Ryan Townley
@drtfromkc.bsky.social
Girl dad x 3 👸 | Dog dad x 2 🐶| Cognitive & Behavioral Neurologist 🧠| Program Director 🎬| Leading clinical trials in AD, DLB, and FTD. 👨🔬🔬Unraveling the mysteries of the mind, one axon at a time.
Interesting. I prefer the hypothesis that APOE4 has more CAA and disrupts BBB enough that more drug gets into the CNS than those without APOE4.
If we could accurately measure BBB integrity we could tweak doses to reduce side effects.
Or we just wait for the transferrin shuttle version :)
If we could accurately measure BBB integrity we could tweak doses to reduce side effects.
Or we just wait for the transferrin shuttle version :)
May 22, 2025 at 12:16 PM
Interesting. I prefer the hypothesis that APOE4 has more CAA and disrupts BBB enough that more drug gets into the CNS than those without APOE4.
If we could accurately measure BBB integrity we could tweak doses to reduce side effects.
Or we just wait for the transferrin shuttle version :)
If we could accurately measure BBB integrity we could tweak doses to reduce side effects.
Or we just wait for the transferrin shuttle version :)
Reposted by Ryan Townley
Read our full statement calling on Sec. Kennedy to stop spreading harmful Alzheimer’s myths: bit.ly/43dRIKw. 4/4
Contrary to Clear, Verifiable Facts, Secretary Kennedy Continues to Repeat Harmful Myths About Alzheimer’s and Dementia Research
The Alzheimer's Association calls on HHS Secretary Kennedy to stop dangerous fabrications about the state of Alzheimer’s and dementia research.
bit.ly
May 15, 2025 at 8:23 PM
Read our full statement calling on Sec. Kennedy to stop spreading harmful Alzheimer’s myths: bit.ly/43dRIKw. 4/4
Exciting! I know uses/cost will vary for UK but we did put together two related CME pieces:
Biomarker training: kuadrc.org/bhb-training
For more comprehensive cognitive evals (putting ptau217 into greater context) see my series:
PCP training: kuadrc.org/pcpguidebook
Biomarker training: kuadrc.org/bhb-training
For more comprehensive cognitive evals (putting ptau217 into greater context) see my series:
PCP training: kuadrc.org/pcpguidebook
KU Primary Care Brain Health Program Empowering Pr
kuadrc.org
May 13, 2025 at 7:26 PM
Exciting! I know uses/cost will vary for UK but we did put together two related CME pieces:
Biomarker training: kuadrc.org/bhb-training
For more comprehensive cognitive evals (putting ptau217 into greater context) see my series:
PCP training: kuadrc.org/pcpguidebook
Biomarker training: kuadrc.org/bhb-training
For more comprehensive cognitive evals (putting ptau217 into greater context) see my series:
PCP training: kuadrc.org/pcpguidebook
They aren’t looking hard enough 😂
The reluctance to diagnose DLB on its own, even when a patient meets full criteria, is baffling to me. I see it often as a 2nd/3rd opinion referral.
Board certified in neurology (ABPN) and BNNP certified - behavioral neurology and neuropsychiatry = wide gap!
The reluctance to diagnose DLB on its own, even when a patient meets full criteria, is baffling to me. I see it often as a 2nd/3rd opinion referral.
Board certified in neurology (ABPN) and BNNP certified - behavioral neurology and neuropsychiatry = wide gap!
April 12, 2025 at 12:20 PM
They aren’t looking hard enough 😂
The reluctance to diagnose DLB on its own, even when a patient meets full criteria, is baffling to me. I see it often as a 2nd/3rd opinion referral.
Board certified in neurology (ABPN) and BNNP certified - behavioral neurology and neuropsychiatry = wide gap!
The reluctance to diagnose DLB on its own, even when a patient meets full criteria, is baffling to me. I see it often as a 2nd/3rd opinion referral.
Board certified in neurology (ABPN) and BNNP certified - behavioral neurology and neuropsychiatry = wide gap!
It’s diagnosed in our clinic:
1. Amnestic dementia with RBD and hallucinations +/- Parkinsonism
2. Multidomain dementia with DLB criteria and hippocampal atrophy
3. Biomarker positivity for AD/DLB
ICD10: major neurocognitive disorder d/t multiple pathologies. Then list AD and DLB underneath
1. Amnestic dementia with RBD and hallucinations +/- Parkinsonism
2. Multidomain dementia with DLB criteria and hippocampal atrophy
3. Biomarker positivity for AD/DLB
ICD10: major neurocognitive disorder d/t multiple pathologies. Then list AD and DLB underneath
April 12, 2025 at 5:18 AM
It’s diagnosed in our clinic:
1. Amnestic dementia with RBD and hallucinations +/- Parkinsonism
2. Multidomain dementia with DLB criteria and hippocampal atrophy
3. Biomarker positivity for AD/DLB
ICD10: major neurocognitive disorder d/t multiple pathologies. Then list AD and DLB underneath
1. Amnestic dementia with RBD and hallucinations +/- Parkinsonism
2. Multidomain dementia with DLB criteria and hippocampal atrophy
3. Biomarker positivity for AD/DLB
ICD10: major neurocognitive disorder d/t multiple pathologies. Then list AD and DLB underneath