Thanks Maxim!!

Congrats, Sara! Looking forward to seeing more great science from you and your collaborators!

▶️ Pour en savoir plus
⏩ Lire l'actu : curie.fr/actualite/di...
⏩ Lire la publication : www.nature.com/articles/s41...

Finally we want to thank our amazing collaborators @foijer-lab.bsky.social , Geert Kops and team, Claire Francastel and team and @khmiga.bsky.social and team.

#6 In summary, this work carried out at @institutcurie.bsky.social @cnrs.fr @stanforduniversity.bsky.social and supported by @agencerecherche.bsky.social @fondationarc.bsky.social @chanzuckerberg.bsky.social ‪provides the first evidence that DNA methylation directly influences centromere function

#5 We also found that gradual methylation loss allows most cells to adapt and survive, whereas rapid loss causes aneuploidy and cell death. This slow adaptation mirrors what often happens during cancer progression.

#4 We show that loss of DNAme leads to disruption of the centromere’s bipartite structure and also controls the presence of another centromere-associated protein, CENP-B. Excessive CENP-B makes centromeric DNA more fragile and prone to breakage.

#3 Using DiMeLo-seq, Rosa Lee and Danilo Dubocanin from the Altemose team mapped CENP-A binding with high precision. They found that when DNA methylation is lost, CENP-A spreads to inappropriate regions, causing centromere alterations and chromosomal imbalances.

#2 During her PhD, Catalina Salinas-Luypaert developed human cell models that allowed us to directly alter DNA methylation at centromeres and observe the consequences. We show that DNA methylation is critical to keep CENP-A correctly positioned and centromeres functioning.

And great time with our long-term friends, the Holland!

Not to forget a great dinner and time with my ex neighbor labs @odlab.bsky.social . San Diego is always the best place to be ♥️

Finally, superb time at UPENN with my friends Alessandro Gardini, Ben Black and @glennislogsdon.bsky.social and great discussion with the faculty members. I felt at home!

Amazing visit also to @stanfordpress.bsky.social with my friend @naltemose.bsky.social and great time with @astraight.bsky.social team members. What a campus and what great labs! You guys rock!

Thank Nico. We feel the same way! More exciting research to come between our teams!