Daniël P Melters
@dpmelters.bsky.social
Studying the dynamics, organization, and evolution of chromatin using high-speed atomic force microscopy. Bilingual tweets. Opinions are my own.
Reposted by Daniël P Melters
Epigenetics Society Special Symposium 2025 | Epigenetics Society
Our exciting conference on epigenetics will be held in Chicago, Oct. 15- 17, 2025. We have an outstanding set of 7 Keynote Speakers. www.esconference25.com/events/epige...
Our exciting conference on epigenetics will be held in Chicago, Oct. 15- 17, 2025. We have an outstanding set of 7 Keynote Speakers. www.esconference25.com/events/epige...
June 12, 2025 at 11:39 AM
Epigenetics Society Special Symposium 2025 | Epigenetics Society
Our exciting conference on epigenetics will be held in Chicago, Oct. 15- 17, 2025. We have an outstanding set of 7 Keynote Speakers. www.esconference25.com/events/epige...
Our exciting conference on epigenetics will be held in Chicago, Oct. 15- 17, 2025. We have an outstanding set of 7 Keynote Speakers. www.esconference25.com/events/epige...
Interested in studying #nucleosomes, #chromatin, or #chromosomes at the single molecule level, atomic force microscopy (#AFM) is easy to use technique. Here is a great methods paper to guide you through the whole process. Big thanks to Keir Neuman and Yamini Dalal.
link.springer.com/protocol/10....
link.springer.com/protocol/10....
Single-Molecule Studies with AFM and High-Speed AFM: From Nucleosomes to Chromosomes
Atomic force microscopy (AFM) is a single-molecule imaging technique invented in 1985. Development of high-speed AFM (HS-AFM) in 2001 now allows for the direct visualization of the dynamics and kineti...
link.springer.com
September 11, 2025 at 2:59 AM
Interested in studying #nucleosomes, #chromatin, or #chromosomes at the single molecule level, atomic force microscopy (#AFM) is easy to use technique. Here is a great methods paper to guide you through the whole process. Big thanks to Keir Neuman and Yamini Dalal.
link.springer.com/protocol/10....
link.springer.com/protocol/10....
It’s a honor to see my first cover ever. Thank you to the co-authors, reviewers, and editors.
www.life-science-alliance.org/content/8/4/...
www.life-science-alliance.org/content/8/4/...
April 1, 2025 at 2:22 PM
It’s a honor to see my first cover ever. Thank you to the co-authors, reviewers, and editors.
www.life-science-alliance.org/content/8/4/...
www.life-science-alliance.org/content/8/4/...
Reposted by Daniël P Melters
A card that a 6-year-old made this weekend for an NIH employee.
February 17, 2025 at 1:50 AM
A card that a 6-year-old made this weekend for an NIH employee.
Reposted by Daniël P Melters
ATTENTION (PLEASE SHARE)
If anyone has or knows of any positions that might be appropriate for the NIH staff members who were terminated, please post the information in this thread.
There are lots of talented and accomplished people who may be looking for new opportunities.
If anyone has or knows of any positions that might be appropriate for the NIH staff members who were terminated, please post the information in this thread.
There are lots of talented and accomplished people who may be looking for new opportunities.
a poster that says if life gives you lemon make lemonade on it
ALT: a poster that says if life gives you lemon make lemonade on it
media.tenor.com
February 15, 2025 at 3:37 PM
ATTENTION (PLEASE SHARE)
If anyone has or knows of any positions that might be appropriate for the NIH staff members who were terminated, please post the information in this thread.
There are lots of talented and accomplished people who may be looking for new opportunities.
If anyone has or knows of any positions that might be appropriate for the NIH staff members who were terminated, please post the information in this thread.
There are lots of talented and accomplished people who may be looking for new opportunities.
Our latest work. We identified two structurally distinct CENP-A nucleosomes at the centromere. One is associated with the CCAN and both are important for regulating centromeric transcription.
Centromeres contain two physically distinct CENP-A nucleosomes, one of which associates with the CENP-C complex and regulating CENP-C levels is critical for accessibility of the centromeric chromatin fiber for transcriptional machinery @dpmelters.bsky.social https://buff.ly/40LsByD
February 10, 2025 at 2:08 AM
Our latest work. We identified two structurally distinct CENP-A nucleosomes at the centromere. One is associated with the CCAN and both are important for regulating centromeric transcription.
Our latest work is now online.
CENP-C is critical in regulating centromere homeostasis by supporting a unique higher-order structure of centromeric chromatin and altering the accessibility of the centromeric chromatin fiber for transcriptional machinery @dpmelters.bsky.social https://buff.ly/40LsByD
February 6, 2025 at 5:01 PM
Our latest work is now online.
The latest work from the Dalal lab. @sweta_sikder and co show how p53, CENP-B, and LSD1 can help rescue CENP-A and CENP-C levels in aged cels.
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Centromere inactivation during aging can be rescued in human cells
Sikder et al. uncover how centromere function is depleted during human aging. They
report reduced CENP-A/C levels and centromeric transcription in aged cells. Using
knockdown approaches, they identify...
www.cell.com
January 13, 2025 at 4:17 PM
The latest work from the Dalal lab. @sweta_sikder and co show how p53, CENP-B, and LSD1 can help rescue CENP-A and CENP-C levels in aged cels.
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
I’m proud to have contributed to this beautiful work by Yvonne Fondufe-Mittendorf lab, a project led by now Dr. Wesley Saintilnord and co — Aberrant expression of histone H2B variants reshape chromatin and alter oncogenic gene expression programs www.biorxiv.org/content/10.1...
Aberrant expression of histone H2B variants reshape chromatin and alter oncogenic gene expression programs
Chromatin architecture governs DNA accessibility and gene expression. Thus, any perturbations to chromatin can significantly alter gene expression programs and promote disease. Prior studies demonstra...
www.biorxiv.org
November 24, 2024 at 8:15 PM
I’m proud to have contributed to this beautiful work by Yvonne Fondufe-Mittendorf lab, a project led by now Dr. Wesley Saintilnord and co — Aberrant expression of histone H2B variants reshape chromatin and alter oncogenic gene expression programs www.biorxiv.org/content/10.1...