@depinwang.bsky.social
Happy to see the release of **GUANACO** — a new Python package for interactive multi-omics single-cell data exploration and sharing, now available on bioRxiv: www.biorxiv.org/content/10.1...
GUANACO: A Unified Web-Based Platform for Single-Cell Multi-Omics Data Visualization
While single-cell multi-omics has advanced our understanding of cellular heterogeneity, the complexity of these datasets remains a barrier for non-computational users. Here, we introduce GUANACO, a Da...
www.biorxiv.org
September 21, 2025 at 9:36 PM
Happy to see the release of **GUANACO** — a new Python package for interactive multi-omics single-cell data exploration and sharing, now available on bioRxiv: www.biorxiv.org/content/10.1...
Reposted
Also, many in the medical profession now try to discourage the military metaphor, and for good reason.
July 17, 2025 at 3:26 PM
Also, many in the medical profession now try to discourage the military metaphor, and for good reason.
Reposted
I blogged about how I use transcription + a fake persona called Diane (from Twin Peaks) to write talks and blog posts etc, just by talking to my Apple Watch
The persona means I can make adjustments while I talk: uh Diane put that last para in the previous section
interconnected.org/home/2025/03...
The persona means I can make adjustments while I talk: uh Diane put that last para in the previous section
interconnected.org/home/2025/03...
Diane, I wrote a lecture by talking about it
Posted on Thursday 20 Mar 2025. 831 words, 8 links. By Matt Webb.
interconnected.org
April 23, 2025 at 6:50 PM
I blogged about how I use transcription + a fake persona called Diane (from Twin Peaks) to write talks and blog posts etc, just by talking to my Apple Watch
The persona means I can make adjustments while I talk: uh Diane put that last para in the previous section
interconnected.org/home/2025/03...
The persona means I can make adjustments while I talk: uh Diane put that last para in the previous section
interconnected.org/home/2025/03...
Reposted
To experiment with multi-agent systems you either need a clear business case and big budget, or you need to be a jabroni with a high credit limit.
I'm just the jabroni for the job, so I taught Claude to play chess, and learned a ton along the way:
jfkirk.github.io/posts/claude...
I'm just the jabroni for the job, so I taught Claude to play chess, and learned a ton along the way:
jfkirk.github.io/posts/claude...
Teaching Claude To Teach Claude To Play Chess
When AI competes against a powerful chess engine, it seems doomed - unless the AI learns how to cheat.
jfkirk.github.io
March 20, 2025 at 11:57 AM
To experiment with multi-agent systems you either need a clear business case and big budget, or you need to be a jabroni with a high credit limit.
I'm just the jabroni for the job, so I taught Claude to play chess, and learned a ton along the way:
jfkirk.github.io/posts/claude...
I'm just the jabroni for the job, so I taught Claude to play chess, and learned a ton along the way:
jfkirk.github.io/posts/claude...
Reposted
Was asked to contribute brief commentary about my views on the present and future of AI models for regulatory genomics. Wud love for others to add their comments to this thread.
Also check out commentaries from @jianma.bsky.social, Katie Pollard, Remo Rohs & others
www.cell.com/molecular-ce...
Also check out commentaries from @jianma.bsky.social, Katie Pollard, Remo Rohs & others
www.cell.com/molecular-ce...
January 19, 2025 at 5:20 AM
Was asked to contribute brief commentary about my views on the present and future of AI models for regulatory genomics. Wud love for others to add their comments to this thread.
Also check out commentaries from @jianma.bsky.social, Katie Pollard, Remo Rohs & others
www.cell.com/molecular-ce...
Also check out commentaries from @jianma.bsky.social, Katie Pollard, Remo Rohs & others
www.cell.com/molecular-ce...
Reposted
Curious about alternative splicing? Kick off the year with our latest review in COSB! authors.elsevier.com/sd/article/S...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
January 7, 2025 at 12:20 PM
Curious about alternative splicing? Kick off the year with our latest review in COSB! authors.elsevier.com/sd/article/S...
Reposted
Effects of Acute PM2.5 Purification on Cognitive Function and Underlying Mechanisms: Evidence from Integrating Alternative Splicing into Multi-Omics
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
January 14, 2025 at 9:23 AM
Effects of Acute PM2.5 Purification on Cognitive Function and Underlying Mechanisms: Evidence from Integrating Alternative Splicing into Multi-Omics
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted
Dr. Yang Li’s team at the University of Chicago revealed that alternative splicing is not just about creating protein isoforms—it also critically controls gene expression levels. This discovery shifts our understanding of RNA processing and its influence on cellular biology.
January 1, 2025 at 4:18 AM
Dr. Yang Li’s team at the University of Chicago revealed that alternative splicing is not just about creating protein isoforms—it also critically controls gene expression levels. This discovery shifts our understanding of RNA processing and its influence on cellular biology.
Reposted
hnRNPLL regulates MYOF alternative splicing and correlates with early metastasis in pancreatic ductal adenocarcinoma 🧪 #PancreaticCancer www.sciencedirect.com/science/arti...
hnRNPLL regulates MYOF alternative splicing and correlates with early metastasis in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer known for its high rate of early metastasis, necessitating the discovery of the underlying …
www.sciencedirect.com
January 1, 2025 at 10:44 AM
hnRNPLL regulates MYOF alternative splicing and correlates with early metastasis in pancreatic ductal adenocarcinoma 🧪 #PancreaticCancer www.sciencedirect.com/science/arti...
Reposted
Coordinated alternative splicing decisions via stepwise exon definition https://www.biorxiv.org/content/10.1101/2024.12.18.629257v1
December 22, 2024 at 3:04 AM
Coordinated alternative splicing decisions via stepwise exon definition https://www.biorxiv.org/content/10.1101/2024.12.18.629257v1
Reposted
The last part of my PhD research 🤓 is out!! If you are interested in RNA Biology -> Alternative Splicing and Epitranscriptomics + Evolution go have a look!
A thread 🧵
A thread 🧵
The conserved landscape of RNA modifications and transcript diversity across mammalian evolution https://www.biorxiv.org/content/10.1101/2024.11.24.624934v1
The conserved landscape of RNA modifications and transcript diversity across mammalian evolution https://www.biorxiv.org/content/10.1101/2024.11.24.624934v1
Gene expression programs underpin the development of shared phenotypes, yet the importance of transc
www.biorxiv.org
November 25, 2024 at 10:41 AM
The last part of my PhD research 🤓 is out!! If you are interested in RNA Biology -> Alternative Splicing and Epitranscriptomics + Evolution go have a look!
A thread 🧵
A thread 🧵
Reposted
Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
ChIP-DIP maps binding of hundreds of proteins to DNA simultaneously and identifies diverse gene regulatory elements - Nature Genetics
ChIP-DIP (ChIP done in parallel) is a highly multiplex assay for protein–DNA binding, scalable to hundreds of proteins including modified histones, chromatin regulators and transcription factors, offe...
www.nature.com
November 27, 2024 at 4:13 AM
Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
The landscape of expression and alternative splicing variation across human traits
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
The landscape of expression and alternative splicing variation across human traits
García-Pérez et al. perform a multi-tissue analysis of the association between demographic
and clinical traits and human transcriptome variation. Ancestry, sex, age, and BMI
and certain diseases make ...
www.cell.com
November 25, 2024 at 11:00 PM
The landscape of expression and alternative splicing variation across human traits
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
Reposted
Beyond HER2 expression in breast cancer: Investigating alternative splicing profiles as a mechanism of resistance to anti-HER2 therapies https://www.medrxiv.org/content/10.1101/2024.11.25.24317569v1
Beyond HER2 expression in breast cancer: Investigating alternative splicing profiles as a mechanism of resistance to anti-HER2 therapies https://www.medrxiv.org/content/10.1101/2024.11.25.24317569v1
Breast cancer is a heterogeneous disease that can be molecularly classified based on the expression
www.medrxiv.org
November 27, 2024 at 1:29 AM
Beyond HER2 expression in breast cancer: Investigating alternative splicing profiles as a mechanism of resistance to anti-HER2 therapies https://www.medrxiv.org/content/10.1101/2024.11.25.24317569v1