Dr Alison Weiss
@dralisonweiss.bsky.social
Assistant Professor at OHSU/ONPRC. Cognitive neuroscientist, aging, MRI/DTI/PET, pre-clinical models
New HD focused article leveraging multi-modal imaging from our long-standing collaboration with @danielebertoglio.bsky.social and colleagues! www.sciencedirect.com/science/arti...
Longitudinal investigation of structural and resting-state effective connectivity alterations in a non-human primate model of Huntington's disease
Huntington's disease (HD) is a genetic neurodegenerative disorder caused by expanded CAG repeats in the huntingtin gene which produce a mutant hunting…
www.sciencedirect.com
October 24, 2025 at 12:12 PM
New HD focused article leveraging multi-modal imaging from our long-standing collaboration with @danielebertoglio.bsky.social and colleagues! www.sciencedirect.com/science/arti...
This perspective on “imprecision medicine” is resonating with me. Author describes a “complementary approach of targeting the brain milieu in order to achieve disease-modifying effects in patients with or at risk of neurodegenerative disease” www.aginganddisease.org/EN/10.14336/...
Targeting the Milieu in Neurodegenerative Disease: Time for “Imprecision Medicine”?
<p>The possibility of developing precision therapies for neurodegenerative disease is tantalizing, and efforts are under way with several diseases, including Alzheimer’s, Parkinson’s and Huntington’s ...
www.aginganddisease.org
October 19, 2025 at 3:07 PM
This perspective on “imprecision medicine” is resonating with me. Author describes a “complementary approach of targeting the brain milieu in order to achieve disease-modifying effects in patients with or at risk of neurodegenerative disease” www.aginganddisease.org/EN/10.14336/...
Reposted by Dr Alison Weiss
✨ SHINY NEW PAPER ✨
Cortico-striatal gray matter atrophy and white matter microstructural degradation across the rhesus macaque adult lifespan.
@dralisonweiss.bsky.social
www.sciencedirect.com/science/article/pii/S0197458025001010
Cortico-striatal gray matter atrophy and white matter microstructural degradation across the rhesus macaque adult lifespan.
@dralisonweiss.bsky.social
www.sciencedirect.com/science/article/pii/S0197458025001010
Age-related differences in cerebral morphology and microstructure in rhesus macaques
The rhesus macaque presents a promising model for translational research into human brain aging due to this species’ long lifespan and close phylogeni…
www.sciencedirect.com
October 16, 2025 at 4:06 AM
✨ SHINY NEW PAPER ✨
Cortico-striatal gray matter atrophy and white matter microstructural degradation across the rhesus macaque adult lifespan.
@dralisonweiss.bsky.social
www.sciencedirect.com/science/article/pii/S0197458025001010
Cortico-striatal gray matter atrophy and white matter microstructural degradation across the rhesus macaque adult lifespan.
@dralisonweiss.bsky.social
www.sciencedirect.com/science/article/pii/S0197458025001010
Reposted by Dr Alison Weiss
New paper in Imaging Neuroscience by Joshua A. Karpf, Christopher D. Kroenke, et al:
Characterization of normative fetal rhesus macaque brain development with magnetic resonance imaging
doi.org/10.1162/IMAG...
Characterization of normative fetal rhesus macaque brain development with magnetic resonance imaging
doi.org/10.1162/IMAG...
October 1, 2025 at 4:58 AM
New paper in Imaging Neuroscience by Joshua A. Karpf, Christopher D. Kroenke, et al:
Characterization of normative fetal rhesus macaque brain development with magnetic resonance imaging
doi.org/10.1162/IMAG...
Characterization of normative fetal rhesus macaque brain development with magnetic resonance imaging
doi.org/10.1162/IMAG...
Reposted by Dr Alison Weiss
This may be the most important paper ever published about NIH funded research.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
What if NIH had been 40% smaller?
Replaying history with less NIH funding shows widespread impacts on drug-linked research
www.science.org
September 25, 2025 at 9:20 PM
This may be the most important paper ever published about NIH funded research.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Dr Alison Weiss
Not Yet AlphaFold for the Mind: Evaluating Centaur as a Synthetic Participant arxiv.org/abs/2508.078...
Not Yet AlphaFold for the Mind: Evaluating Centaur as a Synthetic Participant
Simulators have revolutionized scientific practice across the natural sciences. By generating data that reliably approximate real-world phenomena, they enable scientists to accelerate hypothesis testi...
arxiv.org
August 17, 2025 at 1:45 PM
Not Yet AlphaFold for the Mind: Evaluating Centaur as a Synthetic Participant arxiv.org/abs/2508.078...
Reposted by Dr Alison Weiss
BREAKING: Trump wants to illegally cut off $15 billion in lifesaving NIH research.
Research to cure cancer, Alzheimer's, and so much more is on the line.
These people are LYING about waste, fraud, and abuse at NIH to justify attacking medical research—we all need to say so.
My full statement. ⬇️
Research to cure cancer, Alzheimer's, and so much more is on the line.
These people are LYING about waste, fraud, and abuse at NIH to justify attacking medical research—we all need to say so.
My full statement. ⬇️
Senator Murray Slams Trump Admin for Choking Off Lifesaving NIH Medical Research - Senator Patty Murray
Washington, D.C. – Today, U.S. Senator Patty Murray (D-WA), Vice Chair of the Senate Appropriations Committee, issued the following statement on reports today that President Trump’s Office of Manageme...
www.murray.senate.gov
July 30, 2025 at 2:50 AM
BREAKING: Trump wants to illegally cut off $15 billion in lifesaving NIH research.
Research to cure cancer, Alzheimer's, and so much more is on the line.
These people are LYING about waste, fraud, and abuse at NIH to justify attacking medical research—we all need to say so.
My full statement. ⬇️
Research to cure cancer, Alzheimer's, and so much more is on the line.
These people are LYING about waste, fraud, and abuse at NIH to justify attacking medical research—we all need to say so.
My full statement. ⬇️
Reposted by Dr Alison Weiss
1
To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!
🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...
To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!
🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...
July 27, 2025 at 5:26 PM
1
To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!
🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...
To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!
🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...
New pre-print from an incredibly productive collaboration between my lab and the team led by @danielebertoglio.bsky.social
Longitudinal Investigation of Structural and Resting-State Effective Connectivity Alterations in a Non-Human Primate Model of Huntington's Disease https://www.biorxiv.org/content/10.1101/2025.07.18.665554v1
July 24, 2025 at 12:25 AM
New pre-print from an incredibly productive collaboration between my lab and the team led by @danielebertoglio.bsky.social
Very proud to work at a NHP facility with such stellar leadership and dedication to giving the animals the highest quality of life possible. now.ohsu.edu/member/post/...
ONPRC receives positive review following AAALAC site visit
The AAALAC site visit team recommended “Continued Full Accreditation with No Mandatory Findings or Suggestions for Improvement” — a rare and remarkable distinction that underscores the strength of the...
now.ohsu.edu
July 16, 2025 at 1:26 AM
Very proud to work at a NHP facility with such stellar leadership and dedication to giving the animals the highest quality of life possible. now.ohsu.edu/member/post/...
Reposted by Dr Alison Weiss
Public comment on this new "no animal only studies" is open here:
www.fda.gov/news-events/...
It closes next Monday.
www.fda.gov/news-events/...
It closes next Monday.
July 8, 2025 at 7:32 PM
Public comment on this new "no animal only studies" is open here:
www.fda.gov/news-events/...
It closes next Monday.
www.fda.gov/news-events/...
It closes next Monday.
Reposted by Dr Alison Weiss
We are so excited to see you all soon !!
REGISTRATION IS HAPPENING NOW !!!
Come join us at SimCo 2025 in Durham !! Register now for early bird discount and re-share!!!
www.simiancollective.com/2025-confere...
@janzimmermann.bsky.social
@stevewcchang.bsky.social
@anitadisney.bsky.social
REGISTRATION IS HAPPENING NOW !!!
Come join us at SimCo 2025 in Durham !! Register now for early bird discount and re-share!!!
www.simiancollective.com/2025-confere...
@janzimmermann.bsky.social
@stevewcchang.bsky.social
@anitadisney.bsky.social
www.simiancollective.com
July 1, 2025 at 9:12 PM
We are so excited to see you all soon !!
REGISTRATION IS HAPPENING NOW !!!
Come join us at SimCo 2025 in Durham !! Register now for early bird discount and re-share!!!
www.simiancollective.com/2025-confere...
@janzimmermann.bsky.social
@stevewcchang.bsky.social
@anitadisney.bsky.social
REGISTRATION IS HAPPENING NOW !!!
Come join us at SimCo 2025 in Durham !! Register now for early bird discount and re-share!!!
www.simiancollective.com/2025-confere...
@janzimmermann.bsky.social
@stevewcchang.bsky.social
@anitadisney.bsky.social
Reposted by Dr Alison Weiss
REGISTRATION IS HAPPENING NOW !!!
Come join us at SimCo 2025 in Durham !! Register now for early bird discount and re-share!!!
www.simiancollective.com/2025-confere...
@janzimmermann.bsky.social
@stevewcchang.bsky.social
@anitadisney.bsky.social
Come join us at SimCo 2025 in Durham !! Register now for early bird discount and re-share!!!
www.simiancollective.com/2025-confere...
@janzimmermann.bsky.social
@stevewcchang.bsky.social
@anitadisney.bsky.social
2025 Conference — Simian Collective
www.simiancollective.com
June 26, 2025 at 2:18 AM
REGISTRATION IS HAPPENING NOW !!!
Come join us at SimCo 2025 in Durham !! Register now for early bird discount and re-share!!!
www.simiancollective.com/2025-confere...
@janzimmermann.bsky.social
@stevewcchang.bsky.social
@anitadisney.bsky.social
Come join us at SimCo 2025 in Durham !! Register now for early bird discount and re-share!!!
www.simiancollective.com/2025-confere...
@janzimmermann.bsky.social
@stevewcchang.bsky.social
@anitadisney.bsky.social
Biomedical research saves lives.
Great example of how studies involving NHPs are advancing the fight against HIV!
Great example of how studies involving NHPs are advancing the fight against HIV!
Congratulations to our Picker and Hansen Lab teams and contributors, for the recent publication on neutralizing antibodies and MHC-E-restricted CD8+ T cells. Which have shown the ability to protect against the simian counterpart of HIV.
Read the article here:
pubmed.ncbi.nlm.nih.gov/40529575
Read the article here:
pubmed.ncbi.nlm.nih.gov/40529575
June 24, 2025 at 12:24 AM
Biomedical research saves lives.
Great example of how studies involving NHPs are advancing the fight against HIV!
Great example of how studies involving NHPs are advancing the fight against HIV!
Reposted by Dr Alison Weiss
I wrote a quick-start guide for people to replicate this across the country. It was, in our experience, a very effective way to get real action in a short amount of time.
People are willing to talk to scientists! And when you provide everything, they are happy to contact their reps too. Try it!
People are willing to talk to scientists! And when you provide everything, they are happy to contact their reps too. Try it!
June 16, 2025 at 5:49 PM
I wrote a quick-start guide for people to replicate this across the country. It was, in our experience, a very effective way to get real action in a short amount of time.
People are willing to talk to scientists! And when you provide everything, they are happy to contact their reps too. Try it!
People are willing to talk to scientists! And when you provide everything, they are happy to contact their reps too. Try it!
Reposted by Dr Alison Weiss
Those of you asking what you can do to help save medical research - please sign the support letter to the #BethesdaDeclaration and share it widely.
What is happening is not normal. Every name helps.
actionnetwork.org/forms/add-na...
What is happening is not normal. Every name helps.
actionnetwork.org/forms/add-na...
ADD YOUR NAME: Sign the Open Letter in Support of NIH Staff
Join the courageous and committed National Institutes of Health (NIH) public servants by adding your name now.
actionnetwork.org
June 9, 2025 at 1:27 PM
Those of you asking what you can do to help save medical research - please sign the support letter to the #BethesdaDeclaration and share it widely.
What is happening is not normal. Every name helps.
actionnetwork.org/forms/add-na...
What is happening is not normal. Every name helps.
actionnetwork.org/forms/add-na...
Reposted by Dr Alison Weiss
I spoke with CNN about why scientists like me are leaving the U.S.
🇺🇸: Your research in virology and #LongCovid is not relevant, and we no longer need you.
🇩🇪 🇬🇧 🇵🇹 🇨🇦: Come work with us, we want you.
Read behind the paywall here: dale-confirmation-1.ezihost.net
#BrainDrain #SpeakOut
🇺🇸: Your research in virology and #LongCovid is not relevant, and we no longer need you.
🇩🇪 🇬🇧 🇵🇹 🇨🇦: Come work with us, we want you.
Read behind the paywall here: dale-confirmation-1.ezihost.net
#BrainDrain #SpeakOut
June 1, 2025 at 5:23 PM
I spoke with CNN about why scientists like me are leaving the U.S.
🇺🇸: Your research in virology and #LongCovid is not relevant, and we no longer need you.
🇩🇪 🇬🇧 🇵🇹 🇨🇦: Come work with us, we want you.
Read behind the paywall here: dale-confirmation-1.ezihost.net
#BrainDrain #SpeakOut
🇺🇸: Your research in virology and #LongCovid is not relevant, and we no longer need you.
🇩🇪 🇬🇧 🇵🇹 🇨🇦: Come work with us, we want you.
Read behind the paywall here: dale-confirmation-1.ezihost.net
#BrainDrain #SpeakOut
@repdexteror.bsky.social @jeff-merkley.bsky.social and Ron Wyden… as your constituent I am counting on you to do everything in your power to prevent this! Fight! Oregonians are with you!
May 31, 2025 at 2:46 PM
@repdexteror.bsky.social @jeff-merkley.bsky.social and Ron Wyden… as your constituent I am counting on you to do everything in your power to prevent this! Fight! Oregonians are with you!
An @ohsunews.bsky.social lab is working on a universal flu vaccine that could, in theory, protect people from the virus for life.
#Research on nonhuman primates is critical for being able to replicate how complex systems respond to new therapies. www.oregonlive.com/opinion/2025...
#Research on nonhuman primates is critical for being able to replicate how complex systems respond to new therapies. www.oregonlive.com/opinion/2025...
Opinion: Vital medical breakthroughs still need animal research
Animal research remains critically important in the work of preventing, treating and eradicating debilitating diseases, write OHSU's chief research officer Peter Barr-Gillespie and primate research ce...
www.oregonlive.com
May 28, 2025 at 1:36 AM
@repdexteror.bsky.social @wyden.senate.gov @jeff-merkley.bsky.social
Please take bold actions to protect science funding in Oregon!
Please take bold actions to protect science funding in Oregon!
May 7, 2025 at 2:05 PM
@repdexteror.bsky.social @wyden.senate.gov @jeff-merkley.bsky.social
Please take bold actions to protect science funding in Oregon!
Please take bold actions to protect science funding in Oregon!
Must read!
“A nation without animal research will be less healthy and less safe”
medium.com/@eblissmorea...
“A nation without animal research will be less healthy and less safe”
medium.com/@eblissmorea...
This will kill us: restricting animal research
Tuesday, as my lab gathered to celebrate the completion of one of our big studies, the National Institutes of Health announced that they…
medium.com
May 5, 2025 at 4:33 AM
Must read!
“A nation without animal research will be less healthy and less safe”
medium.com/@eblissmorea...
“A nation without animal research will be less healthy and less safe”
medium.com/@eblissmorea...
Reposted by Dr Alison Weiss
I am thrilled for our upcoming online seminar around brain size, neuron numbers, and connectivity with 2 fantastic evolutionary neuroscientists, Kristina Kverkova and Kei Yamamoto: next Tuesday, April 22, 2pm UTC, 4pm Paris. 🧠 🐦 🐠 🦜. Join us on Crowdcast crowdcast.io/c/brain-size...
April 17, 2025 at 7:57 PM
I am thrilled for our upcoming online seminar around brain size, neuron numbers, and connectivity with 2 fantastic evolutionary neuroscientists, Kristina Kverkova and Kei Yamamoto: next Tuesday, April 22, 2pm UTC, 4pm Paris. 🧠 🐦 🐠 🦜. Join us on Crowdcast crowdcast.io/c/brain-size...
Reposted by Dr Alison Weiss
The result of a large (42 authors!) collaboration:
"Go Figure: Transparency in neuroscience images preserves context and clarifies interpretation"
arxiv.org/abs/2504.07824
TL;DR: The FMRI world can (and should) improve results interpretation and reproducibility *today*, via transparent thresholding.
"Go Figure: Transparency in neuroscience images preserves context and clarifies interpretation"
arxiv.org/abs/2504.07824
TL;DR: The FMRI world can (and should) improve results interpretation and reproducibility *today*, via transparent thresholding.
April 11, 2025 at 12:35 PM
The result of a large (42 authors!) collaboration:
"Go Figure: Transparency in neuroscience images preserves context and clarifies interpretation"
arxiv.org/abs/2504.07824
TL;DR: The FMRI world can (and should) improve results interpretation and reproducibility *today*, via transparent thresholding.
"Go Figure: Transparency in neuroscience images preserves context and clarifies interpretation"
arxiv.org/abs/2504.07824
TL;DR: The FMRI world can (and should) improve results interpretation and reproducibility *today*, via transparent thresholding.
Primates are essential for medical progress. www.oregonlive.com/opinion/2025...
Readers respond: Primates needed for ethical research
Letters to the Editor can be submitted to letters@oregonian.com with full name and place of residence.
www.oregonlive.com
April 11, 2025 at 1:21 AM
Primates are essential for medical progress. www.oregonlive.com/opinion/2025...
Monkeys at OHSU are loved, receive compassionate care, and improve the health of humans AND monkeys www.oregonlive.com/opinion/2025...
Opinion: Vital medical breakthroughs still need animal research
Animal research remains critically important in the work of preventing, treating and eradicating debilitating diseases, write OHSU's chief research officer Peter Barr-Gillespie and primate research ce...
www.oregonlive.com
April 6, 2025 at 4:13 PM
Monkeys at OHSU are loved, receive compassionate care, and improve the health of humans AND monkeys www.oregonlive.com/opinion/2025...