Lee Machado
@drleemachado.bsky.social
Professor of Molecular Medicine @uninorthants researching #infection, #immunity and #cancer. Deputy Chair @BeaCitySixth
Pinned
Lee Machado
@drleemachado.bsky.social
· Aug 21
🚨 New in FEBS Open Bio!
During COVID, with labs disrupted, I undertook an MRes apprenticeship in bioinformatics. As a professor, I was suddenly a student again, learning coding to support my group.
Together with @Weekademia, we propose a unified model of DMD in cancer. 🧵👇
During COVID, with labs disrupted, I undertook an MRes apprenticeship in bioinformatics. As a professor, I was suddenly a student again, learning coding to support my group.
Together with @Weekademia, we propose a unified model of DMD in cancer. 🧵👇
Reposted by Lee Machado
"Due to a variety of circumstances...many science projects will never be finished, despite years of invested resources and effort. By carefully and strategically documenting scientific work achieved, components of unfinished projects can be salvaged and preserved to benefit future researchers." 🧪
When goodbye comes too soon: How to wrap up science projects quickly
Science projects are designed and funded on the scale of years, so what happens when researchers need to finish prematurely? This Community Page discusses solutions for quickly documenting partially f...
journals.plos.org
October 27, 2025 at 9:20 PM
"Due to a variety of circumstances...many science projects will never be finished, despite years of invested resources and effort. By carefully and strategically documenting scientific work achieved, components of unfinished projects can be salvaged and preserved to benefit future researchers." 🧪
Reposted by Lee Machado
Academics! Delighted to announce that the new 3rd edition of Human Evolutionary Genetics is now available to book inspection copies. Available to buy January 9th. 1/5
www.routledge.com/Human-Evolut...
www.routledge.com/Human-Evolut...
Human Evolutionary Genetics
Human Evolutionary Genetics reaches its third edition at a time when sequencing and analyzing whole genomes, modern and ancient, has become rapid, affordable, and routine. These advances have led to a...
www.routledge.com
September 4, 2025 at 4:07 PM
Academics! Delighted to announce that the new 3rd edition of Human Evolutionary Genetics is now available to book inspection copies. Available to buy January 9th. 1/5
www.routledge.com/Human-Evolut...
www.routledge.com/Human-Evolut...
A fab inaugural from Prof Havovi Chichger. Sweet signals, bitter truths: taste sensing and cardiovascular disease youtube.com/live/f9VoIBqPP… via @YouTube
YouTube
Share your videos with friends, family, and the world
https://youtube.com/live/f9VoIBqPP…
October 15, 2025 at 9:19 PM
A fab inaugural from Prof Havovi Chichger. Sweet signals, bitter truths: taste sensing and cardiovascular disease youtube.com/live/f9VoIBqPP… via @YouTube
Reposted by Lee Machado
Read the associated research article here: www.nature.com/articles/s41...
Epstein–Barr virus exploits desmocollin 2 as the principal epithelial cell entry receptor - Nature Microbiology
A genome-wide CRISPR screen helps to identify the Epstein–Barr virus receptor desmocollin 2 for primary epithelial cell infection. Additional infection assays revealed that desmocollin 3 also aids infection.
www.nature.com
October 1, 2025 at 5:55 PM
Read the associated research article here: www.nature.com/articles/s41...
Reposted by Lee Machado
#News&Views
Epstein–Barr virus is associated with cancer and implicated in autoimmune diseases. Three studies reveal desmocollin 2 and R9AP as receptors for Epstein–Barr virus infection, highlighting new avenues for targeted therapies.
#MicroSky 🦠
www.nature.com/articles/s41...
Epstein–Barr virus is associated with cancer and implicated in autoimmune diseases. Three studies reveal desmocollin 2 and R9AP as receptors for Epstein–Barr virus infection, highlighting new avenues for targeted therapies.
#MicroSky 🦠
www.nature.com/articles/s41...
Identified receptors shed light on Epstein–Barr virus infection - Nature Microbiology
Epstein–Barr virus is associated with cancer and implicated in autoimmune diseases. Three studies reveal desmocollin 2 and R9AP as receptors for Epstein–Barr virus infection, highlighting new avenues for targeted therapies.
www.nature.com
October 1, 2025 at 5:55 PM
#News&Views
Epstein–Barr virus is associated with cancer and implicated in autoimmune diseases. Three studies reveal desmocollin 2 and R9AP as receptors for Epstein–Barr virus infection, highlighting new avenues for targeted therapies.
#MicroSky 🦠
www.nature.com/articles/s41...
Epstein–Barr virus is associated with cancer and implicated in autoimmune diseases. Three studies reveal desmocollin 2 and R9AP as receptors for Epstein–Barr virus infection, highlighting new avenues for targeted therapies.
#MicroSky 🦠
www.nature.com/articles/s41...
Looking forward to using our new Seahorse across a bunch of projects for metabolic studies…just having to re-learn my undergraduate biochemistry though 😉
September 26, 2025 at 11:01 PM
Looking forward to using our new Seahorse across a bunch of projects for metabolic studies…just having to re-learn my undergraduate biochemistry though 😉
Reposted by Lee Machado
A unified model for Duchenne muscular dystrophy gene involvement in cancer: context-dependent tumour suppression and oncogenicity
🔦 buff.ly/lBnkwMP
🥼 @drleemachado.bsky.social
#CancerResearch #DuchenneMuscularDystrophy
🔦 buff.ly/lBnkwMP
🥼 @drleemachado.bsky.social
#CancerResearch #DuchenneMuscularDystrophy
September 25, 2025 at 9:15 AM
A unified model for Duchenne muscular dystrophy gene involvement in cancer: context-dependent tumour suppression and oncogenicity
🔦 buff.ly/lBnkwMP
🥼 @drleemachado.bsky.social
#CancerResearch #DuchenneMuscularDystrophy
🔦 buff.ly/lBnkwMP
🥼 @drleemachado.bsky.social
#CancerResearch #DuchenneMuscularDystrophy
Great to catch up with my fab friend Tim (from our undergraduate days) who was recently promoted to Prof. in Structural Biology at the University of Birmingham.
September 9, 2025 at 5:24 PM
Great to catch up with my fab friend Tim (from our undergraduate days) who was recently promoted to Prof. in Structural Biology at the University of Birmingham.
Quite amusing sitting on a train overhearing two international scientists converse about cholera toxins, phage, E.Coli, yeast two hybrids…must be terrifying if you’re a non-scientist passenger sat in earshot 😂
September 9, 2025 at 7:13 AM
Quite amusing sitting on a train overhearing two international scientists converse about cholera toxins, phage, E.Coli, yeast two hybrids…must be terrifying if you’re a non-scientist passenger sat in earshot 😂
Reposted by Lee Machado
David Baltimore, Nobel-Winning Molecular Biologist, Dies at 87 www.nytimes.com/2025/09/07/s...
David Baltimore, Nobel-Winning Molecular Biologist, Dies at 87
www.nytimes.com
September 7, 2025 at 7:26 PM
David Baltimore, Nobel-Winning Molecular Biologist, Dies at 87 www.nytimes.com/2025/09/07/s...
🚨 New in FEBS Open Bio!
During COVID, with labs disrupted, I undertook an MRes apprenticeship in bioinformatics. As a professor, I was suddenly a student again, learning coding to support my group.
Together with @Weekademia, we propose a unified model of DMD in cancer. 🧵👇
During COVID, with labs disrupted, I undertook an MRes apprenticeship in bioinformatics. As a professor, I was suddenly a student again, learning coding to support my group.
Together with @Weekademia, we propose a unified model of DMD in cancer. 🧵👇
August 21, 2025 at 12:48 PM
🚨 New in FEBS Open Bio!
During COVID, with labs disrupted, I undertook an MRes apprenticeship in bioinformatics. As a professor, I was suddenly a student again, learning coding to support my group.
Together with @Weekademia, we propose a unified model of DMD in cancer. 🧵👇
During COVID, with labs disrupted, I undertook an MRes apprenticeship in bioinformatics. As a professor, I was suddenly a student again, learning coding to support my group.
Together with @Weekademia, we propose a unified model of DMD in cancer. 🧵👇
A formative experience for me working at Novartis for a year in the late 90s www.alexkesin.com/p/the-day-no... The Day Novartis Chose Discovery
The Day Novartis Chose Discovery
How a Swiss pharma giant built the last great corporate research skunkworks - and why that model may never work again.
www.alexkesin.com
August 8, 2025 at 7:37 PM
A formative experience for me working at Novartis for a year in the late 90s www.alexkesin.com/p/the-day-no... The Day Novartis Chose Discovery
Cytotoxic IgG: Mechanisms, functions, and applications: Immunity www.cell.com/immunity/ful...
Cytotoxic IgG: Mechanisms, functions, and applications
Cytotoxic antibodies have become an essential tool to remove unwanted cells in patients
with cancer, infection, and autoimmunity. Wöhner and Nimmerjahn summarize recent insights
into how antibody-depe...
www.cell.com
June 16, 2025 at 6:49 AM
Cytotoxic IgG: Mechanisms, functions, and applications: Immunity www.cell.com/immunity/ful...
cancerci.biomedcentral.com/articles/10.... Disruption of DMD gene leads to altered calcium homeostasis and metabolic shift impacting gastric Cancer cell proliferation and migration | Cancer Cell International | Full Text
Disruption of DMD gene leads to altered calcium homeostasis and metabolic shift impacting gastric Cancer cell proliferation and migration - Cancer Cell International
DMD gene has been implicated in the progression and development of several tumors, but its specific contribution to gastric cancer (GC) has not been fully elucidated. We validated DMD gene expression ...
cancerci.biomedcentral.com
June 8, 2025 at 5:38 PM
cancerci.biomedcentral.com/articles/10.... Disruption of DMD gene leads to altered calcium homeostasis and metabolic shift impacting gastric Cancer cell proliferation and migration | Cancer Cell International | Full Text
Tweaking the Fc portion of CBIs is ‘key’. Fc-optimized anti-CTLA-4 antibodies increase tumor-associated high endothelial venules and sensitize refractory tumors to PD-1 blockade: Cell Reports Medicine www.cell.com/cell-reports...
Fc-optimized anti-CTLA-4 antibodies increase tumor-associated high endothelial venules and sensitize refractory tumors to PD-1 blockade
Blanchard et al. reveal that Fc-optimized anti-CTLA-4 antibodies remodel tumor vasculature
and increase tumor-associated high endothelial venules (TA-HEVs) that support T cell
recruitment into tumors....
www.cell.com
June 8, 2025 at 5:27 PM
Tweaking the Fc portion of CBIs is ‘key’. Fc-optimized anti-CTLA-4 antibodies increase tumor-associated high endothelial venules and sensitize refractory tumors to PD-1 blockade: Cell Reports Medicine www.cell.com/cell-reports...
So interesting to see how this story has developed. Inherited chromosomally integrated human herpesvirus 6: regional variation in prevalence, association with angina, and identification of ancestral viral lineages in two large UK studies | Journal of Virology journals.asm.org/doi/10.1128/...
Inherited chromosomally integrated human herpesvirus 6: regional variation in prevalence, association with angina, and identification of ancestral viral lineages in two large UK studies | Journal of V...
Human herpesvirus 6 (HHV-6) has the unusual ability to integrate into the host chromosome
telomeres. Most of the world’s population is infected by HHV-6 in early childhood,
but around 1% inherit the v...
journals.asm.org
June 8, 2025 at 4:42 PM
So interesting to see how this story has developed. Inherited chromosomally integrated human herpesvirus 6: regional variation in prevalence, association with angina, and identification of ancestral viral lineages in two large UK studies | Journal of Virology journals.asm.org/doi/10.1128/...
Reposted by Lee Machado
This is a fun one! David Baltimore looking back on the discovery of reverse transcriptase. Cool images of original notebooks!
www.youtube.com/watch?v=XqUK...
www.youtube.com/watch?v=XqUK...
CSHL Keynote, Dr. David Baltimore, Caltech
YouTube video by CSHL Leading Strand
www.youtube.com
June 7, 2025 at 5:29 AM
This is a fun one! David Baltimore looking back on the discovery of reverse transcriptase. Cool images of original notebooks!
www.youtube.com/watch?v=XqUK...
www.youtube.com/watch?v=XqUK...
The Overexpression of Collagen Receptor DDR1 is Associated With Chromosome Instability and Aneuploidy in Diffuse Large B‐Cell Lymphoma - Margielewska‐Davies - 2025 - Journal of Cellular and Molecular Medicine - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...
The Overexpression of Collagen Receptor DDR1 is Associated With Chromosome Instability and Aneuploidy in Diffuse Large B‐Cell Lymphoma
Although chronic inflammation is implicated in the pathogenesis of diffuse large B-cell lymphoma (DLBCL), the mechanisms responsible are unknown. We demonstrate that the overexpression of the collage....
onlinelibrary.wiley.com
May 26, 2025 at 9:25 PM
The Overexpression of Collagen Receptor DDR1 is Associated With Chromosome Instability and Aneuploidy in Diffuse Large B‐Cell Lymphoma - Margielewska‐Davies - 2025 - Journal of Cellular and Molecular Medicine - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...
