Dr Sanil Rege
@drsanil.bsky.social
Psychiatrist | Educator | Neuroscience Enthusiast | Exploring the intersection of biology, psychology & human behaviour | Sharing insights, ideas & stories to simplify complexity.
🧠 What Happens to Your Brain Without Sleep?🚨
3 Days Without Sleep—Here’s What Happens Next
👉 youtu.be/NY4oNQd-xeY
3 Days Without Sleep—Here’s What Happens Next
👉 youtu.be/NY4oNQd-xeY
March 14, 2025 at 11:00 AM
🧠 What Happens to Your Brain Without Sleep?🚨
3 Days Without Sleep—Here’s What Happens Next
👉 youtu.be/NY4oNQd-xeY
3 Days Without Sleep—Here’s What Happens Next
👉 youtu.be/NY4oNQd-xeY
Psychopharmacology is an art, not just a science.
To learn how to translate this into clinical practice, I’ve created a 7.5-hour course in psychopharmacology that covers these nuances .
👉https://www.academy.psychscene.com/courses/psychopharmacology-masterclass-series/
To learn how to translate this into clinical practice, I’ve created a 7.5-hour course in psychopharmacology that covers these nuances .
👉https://www.academy.psychscene.com/courses/psychopharmacology-masterclass-series/
March 13, 2025 at 10:44 AM
Psychopharmacology is an art, not just a science.
To learn how to translate this into clinical practice, I’ve created a 7.5-hour course in psychopharmacology that covers these nuances .
👉https://www.academy.psychscene.com/courses/psychopharmacology-masterclass-series/
To learn how to translate this into clinical practice, I’ve created a 7.5-hour course in psychopharmacology that covers these nuances .
👉https://www.academy.psychscene.com/courses/psychopharmacology-masterclass-series/
15 Commandments of Psychopharmacology 🚀
Textbooks taught me psychopharmacology-UNTIL I stepped into real-world practice as a consultant psychiatrist. 🚨
Here’s what experience taught me that textbooks don’t (or can’t).
Textbooks taught me psychopharmacology-UNTIL I stepped into real-world practice as a consultant psychiatrist. 🚨
Here’s what experience taught me that textbooks don’t (or can’t).
March 13, 2025 at 10:44 AM
15 Commandments of Psychopharmacology 🚀
Textbooks taught me psychopharmacology-UNTIL I stepped into real-world practice as a consultant psychiatrist. 🚨
Here’s what experience taught me that textbooks don’t (or can’t).
Textbooks taught me psychopharmacology-UNTIL I stepped into real-world practice as a consultant psychiatrist. 🚨
Here’s what experience taught me that textbooks don’t (or can’t).
🧵The Stability Paradox in BPD: Why Attention-Seeking Is Not What You Think 🚨
Most misunderstand attention-seeking in BPD.
Let's break it down 👇Thread on Twitter X
x.com/sanilrege/st...
Most misunderstand attention-seeking in BPD.
Let's break it down 👇Thread on Twitter X
x.com/sanilrege/st...
February 20, 2025 at 7:44 AM
🧵The Stability Paradox in BPD: Why Attention-Seeking Is Not What You Think 🚨
Most misunderstand attention-seeking in BPD.
Let's break it down 👇Thread on Twitter X
x.com/sanilrege/st...
Most misunderstand attention-seeking in BPD.
Let's break it down 👇Thread on Twitter X
x.com/sanilrege/st...
New Video: NAC in Psychiatry –Evidence, Mechanisms & Clinical Use 🚀
N-acetylcysteine (NAC) is one of the few supplements with a reasonable evidence base across psychiatric disorders, including schizophrenia, depression, OCD, bipolar disorder, and addiction.
Video 👉
youtu.be/CfHJGR8NXeE
N-acetylcysteine (NAC) is one of the few supplements with a reasonable evidence base across psychiatric disorders, including schizophrenia, depression, OCD, bipolar disorder, and addiction.
Video 👉
youtu.be/CfHJGR8NXeE
February 17, 2025 at 10:44 AM
New Video: NAC in Psychiatry –Evidence, Mechanisms & Clinical Use 🚀
N-acetylcysteine (NAC) is one of the few supplements with a reasonable evidence base across psychiatric disorders, including schizophrenia, depression, OCD, bipolar disorder, and addiction.
Video 👉
youtu.be/CfHJGR8NXeE
N-acetylcysteine (NAC) is one of the few supplements with a reasonable evidence base across psychiatric disorders, including schizophrenia, depression, OCD, bipolar disorder, and addiction.
Video 👉
youtu.be/CfHJGR8NXeE
Psychedelics and the Free Energy Principle ( FEP) 🍄- Video👇
A while ago, someone asked “explain the Free Energy Principle to a 5-year-old.”
Video 👉
youtu.be/CgkGjKKyyf8
Enjoy the ride! 🚀🐛🧠
A while ago, someone asked “explain the Free Energy Principle to a 5-year-old.”
Video 👉
youtu.be/CgkGjKKyyf8
Enjoy the ride! 🚀🐛🧠
February 1, 2025 at 9:38 AM
Psychedelics and the Free Energy Principle ( FEP) 🍄- Video👇
A while ago, someone asked “explain the Free Energy Principle to a 5-year-old.”
Video 👉
youtu.be/CgkGjKKyyf8
Enjoy the ride! 🚀🐛🧠
A while ago, someone asked “explain the Free Energy Principle to a 5-year-old.”
Video 👉
youtu.be/CgkGjKKyyf8
Enjoy the ride! 🚀🐛🧠
January 25, 2025 at 6:53 AM
Coming up tomorrow on The Psychiatry Simplified Channel 🚀
Why is ADHD on the Rise? 🚨
You can subscribe ( or hit the bell icon) to be notified 👇
www.youtube.com/@psychiatrys...
Why is ADHD on the Rise? 🚨
You can subscribe ( or hit the bell icon) to be notified 👇
www.youtube.com/@psychiatrys...
January 24, 2025 at 8:36 AM
Coming up tomorrow on The Psychiatry Simplified Channel 🚀
Why is ADHD on the Rise? 🚨
You can subscribe ( or hit the bell icon) to be notified 👇
www.youtube.com/@psychiatrys...
Why is ADHD on the Rise? 🚨
You can subscribe ( or hit the bell icon) to be notified 👇
www.youtube.com/@psychiatrys...
Immuno-Metabolic Depression: The Overlooked Subtype?🚨
👉 Affects 20-30% of those with depression.
⚠️ Characterised by:
1️⃣ Energy-related symptoms: hypersomnia, fatigue, hyperphagia, anhedonia.
2️⃣ Inflammation: raised CRP, cytokines.
3️⃣ Metabolic issues: obesity, dyslipidaemia, insulin resistance.
👉 Affects 20-30% of those with depression.
⚠️ Characterised by:
1️⃣ Energy-related symptoms: hypersomnia, fatigue, hyperphagia, anhedonia.
2️⃣ Inflammation: raised CRP, cytokines.
3️⃣ Metabolic issues: obesity, dyslipidaemia, insulin resistance.
January 14, 2025 at 7:33 AM
Immuno-Metabolic Depression: The Overlooked Subtype?🚨
👉 Affects 20-30% of those with depression.
⚠️ Characterised by:
1️⃣ Energy-related symptoms: hypersomnia, fatigue, hyperphagia, anhedonia.
2️⃣ Inflammation: raised CRP, cytokines.
3️⃣ Metabolic issues: obesity, dyslipidaemia, insulin resistance.
👉 Affects 20-30% of those with depression.
⚠️ Characterised by:
1️⃣ Energy-related symptoms: hypersomnia, fatigue, hyperphagia, anhedonia.
2️⃣ Inflammation: raised CRP, cytokines.
3️⃣ Metabolic issues: obesity, dyslipidaemia, insulin resistance.
Embracing complexity ✅
This image shows the non-linear progression from stress to Type 2 Diabetes.
In psychiatry, understanding such complexity is essential, as many conditions involve similar interconnected mechanisms affecting brain networks, neuroinflammation, and long-term adaptation.
This image shows the non-linear progression from stress to Type 2 Diabetes.
In psychiatry, understanding such complexity is essential, as many conditions involve similar interconnected mechanisms affecting brain networks, neuroinflammation, and long-term adaptation.
December 31, 2024 at 11:01 AM
Embracing complexity ✅
This image shows the non-linear progression from stress to Type 2 Diabetes.
In psychiatry, understanding such complexity is essential, as many conditions involve similar interconnected mechanisms affecting brain networks, neuroinflammation, and long-term adaptation.
This image shows the non-linear progression from stress to Type 2 Diabetes.
In psychiatry, understanding such complexity is essential, as many conditions involve similar interconnected mechanisms affecting brain networks, neuroinflammation, and long-term adaptation.
New YT Video📹🚀
We are bundles of habits. 🧠
👉Neuroscience of Addiction: From Survival Circuits to ‘Hijacked’ Habits
youtu.be/9zclgdSdfBA
We are creatures of habit, wired for survival, but the same brain circuits that automate our lives make us all vulnerable to addiction's hijacking!
We are bundles of habits. 🧠
👉Neuroscience of Addiction: From Survival Circuits to ‘Hijacked’ Habits
youtu.be/9zclgdSdfBA
We are creatures of habit, wired for survival, but the same brain circuits that automate our lives make us all vulnerable to addiction's hijacking!
December 22, 2024 at 7:17 AM
New YT Video📹🚀
We are bundles of habits. 🧠
👉Neuroscience of Addiction: From Survival Circuits to ‘Hijacked’ Habits
youtu.be/9zclgdSdfBA
We are creatures of habit, wired for survival, but the same brain circuits that automate our lives make us all vulnerable to addiction's hijacking!
We are bundles of habits. 🧠
👉Neuroscience of Addiction: From Survival Circuits to ‘Hijacked’ Habits
youtu.be/9zclgdSdfBA
We are creatures of habit, wired for survival, but the same brain circuits that automate our lives make us all vulnerable to addiction's hijacking!
Every patient encounter is an opportunity to not only treat the present but also prevent future risks, vulnerabilities, and setbacks.
Sustainable recovery is about thinking beyond the moment.
#MentalHealth #Psychiatry
Sustainable recovery is about thinking beyond the moment.
#MentalHealth #Psychiatry
December 19, 2024 at 12:36 PM
Every patient encounter is an opportunity to not only treat the present but also prevent future risks, vulnerabilities, and setbacks.
Sustainable recovery is about thinking beyond the moment.
#MentalHealth #Psychiatry
Sustainable recovery is about thinking beyond the moment.
#MentalHealth #Psychiatry
Antidepressant Discontinuation and Relapse 🚨
“An increase in amygdala reactivity was associated with risk of relapse after antidepressant discontinuation and may represent a functional neuroimaging marker that could inform clinical decisions around antidepressant discontinuation.”
“An increase in amygdala reactivity was associated with risk of relapse after antidepressant discontinuation and may represent a functional neuroimaging marker that could inform clinical decisions around antidepressant discontinuation.”
November 30, 2024 at 11:46 AM
Antidepressant Discontinuation and Relapse 🚨
“An increase in amygdala reactivity was associated with risk of relapse after antidepressant discontinuation and may represent a functional neuroimaging marker that could inform clinical decisions around antidepressant discontinuation.”
“An increase in amygdala reactivity was associated with risk of relapse after antidepressant discontinuation and may represent a functional neuroimaging marker that could inform clinical decisions around antidepressant discontinuation.”
Evidence Informs, Guidelines Guide, Clinicians Think! 🚀
Sums up today’s 4 hour talk on the Art of Strategic Problem Solving. As clinicians, we must learn patterns across multiple models, disciplines, and concepts to master pattern recognition. The broader the patterns, the sharper the recognition✅
Sums up today’s 4 hour talk on the Art of Strategic Problem Solving. As clinicians, we must learn patterns across multiple models, disciplines, and concepts to master pattern recognition. The broader the patterns, the sharper the recognition✅
November 28, 2024 at 12:18 PM
Evidence Informs, Guidelines Guide, Clinicians Think! 🚀
Sums up today’s 4 hour talk on the Art of Strategic Problem Solving. As clinicians, we must learn patterns across multiple models, disciplines, and concepts to master pattern recognition. The broader the patterns, the sharper the recognition✅
Sums up today’s 4 hour talk on the Art of Strategic Problem Solving. As clinicians, we must learn patterns across multiple models, disciplines, and concepts to master pattern recognition. The broader the patterns, the sharper the recognition✅
A sneak peek at tomorrow's The Art of Strategic Problem Solving in Psychiatry 🚀
3-hour journey through psychosis, affective disorders, trauma, OCD, ED, pain…
We'll explore first principles, apply tools effectively, and use case studies to challenge the “trial and error” view of psychiatry.
3-hour journey through psychosis, affective disorders, trauma, OCD, ED, pain…
We'll explore first principles, apply tools effectively, and use case studies to challenge the “trial and error” view of psychiatry.
November 27, 2024 at 4:31 AM
A sneak peek at tomorrow's The Art of Strategic Problem Solving in Psychiatry 🚀
3-hour journey through psychosis, affective disorders, trauma, OCD, ED, pain…
We'll explore first principles, apply tools effectively, and use case studies to challenge the “trial and error” view of psychiatry.
3-hour journey through psychosis, affective disorders, trauma, OCD, ED, pain…
We'll explore first principles, apply tools effectively, and use case studies to challenge the “trial and error” view of psychiatry.
YT video 📹🚀
1. The Evolution of Dopamine (DA)
2. The Discovery of the Role of DA in medicine 🩸
3. Dopamine Misunderstandings and Its True Role
4. The Risks of a Focus on DA Optimization 🚨
5. How to Improve your Well being through a Scientific Understanding
Video 👉 youtu.be/uo9nI-U7QXo
1. The Evolution of Dopamine (DA)
2. The Discovery of the Role of DA in medicine 🩸
3. Dopamine Misunderstandings and Its True Role
4. The Risks of a Focus on DA Optimization 🚨
5. How to Improve your Well being through a Scientific Understanding
Video 👉 youtu.be/uo9nI-U7QXo
November 26, 2024 at 10:42 PM
YT video 📹🚀
1. The Evolution of Dopamine (DA)
2. The Discovery of the Role of DA in medicine 🩸
3. Dopamine Misunderstandings and Its True Role
4. The Risks of a Focus on DA Optimization 🚨
5. How to Improve your Well being through a Scientific Understanding
Video 👉 youtu.be/uo9nI-U7QXo
1. The Evolution of Dopamine (DA)
2. The Discovery of the Role of DA in medicine 🩸
3. Dopamine Misunderstandings and Its True Role
4. The Risks of a Focus on DA Optimization 🚨
5. How to Improve your Well being through a Scientific Understanding
Video 👉 youtu.be/uo9nI-U7QXo
Depression isn’t one-size-fits-all.
This diagram highlights key subtypes
1. Non-melancholic
2. Melancholic, and
3. Psychotic - each with distinct features.
Matching Treatments to Types 👉Better outcomes ✅
Learn more 👉 www.academy.psychscene.com/courses/mela...
This diagram highlights key subtypes
1. Non-melancholic
2. Melancholic, and
3. Psychotic - each with distinct features.
Matching Treatments to Types 👉Better outcomes ✅
Learn more 👉 www.academy.psychscene.com/courses/mela...
November 25, 2024 at 10:14 AM
Depression isn’t one-size-fits-all.
This diagram highlights key subtypes
1. Non-melancholic
2. Melancholic, and
3. Psychotic - each with distinct features.
Matching Treatments to Types 👉Better outcomes ✅
Learn more 👉 www.academy.psychscene.com/courses/mela...
This diagram highlights key subtypes
1. Non-melancholic
2. Melancholic, and
3. Psychotic - each with distinct features.
Matching Treatments to Types 👉Better outcomes ✅
Learn more 👉 www.academy.psychscene.com/courses/mela...
Insulin Resistance and the Brain -
A Bi-Directional Relationship 🧠🚀
Adding the finishing touches to the article on insulin resistance (IR) and brain insulin resistance.
Join the newsletter to receive the article in your inbox on release 👉psychscenehub.com
A Bi-Directional Relationship 🧠🚀
Adding the finishing touches to the article on insulin resistance (IR) and brain insulin resistance.
Join the newsletter to receive the article in your inbox on release 👉psychscenehub.com
November 24, 2024 at 10:23 AM
Insulin Resistance and the Brain -
A Bi-Directional Relationship 🧠🚀
Adding the finishing touches to the article on insulin resistance (IR) and brain insulin resistance.
Join the newsletter to receive the article in your inbox on release 👉psychscenehub.com
A Bi-Directional Relationship 🧠🚀
Adding the finishing touches to the article on insulin resistance (IR) and brain insulin resistance.
Join the newsletter to receive the article in your inbox on release 👉psychscenehub.com
How long to wait for an antidepressant response? 📚👇
3 response types (WARP)
1️⃣ Immediate (1–2 days)
2️⃣ Fast (up to 1 week)
3️⃣ Slow (1 week+)
Most improvements occur by 2 weeks-early responders are 3x more likely to sustain response.
Act early!
Read here 👉 psychscenehub.com/psychinsight...
3 response types (WARP)
1️⃣ Immediate (1–2 days)
2️⃣ Fast (up to 1 week)
3️⃣ Slow (1 week+)
Most improvements occur by 2 weeks-early responders are 3x more likely to sustain response.
Act early!
Read here 👉 psychscenehub.com/psychinsight...
November 20, 2024 at 11:40 PM
How long to wait for an antidepressant response? 📚👇
3 response types (WARP)
1️⃣ Immediate (1–2 days)
2️⃣ Fast (up to 1 week)
3️⃣ Slow (1 week+)
Most improvements occur by 2 weeks-early responders are 3x more likely to sustain response.
Act early!
Read here 👉 psychscenehub.com/psychinsight...
3 response types (WARP)
1️⃣ Immediate (1–2 days)
2️⃣ Fast (up to 1 week)
3️⃣ Slow (1 week+)
Most improvements occur by 2 weeks-early responders are 3x more likely to sustain response.
Act early!
Read here 👉 psychscenehub.com/psychinsight...
Goes beyond ADHD - multiple mechanisms affecting DA function
Neuroinflammation affects DA circuitry and transmission including production.
psychscenehub.com/psychinsight...
Neuroinflammation affects DA circuitry and transmission including production.
psychscenehub.com/psychinsight...
November 19, 2024 at 11:01 PM
Goes beyond ADHD - multiple mechanisms affecting DA function
Neuroinflammation affects DA circuitry and transmission including production.
psychscenehub.com/psychinsight...
Neuroinflammation affects DA circuitry and transmission including production.
psychscenehub.com/psychinsight...
Have We Misunderstood Diagnosis? 🚨🚀
Diagnosis isn’t the endpoint-it’s a process of discernment.
From its Greek origins (diagnōsis = 'to discern'), it unfolds in layers:
1. Hierarchy
2. Formulation
3. Constructs
Nov 28: www.academy.psychscene.com/events/strat...
Diagnosis isn’t the endpoint-it’s a process of discernment.
From its Greek origins (diagnōsis = 'to discern'), it unfolds in layers:
1. Hierarchy
2. Formulation
3. Constructs
Nov 28: www.academy.psychscene.com/events/strat...
November 19, 2024 at 10:57 PM
Have We Misunderstood Diagnosis? 🚨🚀
Diagnosis isn’t the endpoint-it’s a process of discernment.
From its Greek origins (diagnōsis = 'to discern'), it unfolds in layers:
1. Hierarchy
2. Formulation
3. Constructs
Nov 28: www.academy.psychscene.com/events/strat...
Diagnosis isn’t the endpoint-it’s a process of discernment.
From its Greek origins (diagnōsis = 'to discern'), it unfolds in layers:
1. Hierarchy
2. Formulation
3. Constructs
Nov 28: www.academy.psychscene.com/events/strat...
New YouTube Video 👉ADHD and Emotional Regulation: The Link to BPD and RSD Explained 🚀
👉youtu.be/Ztqm7rVojSU
👉youtu.be/Ztqm7rVojSU
November 18, 2024 at 10:39 AM
New YouTube Video 👉ADHD and Emotional Regulation: The Link to BPD and RSD Explained 🚀
👉youtu.be/Ztqm7rVojSU
👉youtu.be/Ztqm7rVojSU
Iron, ADHD and RLS 🚨
An iron infusion is one of the most common interventions I implement as a psychiatrist.
Why? Iron drives dopamine synthesis, essential for fronto-striatal functioning in ADHD, RLS, and beyond.
Brain iron # serum iron
Read more 👉 psychscenehub.com/psychinsight...
An iron infusion is one of the most common interventions I implement as a psychiatrist.
Why? Iron drives dopamine synthesis, essential for fronto-striatal functioning in ADHD, RLS, and beyond.
Brain iron # serum iron
Read more 👉 psychscenehub.com/psychinsight...
November 18, 2024 at 4:25 AM
Iron, ADHD and RLS 🚨
An iron infusion is one of the most common interventions I implement as a psychiatrist.
Why? Iron drives dopamine synthesis, essential for fronto-striatal functioning in ADHD, RLS, and beyond.
Brain iron # serum iron
Read more 👉 psychscenehub.com/psychinsight...
An iron infusion is one of the most common interventions I implement as a psychiatrist.
Why? Iron drives dopamine synthesis, essential for fronto-striatal functioning in ADHD, RLS, and beyond.
Brain iron # serum iron
Read more 👉 psychscenehub.com/psychinsight...
Working with Addiction it’s important to recognise 👉Addiction is a neuroadaptive process culminating in a behavioural pattern aimed at resolving unmet emotional needs. 🚀
Effective treatment integrates:
👉Social neuroscience
👉Pharmacology
👉Psychodynamic exploration psychscenehub.com/psychinsight...
Effective treatment integrates:
👉Social neuroscience
👉Pharmacology
👉Psychodynamic exploration psychscenehub.com/psychinsight...
November 17, 2024 at 1:08 AM
Working with Addiction it’s important to recognise 👉Addiction is a neuroadaptive process culminating in a behavioural pattern aimed at resolving unmet emotional needs. 🚀
Effective treatment integrates:
👉Social neuroscience
👉Pharmacology
👉Psychodynamic exploration psychscenehub.com/psychinsight...
Effective treatment integrates:
👉Social neuroscience
👉Pharmacology
👉Psychodynamic exploration psychscenehub.com/psychinsight...
GLP-1 as a pan addiction agent?
“Research is increasingly pointing towards the glucagon-like peptide-1 (GLP-1) system as a significant player in the neurobiology of addictive behaviours,……
Article 👉The Neuroscience of Addiction 👉 psychscenehub.com/psychinsight...
“Research is increasingly pointing towards the glucagon-like peptide-1 (GLP-1) system as a significant player in the neurobiology of addictive behaviours,……
Article 👉The Neuroscience of Addiction 👉 psychscenehub.com/psychinsight...
November 16, 2024 at 10:06 PM
GLP-1 as a pan addiction agent?
“Research is increasingly pointing towards the glucagon-like peptide-1 (GLP-1) system as a significant player in the neurobiology of addictive behaviours,……
Article 👉The Neuroscience of Addiction 👉 psychscenehub.com/psychinsight...
“Research is increasingly pointing towards the glucagon-like peptide-1 (GLP-1) system as a significant player in the neurobiology of addictive behaviours,……
Article 👉The Neuroscience of Addiction 👉 psychscenehub.com/psychinsight...