Diefenbacher Laboratory
@diefenbacherlab.bsky.social
Targeting protein stability in #Cancer via #Ubiquitin-System @HelmholtzMunich @LungHealthMUC and @LMU_Muenchen
Impressum: http://www.diefenbacher-lab.com/Impressum/
http://www.diefenbacher-lab.com/
https://www.helmholtz-munich.de/en/environmental-health-ce
Impressum: http://www.diefenbacher-lab.com/Impressum/
http://www.diefenbacher-lab.com/
https://www.helmholtz-munich.de/en/environmental-health-ce
Getting ready to kick off our first Bridging Minds in #MunichCancerResearch #Workshop @bmc-lmu.bsky.social #LMU-Munich ! #Cancer is a devastating disease and the #collaboration and #exchange between #clinicians and #scientists is an important first step to lay the foundation for new #therapies.
March 12, 2025 at 7:49 AM
Getting ready to kick off our first Bridging Minds in #MunichCancerResearch #Workshop @bmc-lmu.bsky.social #LMU-Munich ! #Cancer is a devastating disease and the #collaboration and #exchange between #clinicians and #scientists is an important first step to lay the foundation for new #therapies.
Have a look at this exciting #collaborative #work by Amir Orian, Ashraf Brik Technion Haifa and @diefenbacherlab.bsky.social@www.helmholtz.de on #PROTAC like #degraders to deplete aggressive tumor cells! #ubiquitin and #degradation are indeed #promising #therapeutics www.biorxiv.org/content/10.1...
Eliminating Aggressive Cancers via PROTAC-like Inducers of Ferroptosis
Aggressive and therapy-resistant cancers present a significant challenge to treatment and are associated with poor patients survival. Identifying molecular pathways and compounds that target these pat...
www.biorxiv.org
December 29, 2024 at 3:43 PM
Have a look at this exciting #collaborative #work by Amir Orian, Ashraf Brik Technion Haifa and @diefenbacherlab.bsky.social@www.helmholtz.de on #PROTAC like #degraders to deplete aggressive tumor cells! #ubiquitin and #degradation are indeed #promising #therapeutics www.biorxiv.org/content/10.1...
Reposted by Diefenbacher Laboratory
Hi Bluesky community! 👋
Are you looking forward to 2025 as much as we are? 👀
We just updated our 2025 Annual Poster to include even more events for you to join, so go and have a look!
➡️ s.embl.org/poster-bl
#EMBLEvents #molecularbiology #lifesciencetraining
Are you looking forward to 2025 as much as we are? 👀
We just updated our 2025 Annual Poster to include even more events for you to join, so go and have a look!
➡️ s.embl.org/poster-bl
#EMBLEvents #molecularbiology #lifesciencetraining
December 13, 2024 at 9:06 AM
Hi Bluesky community! 👋
Are you looking forward to 2025 as much as we are? 👀
We just updated our 2025 Annual Poster to include even more events for you to join, so go and have a look!
➡️ s.embl.org/poster-bl
#EMBLEvents #molecularbiology #lifesciencetraining
Are you looking forward to 2025 as much as we are? 👀
We just updated our 2025 Annual Poster to include even more events for you to join, so go and have a look!
➡️ s.embl.org/poster-bl
#EMBLEvents #molecularbiology #lifesciencetraining
Exciting lecture about #lung #transplant at German Center for Lung Research @bmc-lmu.bsky.social @www.helmholtz.de research institute Lung Health and Immunity in Munich!
December 5, 2024 at 10:09 AM
Exciting lecture about #lung #transplant at German Center for Lung Research @bmc-lmu.bsky.social @www.helmholtz.de research institute Lung Health and Immunity in Munich!
Reposted by Diefenbacher Laboratory
Leveraging Dual-Ligase Recruitment to Enhance Protein Degradation via a Heterotrivalent Proteolysis Targeting Chimera | Collaboration with @georgwinter.bsky.social and Kristin Riching labs. Now published in Journal of the American Chemical Society @acsjacs.bsky.social pubs.acs.org/doi/10.1021/...
Leveraging Dual-Ligase Recruitment to Enhance Protein Degradation via a Heterotrivalent Proteolysis Targeting Chimera
Proteolysis targeting chimera (PROTAC) degraders are typically bifunctional with one E3 ligase ligand connected to one target protein ligand via a linker. While augmented valency has been shown with t...
pubs.acs.org
November 30, 2024 at 4:35 PM
Leveraging Dual-Ligase Recruitment to Enhance Protein Degradation via a Heterotrivalent Proteolysis Targeting Chimera | Collaboration with @georgwinter.bsky.social and Kristin Riching labs. Now published in Journal of the American Chemical Society @acsjacs.bsky.social pubs.acs.org/doi/10.1021/...
Reposted by Diefenbacher Laboratory
Promoting a positive research culture is so important to support each other - and to ultimately enable great science!
@colemanlab.bsky.social has put together an array of scientists who are striving for this in many different ways ⤵️
#research #culture 🧪
@colemanlab.bsky.social has put together an array of scientists who are striving for this in many different ways ⤵️
#research #culture 🧪
November 30, 2024 at 1:06 PM
Promoting a positive research culture is so important to support each other - and to ultimately enable great science!
@colemanlab.bsky.social has put together an array of scientists who are striving for this in many different ways ⤵️
#research #culture 🧪
@colemanlab.bsky.social has put together an array of scientists who are striving for this in many different ways ⤵️
#research #culture 🧪
Reposted by Diefenbacher Laboratory
We have an open #PhD #studentship as part of our "Black Leaders in Cancer" programme at @crukconvergence.bsky.social & @icrlondon.bsky.social. About computational modelling of T-cell evolution in cancer. www.findaphd.com/phds/project... I'm looking forward to meeting prospective students #CRUKfunded
www.findaphd.com
November 28, 2024 at 9:40 AM
We have an open #PhD #studentship as part of our "Black Leaders in Cancer" programme at @crukconvergence.bsky.social & @icrlondon.bsky.social. About computational modelling of T-cell evolution in cancer. www.findaphd.com/phds/project... I'm looking forward to meeting prospective students #CRUKfunded
Reposted by Diefenbacher Laboratory
Excited to report our discovery of an important component of the oxidative stress response: the E3 ligase TRIP12. It acts as a chain elongation factor that amplifies CUL3-KEAP1 activity to drive NRF2 degradation as cells recover from stress.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Dynamic regulation of the oxidative stress response by the E3 ligase TRIP12
The oxidative stress response is centered on the transcription factor NRF2 and protects cells from reactive oxygen species (ROS). While ROS inhibit the E3 ligase CUL3-KEAP1 to stabilize NRF2 and elici...
www.biorxiv.org
November 26, 2024 at 2:53 PM
Excited to report our discovery of an important component of the oxidative stress response: the E3 ligase TRIP12. It acts as a chain elongation factor that amplifies CUL3-KEAP1 activity to drive NRF2 degradation as cells recover from stress.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Diefenbacher Laboratory
Welcome to the Tumor Macroenvironment (yes, that's an "a", not a typo). I hope this is helpful for those interested in cancer as a systemic disease. So much to learn!
go.bsky.app/RQuYfnK
go.bsky.app/RQuYfnK
November 26, 2024 at 5:33 PM
Welcome to the Tumor Macroenvironment (yes, that's an "a", not a typo). I hope this is helpful for those interested in cancer as a systemic disease. So much to learn!
go.bsky.app/RQuYfnK
go.bsky.app/RQuYfnK
Reposted by Diefenbacher Laboratory
New week, updated starter pack. Now with 69 profiles to follow if you are interested in anything #ubiquitin or #Ubl: signalling, structure and biochemistry, biology, mechanisms, proteostasis, TPD, chemical biology, etc. Let me know if you or anyone else is missing.
November 25, 2024 at 8:32 AM
New week, updated starter pack. Now with 69 profiles to follow if you are interested in anything #ubiquitin or #Ubl: signalling, structure and biochemistry, biology, mechanisms, proteostasis, TPD, chemical biology, etc. Let me know if you or anyone else is missing.
Reposted by Diefenbacher Laboratory
Check out this list of ubiquitin and Ubl profiles to follow. Repost if you want me to add you to it. Let’s create a good community here ☁️ go.bsky.app/3VPQofn
November 15, 2024 at 7:38 PM
Check out this list of ubiquitin and Ubl profiles to follow. Repost if you want me to add you to it. Let’s create a good community here ☁️ go.bsky.app/3VPQofn