Bruce Gao
@drbrucegao.bsky.social
A full-time clinical microbiologist with a passion for medical economics, I also run a side tutoring business that helps Australian high school students explore opportunities at top-tier US colleges. www.bostoniacs.com
Reposted by Bruce Gao
📊The data behind METAGENE-1:
- Brand-new dataset collected with experts from Southern California & Missouri
- 1.5 trillion base pairs from diverse wastewater samples
- Short reads (100–300 BPs), deep sequencing at scale
- Byte-Pair Encoding customized for genomic sequences
🧵3/
- Brand-new dataset collected with experts from Southern California & Missouri
- 1.5 trillion base pairs from diverse wastewater samples
- Short reads (100–300 BPs), deep sequencing at scale
- Byte-Pair Encoding customized for genomic sequences
🧵3/
January 6, 2025 at 5:04 PM
📊The data behind METAGENE-1:
- Brand-new dataset collected with experts from Southern California & Missouri
- 1.5 trillion base pairs from diverse wastewater samples
- Short reads (100–300 BPs), deep sequencing at scale
- Byte-Pair Encoding customized for genomic sequences
🧵3/
- Brand-new dataset collected with experts from Southern California & Missouri
- 1.5 trillion base pairs from diverse wastewater samples
- Short reads (100–300 BPs), deep sequencing at scale
- Byte-Pair Encoding customized for genomic sequences
🧵3/
Reposted by Bruce Gao
"Used #PacBio #longread #metagenomics with read lengths extending well over typical ARG lengths to enable reliable investigation of sul4 genes. We also used unique methylation patterns to resolve bacterial hosts for sul4 in the complex #wastewater #microbiome." 🧵 1/3
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Sulfonamide resistance gene sul4 is hosted by common wastewater sludge bacteria and found in various newly described contexts and hosts including clinically relevant species
The introduction of the first broad-spectrum antibiotics, sulfonamide drugs fundamentally revolutionized medicine in the 1930s. Shortly after and ever since sulfonamide resistance genes ( sul genes) h...
www.biorxiv.org
January 28, 2025 at 2:50 PM
"Used #PacBio #longread #metagenomics with read lengths extending well over typical ARG lengths to enable reliable investigation of sul4 genes. We also used unique methylation patterns to resolve bacterial hosts for sul4 in the complex #wastewater #microbiome." 🧵 1/3
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Wastewater is an invaluable resource for epidemiological surveillance, for public health and also ag.
Exploring the diversity of plant viruses in reclaimed #Wastewater reveals the presence of harmful viruses like Tomato Brown Rugose Fruit Virus, highlighting the importance of #monitoring. #Metagenomics #Viromics
📄 doi.org/10.1016/j.wa...
EVBC👤: G. Sánchez, A. Pérez-Cataluña
📄 doi.org/10.1016/j.wa...
EVBC👤: G. Sánchez, A. Pérez-Cataluña
Redirecting
doi.org
March 13, 2025 at 12:24 PM
Wastewater is an invaluable resource for epidemiological surveillance, for public health and also ag.
Reposted by Bruce Gao
Exploring the diversity of plant viruses in reclaimed #Wastewater reveals the presence of harmful viruses like Tomato Brown Rugose Fruit Virus, highlighting the importance of #monitoring. #Metagenomics #Viromics
📄 doi.org/10.1016/j.wa...
EVBC👤: G. Sánchez, A. Pérez-Cataluña
📄 doi.org/10.1016/j.wa...
EVBC👤: G. Sánchez, A. Pérez-Cataluña
Redirecting
doi.org
December 3, 2024 at 11:02 AM
Exploring the diversity of plant viruses in reclaimed #Wastewater reveals the presence of harmful viruses like Tomato Brown Rugose Fruit Virus, highlighting the importance of #monitoring. #Metagenomics #Viromics
📄 doi.org/10.1016/j.wa...
EVBC👤: G. Sánchez, A. Pérez-Cataluña
📄 doi.org/10.1016/j.wa...
EVBC👤: G. Sánchez, A. Pérez-Cataluña