Elodie Laine
@laineelodie.bsky.social
Full Professor @Sorbonne_Univ_, working @LCQB_UMR7238 on protein evolution, structures, and interactions. http://www.lcqb.upmc.fr/laine
Our new special collection "Protein-Nucleic Acid Interactions: From Origins to Design (2025)" is now published in Current Opinion in Structural Biology. I'm excited to have both co-edited it with Shandar Ahmad and contributed a review!
www.sciencedirect.com/special-issu...
www.sciencedirect.com/special-issu...
LinkedIn
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November 10, 2025 at 5:54 PM
Our new special collection "Protein-Nucleic Acid Interactions: From Origins to Design (2025)" is now published in Current Opinion in Structural Biology. I'm excited to have both co-edited it with Shandar Ahmad and contributed a review!
www.sciencedirect.com/special-issu...
www.sciencedirect.com/special-issu...
Reposted by Elodie Laine
** Now seeking postdocs **
Join our interdisciplinary and transnational team in Würzburg (Germany) or Paris (France) to drive projects in translational biology and antibiotic drug discovery.
Backgrounds in computational biology, AI, physics, or microbiology are all welcome. Please spread the word.
Join our interdisciplinary and transnational team in Würzburg (Germany) or Paris (France) to drive projects in translational biology and antibiotic drug discovery.
Backgrounds in computational biology, AI, physics, or microbiology are all welcome. Please spread the word.
October 5, 2025 at 9:48 PM
** Now seeking postdocs **
Join our interdisciplinary and transnational team in Würzburg (Germany) or Paris (France) to drive projects in translational biology and antibiotic drug discovery.
Backgrounds in computational biology, AI, physics, or microbiology are all welcome. Please spread the word.
Join our interdisciplinary and transnational team in Würzburg (Germany) or Paris (France) to drive projects in translational biology and antibiotic drug discovery.
Backgrounds in computational biology, AI, physics, or microbiology are all welcome. Please spread the word.
Reposted by Elodie Laine
🚀 As first official act, we are hiring! 🎓
We’re looking for a PhD student to work at the interface of computational biophysics, machine learning & human mutations. 📌 FPI fellowship, 4 years fully funded!
More information here:
www.bsc.es/join-us/job-...
We’re looking for a PhD student to work at the interface of computational biophysics, machine learning & human mutations. 📌 FPI fellowship, 4 years fully funded!
More information here:
www.bsc.es/join-us/job-...
After months of buildup, it’s finally real! 🎉 The Evolutionary Systems Biophysics Group (ESBG) is officially alive at @bsc-cns.bsky.social . Proud to start this new adventure as a Ramon y Cajal Junior Group Leader🧬
Thanks to all who have been part of this process!
tinyurl.com/4r9vf4zx
Thanks to all who have been part of this process!
tinyurl.com/4r9vf4zx
October 2, 2025 at 8:12 AM
🚀 As first official act, we are hiring! 🎓
We’re looking for a PhD student to work at the interface of computational biophysics, machine learning & human mutations. 📌 FPI fellowship, 4 years fully funded!
More information here:
www.bsc.es/join-us/job-...
We’re looking for a PhD student to work at the interface of computational biophysics, machine learning & human mutations. 📌 FPI fellowship, 4 years fully funded!
More information here:
www.bsc.es/join-us/job-...
Reposted by Elodie Laine
À l'occasion de la Fête de la Science, plusieurs de nos collections et laboratoires seront ouverts au public !
📆 RDV les 11 et 12 oct pour visiter nos collections de zoologie, paléontologie et botanique, sans oublier l'ISIR et le @lpnhe-in2p3.bsky.social
👉 Réservez votre ticket : swll.to/4MWnSH0
📆 RDV les 11 et 12 oct pour visiter nos collections de zoologie, paléontologie et botanique, sans oublier l'ISIR et le @lpnhe-in2p3.bsky.social
👉 Réservez votre ticket : swll.to/4MWnSH0
October 3, 2025 at 6:40 PM
À l'occasion de la Fête de la Science, plusieurs de nos collections et laboratoires seront ouverts au public !
📆 RDV les 11 et 12 oct pour visiter nos collections de zoologie, paléontologie et botanique, sans oublier l'ISIR et le @lpnhe-in2p3.bsky.social
👉 Réservez votre ticket : swll.to/4MWnSH0
📆 RDV les 11 et 12 oct pour visiter nos collections de zoologie, paléontologie et botanique, sans oublier l'ISIR et le @lpnhe-in2p3.bsky.social
👉 Réservez votre ticket : swll.to/4MWnSH0
Reposted by Elodie Laine
Si vous avez des adolescentes qui s'intéressent à l'informatique, je signale qu'il reste des places pour les stages #GirlsCanCode en août et septembre.
C'est gratuit et vraiment top. Mes aînées les ont fait en 2018 et 2022, là je viens d'inscrire fille n°3 et elle est ravie.
girlscancode.fr
C'est gratuit et vraiment top. Mes aînées les ont fait en 2018 et 2022, là je viens d'inscrire fille n°3 et elle est ravie.
girlscancode.fr
Girls Can Code!
Stages d'initiation à la programmation Girls Can Code!
girlscancode.fr
July 22, 2025 at 2:00 PM
Si vous avez des adolescentes qui s'intéressent à l'informatique, je signale qu'il reste des places pour les stages #GirlsCanCode en août et septembre.
C'est gratuit et vraiment top. Mes aînées les ont fait en 2018 et 2022, là je viens d'inscrire fille n°3 et elle est ravie.
girlscancode.fr
C'est gratuit et vraiment top. Mes aînées les ont fait en 2018 et 2022, là je viens d'inscrire fille n°3 et elle est ravie.
girlscancode.fr
Very happy to see this out! authors.elsevier.com/a/1lSNA3SNvc...
We built upon DANCE dataset to predict protein motions directly from sequences, without exploiting 3D structures! Code: github.com/PhyloSofS-Te....
We built upon DANCE dataset to predict protein motions directly from sequences, without exploiting 3D structures! Code: github.com/PhyloSofS-Te....
July 18, 2025 at 7:52 PM
Very happy to see this out! authors.elsevier.com/a/1lSNA3SNvc...
We built upon DANCE dataset to predict protein motions directly from sequences, without exploiting 3D structures! Code: github.com/PhyloSofS-Te....
We built upon DANCE dataset to predict protein motions directly from sequences, without exploiting 3D structures! Code: github.com/PhyloSofS-Te....
Reposted by Elodie Laine
Very happy about this collective effort! We provide the community with variant effect predictions for the whole fly proteome. We validated them with annotations, population polymorphism, and CRISPR experiments. Check out your favorite protein with ProteoCast!
Happy to announce the latest preprint of PhD candidate Mariana Abakarova (not yet on bluesky) tinyurl.com/4ewd2v85 in co-supervision with Prof. @laineelodie.bsky.social @sorbonne-universite.fr / @upariscite
tinyurl.com/2ntnfvw3
Funded by @agencerecherche.bsky.social ADAGIO and @erc.europa.eu PROMISE
tinyurl.com/2ntnfvw3
Funded by @agencerecherche.bsky.social ADAGIO and @erc.europa.eu PROMISE
Proteome-wide prediction of the Functional Impact of Missense Variants with ProteoCast
Background: Dissecting the functional impact of genetic mutations is essential to advancing our understanding of genotype-phenotype relationships and identifying new therapeutic targets. Despite the p...
www.biorxiv.org
February 18, 2025 at 2:07 PM
Very happy about this collective effort! We provide the community with variant effect predictions for the whole fly proteome. We validated them with annotations, population polymorphism, and CRISPR experiments. Check out your favorite protein with ProteoCast!
Reposted by Elodie Laine
A little discussion with @pierrepo.bsky.social about our MDverse project and its future with the @lumen-eu.bsky.social project (in French).
"MDverse, un projet pour explorer les données de la dynamique moléculaire"
www.inc.cnrs.fr/fr/cnrsinfo/...
"MDverse, un projet pour explorer les données de la dynamique moléculaire"
www.inc.cnrs.fr/fr/cnrsinfo/...
MDverse, un projet pour explorer les données de la dynamique moléculaire
Et s’il était possible de réutiliser les données issues de simulations de dynamique moléculaire pour limiter l’usage des supercalculateurs ?
www.inc.cnrs.fr
February 17, 2025 at 5:46 PM
A little discussion with @pierrepo.bsky.social about our MDverse project and its future with the @lumen-eu.bsky.social project (in French).
"MDverse, un projet pour explorer les données de la dynamique moléculaire"
www.inc.cnrs.fr/fr/cnrsinfo/...
"MDverse, un projet pour explorer les données de la dynamique moléculaire"
www.inc.cnrs.fr/fr/cnrsinfo/...
Reposted by Elodie Laine
I have two open postdoctoral researcher positions in my group. I am looking for applicants with interest and expertise in computational structural biology and research software development. These positions are part of GANANA, a collaborative European/Indian project Check www.uu.nl/en/organisat...
Postdoc position in computational structural biology
Join our team and contribute to the development of HADDOCK, our integrative modelling software, as part of an exciting EU-India research collaboration.
www.uu.nl
February 14, 2025 at 6:01 PM
I have two open postdoctoral researcher positions in my group. I am looking for applicants with interest and expertise in computational structural biology and research software development. These positions are part of GANANA, a collaborative European/Indian project Check www.uu.nl/en/organisat...
Reposted by Elodie Laine
Excited to share our latest preprint evaluating AlphaFold3, Boltz-1, Chai-1 and Protenix for predicting protein-ligand interactions, featuring our newly introduced benchmark dataset 🌹Runs N’ Poses🌹!
www.biorxiv.org/content/10.1...
🧵👇 (1/n)
www.biorxiv.org/content/10.1...
🧵👇 (1/n)
Have protein-ligand co-folding methods moved beyond memorisation?
Deep learning has driven major breakthroughs in protein structure prediction, however the next critical advance is accurately predicting how proteins interact with other molecules, especially small mo...
www.biorxiv.org
February 8, 2025 at 10:02 AM
Excited to share our latest preprint evaluating AlphaFold3, Boltz-1, Chai-1 and Protenix for predicting protein-ligand interactions, featuring our newly introduced benchmark dataset 🌹Runs N’ Poses🌹!
www.biorxiv.org/content/10.1...
🧵👇 (1/n)
www.biorxiv.org/content/10.1...
🧵👇 (1/n)
Reposted by Elodie Laine
Cryptic pockets are hidden binding sites in proteins that are not visible in their standard ("apo") structure and only stable in the presence of the right ligand.
Here, Bemelmans et al. review how scientists use computer algorithms to detect them.
www.sciencedirect.com/science/arti...
🧪 #CompChem
Here, Bemelmans et al. review how scientists use computer algorithms to detect them.
www.sciencedirect.com/science/arti...
🧪 #CompChem
Computational advances in discovering cryptic pockets for drug discovery
A number of promising therapeutic target proteins have been considered “undruggable” due to the lack of well-defined ligandable pockets. Substantial r…
www.sciencedirect.com
January 8, 2025 at 1:00 PM
Cryptic pockets are hidden binding sites in proteins that are not visible in their standard ("apo") structure and only stable in the presence of the right ligand.
Here, Bemelmans et al. review how scientists use computer algorithms to detect them.
www.sciencedirect.com/science/arti...
🧪 #CompChem
Here, Bemelmans et al. review how scientists use computer algorithms to detect them.
www.sciencedirect.com/science/arti...
🧪 #CompChem
Reposted by Elodie Laine
The Rosetta Commons Research Experience for Undergraduates (REU) program accepts applications until February 1, 2025. Apply now and participate in research using the Rosetta Commons software. Learn more here: rosettacommons.org/education/reu/
#REU #RosettaCommons #Undergraduateprogram
#REU #RosettaCommons #Undergraduateprogram
January 8, 2025 at 5:50 PM
The Rosetta Commons Research Experience for Undergraduates (REU) program accepts applications until February 1, 2025. Apply now and participate in research using the Rosetta Commons software. Learn more here: rosettacommons.org/education/reu/
#REU #RosettaCommons #Undergraduateprogram
#REU #RosettaCommons #Undergraduateprogram
Curious about alternative splicing? Kick off the year with our latest review in COSB! authors.elsevier.com/sd/article/S...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
January 7, 2025 at 12:20 PM
Curious about alternative splicing? Kick off the year with our latest review in COSB! authors.elsevier.com/sd/article/S...
Reposted by Elodie Laine
🧪 Got a curious 7–11 year-old at home? 🔍 Whether they’re wondering how yeast grows or want to craft some red blood cells, the new Crick Kids website has them covered! 🎉
Discover fun science activities, hands-on experiments, and lots of quizzes 🧬👩🔬🔬
👉 Check it out here: kids.crick.ac.uk
Discover fun science activities, hands-on experiments, and lots of quizzes 🧬👩🔬🔬
👉 Check it out here: kids.crick.ac.uk
Home
We’ve got loads of science experiments, quizzes and crafts for kids and families. Get exploring and see what you discover on Crick Kids.
kids.crick.ac.uk
January 2, 2025 at 5:48 PM
🧪 Got a curious 7–11 year-old at home? 🔍 Whether they’re wondering how yeast grows or want to craft some red blood cells, the new Crick Kids website has them covered! 🎉
Discover fun science activities, hands-on experiments, and lots of quizzes 🧬👩🔬🔬
👉 Check it out here: kids.crick.ac.uk
Discover fun science activities, hands-on experiments, and lots of quizzes 🧬👩🔬🔬
👉 Check it out here: kids.crick.ac.uk
Reposted by Elodie Laine
🚨 I am super happy to announce that our analysis of how the structure of protein-RNA interfaces evolves is now published (early access) at @plos.bsky.social Computational Biology:
doi.org/10.1371/jour...
🧬🧶
doi.org/10.1371/jour...
🧬🧶
December 3, 2024 at 10:03 PM
🚨 I am super happy to announce that our analysis of how the structure of protein-RNA interfaces evolves is now published (early access) at @plos.bsky.social Computational Biology:
doi.org/10.1371/jour...
🧬🧶
doi.org/10.1371/jour...
🧬🧶
Reposted by Elodie Laine
#ICYMI: In a Science study, researchers present “Evo”—a #MachineLearning model capable of decoding and designing DNA, RNA, and protein sequences, from molecular to genome scale, with unparalleled accuracy.
Learn more: scim.ag/41bmK6u
Learn more: scim.ag/41bmK6u
December 3, 2024 at 9:26 PM
#ICYMI: In a Science study, researchers present “Evo”—a #MachineLearning model capable of decoding and designing DNA, RNA, and protein sequences, from molecular to genome scale, with unparalleled accuracy.
Learn more: scim.ag/41bmK6u
Learn more: scim.ag/41bmK6u
Reposted by Elodie Laine
Chai-1, the open source AF3 clone, is now available with an Apache 2 license github.com/chaidiscover...
November 27, 2024 at 4:58 PM
Chai-1, the open source AF3 clone, is now available with an Apache 2 license github.com/chaidiscover...
Reposted by Elodie Laine
Here is the graphical summary of our findings that helped us to engineer new variants of the protein AstaP that are 51 amino acid shorter than WT yet soluble, express well and bind and transfer carotenoids
November 18, 2024 at 4:17 PM
Here is the graphical summary of our findings that helped us to engineer new variants of the protein AstaP that are 51 amino acid shorter than WT yet soluble, express well and bind and transfer carotenoids
Very happy to introduce VespaG, for ultra-fast and accurate prediction of protein mutational effects. github.com/JSchlensok/V.... Big thanks to all authors for the great work and effort. Exciting collab with Rost lab! www.biorxiv.org/content/10.1...
VespaG: Expert-guided protein Language Models enable accurate and blazingly fast fitness prediction
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
May 1, 2024 at 4:55 PM
Very happy to introduce VespaG, for ultra-fast and accurate prediction of protein mutational effects. github.com/JSchlensok/V.... Big thanks to all authors for the great work and effort. Exciting collab with Rost lab! www.biorxiv.org/content/10.1...
Making protein movies from (sparse) static snapshots! Try out ou method DANCE: github.com/PhyloSofS-Te.... And our PDB-wide analysis of protein conformational variability: www.biorxiv.org/content/10.1.... Joint work with Valentin Lombard and Sergei Grudinin.
February 10, 2024 at 3:00 PM
Making protein movies from (sparse) static snapshots! Try out ou method DANCE: github.com/PhyloSofS-Te.... And our PDB-wide analysis of protein conformational variability: www.biorxiv.org/content/10.1.... Joint work with Valentin Lombard and Sergei Grudinin.
Reposted by Elodie Laine
"Cerebra: a computationally efficient framework for accurate protein structure prediction" presents a structure module without invariant point attention, used in almost all protein structure prediction networks so far (with the notable exception of RosettaFold)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 8, 2024 at 5:55 AM
"Cerebra: a computationally efficient framework for accurate protein structure prediction" presents a structure module without invariant point attention, used in almost all protein structure prediction networks so far (with the notable exception of RosettaFold)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Elodie Laine
Join the RCSB PDB Team and transform research and education around the world
Open positions include Data Science Workflows Architect, Backend Software Engineer, Senior Front-End Web Developer, and more
Details at RCSB PDB: www.rcsb.org/pages/jobs
Open positions include Data Science Workflows Architect, Backend Software Engineer, Senior Front-End Web Developer, and more
Details at RCSB PDB: www.rcsb.org/pages/jobs
RCSB PDB: Join the RCSB PDB Team
The RCSB PDB creates tools and resources for research. Participate in exciting projects with significant impact on the scientific community.
www.rcsb.org
January 6, 2024 at 6:11 PM
Join the RCSB PDB Team and transform research and education around the world
Open positions include Data Science Workflows Architect, Backend Software Engineer, Senior Front-End Web Developer, and more
Details at RCSB PDB: www.rcsb.org/pages/jobs
Open positions include Data Science Workflows Architect, Backend Software Engineer, Senior Front-End Web Developer, and more
Details at RCSB PDB: www.rcsb.org/pages/jobs
Reposted by Elodie Laine
1/n I'm thrilled to share *Deep generative modelling of the human proteome reveals over a hundred novel genes involved in rare genetic disorders* t.co/DoN4DrSFbS from a wonderful collaboration between the Marks Lab and Dias and Frazer group, with @roseorenbuch as lead! 🧵:
November 28, 2023 at 9:16 PM
1/n I'm thrilled to share *Deep generative modelling of the human proteome reveals over a hundred novel genes involved in rare genetic disorders* t.co/DoN4DrSFbS from a wonderful collaboration between the Marks Lab and Dias and Frazer group, with @roseorenbuch as lead! 🧵:
Reposted by Elodie Laine
New in Science with @jaescudero.bsky.social . A combinatorially complete fitness landscape with >260.000 E.coli genotypes shows unexpected properties. Despite ~500 fitness peaks in this landscape, adaptive evolution can easily navigate to highest fitness peaks www.science.org/doi/10.1126/...
A rugged yet easily navigable fitness landscape
A high number of genetic fitness peaks does not impair adaptive evolution in a large empirical fitness landscape.
www.science.org
November 24, 2023 at 1:29 PM
New in Science with @jaescudero.bsky.social . A combinatorially complete fitness landscape with >260.000 E.coli genotypes shows unexpected properties. Despite ~500 fitness peaks in this landscape, adaptive evolution can easily navigate to highest fitness peaks www.science.org/doi/10.1126/...