Esther Pearl
@drejpearl.bsky.social
Programme Manager - Experimental Design at @nc3rs.bsky.social
https://orcid.org/0000-0001-6510-0959
#ExperimentalDesignAssistant's number one fan (https://eda.nc3rs.org.uk) (she/her)
https://orcid.org/0000-0001-6510-0959
#ExperimentalDesignAssistant's number one fan (https://eda.nc3rs.org.uk) (she/her)
Reposted by Esther Pearl
The NC3Rs has a strong track record in investing in in vitro models of human disease that replace the use of animals. We have recently partnered with the MRC, Wellcome and Innovate UK on a £15.9M funding call to develop human in vitro models of complex disease.
nc3rs.org.uk/news/nc3rs-g...
nc3rs.org.uk/news/nc3rs-g...
NC3Rs grant holders receive funding in MRC call
£15.9M awarded to develop human in vitro models of complex disease.
nc3rs.org.uk
November 12, 2025 at 10:37 AM
The NC3Rs has a strong track record in investing in in vitro models of human disease that replace the use of animals. We have recently partnered with the MRC, Wellcome and Innovate UK on a £15.9M funding call to develop human in vitro models of complex disease.
nc3rs.org.uk/news/nc3rs-g...
nc3rs.org.uk/news/nc3rs-g...
Reposted by Esther Pearl
❗Survey deadline extended: Friday 12 December❗
If you have experience of the monocyte activation test as a replacement for the rabbit pyrogen test, please take 30 minutes to share your insights: nc3rs.org.uk/our-portfoli...
If you have experience of the monocyte activation test as a replacement for the rabbit pyrogen test, please take 30 minutes to share your insights: nc3rs.org.uk/our-portfoli...
NEW SURVEY. Do you manufacture, regulate or produce biological therapeutics? Help the NC3Rs shape the future of non-animal pyrogenicity testing of biologics: nc3rs.org.uk/our-portfoli...
Supporting 3Rs approaches in biologicals testing
nc3rs.org.uk
November 10, 2025 at 12:54 PM
❗Survey deadline extended: Friday 12 December❗
If you have experience of the monocyte activation test as a replacement for the rabbit pyrogen test, please take 30 minutes to share your insights: nc3rs.org.uk/our-portfoli...
If you have experience of the monocyte activation test as a replacement for the rabbit pyrogen test, please take 30 minutes to share your insights: nc3rs.org.uk/our-portfoli...
Reposted by Esther Pearl
⏳ Pyrogenicity testing survey closing on Thursday 7 November.
Please take 30 minutes to share your insights into the monocyte activation test and support our work to drive wider adoption of non-animal approaches in biologics quality control testing.
Take the survey: nc3rs.org.uk/our-portfoli...
Please take 30 minutes to share your insights into the monocyte activation test and support our work to drive wider adoption of non-animal approaches in biologics quality control testing.
Take the survey: nc3rs.org.uk/our-portfoli...
NEW SURVEY. Do you manufacture, regulate or produce biological therapeutics? Help the NC3Rs shape the future of non-animal pyrogenicity testing of biologics: nc3rs.org.uk/our-portfoli...
Supporting 3Rs approaches in biologicals testing
nc3rs.org.uk
November 3, 2025 at 3:13 PM
⏳ Pyrogenicity testing survey closing on Thursday 7 November.
Please take 30 minutes to share your insights into the monocyte activation test and support our work to drive wider adoption of non-animal approaches in biologics quality control testing.
Take the survey: nc3rs.org.uk/our-portfoli...
Please take 30 minutes to share your insights into the monocyte activation test and support our work to drive wider adoption of non-animal approaches in biologics quality control testing.
Take the survey: nc3rs.org.uk/our-portfoli...
Looking for a more interactive way to teach experimental design for researchers? Make the @nc3rs.bsky.social's Experimental Design Assistant (EDA) part of your course! For ideas check out how Inserm designed their course, including tips for others wanting to do something similar 👇
@inserm.fr have reached approaching 1,000 researchers with a training course that uses the NC3Rs Experimental Design Assistant (EDA) to teach best practice for experimental design of in vivo studies.
Learn more in our interview with the organiser behind Parcours-EDA: nc3rs.org.uk/news/experim...
Learn more in our interview with the organiser behind Parcours-EDA: nc3rs.org.uk/news/experim...
The Experimental Design Assistant: From research planning to training tool
A national training initiative in France is using the EDA to embed robust experimental design into real-world research practice.
nc3rs.org.uk
October 31, 2025 at 11:07 AM
Looking for a more interactive way to teach experimental design for researchers? Make the @nc3rs.bsky.social's Experimental Design Assistant (EDA) part of your course! For ideas check out how Inserm designed their course, including tips for others wanting to do something similar 👇
Part of an ethical review body? Want more information on key considerations to help improve rigour and reproducibility of animal research? Check out the new chapter in the 4th edition of the IACUC Handbook: ‘Research Reproducibility and the Role of the IACUC’ www.taylorfrancis.com/chapters/oa-...
October 22, 2025 at 1:40 PM
Part of an ethical review body? Want more information on key considerations to help improve rigour and reproducibility of animal research? Check out the new chapter in the 4th edition of the IACUC Handbook: ‘Research Reproducibility and the Role of the IACUC’ www.taylorfrancis.com/chapters/oa-...
The @nc3rs.bsky.social's Experimental Design Assistant (EDA) is back online following planned maintenance. Thank you for your patience.
🚨⚠️ The @nc3rs.bsky.social's Experimental Design Assistant will be offline for planned maintenance today (Tuesday 23 September) from 4pm BST. Please ensure your work is saved before 4pm. We apologise for any inconvenience caused and will notify you when the EDA is back online. ⚠️🚨
September 23, 2025 at 4:34 PM
The @nc3rs.bsky.social's Experimental Design Assistant (EDA) is back online following planned maintenance. Thank you for your patience.
🚨⚠️ The @nc3rs.bsky.social's Experimental Design Assistant will be offline for planned maintenance today (Tuesday 23 September) from 4pm BST. Please ensure your work is saved before 4pm. We apologise for any inconvenience caused and will notify you when the EDA is back online. ⚠️🚨
September 23, 2025 at 8:01 AM
🚨⚠️ The @nc3rs.bsky.social's Experimental Design Assistant will be offline for planned maintenance today (Tuesday 23 September) from 4pm BST. Please ensure your work is saved before 4pm. We apologise for any inconvenience caused and will notify you when the EDA is back online. ⚠️🚨
🚨⚠️The @nc3rs.bsky.social's Experimental Design Assistant (EDA) will be offline for planned maintenance on Tuesday 23 September from 4pm BST. We anticipate it will be back online by the morning of Wednesday 24 September. We apologise for any inconvenience caused.⚠️🚨
September 19, 2025 at 4:53 PM
🚨⚠️The @nc3rs.bsky.social's Experimental Design Assistant (EDA) will be offline for planned maintenance on Tuesday 23 September from 4pm BST. We anticipate it will be back online by the morning of Wednesday 24 September. We apologise for any inconvenience caused.⚠️🚨
Reposted by Esther Pearl
Spaces still available for this excellent scientific webinar later this week - register via link below 👇
Join us next week to learn more about misconceptions around sex-inclusive research and how the Sex Inclusive Research Framework can be used by scientists, ethical review bodies and funders: nc3rs.org.uk/events/tackl...
📅 18 September, 15.00 – 16.00
📜 One hour of continuing professional development
📅 18 September, 15.00 – 16.00
📜 One hour of continuing professional development
September 15, 2025 at 3:35 PM
Spaces still available for this excellent scientific webinar later this week - register via link below 👇
Reposted by Esther Pearl
Join us next week to learn more about misconceptions around sex-inclusive research and how the Sex Inclusive Research Framework can be used by scientists, ethical review bodies and funders: nc3rs.org.uk/events/tackl...
📅 18 September, 15.00 – 16.00
📜 One hour of continuing professional development
📅 18 September, 15.00 – 16.00
📜 One hour of continuing professional development
September 11, 2025 at 8:53 AM
Join us next week to learn more about misconceptions around sex-inclusive research and how the Sex Inclusive Research Framework can be used by scientists, ethical review bodies and funders: nc3rs.org.uk/events/tackl...
📅 18 September, 15.00 – 16.00
📜 One hour of continuing professional development
📅 18 September, 15.00 – 16.00
📜 One hour of continuing professional development
Interested in tools to help teach experimental design? Is your institution part of the UKRN Open Research Programme? www.ukrn.org/partner-inst...
👇 Register for the online workshop on how to use, and teach others to use, the Experimental Design Assistant (EDA). Registrations close 17 September. 👇
👇 Register for the online workshop on how to use, and teach others to use, the Experimental Design Assistant (EDA). Registrations close 17 September. 👇
September 9, 2025 at 2:28 PM
Interested in tools to help teach experimental design? Is your institution part of the UKRN Open Research Programme? www.ukrn.org/partner-inst...
👇 Register for the online workshop on how to use, and teach others to use, the Experimental Design Assistant (EDA). Registrations close 17 September. 👇
👇 Register for the online workshop on how to use, and teach others to use, the Experimental Design Assistant (EDA). Registrations close 17 September. 👇
Reposted by Esther Pearl
We are supporting in-person training workshops to promote the use of skin swabbing as a refined approach for genotyping zebrafish.
🐟 Suitable for technical staff and researchers
🤝 Personalised support in small groups
📍 Delivered at your facility (UK only)
Find out more: nc3rs.org.uk/training-wor...
🐟 Suitable for technical staff and researchers
🤝 Personalised support in small groups
📍 Delivered at your facility (UK only)
Find out more: nc3rs.org.uk/training-wor...
September 3, 2025 at 11:36 AM
We are supporting in-person training workshops to promote the use of skin swabbing as a refined approach for genotyping zebrafish.
🐟 Suitable for technical staff and researchers
🤝 Personalised support in small groups
📍 Delivered at your facility (UK only)
Find out more: nc3rs.org.uk/training-wor...
🐟 Suitable for technical staff and researchers
🤝 Personalised support in small groups
📍 Delivered at your facility (UK only)
Find out more: nc3rs.org.uk/training-wor...
The @nc3rs.bsky.social contingent has ARRIVEd in Brazil for #WC13. Yesterday kicked off with the opening ceremony. Today join me in session 118: Ethics in action. I will be highlighting resources to support reduction and how ethical review bodies can use them.
September 1, 2025 at 9:21 AM
The @nc3rs.bsky.social contingent has ARRIVEd in Brazil for #WC13. Yesterday kicked off with the opening ceremony. Today join me in session 118: Ethics in action. I will be highlighting resources to support reduction and how ethical review bodies can use them.
Reposted by Esther Pearl
⏳ Registration closing on Thursday 28 August!
Interested in driving the uptake and impact of 3Rs models and technologies through cross sector collaborations? Join us and the BBSRC in London on September 12 as we launch our new joint funding initiative.
Find out more: nc3rs.org.uk/events/nc3rs...
Interested in driving the uptake and impact of 3Rs models and technologies through cross sector collaborations? Join us and the BBSRC in London on September 12 as we launch our new joint funding initiative.
Find out more: nc3rs.org.uk/events/nc3rs...
August 26, 2025 at 2:52 PM
⏳ Registration closing on Thursday 28 August!
Interested in driving the uptake and impact of 3Rs models and technologies through cross sector collaborations? Join us and the BBSRC in London on September 12 as we launch our new joint funding initiative.
Find out more: nc3rs.org.uk/events/nc3rs...
Interested in driving the uptake and impact of 3Rs models and technologies through cross sector collaborations? Join us and the BBSRC in London on September 12 as we launch our new joint funding initiative.
Find out more: nc3rs.org.uk/events/nc3rs...
Now that the 20th International Xenopus conference is over it is time to rest my geeky earrings. I had a great time catching up with people and discussing welfare research priorities. Interested in the amphibian welfare webinars I mentioned? Here’s the link: nc3rs.org.uk/3rs-resource... #IXC25
August 22, 2025 at 8:11 AM
Now that the 20th International Xenopus conference is over it is time to rest my geeky earrings. I had a great time catching up with people and discussing welfare research priorities. Interested in the amphibian welfare webinars I mentioned? Here’s the link: nc3rs.org.uk/3rs-resource... #IXC25
Having some great conversations about Xenopus welfare at the 20th International Xenopus conference. Also got to wear my Xenopus earrings!! #IXC25
August 19, 2025 at 12:37 PM
Having some great conversations about Xenopus welfare at the 20th International Xenopus conference. Also got to wear my Xenopus earrings!! #IXC25
August 17, 2025 at 10:12 AM
Reposted by Esther Pearl
Looking for support to teach experimental design? Join our online workshop with @ukrepro.bsky.social on using the Experimental Design Assistant (EDA) to plan rigorous, reproducible animal studies.
📅 13 November, 10.00 – 16.00 (GMT)
❗ Registration closes: 17 September
👉 nc3rs.org.uk/events/ukrn-...
📅 13 November, 10.00 – 16.00 (GMT)
❗ Registration closes: 17 September
👉 nc3rs.org.uk/events/ukrn-...
August 4, 2025 at 1:34 PM
Looking for support to teach experimental design? Join our online workshop with @ukrepro.bsky.social on using the Experimental Design Assistant (EDA) to plan rigorous, reproducible animal studies.
📅 13 November, 10.00 – 16.00 (GMT)
❗ Registration closes: 17 September
👉 nc3rs.org.uk/events/ukrn-...
📅 13 November, 10.00 – 16.00 (GMT)
❗ Registration closes: 17 September
👉 nc3rs.org.uk/events/ukrn-...
A recent study showed more than half of publications using animal models of neurological disorders involved pseudoreplication (doi.org/10.1186/s132...). Avoid pseudoreplication - use the EDA to help you identify your experimental unit accurately: eda.nc3rs.org.uk/experimental...
Experimental unit | NC3Rs EDA
How to identify the experimental unit in an in vivo experiment
eda.nc3rs.org.uk
August 5, 2025 at 7:49 AM
A recent study showed more than half of publications using animal models of neurological disorders involved pseudoreplication (doi.org/10.1186/s132...). Avoid pseudoreplication - use the EDA to help you identify your experimental unit accurately: eda.nc3rs.org.uk/experimental...
Are you looking for something to help you teach experimental design? Also at a @ukrepro.bsky.social Open Research partner institution (www.ukrn.org/partner-inst...)? Join us and learn how to the EDA can help!
August 4, 2025 at 2:57 PM
Are you looking for something to help you teach experimental design? Also at a @ukrepro.bsky.social Open Research partner institution (www.ukrn.org/partner-inst...)? Join us and learn how to the EDA can help!
Want a bit of extra help designing your next in vivo experiment? Join me tomorrow for a demonstration of the @nc3rs.bsky.social Experimental Design Assistant: nc3rs.org.uk/3rs-resource...
Virtual demonstrations of the Experimental Design Assistant
Learn how our online EDA tool can help you plan rigorous experiments.
nc3rs.org.uk
July 23, 2025 at 7:08 AM
Want a bit of extra help designing your next in vivo experiment? Join me tomorrow for a demonstration of the @nc3rs.bsky.social Experimental Design Assistant: nc3rs.org.uk/3rs-resource...
🎉🥳 Happy Birthday ARRIVE 2.0! 🥳🎉 ARRIVE goes further than reporting guidelines, check out the free resources to help us improve the way we plan, conduct and report animal research! 👇
ARRIVE 2.0 turns five! Since we launched our updated guidelines in July 2020, we have developed a suite of resources to embed transparency and reproducibility throughout the research lifecycle, from planning to peer review: arriveguidelines.org/resources
July 17, 2025 at 3:45 PM
🎉🥳 Happy Birthday ARRIVE 2.0! 🥳🎉 ARRIVE goes further than reporting guidelines, check out the free resources to help us improve the way we plan, conduct and report animal research! 👇
Ever been frustrated by antibodies not working they way you think they should? This year's 3Rs prize winners 🏆 tested over 600 antibodies leading to 73 inadequately performing antibodies being withdrawn from the market. Find out more on Wednesday 23 July 👇
A scalable system to assess antibody performance and build confidence in recombinant reagents to replace animal-derived antibodies has won this year's International 3Rs Prize, sponsored by GSK: nc3rs.org.uk/news/buildin...
July 14, 2025 at 5:04 PM
Ever been frustrated by antibodies not working they way you think they should? This year's 3Rs prize winners 🏆 tested over 600 antibodies leading to 73 inadequately performing antibodies being withdrawn from the market. Find out more on Wednesday 23 July 👇
The Medical Research Council want to know about the impact of their policy on embedding diversity into research design.
Survey closes 13 June, don't miss the opportunity to have your say! 👇
Survey closes 13 June, don't miss the opportunity to have your say! 👇
Help shape MRC support for researchers and reviewers implementing the requirement to use female and male animals in preclinical research – take their survey: engagementhub.ukri.org/mrc-peg/edd5...
June 5, 2025 at 12:30 PM
The Medical Research Council want to know about the impact of their policy on embedding diversity into research design.
Survey closes 13 June, don't miss the opportunity to have your say! 👇
Survey closes 13 June, don't miss the opportunity to have your say! 👇