Dominic Denk
@domdenkmd.bsky.social
MD | physician-scientist | GI-oncology and immunology. Likes ducks.
Pinned
Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial - Nature Aging
Immune aging fosters multimorbidity and compromises control of infection and cancer. In a phase 1 randomized controlled trial in middle-aged adults, Denk and colleagues administer the mitophagy induce...
www.nature.com
Excited to share our new study in @nataging.nature.com !🎉
www.nature.com/articles/s43...
We show that Urolithin A, a pomegranate-derived gut metabolite, counteracts key signs of immune #aging in a phase I trial!
#immunology #aging @loewe-fci.bsky.social @goetheuni.bsky.social #immunosky
www.nature.com/articles/s43...
We show that Urolithin A, a pomegranate-derived gut metabolite, counteracts key signs of immune #aging in a phase I trial!
#immunology #aging @loewe-fci.bsky.social @goetheuni.bsky.social #immunosky
Reposted by Dominic Denk
Urolithin A supplementation for 28 days shifted immune cell profiles in older adults toward a more youthful, less exhausted state and enhanced mitochondrial fatty acid oxidation capacity. doi.org/g99kft
Urolithin A nudges aging immune cells toward a youthful profile in 28 days
An international research team focused on aging reports that urolithin A at 1,000 mg per day shifted human immune profiles toward a more naive-like, less exhausted CD8+ state and increased fatty acid oxidation capacity, with additional functional gains.
medicalxpress.com
November 7, 2025 at 3:40 PM
Urolithin A supplementation for 28 days shifted immune cell profiles in older adults toward a more youthful, less exhausted state and enhanced mitochondrial fatty acid oxidation capacity. doi.org/g99kft
Reposted by Dominic Denk
In a RCT, Urolithin-A boosted CD8⁺ T cells and improved immune metabolism, hinting at a new way to slow age-related immune system decline and inflammaging. buff.ly/qaGyGF0
Urolithin A works by inducing mitophagy (clearance of damaged mitochondria).
#medsky #aging
Urolithin A works by inducing mitophagy (clearance of damaged mitochondria).
#medsky #aging
November 2, 2025 at 12:53 AM
In a RCT, Urolithin-A boosted CD8⁺ T cells and improved immune metabolism, hinting at a new way to slow age-related immune system decline and inflammaging. buff.ly/qaGyGF0
Urolithin A works by inducing mitophagy (clearance of damaged mitochondria).
#medsky #aging
Urolithin A works by inducing mitophagy (clearance of damaged mitochondria).
#medsky #aging
Excited to share our new study in @nataging.nature.com !🎉
www.nature.com/articles/s43...
We show that Urolithin A, a pomegranate-derived gut metabolite, counteracts key signs of immune #aging in a phase I trial!
#immunology #aging @loewe-fci.bsky.social @goetheuni.bsky.social #immunosky
www.nature.com/articles/s43...
We show that Urolithin A, a pomegranate-derived gut metabolite, counteracts key signs of immune #aging in a phase I trial!
#immunology #aging @loewe-fci.bsky.social @goetheuni.bsky.social #immunosky
Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial - Nature Aging
Immune aging fosters multimorbidity and compromises control of infection and cancer. In a phase 1 randomized controlled trial in middle-aged adults, Denk and colleagues administer the mitophagy induce...
www.nature.com
October 31, 2025 at 11:41 AM
Excited to share our new study in @nataging.nature.com !🎉
www.nature.com/articles/s43...
We show that Urolithin A, a pomegranate-derived gut metabolite, counteracts key signs of immune #aging in a phase I trial!
#immunology #aging @loewe-fci.bsky.social @goetheuni.bsky.social #immunosky
www.nature.com/articles/s43...
We show that Urolithin A, a pomegranate-derived gut metabolite, counteracts key signs of immune #aging in a phase I trial!
#immunology #aging @loewe-fci.bsky.social @goetheuni.bsky.social #immunosky
Reposted by Dominic Denk
Happy to repost the study in @cp-immunity.bsky.social now with the cover illustrating the Janus-faced role of IL-17RA in #colorectalcancer.
More information below by @domdenkmd.bsky.social or the latest issue of Immunity:
www.cell.com/immunity/cur...
#DarmkrebsmonatMärz
@proloewe.bsky.social
More information below by @domdenkmd.bsky.social or the latest issue of Immunity:
www.cell.com/immunity/cur...
#DarmkrebsmonatMärz
@proloewe.bsky.social
March 11, 2025 at 2:43 PM
Happy to repost the study in @cp-immunity.bsky.social now with the cover illustrating the Janus-faced role of IL-17RA in #colorectalcancer.
More information below by @domdenkmd.bsky.social or the latest issue of Immunity:
www.cell.com/immunity/cur...
#DarmkrebsmonatMärz
@proloewe.bsky.social
More information below by @domdenkmd.bsky.social or the latest issue of Immunity:
www.cell.com/immunity/cur...
#DarmkrebsmonatMärz
@proloewe.bsky.social
Reposted by Dominic Denk
Online now: Online now: IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis
IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis
Members of the interleukin-17 family are associated with tumor progression in various settings. Denk et al. find that, in colorectal cancer, IL-17RA switches from tumor promotion during early tumorigenesis to tumor suppression during tumor invasion and…
dlvr.it
March 1, 2025 at 1:52 PM
Online now: Online now: IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis
Reposted by Dominic Denk
Fresh from @cp-immunity.bsky.social
"A Surprising Shift from Foe to Friend:
Researchers discover dual role of inflammatory signaling in colorectal cancer"
👏Congratulations @domdenkmd.bsky.social and all coauthors!! 🎉
Read the full article here:
www.cell.com/immunity/ful...
@proloewe.bsky.social
"A Surprising Shift from Foe to Friend:
Researchers discover dual role of inflammatory signaling in colorectal cancer"
👏Congratulations @domdenkmd.bsky.social and all coauthors!! 🎉
Read the full article here:
www.cell.com/immunity/ful...
@proloewe.bsky.social
Finally announcing our new study in @cp-immunity.bsky.social!
We show that IL-17RA fulfills dual tumor suppressor function in late-stage colorectal cancer (CRC)!
#immunosky #cancer #immunology @loewe-fci.bsky.social
@cellpress.bsky.social
@goetheuni.bsky.social
Read here🧵👇:
tinylink.net/OS41F
We show that IL-17RA fulfills dual tumor suppressor function in late-stage colorectal cancer (CRC)!
#immunosky #cancer #immunology @loewe-fci.bsky.social
@cellpress.bsky.social
@goetheuni.bsky.social
Read here🧵👇:
tinylink.net/OS41F
IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis
Members of the interleukin-17 family are associated with tumor progression in various
settings. Denk et al. find that, in colorectal cancer, IL-17RA switches from tumor
promotion during early tumorige...
www.cell.com
March 1, 2025 at 10:38 AM
Fresh from @cp-immunity.bsky.social
"A Surprising Shift from Foe to Friend:
Researchers discover dual role of inflammatory signaling in colorectal cancer"
👏Congratulations @domdenkmd.bsky.social and all coauthors!! 🎉
Read the full article here:
www.cell.com/immunity/ful...
@proloewe.bsky.social
"A Surprising Shift from Foe to Friend:
Researchers discover dual role of inflammatory signaling in colorectal cancer"
👏Congratulations @domdenkmd.bsky.social and all coauthors!! 🎉
Read the full article here:
www.cell.com/immunity/ful...
@proloewe.bsky.social
Finally announcing our new study in @cp-immunity.bsky.social!
We show that IL-17RA fulfills dual tumor suppressor function in late-stage colorectal cancer (CRC)!
#immunosky #cancer #immunology @loewe-fci.bsky.social
@cellpress.bsky.social
@goetheuni.bsky.social
Read here🧵👇:
tinylink.net/OS41F
We show that IL-17RA fulfills dual tumor suppressor function in late-stage colorectal cancer (CRC)!
#immunosky #cancer #immunology @loewe-fci.bsky.social
@cellpress.bsky.social
@goetheuni.bsky.social
Read here🧵👇:
tinylink.net/OS41F
IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis
Members of the interleukin-17 family are associated with tumor progression in various
settings. Denk et al. find that, in colorectal cancer, IL-17RA switches from tumor
promotion during early tumorige...
www.cell.com
February 28, 2025 at 7:49 PM
Finally announcing our new study in @cp-immunity.bsky.social!
We show that IL-17RA fulfills dual tumor suppressor function in late-stage colorectal cancer (CRC)!
#immunosky #cancer #immunology @loewe-fci.bsky.social
@cellpress.bsky.social
@goetheuni.bsky.social
Read here🧵👇:
tinylink.net/OS41F
We show that IL-17RA fulfills dual tumor suppressor function in late-stage colorectal cancer (CRC)!
#immunosky #cancer #immunology @loewe-fci.bsky.social
@cellpress.bsky.social
@goetheuni.bsky.social
Read here🧵👇:
tinylink.net/OS41F
Reposted by Dominic Denk
Good morning, all. A rich and diverse list of curated papers in #cancermetabolism and #mitochondrialbiology is ready for you! Don't miss it! Find it here: biomed.news/bims-camemi/... @biomednews.bsky.social
"In the midst of winter, I found there was, within me, an invincible summer."-Albert Camus
"In the midst of winter, I found there was, within me, an invincible summer."-Albert Camus
a pink penguin sits at a table reading a newspaper titled penguin ones
ALT: a pink penguin sits at a table reading a newspaper titled penguin ones
media.tenor.com
February 2, 2025 at 6:21 AM
Good morning, all. A rich and diverse list of curated papers in #cancermetabolism and #mitochondrialbiology is ready for you! Don't miss it! Find it here: biomed.news/bims-camemi/... @biomednews.bsky.social
"In the midst of winter, I found there was, within me, an invincible summer."-Albert Camus
"In the midst of winter, I found there was, within me, an invincible summer."-Albert Camus
Reposted by Dominic Denk
Good Sunday, all! A short but rich summary of papers in #cancermetabolism and #mitochondrialbiology is waiting for you here: biomed.news/bims-camemi/... @biomednews.bsky.social #dontstopreading
“The Eyes See Only What The Mind Is Prepared To Comprehend.”
― Henri Bergson
“The Eyes See Only What The Mind Is Prepared To Comprehend.”
― Henri Bergson
a penguin sits in a chair reading a book
ALT: a penguin sits in a chair reading a book
media.tenor.com
December 15, 2024 at 6:29 AM
Good Sunday, all! A short but rich summary of papers in #cancermetabolism and #mitochondrialbiology is waiting for you here: biomed.news/bims-camemi/... @biomednews.bsky.social #dontstopreading
“The Eyes See Only What The Mind Is Prepared To Comprehend.”
― Henri Bergson
“The Eyes See Only What The Mind Is Prepared To Comprehend.”
― Henri Bergson