Mike DiCuccio
@dicuccio.bsky.social
My son is my clan leader. I am nobody.
Genomics. Medicine. Computational biology. Fly fishing. Photography.
Genomics. Medicine. Computational biology. Fly fishing. Photography.
Reposted by Mike DiCuccio
Eleven years ago, I wrote to Tom Stoppard to ask about this coup de théâtre from 1949. It took me down an unexpected rabbit hole - in memory of Stoppard, here's what I found.
November 30, 2025 at 1:38 PM
Eleven years ago, I wrote to Tom Stoppard to ask about this coup de théâtre from 1949. It took me down an unexpected rabbit hole - in memory of Stoppard, here's what I found.
Reposted by Mike DiCuccio
I taught (and co-taught) a course on human population genetics from 2000-2024. Having retired, I'm now making all the course materials public: github.com/alanrogers/p... #popgen #evbio
GitHub - alanrogers/popgen: A course on population genetics
A course on population genetics. Contribute to alanrogers/popgen development by creating an account on GitHub.
github.com
November 27, 2025 at 7:10 PM
I taught (and co-taught) a course on human population genetics from 2000-2024. Having retired, I'm now making all the course materials public: github.com/alanrogers/p... #popgen #evbio
Reposted by Mike DiCuccio
Reposted by Mike DiCuccio
I am grateful for @adamjkucharski.bsky.social. He takes such care to deconstruct a claim made by the director of National Institutes of Health on excess mortality during the pandemic. We need sober analyses more than ever right now, even amidst the madness.
kucharski.substack.com/p/excess-mor...
kucharski.substack.com/p/excess-mor...
Excess mortality or excessive assumptions?
How to make a popular metric tell any story you like
kucharski.substack.com
November 22, 2025 at 10:29 PM
I am grateful for @adamjkucharski.bsky.social. He takes such care to deconstruct a claim made by the director of National Institutes of Health on excess mortality during the pandemic. We need sober analyses more than ever right now, even amidst the madness.
kucharski.substack.com/p/excess-mor...
kucharski.substack.com/p/excess-mor...
Reposted by Mike DiCuccio
In Gettysburg, Pennsylvania, 162 years ago today, President Lincoln gave one of the most famous speeches in American history, extolling the sacrifices of the men who died in the battle there. There are five known manuscript copies of the Gettysburg Address. The Library of Congress has two of those.
November 19, 2025 at 5:03 PM
In Gettysburg, Pennsylvania, 162 years ago today, President Lincoln gave one of the most famous speeches in American history, extolling the sacrifices of the men who died in the battle there. There are five known manuscript copies of the Gettysburg Address. The Library of Congress has two of those.
Reposted by Mike DiCuccio
wake up babe, new units of measurement just dropped www.nytimes.com/2025/11/17/s...
November 17, 2025 at 4:26 PM
wake up babe, new units of measurement just dropped www.nytimes.com/2025/11/17/s...
Reposted by Mike DiCuccio
65 Years Ago,,, History was made. #RubyBridges
November 15, 2025 at 4:41 AM
65 Years Ago,,, History was made. #RubyBridges
Reposted by Mike DiCuccio
Fall is here and many of you may be shopping for an overcoat.
Let me show what you can get as you move up the price ladder. 🧵
Let me show what you can get as you move up the price ladder. 🧵
Here are four overcoats.
— Which do you think is the most expensive?
— Which do you think is the least expensive?
— Which do you think provides the best value?
Answer below. Tomorrow, I will show what you get as you climb up the price ladder for overcoats.
— Which do you think is the most expensive?
— Which do you think is the least expensive?
— Which do you think provides the best value?
Answer below. Tomorrow, I will show what you get as you climb up the price ladder for overcoats.
November 7, 2025 at 9:09 PM
Fall is here and many of you may be shopping for an overcoat.
Let me show what you can get as you move up the price ladder. 🧵
Let me show what you can get as you move up the price ladder. 🧵
Reposted by Mike DiCuccio
HAPPY FOUR SEASONS TOTAL LANDSCAPING DAY TO ALL WHO CELEBRATE
November 7, 2025 at 6:44 PM
HAPPY FOUR SEASONS TOTAL LANDSCAPING DAY TO ALL WHO CELEBRATE
Reposted by Mike DiCuccio
So pleased to see the mRNA platform being used to develop new vaccines against tuberculosis!!!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Immunopeptidomics can inform the design of mRNA vaccines for the delivery of Mycobacterium tuberculosis MHC class II antigens
MHC class II immunopeptidomics in human phagocytes infected with Mycobacterium tuberculosis enables vaccine immunogen design and optimization.
www.science.org
November 5, 2025 at 10:08 PM
So pleased to see the mRNA platform being used to develop new vaccines against tuberculosis!!!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Mike DiCuccio
Good morning.
I don't know who did this, but I love you.
I don't know who did this, but I love you.
November 3, 2025 at 3:01 PM
Good morning.
I don't know who did this, but I love you.
I don't know who did this, but I love you.
Reposted by Mike DiCuccio
Stack of Jacquard loom cards, about two meters in length at Queen’s Street Mill, near Burnley
By my calculation about 120kb of data
By my calculation about 120kb of data
November 1, 2025 at 3:46 PM
Stack of Jacquard loom cards, about two meters in length at Queen’s Street Mill, near Burnley
By my calculation about 120kb of data
By my calculation about 120kb of data
Reposted by Mike DiCuccio
Reposted by Mike DiCuccio
This is just to say
I have looked on
the works
that were in
the desert
and which
you were probably
thinking
would still stand
Forgive me
they were trunkless
so vast
and so old
I have looked on
the works
that were in
the desert
and which
you were probably
thinking
would still stand
Forgive me
they were trunkless
so vast
and so old
Once upon a desert sandy
As through winds the trav'ling man he
Spied the face of Ozymandy
Lying, simply lying there
Suddenly there was some writing
Pon the plinth that he was sighting
That the sand and time were blighting
Quoth the statue, "Now despair"
As through winds the trav'ling man he
Spied the face of Ozymandy
Lying, simply lying there
Suddenly there was some writing
Pon the plinth that he was sighting
That the sand and time were blighting
Quoth the statue, "Now despair"
There was an old man you could gaze
At his works in despair in a daze
If you looked upon them
And were mere mortal men
'Ozymandias mighty', it says
At his works in despair in a daze
If you looked upon them
And were mere mortal men
'Ozymandias mighty', it says
October 30, 2025 at 12:53 AM
This is just to say
I have looked on
the works
that were in
the desert
and which
you were probably
thinking
would still stand
Forgive me
they were trunkless
so vast
and so old
I have looked on
the works
that were in
the desert
and which
you were probably
thinking
would still stand
Forgive me
they were trunkless
so vast
and so old
Reposted by Mike DiCuccio
Once upon a desert sandy
As through winds the trav'ling man he
Spied the face of Ozymandy
Lying, simply lying there
Suddenly there was some writing
Pon the plinth that he was sighting
That the sand and time were blighting
Quoth the statue, "Now despair"
As through winds the trav'ling man he
Spied the face of Ozymandy
Lying, simply lying there
Suddenly there was some writing
Pon the plinth that he was sighting
That the sand and time were blighting
Quoth the statue, "Now despair"
There was an old man you could gaze
At his works in despair in a daze
If you looked upon them
And were mere mortal men
'Ozymandias mighty', it says
At his works in despair in a daze
If you looked upon them
And were mere mortal men
'Ozymandias mighty', it says
My name is Pagliacci, Clown of Clowns. Look on my works, ye doctors; I despair.
October 30, 2025 at 12:41 AM
Once upon a desert sandy
As through winds the trav'ling man he
Spied the face of Ozymandy
Lying, simply lying there
Suddenly there was some writing
Pon the plinth that he was sighting
That the sand and time were blighting
Quoth the statue, "Now despair"
As through winds the trav'ling man he
Spied the face of Ozymandy
Lying, simply lying there
Suddenly there was some writing
Pon the plinth that he was sighting
That the sand and time were blighting
Quoth the statue, "Now despair"
Reposted by Mike DiCuccio
COOLEST RUNNINGS,,, cuz it’s Cooler than Cool Runnings.
Your boy Flavor Flav is now an Official Sponsor and The Official Hype Man of the USA Olympic Bobsled + Skeleton team. YEAH BOOYYYEEEE,!!
Your boy Flavor Flav is now an Official Sponsor and The Official Hype Man of the USA Olympic Bobsled + Skeleton team. YEAH BOOYYYEEEE,!!
October 27, 2025 at 4:54 PM
COOLEST RUNNINGS,,, cuz it’s Cooler than Cool Runnings.
Your boy Flavor Flav is now an Official Sponsor and The Official Hype Man of the USA Olympic Bobsled + Skeleton team. YEAH BOOYYYEEEE,!!
Your boy Flavor Flav is now an Official Sponsor and The Official Hype Man of the USA Olympic Bobsled + Skeleton team. YEAH BOOYYYEEEE,!!
Reposted by Mike DiCuccio
Random math fact: the golden ratio (1.618) is very close to the conversion ratio from miles to kilometers (1.609), meaning you can use the Fibonacci sequence to convert between miles and km: 1, 1, 2, 3, 5, 8, 13, 21, 34, 55, 89, 144, 233, 377, 610, 987, 1597, etc.
October 25, 2025 at 12:11 PM
Random math fact: the golden ratio (1.618) is very close to the conversion ratio from miles to kilometers (1.609), meaning you can use the Fibonacci sequence to convert between miles and km: 1, 1, 2, 3, 5, 8, 13, 21, 34, 55, 89, 144, 233, 377, 610, 987, 1597, etc.
Reposted by Mike DiCuccio
welcome to linux, please pick your starter distro:
- difficult linux
- racism linux
- backdoored linux
- bloat linux
- slop linux
- difficult linux
- racism linux
- backdoored linux
- bloat linux
- slop linux
October 23, 2025 at 6:01 PM
welcome to linux, please pick your starter distro:
- difficult linux
- racism linux
- backdoored linux
- bloat linux
- slop linux
- difficult linux
- racism linux
- backdoored linux
- bloat linux
- slop linux
Reposted by Mike DiCuccio
NEW STUDY PUBLISHED IN NATURE: People who got an mRNA COVID vaccine within ~3 months before or after starting immunotherapy for cancer lived longer overall than those who didn’t get the vaccine.
www.washingtonpost.com/science/2025...
www.washingtonpost.com/science/2025...
October 23, 2025 at 11:51 PM
NEW STUDY PUBLISHED IN NATURE: People who got an mRNA COVID vaccine within ~3 months before or after starting immunotherapy for cancer lived longer overall than those who didn’t get the vaccine.
www.washingtonpost.com/science/2025...
www.washingtonpost.com/science/2025...
Reposted by Mike DiCuccio
🧠🌟🐭 Excited to share some of my postdoc work on the evolution of dexterity!
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
October 22, 2025 at 8:41 PM
🧠🌟🐭 Excited to share some of my postdoc work on the evolution of dexterity!
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
Reposted by Mike DiCuccio
This fantastic map by Francis Galton shows travel time from London to the rest of the world in 1881.
October 21, 2025 at 10:54 PM
This fantastic map by Francis Galton shows travel time from London to the rest of the world in 1881.
Reposted by Mike DiCuccio
‘“A hundred and fifteen years that they haven’t been here, and they still have that GPS unit inside of them,” said the visibly giddy Klamath Tribal Chair William Ray, Jr. “It’s truly an awesome feat if you think about the gauntlet they had to go through.”’
Salmon clear last Klamath dams, reaching Williamson and Sprague rivers
Just a year after four dams were removed, a group of fall Chinook have migrated nearly 300 miles into the Upper Klamath Basin.
www.opb.org
October 19, 2025 at 12:03 PM
‘“A hundred and fifteen years that they haven’t been here, and they still have that GPS unit inside of them,” said the visibly giddy Klamath Tribal Chair William Ray, Jr. “It’s truly an awesome feat if you think about the gauntlet they had to go through.”’
Reposted by Mike DiCuccio
The HlaH35A fusion, an HLA mutant, acts as novel carrier protein that modulates cDC2 differentiation via the ADAM10-Notch2 signaling pathway, suggesting a promising strategy for Th17/Tfh-oriented #VaccineDesign. #medsky
#OpenAccess: doi.org/10.1038/s413...
#OpenAccess: doi.org/10.1038/s413...
October 18, 2025 at 11:01 PM
The HlaH35A fusion, an HLA mutant, acts as novel carrier protein that modulates cDC2 differentiation via the ADAM10-Notch2 signaling pathway, suggesting a promising strategy for Th17/Tfh-oriented #VaccineDesign. #medsky
#OpenAccess: doi.org/10.1038/s413...
#OpenAccess: doi.org/10.1038/s413...
Reposted by Mike DiCuccio
Proud papa moment: my son J published a letter in the @nytimes.com today (in print tomorrow) on the need to think our definitions of autism.
October 18, 2025 at 8:06 PM
Proud papa moment: my son J published a letter in the @nytimes.com today (in print tomorrow) on the need to think our definitions of autism.