DrugDomain2.0: comprehensive database of protein domains-ligands/drugs interactions across the whole Protein Data Bank https://www.biorxiv.org/content/10.1101/2025.07.03.663025v1

I love papers comparing pipelines! They’re under-appreciated, and we could use more of them, in my opinion.

I love the USCPSC.

Agreed. But hopefully we work towards a society where higher and higher percentages of doctors *can’t* be replaced, which requires that they be given the support/resources/systems needed to be irreplaceable.

"Any doctor who could be replaced by a computer, should be replaced by a computer" ~ Jonathan Chen's talk at #psb25

Questionable practices in machine learning arxiv.org/pdf/2407.12220 #machinelearning #artificialintelligence #datascience

I'm reading Hidden Potential by psychologist Adam Grant. I put together a list of my favorite insights from the book to help you unlock your hidden potential.

Check out the thread below, and if you find it helpful please share and follow!

🧵
#booksky #psychology #self-improvement

In fact, we use this kind of operant conditioning in how we raise kids: we link positive outcomes to prosocial behaviors, negative outcomes to antisocial behaviors.

But this leaves us vulnerable to thinking that is hyper-detection of causality, even in random, unlinked events.

why is that financial company spelled Schwab and not əb

I'm back on Youtube after nearly a decade! I'd be super grateful if you watched my latest video and leave a comment letting me know what you think! It's on the imposter syndrome, and how the anxiety from imposter syndrome can actually fuel genuine confidence. youtu.be/qwlmlhFWv3w

variable names *are* code comments

I can’t wait for this to finish processing in bioRxiv and become available. Mapping spatial omics data from separate samples onto a common tissue coordinate system so they can be analyzed jointly (e.g., for condition/group comparison) is 1 of the most pressing needs in biology right now in my view.

Still reading through it but seems to be a neat ex. of using spatial tx’omics + IF, scRNA-seq/Tangram, & RNA velocity/spatial pseudotime to not only map landscape but mechanisms by probing cell-cell ixs. Substantively interesting, but may also be of interest to folks looking to combine these methods

I never did master the art of convincing people that UMAP white space does not mean what it tempts you to think it means. Has anyone succeeded at communicating this?

I just wrote a new post on my substack! It's about love, fear, control, and Christmas trees. Please take a look and let me know what you think :-) writing.danielwendler.com/p/how-to-lov...

Cell types as scientist-imposed naming schemes that, rather than being some ground-level truth, summarize useful information/group similar entities, is the part of #biology that most reminds me of the challenges of “fuzzy” aspects of #psychology research (e.g., naming factors of psychopathology).