Raffaella De Pace
@depaceraffa.bsky.social
Staff Scientist
Currently at NIH/NICHD, Bonifacino Lab
Neurobiology-Cell Biology-Intracellular Trafficking. The views expressed in this account are mine alone.
Currently at NIH/NICHD, Bonifacino Lab
Neurobiology-Cell Biology-Intracellular Trafficking. The views expressed in this account are mine alone.
Reposted by Raffaella De Pace
🚨🚨🚨 Please repost
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...
September 8, 2025 at 3:15 PM
🚨🚨🚨 Please repost
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...
Reposted by Raffaella De Pace
BLOC-1 and BORC: Complex regulators of endolysosomal dynamics http://dlvr.it/TN9mpn
September 19, 2025 at 5:31 PM
BLOC-1 and BORC: Complex regulators of endolysosomal dynamics http://dlvr.it/TN9mpn
Reposted by Raffaella De Pace
Thank you, @mishtudey.bsky.social and @cp-cellchembiol.bsky.social for featuring this interview with @depaceraffa.bsky.social and Chad Williamson in connection to our article on BLOC-1 and BORC dlvr.it/TN9mpn
Meet the authors: Raffaella De Pace, Chad Williamson, and Juan Bonifacino http://dlvr.it/TN9cVw
September 21, 2025 at 4:26 PM
Thank you, @mishtudey.bsky.social and @cp-cellchembiol.bsky.social for featuring this interview with @depaceraffa.bsky.social and Chad Williamson in connection to our article on BLOC-1 and BORC dlvr.it/TN9mpn
Reposted by Raffaella De Pace
Job ad is here! Check it out :)
April 16, 2025 at 6:09 PM
Job ad is here! Check it out :)
Reposted by Raffaella De Pace
👉 New publication ahead of print from our lab: tinyurl.com/ye7pntte
We show that the protein SPG21, mutated in hereditary spastic paraplegia 21, localizes to endolysosomes via RAB7A, where it promotes mTORC1-dependent TFEB phosphorylation, reducing expression of a subset of TFEB regulated genes
We show that the protein SPG21, mutated in hereditary spastic paraplegia 21, localizes to endolysosomes via RAB7A, where it promotes mTORC1-dependent TFEB phosphorylation, reducing expression of a subset of TFEB regulated genes
August 21, 2025 at 6:03 PM
👉 New publication ahead of print from our lab: tinyurl.com/ye7pntte
We show that the protein SPG21, mutated in hereditary spastic paraplegia 21, localizes to endolysosomes via RAB7A, where it promotes mTORC1-dependent TFEB phosphorylation, reducing expression of a subset of TFEB regulated genes
We show that the protein SPG21, mutated in hereditary spastic paraplegia 21, localizes to endolysosomes via RAB7A, where it promotes mTORC1-dependent TFEB phosphorylation, reducing expression of a subset of TFEB regulated genes
Reposted by Raffaella De Pace
New from @depaceraffa.bsky.social from our lab #NICHD #NIH in collaboration with Adeline Vanderver @childrensphila.bsky.social and colleagues reporting mutations in the BLOC1S1 subunit of the BLOC-1 and BORC complexes in children with a neurodevelopmental disorder www.medrxiv.org/content/10.1...
August 24, 2025 at 2:37 PM
New from @depaceraffa.bsky.social from our lab #NICHD #NIH in collaboration with Adeline Vanderver @childrensphila.bsky.social and colleagues reporting mutations in the BLOC1S1 subunit of the BLOC-1 and BORC complexes in children with a neurodevelopmental disorder www.medrxiv.org/content/10.1...
Reposted by Raffaella De Pace
Happy to share an exciting study from Yihong Ye’s lab at NIH, with a minor contribution from our lab: ceroid lipofuscinosis-4 (CLN4)-linked DNAJC5 mutations cause lysosomal damage as a driver of neurodegeneration in iPSC-derived neurons. CHIP safeguards lysosomes via microautophagy 👉 rdcu.be/eChof
CHIP protects lysosomes from CLN4 mutant-induced membrane damage
Nature Cell Biology - Lee et al. use an aggregation-prone CLN4 mutant that causes lysosomal damage in neurons and show that in non-neurons, the ubiquitin ligase CHIP prevents CLN4-dependent...
rdcu.be
August 25, 2025 at 1:23 PM
Happy to share an exciting study from Yihong Ye’s lab at NIH, with a minor contribution from our lab: ceroid lipofuscinosis-4 (CLN4)-linked DNAJC5 mutations cause lysosomal damage as a driver of neurodegeneration in iPSC-derived neurons. CHIP safeguards lysosomes via microautophagy 👉 rdcu.be/eChof
Reposted by Raffaella De Pace
Excited to share our new review with @depaceraffa.bsky.social, @saikat2025.bsky.social, and Chad Williamson on the BLOC-1 and BORC complexes—key regulators of endolysosomal processes and linked to several genetic diseases. #NIH #Lysosomes #RareDiseases authors.elsevier.com/a/1lg4i8jWWJ...
August 26, 2025 at 3:30 PM
Excited to share our new review with @depaceraffa.bsky.social, @saikat2025.bsky.social, and Chad Williamson on the BLOC-1 and BORC complexes—key regulators of endolysosomal processes and linked to several genetic diseases. #NIH #Lysosomes #RareDiseases authors.elsevier.com/a/1lg4i8jWWJ...
🚨 Exciting postdoc opportunity in @juanbonifacino.bsky.social lab!! If you have a passion for protein trafficking and neurodevelopmental disorders, and want to join a dynamic and collaborative team consider applying! Positions will be available starting in October.🍁🍂
Our lab at the NIH (Bethesda, MD) is looking for postdoctoral fellows to join our team studying the molecular mechanisms of protein trafficking and their links to neurodevelopmental disorders starting on or after 10-1-2025. Send your application to juan.bonifacino@nih.gov. Please share and repost!
April 14, 2025 at 11:34 AM
🚨 Exciting postdoc opportunity in @juanbonifacino.bsky.social lab!! If you have a passion for protein trafficking and neurodevelopmental disorders, and want to join a dynamic and collaborative team consider applying! Positions will be available starting in October.🍁🍂
Reposted by Raffaella De Pace
I’m so excited to organize the #Lysosomes Subgroup at @ASCBiology 2024 meeting on Sunday, Dec. 15 at 3:15pm, Room 33B.
Lysosomes naturally lend themselves to puns. So…Don’t be 𝒃𝒂𝒔𝒊𝒄. Join us for fresh, 𝒄𝒖𝒕𝒕𝒊𝒏𝒈-edge talks and puntastic times. It will 𝒆𝒂𝒕 𝒂𝒕 𝒚𝒐𝒖 if you miss it.
Lysosomes naturally lend themselves to puns. So…Don’t be 𝒃𝒂𝒔𝒊𝒄. Join us for fresh, 𝒄𝒖𝒕𝒕𝒊𝒏𝒈-edge talks and puntastic times. It will 𝒆𝒂𝒕 𝒂𝒕 𝒚𝒐𝒖 if you miss it.
December 5, 2024 at 12:14 AM
I’m so excited to organize the #Lysosomes Subgroup at @ASCBiology 2024 meeting on Sunday, Dec. 15 at 3:15pm, Room 33B.
Lysosomes naturally lend themselves to puns. So…Don’t be 𝒃𝒂𝒔𝒊𝒄. Join us for fresh, 𝒄𝒖𝒕𝒕𝒊𝒏𝒈-edge talks and puntastic times. It will 𝒆𝒂𝒕 𝒂𝒕 𝒚𝒐𝒖 if you miss it.
Lysosomes naturally lend themselves to puns. So…Don’t be 𝒃𝒂𝒔𝒊𝒄. Join us for fresh, 𝒄𝒖𝒕𝒕𝒊𝒏𝒈-edge talks and puntastic times. It will 𝒆𝒂𝒕 𝒂𝒕 𝒚𝒐𝒖 if you miss it.
Reposted by Raffaella De Pace
This post is about a commentary that I wrote with Xin Yong about recognition of cargo vesicles by tethering factors involved in endosomes to TGN retrograde transport.
November 19, 2024 at 11:34 PM
This post is about a commentary that I wrote with Xin Yong about recognition of cargo vesicles by tethering factors involved in endosomes to TGN retrograde transport.
Reposted by Raffaella De Pace
Kudos to authors Morié Ishida, Adriana Golding, @TalKerenKaplan @NICHD_NIH and our collaborators Tamas Balla @NICHD_NIH and Yan Li @NIH_NINDS! Great teamwork!
November 23, 2024 at 1:32 PM
Kudos to authors Morié Ishida, Adriana Golding, @TalKerenKaplan @NICHD_NIH and our collaborators Tamas Balla @NICHD_NIH and Yan Li @NIH_NINDS! Great teamwork!
Reposted by Raffaella De Pace
Excited to share our latest findings on how the phosphoinositide PI4P pool at the trans-Golgi network (TGN) is regulated through a SYS1-ARFRP1-ARL5-ARMH3-PI4KB pathway, in which ARMH3 (also known as C10orf76) acts as an ARL5 effector to activate PI4KB. rdcu.be/d1dZ2
November 23, 2024 at 1:32 PM
Excited to share our latest findings on how the phosphoinositide PI4P pool at the trans-Golgi network (TGN) is regulated through a SYS1-ARFRP1-ARL5-ARMH3-PI4KB pathway, in which ARMH3 (also known as C10orf76) acts as an ARL5 effector to activate PI4KB. rdcu.be/d1dZ2
Reposted by Raffaella De Pace
Reposting @yousufakhan.bsky.social reference to a preprint demonstrating that programmed ribosomal frameshifting generates a PLEKHM2 proteoform that behaves as a constitutively active adaptor for ARL8-dependent coupling of lysosomes to kinesin-1, with collaboration from our lab tinyurl.com/mtrkzdrm
November 23, 2024 at 6:49 PM
Reposting @yousufakhan.bsky.social reference to a preprint demonstrating that programmed ribosomal frameshifting generates a PLEKHM2 proteoform that behaves as a constitutively active adaptor for ARL8-dependent coupling of lysosomes to kinesin-1, with collaboration from our lab tinyurl.com/mtrkzdrm