochondrial-based Determinants of Sex Differences in Acute Kidney Injury"🧪 1/n
taggs.hhs.gov/Content/Data...
taggs.hhs.gov/Content/Data...
Reposted by David Shechter
Jeffrey Goldberg thinking he was being pranked and then realizing he was actually just in the war plans group chat is such a good microcosm of how it feels to be alive right now, everything seems fake until you realize it’s actually real and incredibly stupid
March 24, 2025 at 10:03 PM
Jeffrey Goldberg thinking he was being pranked and then realizing he was actually just in the war plans group chat is such a good microcosm of how it feels to be alive right now, everything seems fake until you realize it’s actually real and incredibly stupid
Reposted by David Shechter
Trump and Musk are basically trying to deskill America:
1) kill all white-collar jobs and replace them with AI
2) kill universities
3) use tariffs to turn the U.S. into an economic island manufacturing, oil and ag hub
4) empty the cities
5) push men into manual labor & women back into the kitchen
1) kill all white-collar jobs and replace them with AI
2) kill universities
3) use tariffs to turn the U.S. into an economic island manufacturing, oil and ag hub
4) empty the cities
5) push men into manual labor & women back into the kitchen
March 15, 2025 at 5:21 PM
Trump and Musk are basically trying to deskill America:
1) kill all white-collar jobs and replace them with AI
2) kill universities
3) use tariffs to turn the U.S. into an economic island manufacturing, oil and ag hub
4) empty the cities
5) push men into manual labor & women back into the kitchen
1) kill all white-collar jobs and replace them with AI
2) kill universities
3) use tariffs to turn the U.S. into an economic island manufacturing, oil and ag hub
4) empty the cities
5) push men into manual labor & women back into the kitchen