Luca Posa
@dr-lupo.bsky.social
Behavioral neuroscientist 🧠 Postdoc @weillcornell.bsky.social #PharmDPhD #pain #emotion #GPCRs #opioids 🔬 #DiversitySTEM #firstgen. He/him🌈 Traveller
Pinned
Luca Posa
@dr-lupo.bsky.social
· Dec 23
Excited to share our new preprint here! A photocromic morphinian-azobenzene, efficacy switch and peripherally restricted analgesic. Great collaboration between Levitz, @dirktrauner.bsky.social @gati.bsky.social and Seva Katritch's labs! 👇🏻👇🏻 www.biorxiv.org/content/10.1...
Great structure work about MOR binding states from the Cornelius Gati lab! Congrats to all the authors, particularly Saif Khan. Looking forward!
November 5, 2025 at 11:08 PM
Great structure work about MOR binding states from the Cornelius Gati lab! Congrats to all the authors, particularly Saif Khan. Looking forward!
Very cool findings about the connection of touch and mating processes!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A circuit that integrates drive state and social contact to gate mating - Nature
Analyses of consummatory reproductive behaviours in male mice uncover a brain mechanism whereby an internal state can attribute a social quality to a generic touch to initiate purposeful reproductive ...
www.nature.com
September 14, 2025 at 1:23 AM
Very cool findings about the connection of touch and mating processes!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
So cool! 👇🏼👇🏼👇🏼A β-arrestin-2-biased modulator of neurotensin receptor 1 relieves acute and chronic pain by blocking neural sensitization while also reducing opioid abuse risk without affecting motor or cognitive functions
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain
SBI-810, an arrestin-biased allosteric modulator of neurotensin receptor 1, can effectively
alleviate acute and chronic pain in rodent models via peripheral and central modulation
and can also mitigat...
www.cell.com
August 10, 2025 at 2:14 AM
So cool! 👇🏼👇🏼👇🏼A β-arrestin-2-biased modulator of neurotensin receptor 1 relieves acute and chronic pain by blocking neural sensitization while also reducing opioid abuse risk without affecting motor or cognitive functions
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
A bit late but definitely proud of my first talk @INRC2025!
July 25, 2025 at 2:04 AM
A bit late but definitely proud of my first talk @INRC2025!
My first time at #usasp2025. Great science, new and old friends. First talk in a symposium at an international conference. Thank you to my co-speakers @stefpuig.bsky.social and Ream Al-Asani
May 3, 2025 at 1:40 AM
My first time at #usasp2025. Great science, new and old friends. First talk in a symposium at an international conference. Thank you to my co-speakers @stefpuig.bsky.social and Ream Al-Asani
Reposted by Luca Posa
our NIH HEAL initiative funded biomarkers study now out @jama.com JAMA Neurology
open access, open data and code
w/ @drsmschabrun.bsky.social
jamanetwork.com/journals/jam...
open access, open data and code
w/ @drsmschabrun.bsky.social
jamanetwork.com/journals/jam...
Predicting Individual Pain Sensitivity Using a Novel Cortical Biomarker Signature
This cohort study analyzes electroencephalography data from healthy participants to analyze and validate a cortical biomarker signature for pain, which comprised the measures sensorimotor peak alpha f...
jamanetwork.com
January 27, 2025 at 4:43 PM
our NIH HEAL initiative funded biomarkers study now out @jama.com JAMA Neurology
open access, open data and code
w/ @drsmschabrun.bsky.social
jamanetwork.com/journals/jam...
open access, open data and code
w/ @drsmschabrun.bsky.social
jamanetwork.com/journals/jam...
Reposted by Luca Posa
Excited to present our lab's new work on GPCR antagonism: Contrary to popular belief, we propose that inverse agonists can bind to and act via GPCR:G protein complexes. We show this at KOR, through cellular assays, radioligand binding and cryoEM studies. A thread. 💊 🧪 www.nature.com/articles/s41...
January 7, 2025 at 4:09 PM
Excited to present our lab's new work on GPCR antagonism: Contrary to popular belief, we propose that inverse agonists can bind to and act via GPCR:G protein complexes. We show this at KOR, through cellular assays, radioligand binding and cryoEM studies. A thread. 💊 🧪 www.nature.com/articles/s41...
Excited to share our new preprint here! A photocromic morphinian-azobenzene, efficacy switch and peripherally restricted analgesic. Great collaboration between Levitz, @dirktrauner.bsky.social @gati.bsky.social and Seva Katritch's labs! 👇🏻👇🏻 www.biorxiv.org/content/10.1...
December 23, 2024 at 2:02 PM
Excited to share our new preprint here! A photocromic morphinian-azobenzene, efficacy switch and peripherally restricted analgesic. Great collaboration between Levitz, @dirktrauner.bsky.social @gati.bsky.social and Seva Katritch's labs! 👇🏻👇🏻 www.biorxiv.org/content/10.1...