@dfachinetti.bsky.social
The 21st Course on Epigenetics which will take place from March 25th to April 1st, 2026 at the Institut Curie (Paris).
The Course is open to M2 and PhD students. Application via the Advanced Training Office website before December 15th, 2025 at:
minilien.curie.fr/3avv47
The Course is open to M2 and PhD students. Application via the Advanced Training Office website before December 15th, 2025 at:
minilien.curie.fr/3avv47
Epigenetics - 21st Course on Epigenetics 2026: Towards a quantitative understanding of nuclear dynamics during development and diseases | Institut Curie Advanced Training
The aim of this course is to provide an overview of epigenetic mechanisms and their links to gene expression and chromatin dynamics, in different systems. The diverse functions of the nucleus involvin...
minilien.curie.fr
November 12, 2025 at 10:58 AM
The 21st Course on Epigenetics which will take place from March 25th to April 1st, 2026 at the Institut Curie (Paris).
The Course is open to M2 and PhD students. Application via the Advanced Training Office website before December 15th, 2025 at:
minilien.curie.fr/3avv47
The Course is open to M2 and PhD students. Application via the Advanced Training Office website before December 15th, 2025 at:
minilien.curie.fr/3avv47
Very excited and honored that our project CenAGE with @manellab.bsky.social and Elsa Logarinho was granted! Looking forward to discover how centromere instability affects the immune cells contributing to systemic ageing. More Info here: curie.fr/actualite/no... Open positions soon, stay tuned!
November 6, 2025 at 8:59 PM
Very excited and honored that our project CenAGE with @manellab.bsky.social and Elsa Logarinho was granted! Looking forward to discover how centromere instability affects the immune cells contributing to systemic ageing. More Info here: curie.fr/actualite/no... Open positions soon, stay tuned!
My team is recruiting a Study Engineer (IE) with experience in mammalian cell culture - ideally human iPSCs - to work on a project exploring the role of aneuploidy and centromere regulation in neuroblastoma initiation and progression.
info and application here
institut-curie.org/job/study-en....
info and application here
institut-curie.org/job/study-en....
Study Engineer (F/M) - Institut Curie
The Curie Institute Research CenterThe Institut Curie is a major player in the research and fight against cancer. It consists of a hospital and a Research Center of more than 1000 employees with a str...
institut-curie.org
November 4, 2025 at 10:38 AM
My team is recruiting a Study Engineer (IE) with experience in mammalian cell culture - ideally human iPSCs - to work on a project exploring the role of aneuploidy and centromere regulation in neuroblastoma initiation and progression.
info and application here
institut-curie.org/job/study-en....
info and application here
institut-curie.org/job/study-en....
Thanks to @erhardtlab.bsky.social for the news and views on our paper on DNA methylation¢romere www.nature.com/articles/s41....
Dipping into the function of DNA methylation at centromeres - Nature Genetics
Human centromeres contain a small chromatin region with low levels of DNA cytosine methylation that resides with CENP-A. Salinas-Luypaert et al. find a role of DNA methylation in maintaining the size and function of centromeres by controlling the binding affinity of key centromere components.
www.nature.com
October 6, 2025 at 6:58 AM
Thanks to @erhardtlab.bsky.social for the news and views on our paper on DNA methylation¢romere www.nature.com/articles/s41....
10-year celebration of the Fachinetti team!
Thank you to all my amazing current and former members for making these two days so special for me! I feel so lucky to have met you all!
Thank you to all my amazing current and former members for making these two days so special for me! I feel so lucky to have met you all!
October 4, 2025 at 1:08 PM
10-year celebration of the Fachinetti team!
Thank you to all my amazing current and former members for making these two days so special for me! I feel so lucky to have met you all!
Thank you to all my amazing current and former members for making these two days so special for me! I feel so lucky to have met you all!
Reposted
#ResultatScientifique🔎| La méthylation de l’ADN agit comme un code caché des centromères, garantissant une division cellulaire stable et freinant l’instabilité génomique 🧬
🤝@cnrs-paris.bsky.social @institutcurie.bsky.social
✍️ @dfachinetti.bsky.social
📕 @natgenet.nature.com |https://buff.ly/hxb1yxh
🤝@cnrs-paris.bsky.social @institutcurie.bsky.social
✍️ @dfachinetti.bsky.social
📕 @natgenet.nature.com |https://buff.ly/hxb1yxh
September 9, 2025 at 12:32 PM
#ResultatScientifique🔎| La méthylation de l’ADN agit comme un code caché des centromères, garantissant une division cellulaire stable et freinant l’instabilité génomique 🧬
🤝@cnrs-paris.bsky.social @institutcurie.bsky.social
✍️ @dfachinetti.bsky.social
📕 @natgenet.nature.com |https://buff.ly/hxb1yxh
🤝@cnrs-paris.bsky.social @institutcurie.bsky.social
✍️ @dfachinetti.bsky.social
📕 @natgenet.nature.com |https://buff.ly/hxb1yxh
Reposted
📢ONLINE @natgenet.nature.com
📰DNA methylation influences human centromere positioning and function.
By Catalina Salinas-Luypaert, @dfachinetti.bsky.social, @naltemose.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
📰DNA methylation influences human centromere positioning and function.
By Catalina Salinas-Luypaert, @dfachinetti.bsky.social, @naltemose.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
DNA methylation influences human centromere positioning and function - Nature Genetics
Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.
www.nature.com
September 5, 2025 at 12:32 PM
📢ONLINE @natgenet.nature.com
📰DNA methylation influences human centromere positioning and function.
By Catalina Salinas-Luypaert, @dfachinetti.bsky.social, @naltemose.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
📰DNA methylation influences human centromere positioning and function.
By Catalina Salinas-Luypaert, @dfachinetti.bsky.social, @naltemose.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
Reposted
▶️ Pour en savoir plus
⏩ Lire l'actu : curie.fr/actualite/di...
⏩ Lire la publication : www.nature.com/articles/s41...
⏩ Lire l'actu : curie.fr/actualite/di...
⏩ Lire la publication : www.nature.com/articles/s41...
DNA methylation influences human centromere positioning and function - Nature Genetics
Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.
www.nature.com
September 4, 2025 at 12:37 PM
▶️ Pour en savoir plus
⏩ Lire l'actu : curie.fr/actualite/di...
⏩ Lire la publication : www.nature.com/articles/s41...
⏩ Lire l'actu : curie.fr/actualite/di...
⏩ Lire la publication : www.nature.com/articles/s41...
#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...
DNA methylation influences human centromere positioning and function - Nature Genetics
Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.
www.nature.com
September 4, 2025 at 1:10 PM
#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...
Great time with @hirofunabiki.bsky.social @rockefelleruniv.bsky.social with amazing discussion with @prasad.bsky.social , @johnmaciejowski.bsky.social @agnelsfeir.bsky.social and Simona Giunta. Thanks also to Hiro’s lab for all the great chat! Happy to have seen my PhD friend Fabio Vanoli
August 15, 2025 at 6:16 AM
Great time with @hirofunabiki.bsky.social @rockefelleruniv.bsky.social with amazing discussion with @prasad.bsky.social , @johnmaciejowski.bsky.social @agnelsfeir.bsky.social and Simona Giunta. Thanks also to Hiro’s lab for all the great chat! Happy to have seen my PhD friend Fabio Vanoli
Congrats to the team! Happy that we could help!
Thrilled to share our latest @cp-cell.bsky.social.
We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS.
www.cell.com/cell/abstrac...
We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS.
www.cell.com/cell/abstrac...
Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS
Herpesvirus proteins disrupt centromeres, triggering centromeric DNA amplification
and local nuclear activation of the nucleic acid sensor cGAS. This reveals an immune
surveillance mechanism in the nu...
www.cell.com
June 2, 2025 at 7:02 PM
Congrats to the team! Happy that we could help!
Hi all, my team institut-curie.org/team/fachine... @institutcurie.bsky.social is looking for a Bioinformatician.
You can find more details about the position here: euraxess.ec.europa.eu/jobs/344508 Is anyone looking for a job in the lovely Paris?
You can find more details about the position here: euraxess.ec.europa.eu/jobs/344508 Is anyone looking for a job in the lovely Paris?
May 21, 2025 at 9:36 AM
Hi all, my team institut-curie.org/team/fachine... @institutcurie.bsky.social is looking for a Bioinformatician.
You can find more details about the position here: euraxess.ec.europa.eu/jobs/344508 Is anyone looking for a job in the lovely Paris?
You can find more details about the position here: euraxess.ec.europa.eu/jobs/344508 Is anyone looking for a job in the lovely Paris?
The @embo.org #chromoploidy2025 is over. It was an amazing workshop organized by a perfect match of scientists and friends @mcclellandlab.bsky.social @bendavidlab.bsky.social @stesantaguida.bsky.social @foijer-lab.bsky.social, Elsa Logarinho, Caroline Audouin and myself
May 4, 2025 at 3:34 PM
The @embo.org #chromoploidy2025 is over. It was an amazing workshop organized by a perfect match of scientists and friends @mcclellandlab.bsky.social @bendavidlab.bsky.social @stesantaguida.bsky.social @foijer-lab.bsky.social, Elsa Logarinho, Caroline Audouin and myself
Reposted
So thrilled to participate in the #EMBO workshop on aneuploidy in the magnificient Stresa. Cheers to the many organizers including @dfachinetti.bsky.social
April 27, 2025 at 12:17 PM
So thrilled to participate in the #EMBO workshop on aneuploidy in the magnificient Stresa. Cheers to the many organizers including @dfachinetti.bsky.social
Reposted
Excited to get the #EMBOChromoploidy meeting started! 3 days of fantastic science and fun in beautiful Stresa are beginning now!
meetings.embo.org/event/25-ane...
meetings.embo.org/event/25-ane...
Chromosome Segregation and Aneuploidy
Aneuploidy is a hallmark of cancer and developmental disorders such as Down syndrome. Understanding how cells accomplish faithful chromosome segregation and how chromosomal instability (CIN) impacts …
meetings.embo.org
April 27, 2025 at 12:55 PM
Excited to get the #EMBOChromoploidy meeting started! 3 days of fantastic science and fun in beautiful Stresa are beginning now!
meetings.embo.org/event/25-ane...
meetings.embo.org/event/25-ane...
The Fachinetti team was there! #UneJonquilleContreleCancer
March 15, 2025 at 10:54 AM
The Fachinetti team was there! #UneJonquilleContreleCancer
“Stand up for Science” demonstration in Paris!
March 8, 2025 at 9:14 AM
“Stand up for Science” demonstration in Paris!
Last week to register (March 2nd) to the next Genome Instability and Human Disease international course at @institut_curie! Gain knowledge of mechanisms ensuring genome stability, from fundamental molecular pathways up to large scale approaches.
Genome Instability and Human Disease | Institut Curie Advanced Training
Genome instability is a hallmark of cancer cells but also a cause of genetic diseases in humans. Our understanding of the causal relationships between genome instability and the development of human d...
training.institut-curie.org
February 21, 2025 at 6:55 AM
Last week to register (March 2nd) to the next Genome Instability and Human Disease international course at @institut_curie! Gain knowledge of mechanisms ensuring genome stability, from fundamental molecular pathways up to large scale approaches.
A chance to raise our voices!
A sit-in Monday Jan 27th 16h30 will happen in front of the College de France in protest against the government cuts to higher education and research.
January 26, 2025 at 9:23 AM
A chance to raise our voices!
Reposted
We have a research laboratory technician post available in my group - the role will support plant work, and molecular biology, associated with our research on centromeres.
www.jobs.cam.ac.uk/job/47342/
www.jobs.cam.ac.uk/job/47342/
Research Laboratory Technician - Job Opportunities - University of Cambridge
Research Laboratory Technician in the Department of Plant Sciences at the University of Cambridge.
www.jobs.cam.ac.uk
January 20, 2025 at 1:57 PM
We have a research laboratory technician post available in my group - the role will support plant work, and molecular biology, associated with our research on centromeres.
www.jobs.cam.ac.uk/job/47342/
www.jobs.cam.ac.uk/job/47342/
Thanks to Elsa and Reto for inviting me at I3S, Porto! A blast to see old friends and great time with @carloscondetv.bsky.social
January 18, 2025 at 12:51 AM
Thanks to Elsa and Reto for inviting me at I3S, Porto! A blast to see old friends and great time with @carloscondetv.bsky.social
Thanks to @cnrsbiologie.bsky.social for covering our work from @sol-herve.bsky.social and Andrea Scelfo with @katemiro.bsky.social
#RésultatScientifique🔎
Une étude publiée dans @naturecellbiology.bsky.social révèle comment sont détectés des anomalies chromosomiques. Des résultats qui mettent en lumière un rôle inédit de la mécanique du noyau.
🤝 @dfachinetti.bsky.social @institutcurie.bsky.social
Une étude publiée dans @naturecellbiology.bsky.social révèle comment sont détectés des anomalies chromosomiques. Des résultats qui mettent en lumière un rôle inédit de la mécanique du noyau.
🤝 @dfachinetti.bsky.social @institutcurie.bsky.social
Quand le nombre de chromosomes déraille : un mécanisme inédit pour protéger l’intégrité du génome
La mauvaise ségrégation des chromosomes lors de la division cellulaire entraîne des anomalies qui perturbent le bon fonctionnement de la cellule. L
buff.ly
January 17, 2025 at 9:02 AM
Thanks to @cnrsbiologie.bsky.social for covering our work from @sol-herve.bsky.social and Andrea Scelfo with @katemiro.bsky.social
Reposted
Excited to share the first paper from my lab 🤩 - a great collaboration with Dani Fachinetti lab - we discover a #mechanosensitive nuclear envelope #checkpoint that arrests cells directly post chromosome mis-segregation rdcu.be/d5AC9 👇🧵 #cancer #mechanics #p53 #chromatin
January 8, 2025 at 12:14 PM
Excited to share the first paper from my lab 🤩 - a great collaboration with Dani Fachinetti lab - we discover a #mechanosensitive nuclear envelope #checkpoint that arrests cells directly post chromosome mis-segregation rdcu.be/d5AC9 👇🧵 #cancer #mechanics #p53 #chromatin
#1 Happy to share our last work published in @NatureCellBio about a new cell cycle checkpoint that senses nuclear shape & mechanics to guarantee genome integrity
www.nature.com/articles/s41.... Great work from @sol-herve.bsky.social & Andrea Scelfo in close collaboration with @katemiro.bsky.social
www.nature.com/articles/s41.... Great work from @sol-herve.bsky.social & Andrea Scelfo in close collaboration with @katemiro.bsky.social
Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint - Nature Cell Biology
Hervé, Scelfo et al. show that chromosome mis-segregation induces mTORC2- and ATR-mediated p53 activation through a mechanosensitive checkpoint at the nuclear envelope triggered by altered heterochrom...
www.nature.com
January 8, 2025 at 12:11 PM
#1 Happy to share our last work published in @NatureCellBio about a new cell cycle checkpoint that senses nuclear shape & mechanics to guarantee genome integrity
www.nature.com/articles/s41.... Great work from @sol-herve.bsky.social & Andrea Scelfo in close collaboration with @katemiro.bsky.social
www.nature.com/articles/s41.... Great work from @sol-herve.bsky.social & Andrea Scelfo in close collaboration with @katemiro.bsky.social
We are very pleased to announce our 20th Course on Epigenetics, which will take place from March 11th to March 18th 2025 @institutcurie.bsky.social. Applications are open to M2 and PhD students. training.institut-curie.org/courses/epig...
December 21, 2024 at 10:34 AM
We are very pleased to announce our 20th Course on Epigenetics, which will take place from March 11th to March 18th 2025 @institutcurie.bsky.social. Applications are open to M2 and PhD students. training.institut-curie.org/courses/epig...