Karim Gharbi
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drkarimgharbi.bsky.social
Karim Gharbi
@drkarimgharbi.bsky.social
Genomics veteran • Data-minded biologist • Head of Technical Genomics at Earlham Institute (Norwich, England) • he/him
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Really nice work led by @conradn.bsky.social , and a prime example of how transformative technology can reveal new biology.
A study from the Earlham Institute and @ox.ac.uk has generated ultra #longread @nanoporetech.com reads, to reveal the majority of the human #genome is replicated from dispersed initiation sites, with around 80% of the sites never reported before. 🖥️🧬

@conradn.bsky.social @drkarimgharbi.bsky.social
Starting point of DNA replication mystery solved
The question of where DNA replication starts in the human genome has finally been addressed, with the conclusion it is largely random.
buff.ly
Reposted by Karim Gharbi
💬 “This work demonstrates the power of technology to reveal novel biology, in this case hidden functional diversity which had not been documented before." - @drkarimgharbi.bsky.social

Newly-discovered diversity in the #wheat #genome could improve one of the world’s most important staple #crops.
New wheat diversity discovery could provide an urgently-needed solution to global food security
Newly-discovered diversity in the wheat genome could offer vital new opportunities to improve and ‘climate-proof’ one of the world’s most important staple crops.
buff.ly
October 14, 2025 at 9:01 AM
Reposted by Karim Gharbi
Two of our students - Rosie and Archie - shared their experience working with our Technical Genomics and Earlham Biofoundry Groups, developing their skills and gaining practical training in #genomics and #laboratory #automation. 🧬

🔗 buff.ly/KF08OL9

@drkarimgharbi.bsky.social @cgrandel.bsky.social
Developing the next generation of technical specialists with T-Levels
The Earlham Institute T-Level industry placement programme inspires the next generation of young people pursuing careers in science.
www.earlham.ac.uk
July 9, 2025 at 12:02 PM
Reposted by Karim Gharbi
We're proud to support T Level Students at the Earlham Institute and a new report from @uk-itss.bsky.social today showcases the impact of industry placements for supporting young people to thrive in a range of scientific careers. 🥼

🔗 buff.ly/7JMmK1V?

@tech-commit.bsky.social
T Level industry placements in higher education and research
Sector insights and practical guidance
itss.org.uk
July 9, 2025 at 12:02 PM
Reposted by Karim Gharbi
A great day with #Tecan bringing together those involved in lab #automation for #genomics to discuss the latest trends, considerations, and applications of this technology.
June 26, 2025 at 3:00 PM
Join us in Norwich for a day of automation goodness, including talks, lab tours, and more.
Next month we're co-hosting an 'Innovation in Laboratory Automation Day' with the team from Tecan, showcasing the latest in #labautomation, and insights into emerging trends.

🗓️ 26 June 2025
ℹ️ Free of charge, but spaces are limited

@drkarimgharbi.bsky.social
Tecan Innovation in Laboratory Automation Day
buff.ly
May 14, 2025 at 8:16 AM
Really nice work led by @conradn.bsky.social , and a prime example of how transformative technology can reveal new biology.
A study from the Earlham Institute and @ox.ac.uk has generated ultra #longread @nanoporetech.com reads, to reveal the majority of the human #genome is replicated from dispersed initiation sites, with around 80% of the sites never reported before. 🖥️🧬

@conradn.bsky.social @drkarimgharbi.bsky.social
Starting point of DNA replication mystery solved
The question of where DNA replication starts in the human genome has finally been addressed, with the conclusion it is largely random.
buff.ly
May 12, 2025 at 12:25 PM
Reposted by Karim Gharbi
Great to see Group Leader Dr Wilfried Haerty (@whaerty.bsky.social) presenting his work at #PacBioPRISM this afternoon!

Dr Haerty leads our #CellularGenomics research programme and is interested in the impact of variation on gene and transcript expression across scale.

@pacbio.bsky.social
Haerty Group - Comparative Genomics and Population Genetics
Investigating the evolution of functional noncoding sequences
buff.ly
April 29, 2025 at 1:18 PM
Reposted by Karim Gharbi
TALK: We're looking forward to hearing from @katielong.bsky.social next month, presenting research from her collaboration with our #singlecell team using #spatialtranscriptomics on expression in developing wheat spikelets.

Register to join: https://buff.ly/3QAK2w4

@johninnescentre.bsky.social
NBRI Transformative Genomics - Annual User Meeting
A one-day meeting of the bioscience community to hear the latest updates and applications from the BBSRC-funded National Bioscience Research Infrastructure in Transformative Genomics at the Earlham…
buff.ly
February 27, 2025 at 8:05 AM
Reposted by Karim Gharbi
TALK: Interested in #genomics for #bioscience? Caoimhe Morley from @ucl.ac.uk will be joining us next month at our User Group meeting, to share her research on targeted #longread sequencing for somatic structural variant discovery in Multiple System Atrophy brains.

Register to join 👇
NBRI Transformative Genomics - Annual User Meeting
A one-day meeting of the bioscience community to hear the latest updates and applications from the BBSRC-funded National Bioscience Research Infrastructure in Transformative Genomics at the Earlham…
buff.ly
February 28, 2025 at 10:01 AM
Reposted by Karim Gharbi
🔬 Discover how #SpatialTranscriptomics is unlocking insights into the ageing brain with @parker-aim.bsky.social (@quadraminstitute.bsky.social) at the NBRI Transformative Genomics User Meeting.

📅 Register:
NBRI Transformative Genomics - Annual User Meeting
A one-day meeting of the bioscience community to hear the latest updates and applications from the BBSRC-funded National Bioscience Research Infrastructure in Transformative Genomics at the Earlham…
buff.ly
March 1, 2025 at 2:01 PM
Reposted by Karim Gharbi
🦠 Multidrug resistance in human fungal pathogens is a growing threat. Join Mat Fisher (@imperialcollegeldn.bsky.social) at the NBRI Transformative Genomics User Meeting as he explores the drivers behind this challenge.

📅 Registration closes tomorrow: buff.ly/3EUgAyx

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f="/hashtag/Genomics" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#Genomics #Sequencing
March 2, 2025 at 1:00 PM
Reposted by Karim Gharbi
Make sure you join our NBRI Transformative Genomics User Meeting to hear @conradn.bsky.social discuss how ultra-long read sequencing reveals patterns of replication site initiation across the human genome.

Join us here 👉 https://buff.ly/4blYAJl

#genomics #sequencing @drkarimgharbi.bsky.social
February 27, 2025 at 4:00 PM
Reposted by Karim Gharbi
💬 “By using a much-expanded set of robust barcodes, we can pool more samples in the sequencing lane, making better use of our capacity and further lowering the cost per sample.” - @drkarimgharbi.bsky.social

LITE2 takes affordable genome sequencing to a new level
LITE2: Reduced bias and increased throughput
The Earlham Institute's improved Low Input, Transposase Enabled (LITE) protocol is a low-cost method for high-throughput whole genome sequencing with reduced DNA input.
buff.ly
February 12, 2025 at 1:06 PM
Reposted by Karim Gharbi
Technological advances have transformed #sequencing, but costs and timescales can still be limiting, especially in library generation.

Earlham Institute's updated Low Input, Transposase Enabled (LITE) protocol offers low-cost, high-throughput whole #genome sequencing with reduced DNA input. 💻🧬🧪
LITE2 takes affordable genome sequencing to a new level
The Earlham Institute's improved Low Input, Transposase Enabled (LITE) protocol is a low-cost method for high-throughput whole genome sequencing with reduced DNA input.
buff.ly
February 5, 2025 at 11:00 AM
Reposted by Karim Gharbi
A team from the Earlham Institute and the Czech Academy of Sciences have #sequenced and assembled the first near-complete annotated #genome of the wood-decaying bracket fungus, Somion occarium, as part of @ergabiodiv.bsky.social. 🧪

🖥️ 🧬

@rowenahill.bsky.social @drkarimgharbi.bsky.social
Nuclear and mitochondrial genome assemblies for the endangered wood-decaying fungus Somion occarium
Abstract. Somion occarium is a wood-decaying bracket fungus belonging to an order known to be rich in useful chemical compounds. Despite its widespread dis
academic.oup.com
January 20, 2025 at 8:35 AM
Reposted by Karim Gharbi
Catch our scientists at the #FestivalofGenomics later this month where they'll be discussing overcoming data challenges in #singlecell biology, and ultra #longread #sequencing in #DNAreplication.👇🧬🖥️

@flgenomics.bsky.social @drkarimgharbi.bsky.social @conradn.bsky.social @whatchamacaulay.bsky.social
January 16, 2025 at 11:14 AM
Reposted by Karim Gharbi
A new study in Scientific Data from the Earlham Institute, @rothamsted.bsky.social, @rbgkew.bsky.social, and @ergabiodiv.bsky.social presents a high-quality annotated orange foxtail grass #genome, shedding light on what makes it such an exceptional survivor in modern #crop systems.

🧬🖥️🌿
New sequenced genome sheds light on weed resistance
Genomic advances reveal how similar weeds can dominate wheat fields that are geographically separated by over 5,000 miles.
www.earlham.ac.uk
January 9, 2025 at 8:55 AM
Reposted by Karim Gharbi
💬 “This development will deliver the computational performance we need to support our science into the future." - @neilhall.bsky.social, Director.

New #DataCentre at #NorwichResearchPark set to bolster UK’s #bioscience capability.

@quadraminstitute.bsky.social @thesainsburylab.bsky.social
New Data Centre at Norwich Research Park set to bolster UK’s bioscience capability
A new state-of-the-art Data Centre at Norwich Research Park has been given the green light for construction.
www.earlham.ac.uk
December 9, 2024 at 9:15 AM
Reposted by Karim Gharbi
Huge thanks to @elinork.bsky.social for her brilliant talk about #comparative #genomics and the #Zoomomia project at today's inaugural Dame Janet Thornton Lecture. We were pleased to be joined by Prof Thornton to introduce the lecture.

@neilhall.bsky.social @broadinstitute.org
November 25, 2024 at 3:21 PM
Reposted by Karim Gharbi
Great to see this important resource published.

The reference #genome was supported by @pacbio.bsky.social HiFi data generated through the Transformative Genomics National Bioscience Research Infrastructure at the Earlham Institute, led by @drkarimgharbi.bsky.social.

nisd.ac.uk/new-grasspea...
New grasspea genome unlocks rapid climate-smart breeding
New grasspea genome has been published online, providing researchers with a new tool to unlocks potential for rapid climate-smart breeding
nisd.ac.uk
October 25, 2024 at 7:44 AM