Dima Daccache
@dimadaccache.bsky.social
Enjoying biochemistry and life.
PhD graduate from @ccb-lab.bsky.social
PhD graduate from @ccb-lab.bsky.social
Reposted by Dima Daccache
🧬 Preprint alert!
"Distinct ATRX functions cooperate with 9-1-1 and CST complexes to safeguard replication and telomere integrity."
Read the manuscript here 👉 www.biorxiv.org/content/10.1...
"Distinct ATRX functions cooperate with 9-1-1 and CST complexes to safeguard replication and telomere integrity."
Read the manuscript here 👉 www.biorxiv.org/content/10.1...
Distinct ATRX functions cooperate with 9-1-1 and CST complexes to safeguard replication and telomere integrity
Mutations in the ATRX chromatin remodeller predispose to a developmental genetic disorder and cancer, but how it safeguards genome and telomere stability remains unresolved. Here, we uncover critical ...
www.biorxiv.org
October 7, 2025 at 9:49 PM
🧬 Preprint alert!
"Distinct ATRX functions cooperate with 9-1-1 and CST complexes to safeguard replication and telomere integrity."
Read the manuscript here 👉 www.biorxiv.org/content/10.1...
"Distinct ATRX functions cooperate with 9-1-1 and CST complexes to safeguard replication and telomere integrity."
Read the manuscript here 👉 www.biorxiv.org/content/10.1...
Reposted by Dima Daccache
The 2025 call for #MSCA Postdoctoral Fellowships drew 17,058 applications worldwide.
A 64.6% increase from 2024, it's the most popular call in over four decades.
Excellence thrives where it is enabled, protected and shared — and Europe provides that environment.
→ europa.eu/!jcnGgP
#ChooseEurope
A 64.6% increase from 2024, it's the most popular call in over four decades.
Excellence thrives where it is enabled, protected and shared — and Europe provides that environment.
→ europa.eu/!jcnGgP
#ChooseEurope
September 11, 2025 at 1:19 PM
The 2025 call for #MSCA Postdoctoral Fellowships drew 17,058 applications worldwide.
A 64.6% increase from 2024, it's the most popular call in over four decades.
Excellence thrives where it is enabled, protected and shared — and Europe provides that environment.
→ europa.eu/!jcnGgP
#ChooseEurope
A 64.6% increase from 2024, it's the most popular call in over four decades.
Excellence thrives where it is enabled, protected and shared — and Europe provides that environment.
→ europa.eu/!jcnGgP
#ChooseEurope
Couldn't be prouder of this amazing achievement. Congratulations @ccb-lab.bsky.social 💃🏻🥳
🥳Just published @nature.com. Over 25 years after the discovery of SPO11 as the enzyme responsible for initiating meiotic recombination, we finally succeeded in reconstituting its DNA cleavage activity.🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...
SPO11 dimers are sufficient to catalyse DNA double-strand breaks in vitro - Nature
A biochemical system recapitulates the hallmarks of meiotic double-strand break formation, with mouse SPO11 catalysing break formation in the absence of any partners and remaining covalently atta...
www.nature.com
February 19, 2025 at 7:21 PM
Couldn't be prouder of this amazing achievement. Congratulations @ccb-lab.bsky.social 💃🏻🥳
Reposted by Dima Daccache
New preprint from the lab! We defined the kinetics of strand invasion during meiosis in C. elegans. Great work from Antonia, Henry and Divya.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
January 15, 2025 at 7:38 PM
New preprint from the lab! We defined the kinetics of strand invasion during meiosis in C. elegans. Great work from Antonia, Henry and Divya.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Dima Daccache
Delighted to share the ground-breaking work from BBSRC Discovery Fellow @whgittens.bsky.social mapping physiological Top2 activity without poisons. Acute sensitivity enables sub-minute visualisation of Top2 hotspots hidden within sites of latent topological stress: www.nature.com/articles/s41...
Osmotic disruption of chromatin induces Topoisomerase 2 activity at sites of transcriptional stress - Nature Communications
Transcription creates superhelical stress in DNA, challenging genome stability. Here the authors find Top2 activity is uncorrelated with transcription unless chromatin is disrupted suggesting that chr...
www.nature.com
December 5, 2024 at 2:30 PM
Delighted to share the ground-breaking work from BBSRC Discovery Fellow @whgittens.bsky.social mapping physiological Top2 activity without poisons. Acute sensitivity enables sub-minute visualisation of Top2 hotspots hidden within sites of latent topological stress: www.nature.com/articles/s41...
Reposted by Dima Daccache
Registration now open for the 2025 EMBO workshop on Meiosis! June 22-26, 2025, Engelberg, Switzerland.
Deadline for abstract submissions and registration is Feb 15th, 2025. Lots of speaker slots will be selected from abstracts, so apply now! meetings.embo.org/event/25-mei...
Deadline for abstract submissions and registration is Feb 15th, 2025. Lots of speaker slots will be selected from abstracts, so apply now! meetings.embo.org/event/25-mei...
Meiosis: Exploring diversity to discover the fundamentals
Meiosis is an essential cell division for sexual reproduction and fertility across eukaryotes. It involves a series of tightly regulated processes, including entry into meiosis, pairing of homologs, …
meetings.embo.org
December 10, 2024 at 2:11 AM
Registration now open for the 2025 EMBO workshop on Meiosis! June 22-26, 2025, Engelberg, Switzerland.
Deadline for abstract submissions and registration is Feb 15th, 2025. Lots of speaker slots will be selected from abstracts, so apply now! meetings.embo.org/event/25-mei...
Deadline for abstract submissions and registration is Feb 15th, 2025. Lots of speaker slots will be selected from abstracts, so apply now! meetings.embo.org/event/25-mei...
Reposted by Dima Daccache
Hi Bluesky. For my first post, I'd like to advertise the latest preprint from my lab, describing at long last our reconstitution of SPO11-dependent double-strand break formation from purified recombinant proteins. Outstanding work from PhD student Zhi (Zack) Zheng.
November 23, 2024 at 4:00 PM
Hi Bluesky. For my first post, I'd like to advertise the latest preprint from my lab, describing at long last our reconstitution of SPO11-dependent double-strand break formation from purified recombinant proteins. Outstanding work from PhD student Zhi (Zack) Zheng.
Reposted by Dima Daccache
Here is the paper by the Keeney lab:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 23, 2024 at 9:27 AM
Here is the paper by the Keeney lab:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
So happy to see this amazing achievement from @ccb-lab.bsky.social out!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
SPO11 dimerization controls meiotic DNA double-strand break formation
SPO11 initiates meiotic recombination through the induction of programmed DNA double-strand breaks (DSBs), but this catalytic activity had never been reconstituted in vitro. Here, using Mus musculus S...
www.biorxiv.org
November 21, 2024 at 2:56 PM
So happy to see this amazing achievement from @ccb-lab.bsky.social out!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Dima Daccache
Hello Bluesky, for my first post here I'm happy to share our latest preprint reporting the first biochemical reconstitution of DNA double-strand break formation by SPO11.
SPO11 dimerization controls meiotic DNA double-strand break formation.
www.biorxiv.org/content/10.1...
SPO11 dimerization controls meiotic DNA double-strand break formation.
www.biorxiv.org/content/10.1...
SPO11 dimerization controls meiotic DNA double-strand break formation
SPO11 initiates meiotic recombination through the induction of programmed DNA double-strand breaks (DSBs), but this catalytic activity had never been reconstituted in vitro. Here, using Mus musculus S...
www.biorxiv.org
November 21, 2024 at 10:18 AM
Hello Bluesky, for my first post here I'm happy to share our latest preprint reporting the first biochemical reconstitution of DNA double-strand break formation by SPO11.
SPO11 dimerization controls meiotic DNA double-strand break formation.
www.biorxiv.org/content/10.1...
SPO11 dimerization controls meiotic DNA double-strand break formation.
www.biorxiv.org/content/10.1...
Reposted by Dima Daccache
Official website for EMBO meiosis 2025 is live now! Looking forward to seeing you in Switzerland next June! #meiosis4eva
meetings.embo.org/event/25-mei...
meetings.embo.org/event/25-mei...
Meiosis: Exploring diversity to discover the fundamentals
Meiosis is an essential cell division for sexual reproduction and fertility across eukaryotes. It involves a series of tightly regulated processes, including entry into meiosis, pairing of homologs, …
meetings.embo.org
November 14, 2024 at 3:45 AM
Official website for EMBO meiosis 2025 is live now! Looking forward to seeing you in Switzerland next June! #meiosis4eva
meetings.embo.org/event/25-mei...
meetings.embo.org/event/25-mei...